Disintegration tester for drug detection

Abstract

The utility model discloses a disintegration tester for medicine detection, which relates to the technical field of equipment for medicine detection, and is characterized by comprising a disintegration tester body, a transparent placing frame is arranged on the surface of the front side of the disintegration tester body, and three groups of magnetic stirring and heating mechanisms are arranged at the bottom of an inner cavity of the transparent placing frame; and three groups of medicine disintegration experiment mechanisms located above the magnetic stirring and heating mechanism are placed in the transparent placing frame. The three groups of magnetic stirring and heating mechanisms are arranged in the disintegration instrument and are matched with the magnetic rotor in the beaker, so that the effects of solution flowing and heating can be achieved in a medicine disintegration process, and the real disintegration condition of the medicine in intestines and stomach is simulated; meanwhile, 8-12 miniature cameras in an annular array are arranged on the periphery of the beaker for medicine disintegration, so that medicine disintegration pictures can be transmitted to a display panel in real time, and the situation that details of medicine disintegration are ignored due to visual inspection is avoided.

Description

Technical Field

[0001] This utility model relates to the technical field of equipment for drug detection, and more specifically, to a disintegration device for drug detection. Background Technology

[0002] A disintegration apparatus is an instrument used to test the disintegration time of solid dosage forms such as tablets, sugar-coated tablets, film-coated tablets, enteric-coated tablets, extract tablets, and capsules. Currently, disintegration apparatuses often place the drug in a disintegration solution to dissolve naturally during disintegration experiments. However, they cannot replicate the flow of gastric juices or the body temperature environment of the gastrointestinal tract, leading to discrepancies between the reported disintegration time and the actual disintegration time after administration. Furthermore, since the drug disintegration process is primarily observed visually, the details and processes of disintegration cannot be recorded or clearly observed.

[0003] Therefore, this application aims to design and provide a disintegration device for drug detection to solve the above-mentioned problems. Utility Model Content

[0004] The purpose of this invention is to address the shortcomings of existing technologies by providing a disintegration device for drug testing, thereby solving the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] A disintegration apparatus for drug testing includes a disintegration apparatus body, a transparent placement frame on the front surface of the disintegration apparatus body, three sets of magnetic stirring and heating mechanisms at the bottom of the inner cavity of the transparent placement frame, and three sets of drug disintegration experimental mechanisms located above the magnetic stirring and heating mechanisms placed inside the transparent placement frame.

[0007] The disintegration device is equipped with a display panel on the top front side of its body;

[0008] The top surface of the transparent placement frame has three beaker slots for inserting the drug disintegration test mechanism;

[0009] Each of the magnetic stirring and heating mechanisms includes three outer shells fixed to the bottom side wall of the inner cavity of the transparent placement frame, a magnetic coil fixed in the inner cavity of the outer shell, and a cover panel fixedly connected to the upper and lower end faces of the outer shell, and a stainless steel heating plate is provided on the upper surface of the top cover panel.

[0010] The drug disintegration test mechanism includes a beaker placed on the upper surface of a stainless steel heating plate, a lifting rod located above the beaker, and a ring located around the outer edge of the beaker. A neodymium iron boron permanent magnet stirring rotor is provided on the bottom side wall of the inner cavity of the beaker. A tray is connected to the bottom end of the lifting rod. 5-6 mesh cylinders are inserted and snapped into the inside of the tray in a ring array. The end of the lifting rod away from the tray is connected to the lifting end of the disintegration instrument body.

[0011] The inner part of the ring is inlaid with 8-12 miniature cameras in a circular array, and the camera ends of the miniature cameras are all facing the beaker.

[0012] Furthermore, each of the four corners of the bottom surface of the disintegration device body is fixedly connected to a foot, and a platform is fixedly attached to the bottom of the front surface of the disintegration device body. The bottom surface of the transparent placement frame is fixedly connected to the upper surface of the platform.

[0013] Furthermore, the port edges of the beaker latch are respectively engaged and contacted with the outer edge of the beaker port.

[0014] Furthermore, the bottom end face of the beaker is in contact with the upper heating end face of the stainless steel heating plate.

[0015] Furthermore, the tray has 5-6 placement holes arranged in a circular array inside.

[0016] Furthermore, a circular frame is fixedly connected to the outer ring of the top port of the mesh cylinder, and the outer diameter of the circular frame is larger than the inner diameter of the placement hole.

[0017] Furthermore, the inner cavity of the mesh tube contains the drug to be tested for disintegration.

[0018] Furthermore, a connecting rod is fixed to the rear end face of each ring, and the rear end of the connecting rod is fixedly connected to the inner cavity side wall of the transparent placement frame.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] In this invention, three sets of magnetic stirring and heating mechanisms are designed inside the disintegrator, and rely on the magnetic rotor in the beaker to cooperate with them to achieve the effect of solution flow and heating during the drug disintegration process, thereby simulating the real situation of drug disintegration in the gastrointestinal tract; at the same time, 8-12 miniature cameras are designed in a ring array around the beaker of drug disintegration, so that the drug disintegration scene can be transmitted to the display panel in real time, which can avoid the situation of ignoring the details of drug disintegration by visual observation. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the overall structure of the disintegration device in this utility model;

[0022] Figure 2 This is a schematic diagram of the transparent placement frame of the disintegration device in this utility model after being cut open;

[0023] Figure 3 This is a schematic diagram of the magnetic stirring and heating mechanism of the disintegration apparatus in this utility model;

[0024] Figure 4 This is a schematic diagram of the drug disintegration experimental mechanism of the disintegration apparatus in this utility model.

[0025] The component markings in the attached diagram are as follows:

[0026] 1. Disintegration apparatus body; 2. Transparent placement frame; 3. Magnetic stirring and heating mechanism; 31. Outer shell; 32. Cover panel; 33. Stainless steel heating plate; 34. Magnetic coil; 4. Drug disintegration experimental mechanism; 41. Beaker; 42. Neodymium iron boron permanent magnet stirring rotor; 43. Tray; 44. Lifting rod; 45. Circular frame; 46. Mesh tube; 47. Placement hole; 48. Connecting rod; 49. Ring; 410. Miniature camera; 5. Beaker bayonet; 6. Display panel. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0028] The specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings and several examples.

[0029] Example 1: Overall Device Structure Design

[0030] See Figure 1-4 As shown in the figure, the disintegration apparatus for drug detection provided by this utility model mainly consists of an apparatus body 1, a transparent placement frame 2, three sets of magnetic stirring and heating mechanisms 3, and a drug disintegration experimental mechanism 4. The design and arrangement of these components aim to simulate gastrointestinal motility during drug disintegration and enhance observation during the drug disintegration process, making it particularly suitable for operations in the disintegration detection of experimental or clinical drugs. Details are as follows:

[0031] Disintegration apparatus body 1: The disintegration apparatus body 1 adopts a drug disintegration apparatus that meets the requirements of the Pharmacopoeia of the People's Republic of China; and a display panel 6 is provided on the top front side of the disintegration apparatus body 1. Each of the four corners of the bottom surface of the disintegration apparatus body 1 is fixedly connected to a foot. A platform is fixedly provided on the bottom front surface of the disintegration apparatus body 1. The bottom surface of the transparent placement frame 2 is fixedly connected to the upper surface of the platform.

[0032] Transparent placement frame 2: The top surface of the transparent placement frame 2 has 3 beaker slots 5 for inserting the drug disintegration test mechanism 4; and the port edges of the beaker slots 5 respectively engage with the outer edge of the port of the beaker 41. The function of the beaker slots 5 is to keep the beaker 41 stable while allowing the bottom of the beaker 41 to contact the heating end face of the stainless steel heating plate 33, thereby heating and controlling the temperature of the drug and disintegration solution inside the beaker 41.

[0033] Magnetic stirring and heating mechanism 3: Each magnetic stirring and heating mechanism 3 includes three outer shells 31 fixed on the bottom side wall of the inner cavity of the transparent placement frame 2, magnetic coils 34 fixed in the inner cavity of the outer shells 31, and cover panels 32 fixedly connected to the upper and lower end faces of the outer shells 31. A stainless steel heating plate 33 is provided on the upper surface of the top cover panel 32.

[0034] Drug disintegration test apparatus 4: Drug disintegration test apparatus 4 includes a beaker 41 placed on the upper surface of a stainless steel heating plate 33, a lifting rod 44 located above the beaker 41, and a ring 49 located around the outer circumference of the beaker 41. A neodymium iron boron permanent magnet stirring rotor 42 is provided on the bottom side wall of the inner cavity of the beaker 41. The bottom end of the lifting rod 44 is connected to a tray 43. The inside of the tray 43 is fitted with 5-6 mesh cylinders 46 in a ring array. The end of the lifting rod 44 away from the tray 43 is connected to the lifting end of the disintegration instrument body 1. The inside of the ring 49 is inlaid with 8-12 miniature cameras 410 in a ring array. The camera ends of the miniature cameras 410 are all facing the beaker 41.

[0035] The bottom end face of beaker 41 is in contact with the upper surface heating end face of stainless steel heating plate 33. The inside of tray 43 has 5-6 placement holes 47 arranged in a ring array. The top port of mesh tube 46 is fixedly connected to a circular frame 45, and the outer diameter of the circular frame 45 is larger than the inner diameter of the placement hole 47. The inner cavity of mesh tube 46 contains the drug to be disintegrated. A connecting rod 48 is fixedly attached to the rear end face of ring 49. The rear end of the connecting rod 48 is fixedly connected to the inner cavity side wall of transparent placement frame 2.

[0036] Example 2: Usage Method

[0037] See Figure 1-4 As shown, to make the disintegration device more convenient and effective to use, the following are detailed usage steps:

[0038] Preparation: Place the drug (capsule, tablet, pill) to be disintegrated into the mesh tube 46, and put the disintegration solution into the beaker 41. Use the stainless steel heating plate 33 to heat the disintegration solution in the beaker 41 and keep the temperature between 35℃ and 37℃.

[0039] When the mesh tube 46 is placed into the placement hole 47, after the disintegrator body 1 drives the lifting rod 44 and the tray 43 to descend, the mesh tube 46 inside the placement hole 47 will carry the drug into the beaker 41.

[0040] After the drug inside the mesh cylinder 46 is soaked in the disintegration solution, it begins to disintegrate. At this time, the magnetic coil 34 controls the neodymium iron boron permanent magnet stirring rotor 42 inside the beaker 41 to rotate slowly and uniformly, thereby stirring the disintegration solution inside the beaker 41, simulating the environment in which the drug is agitated by gastric juice and affected by body temperature in the stomach and intestines.

[0041] During the process of drug disintegration inside the mesh tube 46, multiple sets of miniature cameras 410 on the periphery of the beaker 41 will record from multiple angles of the beaker 41, thereby recording the entire process and details of drug disintegration.

[0042] After the drug has disintegrated, the mesh tube 46 is lifted out of the beaker 41 again by lifting rod 44.

[0043] Example 3: Materials and Manufacturing Process

[0044] See Figure 1-4 As shown, the material selection for transparent placement frame 2 is as follows:

[0045] The transparent placement frame 2 can be made of acrylic, ordinary glass, or ultra-clear glass. Without affecting the transparency of the transparent placement frame 2 so that the interior of the transparent placement frame 2 can be observed, the transparent placement frame 2 also has a protective function.

[0046] Beaker 41 Materials:

[0047] Beaker 41 is made of heat-resistant glass, which ensures that beaker 41 has light transmittance while preventing beaker 41 from cracking due to the heating of beaker 41 by stainless steel heating plate 33.

[0048] Selection of the Miniature Camera 410:

[0049] The miniature camera 410 uses a medical pinhole camera or a miniature high-definition camera.

[0050] Example 4: Real-world application scenario

[0051] This disintegration apparatus is suitable for use in disintegration experiments of drugs in clinical or laboratory stages, including capsules, tablets, and pills. Through the cooperation of the magnetic stirring and heating mechanism 3 and the drug disintegration experimental mechanism 4, it can accurately simulate the disintegration environment of drugs in the gastrointestinal tract and record the entire drug disintegration process.

[0052] The contents not described in detail in this description are existing technologies known to those skilled in the art. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A disintegration apparatus for drug testing, comprising an apparatus body (1), characterized in that, The front surface of the disintegration apparatus body (1) is provided with a transparent placement frame (2), and the bottom of the inner cavity of the transparent placement frame (2) is provided with three sets of magnetic stirring and heating mechanisms (3). Inside the transparent placement frame (2) are three sets of drug disintegration experimental mechanisms (4) located above the magnetic stirring and heating mechanisms (3). The disintegration device body (1) is provided with a display panel (6) on the top front side; The top surface of the transparent placement frame (2) is provided with three beaker slots (5) for the drug disintegration test mechanism (4) to be inserted; The magnetic stirring heating mechanism (3) includes three outer shells (31) fixed on the bottom side wall of the inner cavity of the transparent placement frame (2), a magnetic coil (34) fixed in the inner cavity of the outer shell (31), and a cover panel (32) fixedly connected to the upper and lower end faces of the outer shell (31). A stainless steel heating plate (33) is provided on the upper surface of the top cover panel (32). The drug disintegration test mechanism (4) includes a beaker (41) placed on the upper surface of a stainless steel heating plate (33), a lifting rod (44) located above the beaker (41), and a ring (49) located around the outer ring of the beaker (41). A neodymium iron boron permanent magnet stirring rotor (42) is provided on the bottom side wall of the inner cavity of the beaker (41). The bottom end of the lifting rod (44) is connected to a tray (43). The tray (43) has 5-6 mesh cylinders (46) inserted and snapped into the interior in a ring array. The end of the lifting rod (44) away from the tray (43) is connected to the lifting end of the disintegration instrument body (1). The inner part of the ring (49) is inlaid with 8-12 miniature cameras (410) in a ring array, and the camera ends of the miniature cameras (410) are all facing the beaker (41).

2. The disintegration apparatus for drug detection according to claim 1, characterized in that: The disintegration device body (1) has a foot fixedly connected to each of the four corners of its bottom surface. The bottom of the front surface of the disintegration device body (1) is fixedly connected to a platform. The bottom surface of the transparent placement frame (2) is fixedly connected to the upper surface of the platform.

3. The disintegration apparatus for drug detection according to claim 1, characterized in that: The port edge of the beaker bayonet (5) is engaged with the outer edge of the port of the beaker (41).

4. The disintegration apparatus for drug detection according to claim 1, characterized in that: The bottom end face of the beaker (41) is in contact with the upper surface heating end face of the stainless steel heating plate (33).

5. The disintegration apparatus for drug detection according to claim 1, characterized in that: The tray (43) has 5-6 placement holes (47) arranged in a ring array inside.

6. The disintegration apparatus for drug detection according to claim 1, characterized in that: The top port of the mesh tube (46) is fixedly connected to a circular frame (45), and the outer diameter of the circular frame (45) is larger than the inner diameter of the placement hole (47).

7. The disintegration apparatus for drug detection according to claim 1, characterized in that: The inner cavity of the mesh tube (46) contains the drug to be tested for disintegration.

8. The disintegration apparatus for drug detection according to claim 1, characterized in that: A connecting rod (48) is fixed on the rear end face of each ring (49), and the rear end of the connecting rod (48) is fixedly connected to the inner cavity side wall of the transparent placement frame (2).

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