Drug synthesis system
By using a plate centrifuge and an online pH meter in the drug synthesis system, the problems of insufficient pH detection and poor centrifugation separation effect in the prior art have been solved, achieving precise control of reaction conditions and improving product quality.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-09
- Publication Date
- 2026-03-27
AI Technical Summary
Existing drug synthesis processes lack means to monitor pH values in real time, making it difficult to control reaction conditions precisely. Furthermore, tubular centrifuges have poor separation efficiency, low material utilization, and issues such as material residue and insufficient equipment stability.
A flat-plate centrifuge is used instead of a tubular centrifuge, and an online pH meter is equipped to monitor the pH changes inside the tank in real time. Combined with an online temperature meter, the influence of temperature is eliminated, ensuring precise control of reaction conditions.
It improves product purity and performance, reduces target product loss, lowers maintenance costs and equipment vibration and noise, and extends equipment life.
Smart Images
Figure CN224040908U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the technical field of drug synthesis, especially to a drug synthesis system. BACKGROUND
[0002] In the field of drug synthesis, the existing synthesis process system includes key equipment such as modification tank, coupling tank and centrifuge.
[0003] The modification tank is mainly used for further modification reaction of the initially synthesized compound to change its chemical properties, improve its purity or endow it with specific functional groups. The modification tank usually has a stirring device, a heating or cooling system and a material adding port.
[0004] The coupling tank is used for intermolecular coupling reaction to connect different pharmacophores through coupling reaction to form drug molecules with specific biological activity. The coupling tank is also usually equipped with stirring, heating, cooling and material adding devices to ensure that the coupling reaction can be uniformly and efficiently carried out.
[0005] The main function of the centrifuge is to separate the mixture after reaction in the coupling tank. The separated solid can be further washed, dried and treated to obtain pure target product; and the separated liquid can be recycled, reused or further treated according to needs.
[0006] Generally, the synthesis reaction is first carried out in the modification tank and the coupling tank. After the completion of the modification reaction and the coupling reaction, the reaction mixture is transferred to the centrifuge for solid-liquid separation to obtain the target product and remove impurities.
[0007] In the synthesis process, the pH value in the modification tank and the coupling tank has a crucial influence on the reaction progress and product quality. However, the existing synthesis process system lacks effective means for real-time detection of pH value, and the operator cannot timely and accurately master the change of pH value in the tank, so as to accurately control the reaction conditions, which easily leads to incomplete reaction, increased side reaction and other quality problems, and finally affects the purity and performance of the product. In addition, the centrifuge is a tubular centrifuge, which has the problem of poor separation effect based on its structural characteristics, resulting in the loss of part of the target product with waste liquid, reducing the material utilization rate and the yield of the final product. At the same time, its complex pipeline design is easy to cause material residue and blockage, increasing the difficulty and cost of cleaning and maintenance, and the stability is insufficient during operation, which is easy to cause excessive vibration and noise, affecting the production environment and equipment life. SUMMARY
[0008] In view of the above problems, the utility model provides a drug synthesis system, aims at solving the technical problem of lacking effective means of real-time detection of pH value in the prior synthesis process system and defects of tubular centrifuge itself.
[0009] To achieve the above object, the utility model provides the following technical scheme:
[0010] The utility model provides a drug synthesis system, including the modification jar, the coupling jar and the flat plate type centrifuge which connect gradually, still include:
[0011] The cup body is through the upper and lower ends,
[0012] The base is used for plugging the lower end of the cup body, and the base is connected with the coupling jar or the modification jar through the discharge pipe,
[0013] The top cover is used for plugging the upper end of the cup body, and the base is connected with the coupling jar or the modification jar through the feeding pipe,
[0014] The fastener is used for fastening the base, the top cover and the cup body together,
[0015] The pH value on -line detector is used for measuring the pH value by potential determination,
[0016] The sealing assembly is arranged between the probe of the pH value on -line detector and the cup body,
[0017] The temperature on -line detector is installed on the top cover, and the probe of the temperature on -line detector is arranged close to the probe of the pH value on -line detector.
[0018] In some embodiments of the utility model, the sealing assembly includes:
[0019] The inner gasket is attached to the inner side of the cup body,
[0020] The outer gasket is attached to the outer side of the cup body,
[0021] The sleeve is through the inner gasket, one side of the cup body and the outer gasket, the probe of the pH value on -line detector is through the sleeve, and at least one first sealing ring is arranged between the sleeve and the probe, one end of the sleeve is located in the cup body and has a convex ring, one side of the convex ring is attached to the inner gasket, and a second sealing ring is arranged between the convex ring and the inner gasket,
[0022] The fastening ring is located outside the cup body and is threadedly connected with the outer wall of the sleeve.
[0023] In some embodiments of the utility model, the sealing assembly further includes a connecting rod, one end of the connecting rod is fixedly connected with the probe of the pH value on -line detector, and the other end is rotatably connected with the fastening ring.
[0024] In some embodiments of the utility model, the fastener includes screw rod and nut, one end of screw rod is connected with base, the other end is connected with nut after penetrating top cover.
[0025] In some embodiments of the utility model, multiple screw rods and nuts are distributed along the circumference of cup body.
[0026] In some embodiments of the utility model, feed pipe is connected with modification tank through pipeline pump.
[0027] In some embodiments of the utility model, cup body adopts transparent material.
[0028] In some embodiments of the utility model, cup body is provided with scale.
[0029] In some embodiments of the utility model, top cover adopts stainless steel material.
[0030] In some embodiments of the utility model, top cover is further connected with air jet pipe, the air outlet direction of air jet pipe is along the tangent direction of circumferential side of cup body.
[0031] The utility model embodiment has at least the following advantages or beneficial effects:
[0032] 1, replace the tubular centrifuge with the flat plate type centrifuge, overcome the shortcoming of the tubular centrifuge of the original adoption.
[0033] 2, a set of pH value detection device is designed newly, connect pH value detection device with coupling tank or modification tank, monitor the pH value change situation inside coupling tank or modification tank in real time, thereby convenient accurate control reaction condition, guarantee the purity and performance of product.
[0034] 3, through the temperature on - line detection instrument of setting, monitor the temperature of solution in cup body, can eliminate the influence of temperature sharp change to the inspection result.
[0035] The other features and advantages of the utility model will be described in the subsequent specification, and, partially become obvious from the specification, or be understood by implementing the utility model. DRAWINGS
[0036] In order to more clearly illustrate the technical scheme in the embodiment of the present application or prior art, the drawings needed in the embodiment description will be briefly introduced, obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained without creative labor according to these drawings.
[0037] Figure 1 It is the structural schematic diagram of drug synthesis system;
[0038] Figure 2 Structure diagram of pH detection device and coupling tank;
[0039] Figure 3 Structure diagram of pH detection device in Figure 2 Structure diagram of pH detection device in
[0040] Figure 4 Structure diagram of pH detection device in Figure 3 Local enlarged view of A position in
[0041] Figure:
[0042] 1-modification tank, 2-coupling tank, 3-flat plate centrifuge, 4-pH detection device,
[0043] 41-cup body, 42-bottom, 43-top cover, 441-screw rod, 442-nut, 45-pH online detector,
[0044] 46-sealing assembly, 461-inner gasket, 462-outer gasket, 463-sleeve, 464-fastening ring, 465-connecting rod, 466-first sealing ring, 467-second sealing ring, 468-convex ring,
[0045] 47-temperature online detector, 48-discharge pipe, 481-discharge valve, 49-feeding pipe, 491-feeding valve, 51-jet pipe, 511-jet valve, 52-pipeline pump. DETAILED DESCRIPTION
[0046] Hereinafter, only some exemplary embodiments are simply described. As can be appreciated by those skilled in the art, the described embodiments can be modified in various different ways without departing from the spirit or scope of the embodiments of the present application.
[0047] In the description of the embodiments of the present application, it is understood that the terms "center", "upper", "lower", "top", "bottom", "inner", "outer", "circumferential" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the embodiments of the present application and simplifying the description, and therefore cannot be understood as indicating or implying that the indicated device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the embodiments of the present application.
[0048] In addition, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features limited by "first", "second" can explicitly or implicitly include one or more of the features. In the description of the embodiments of the present application, the meaning of "multiple" is two or more, unless otherwise specifically limited.
[0049] In the embodiments of the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting", "fixing" and the like should be understood in a broad sense, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be directly connected, or it can be indirectly connected through an intermediate medium, it can be the communication or interaction relationship between two elements. For those skilled in the art, the specific meanings of the above terms in the embodiments of the present application can be understood according to the specific circumstances.
[0050] The embodiments of the present application will be described in detail below.
[0051] Embodiments
[0052] Referring to Figures 1-4 The present embodiment provides a drug synthesis system, comprising a modification tank 1, a coupling tank 2 and a centrifuge connected in sequence; the synthesis reaction is first carried out in the modification tank 1 and the coupling tank 2, and the reaction mixture obtained after the modification reaction and the coupling reaction are completed in turn is transferred to the centrifuge for solid-liquid separation to obtain the target product.
[0053] The centrifuge adopts a flat plate type centrifuge 3 to replace the tubular centrifuge, so as to overcome the shortcomings of the original tubular centrifuge. The flat plate type centrifuge 3 and the tubular centrifuge are both prior art. The flat plate type centrifuge 3 adopts a unique flat plate design, which can make the material be subjected to more uniform centrifugal force during the centrifugation process, effectively improve the separation efficiency, reduce the loss of the target product, improve the material utilization rate and product yield; simplify the internal structure, reduce the risk of material residue and blockage, and be more convenient for cleaning and maintenance, reduce the maintenance cost and equipment downtime; run more stably, effectively reduce vibration and noise, improve the production environment, and prolong the service life of the equipment.
[0054] The drug synthesis system further comprises a pH value detection device 4, and the pH value detection device 4 comprises a cup body 41, a base 42, a top cover 43, a fastener, a pH value on-line detector 45, a sealing assembly 46 and a temperature on-line detector 47.
[0055] The upper and lower ends of the cup body 41 are through, the cup body 41 adopts a transparent material, and a scale is arranged on the cup body 41.
[0056] The base 42 is used for plugging the lower end of the cup body 41, the center of the base 42 is connected with the top of the coupling tank 2 or the modification tank 1 through a discharge pipe 48, and a discharge valve 481 is arranged on the discharge pipe 48. The base 42 adopts a stainless steel material. The base 42 and the cup body 41 are sealed.
[0057] The top cover 43 is used to seal the upper end of the cup body 41. The center of the base 42 is connected with the top of the coupling tank 2 or the modification tank 1 through the feeding pipe 49, and the feeding valve 491 is arranged on the feeding pipe 49. The feeding pipe 49 is connected with the modification tank 1 through the pipe pump 52. The top cover 43 is made of stainless steel. The top cover 43 and the cup body 41 are sealed.
[0058] The fastener is used to fasten the base 42, the top cover 43 and the cup body 41 together.
[0059] The probe of the pH on-line detector 45 penetrates through the lower sidewall of the cup body 41 and extends into the cup body 41.
[0060] The sealing assembly 46 is arranged between the probe of the pH on-line detector 45 and the cup body 41.
[0061] The temperature on-line detector 47 is installed on the top cover 43, and the probe of the temperature on-line detector 47 is arranged close to the probe of the pH on-line detector 45.
[0062] The pH detection device 4 is newly designed in the embodiment, which is connected with the coupling tank 2 or the modification tank 1, so as to monitor the pH change in the coupling tank 2 or the modification tank 1 in real time, thereby facilitating the accurate control of the reaction condition and ensuring the purity and performance of the product.
[0063] The pH on-line detector 45 adopts the potentiometric method to accurately measure the pH value. The basic principle of the potentiometric method is that a indicating electrode and a reference electrode are placed in the solution to be measured to form a primary cell. The potential of the indicating electrode changes with the concentration of hydrogen ions in the solution, while the potential of the reference electrode remains constant. By measuring the potential difference between the two electrodes, the pH value of the solution can be calculated according to the Nernst equation.
[0064] The temperature on-line detector 47 is arranged to monitor the temperature of the solution in the cup body 41, so as to eliminate the influence of the large temperature change on the inspection result (some coupling tanks 2 and modification tanks 1 have heating and cooling functions, and there is temperature fluctuation in different links). For example, when the pH value changes too much, first check whether the temperature detected by the temperature on-line detector 47 has a large change. If yes, the corresponding pH monitoring data is rejected; if no, the corresponding pH monitoring data is accurate.
[0065] The sealing assembly 46 includes an inner gasket 461, an outer gasket 462, a sleeve 463, a fastening ring 464 and a connecting rod 465.
[0066] The inner gasket 461 is attached to the inner side of the cup body 41.
[0067] The outer gasket 462 is attached to the outer side of the cup body 41.
[0068] The sleeve 463 penetrates the inner gasket 461, one side of the cup body 41 and the outer gasket 462; the probe of the pH on-line detector 45 penetrates the sleeve 463, and at least one first sealing ring 466 is arranged between the two; one end of the sleeve 463 is located in the cup body 41 and has a convex ring 468, one side of the convex ring 468 is attached to the inner gasket 461, and a second sealing ring 467 is arranged between the convex ring 468 and the inner gasket 461.
[0069] The fastening ring 464 is located outside the cup body 41 and is threadedly connected to the outer wall of the sleeve 463.
[0070] One end of the connecting rod 465 is fixedly connected to the probe of the pH on-line detector 45, and the other end is rotatably connected to the fastening ring 464.
[0071] When the pH on-line detector 45 is installed, first, the top cover 43 is opened, the inner gasket 461 is sleeved on the sleeve 463, the sleeve 463 is penetrated through the hole on the cup body 41, the outer gasket 462 is sleeved on the sleeve 463, the probe of the pH on-line detector 45 is penetrated through the sleeve 463 and extends into the cup body 41, and then the fastening ring 464 is rotated to fix the sleeve 463 and fix the pH on-line detector 45 at the same time. Through the arrangement of the first sealing ring 466, the sealing problem between the probe of the pH on-line detector 45 and the sleeve 463 is solved, and through the arrangement of the second sealing ring 467, the sealing problem between the cup body 41 and the sleeve 463 is solved.
[0072] The fastener includes a screw rod 441 and a nut 442, one end of the screw rod 441 is connected to the base 42, the other end penetrates through the top cover 43 and is connected to the nut 442. When the nut 442 is tightened, the base 42, the top cover 43 and the cup body 41 are fastened together. A plurality of screw rods 441 and nuts 442 are distributed along the circumference of the cup body 41.
[0073] The top cover 43 is also connected with a gas injection pipe 51 for injecting nitrogen, the gas injection pipe 51 is provided with a gas injection valve 511, and the gas outlet direction of the gas injection pipe 51 is along the tangent direction of the circumferential side surface of the cup body 41. In this way, when it is necessary to discharge the solution in the cup body 41, the feeding valve 491 can be closed, the discharging valve 481 and the gas injection valve 511 can be opened, and nitrogen can be injected into the cup body 41. After the nitrogen enters the cup body 41, on one hand, the solution will be quickly squeezed out, and on the other hand, the nitrogen will rotate and flush the inner wall of the cup body 41 and the probe of the pH on-line detector 45, so that cleaning is realized.
[0074] Finally, it should be noted that the above is only a preferred embodiment of the present application and is not intended to limit the present application, and for those skilled in the art, the present application can have various changes and variations, and the embodiments of the present application and the features in the embodiments can be arbitrarily combined with each other without conflict. Any modification, equivalent replacement, improvement, etc. within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims
1. A pharmaceutical synthesis system, characterized by, The device comprises a modification tank, a coupling tank and a flat plate centrifuge connected in sequence, and further comprises: a cup body with its upper and lower ends being through each other; a base for plugging the lower end of the cup body, the base being connected with the coupling tank or the modification tank through a discharge pipe; a top cover for plugging the upper end of the cup body, the base being connected with the coupling tank or the modification tank through a feeding pipe; a fastener for fastening the base, the top cover and the cup body together; a pH value on-line detector with its probe penetrating the lower sidewall of the cup body and extending into the cup body, the pH value on-line detector measuring the pH value by using a potential measurement method; a sealing assembly arranged between the probe of the pH value on-line detector and the cup body; a temperature on-line detector installed on the top cover, the probe of the temperature on-line detector being arranged close to the probe of the pH value on-line detector.
2. The pharmaceutical synthesis system of claim 1, wherein, The sealing assembly comprises: an inner gasket adhering to the inner side of the cup body; an outer gasket adhering to the outer side of the cup body; a sleeve penetrating the inner gasket, one side of the cup body and the outer gasket, the probe of the pH value on-line detector penetrating the sleeve, at least one first sealing ring being arranged between the sleeve and the probe of the pH value on-line detector, one end of the sleeve being located in the cup body and having a convex ring, one side of the convex ring adhering to the inner gasket, a second sealing ring being arranged between the convex ring and the inner gasket; a fastening ring located outside the cup body and being threadedly connected with the outer wall of the sleeve.
3. The pharmaceutical synthesis system of claim 2, wherein, The sealing assembly further comprises a connecting rod, one end of the connecting rod being fixedly connected with the probe of the pH value on-line detector and the other end being rotatably connected with the fastening ring.
4. The pharmaceutical synthesis system of claim 1, wherein, The fastener comprises a screw rod and a nut, one end of the screw rod being connected with the base and the other end of the screw rod being connected with the nut after penetrating the top cover.
5. The pharmaceutical synthesis system of claim 4, wherein, A plurality of screw rods and nuts are distributed along the circumference of the cup body.
6. The pharmaceutical synthesis system of claim 1, wherein, The feeding pipe is connected with the modification tank through a pipeline pump.
7. The pharmaceutical synthesis system of claim 1, wherein, The cup body is made of transparent material.
8. The pharmaceutical synthesis system of claim 1, wherein, A scale is arranged on the cup body.
9. The pharmaceutical synthesis system of claim 1, wherein, The top cover is made of stainless steel.
10. The pharmaceutical synthesis system according to any one of claims 1 to 9, characterized in that, An air jet pipe is further connected with the top cover, the air outlet direction of the air jet pipe being along the tangential direction of the circumferential side surface of the cup body.