Exosome culture and collection equipment

Abstract

The utility model discloses exosome culturing and collecting equipment which comprises a collecting incubator and a culturing main machine arranged at the rear end of the collecting incubator, the culturing main machine is communicated with the interior of the collecting incubator through a plurality of ventilation strip holes, and a box cover is arranged at the top end of the collecting incubator. A novel expansion encryption device is additionally arranged outside the box cover of the exosome culture and collection equipment, and after the box cover is closed to the top end of the collection incubator, the interior of a U-shaped expansion air bag can be pressurized through a pressurization air cylinder of the device, so that the U-shaped expansion air bag is pressurized and expanded; the expanded U-shaped expansion air bag can be firmly extruded and attached to the exterior of the closed position of the box cover and the collection incubator, so that the sealing performance of the equipment can be remarkably improved, impurities such as external air, dust and microorganisms are effectively prevented from entering the collection incubator, and the exosome culture environment is prevented from being polluted by the collection incubator; the stability and the purity of the exosome culture process are ensured.

Description

TECHNICAL FIELD

[0001] The utility model belongs to biological sample culture related technical field, concretely relates to a kind of exosome culture and collection equipment. BACKGROUND

[0002] As an important medium for intercellular communication, exosomes show great application potential in the fields of disease diagnosis, treatment and drug delivery, and the culture and collection of exosomes are crucial. In the existing exosome culture and collection process, the sealing of the equipment plays a key role in maintaining the stable environment required for exosome culture.

[0003] When the exosome sample is placed in the collection culture test tube for culture, the box cover needs to be closed, so that the box cover is closed and sealed at the top end of the collection culture box through the sealing gasket, so that the inside of the collection culture box is in an environment conducive to exosome culture. However, the existing sealing method has many problems. The sealing gasket currently used is easily affected by external forces, temperature, humidity or other factors, which can cause the sealing gasket to leak locally. For example, during the daily use and handling of the equipment, unavoidable external forces such as vibration and impact can cause the sealing gasket to shift or deform, thereby damaging the sealing effect; fluctuations in environmental temperature can cause the sealing gasket material to expand and contract with heat, causing gaps in the originally tightly fitted sealing part; changes in humidity can cause the sealing gasket to become damp, soft or hard, reducing its sealing performance. Once the sealing gasket leaks locally, pollutants such as air, dust and microorganisms from the outside can easily enter the inside of the collection culture box, disturbing the culture environment of the exosomes. SUMMARY

[0004] The utility model aims to provide an exosome culture and collection equipment to solve the problem of the existing exosome culture and collection equipment, which is easily affected by external forces, temperature, humidity and other factors and causes local leakage, resulting in the entry of external pollutants and the destruction of the culture environment, and the lack of self-adaptive adjustment capability of the traditional sealing structure, which affects the culture and collection of exosomes.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical scheme: an exosome culture and collection equipment, comprising a collection culture box and a culture main machine arranged at the rear end of the collection culture box, the culture main machine is in communication with the inside of the collection culture box through a plurality of ventilation strip holes, a box cover is arranged at the top end of the collection culture box, the left rear corner and the right rear corner of the box cover are rotatably connected to the collection culture box through hinges, a plurality of placing feet are arranged at the bottom end of the collection culture box and the culture main machine, a sealing gasket is further fixedly attached to the outer wall of the bottom end of the box cover, the bottom end of the sealing gasket can be completely attached to the outer wall of the top end of the collection culture box, and an inflation encryption device is connected to the front end and the left and right ends of the box cover.

[0006] Preferably, the inflation encryption device comprises a U-shaped fixed top plate, a U-shaped cover plate, a sealing fixed sleeve, a pressure cylinder and a U-shaped inflation air bag, the front end and the outer walls of the left and right ends of the box cover are fixedly connected with the U-shaped fixed top plate, the bottom end of the U-shaped fixed top plate is fixedly connected with the U-shaped cover plate, the front end and the outer walls of the left and right ends of the U-shaped cover plate are flush with the U-shaped fixed top plate, the U-shaped inner wall of the U-shaped cover plate is fixedly attached with the U-shaped inflation air bag, when the inside of the U-shaped inflation air bag is not pressurized, the box cover can be normally rotated and closed to the top end of the collection incubator, after the box cover is closed to the top end of the collection incubator, the U-shaped inflation air bag can be completely sleeved on the front end and the outside of the left and right ends of the closed part of the box cover and the collection incubator, the rear side of the right end center of the U-shaped cover plate is provided with a sealing fixed sleeve, and the sealing fixed sleeve is fixedly inserted with a pressure cylinder.

[0007] Preferably, the U-shaped inflation air bag and the rear side inside of the right end center of the U-shaped cover plate are connected with an air hole, the sealing fixed sleeve is sleeved on the right end outside of the air hole, and the pressure cylinder communicates with the inside of the U-shaped inflation air bag through the air hole.

[0008] Preferably, the inflation encryption device further comprises a rubber plunger, a push-pull screw rod, an internally threaded adjusting sleeve and a screw knob, the right end of the pressure cylinder is fixedly connected with the internally threaded adjusting sleeve, the inside of the right end center of the pressure cylinder is provided with a perforation, the perforation is inserted with the push-pull screw rod, the right end of the push-pull screw rod is provided with the screw knob, the screw knob is located on the right side of the internally threaded adjusting sleeve, and the left end of the push-pull screw rod is rotationally connected with the rubber plunger, and the rubber plunger is located in the inside of the pressure cylinder.

[0009] Preferably, the screw knob can drive the push-pull screw rod to rotate clockwise and counterclockwise, the push-pull screw rod rotating clockwise and counterclockwise can move left and right through the thread action of the internally threaded adjusting sleeve, the rubber plunger is made of elastic soft rubber, and the rubber plunger is in interference fit with the pressure cylinder.

[0010] Preferably, the front end outer wall of the upper half of the culture main machine is provided with an inclined surface, the front end outer wall of the upper half of the culture main machine is provided with a display screen inside, and a plurality of control buttons are arranged on the left and right sides of the display screen.

[0011] Preferably, the front end inside of the collection incubator and the inside of the top end of the box cover are both reserved with a rectangular viewing window, the rectangular viewing window is fixedly connected with a perspective glass, and the connection part of the perspective glass and the collection incubator and the box cover is further treated with glass cement.

[0012] Preferably, the collecting incubator is internally provided with a collecting incubation mechanism, which is composed of a heat insulation base, an anti-extraction sleeve, a collecting incubation base, a collecting incubation test tube and a test tube fixing jack.

[0013] Preferably, the collecting incubation base is internally provided with a plurality of test tube fixing jacks at equal intervals, and the test tube fixing jacks are all upwardly open.

[0014] Compared with the prior art, the exosome culture and collection equipment has the following beneficial effects:

[0015] The exosome culture and collection equipment is provided with a novel expansion encryption device outside the box cover, and when the box cover is closed to the top end of the collecting incubator, the U-shaped expansion air bag can be inflated and pressurized by the inflation cylinder of the device, so that the U-shaped expansion air bag is tightly pressed and attached to the outside of the closed part of the box cover and the collecting incubator, thereby significantly improving the sealing performance of the equipment, effectively preventing external air, dust and microorganisms and other impurities from entering the collecting incubator, avoiding pollution of the exosome culture environment, and ensuring the stability and purity of the exosome culture process. In addition, compared with the traditional sealing structure, the expansion encryption method can better adapt to the use requirements of the equipment in different environments, that is, even when the temperature, humidity and other environmental factors change, the U-shaped expansion air bag can automatically adjust the sealing pressure through its inflation characteristics, and always maintain good sealing effect. Moreover, the structure design of the device makes its installation and operation relatively simple, and the operator can easily control the movement of the rubber plunger in the inflation cylinder by rotating the screw knob, thereby realizing the pressurization operation of the U-shaped expansion air bag, reducing the use difficulty and maintenance cost of the equipment. At the same time, when the equipment needs to be cleaned or maintained, the U-shaped expansion air bag can also be quickly depressurized to facilitate the opening of the box cover, thereby improving the operability and maintenance efficiency of the equipment. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 It is a use state perspective structure schematic diagram of the exosome culture and collection equipment of the utility model.

[0017] Figure 2 It is an open state perspective structure schematic diagram of the exosome culture and collection equipment of the utility model.

[0018] Figure 3 It is a use state side plane structure schematic diagram of the exosome culture and collection equipment of the utility model.

[0019] Figure 4 It is a three-dimensional structure schematic diagram of the collecting and culturing mechanism of the utility model.

[0020] Figure 5 It is a three-dimensional structure schematic diagram of the inflation encryption device in use state of the utility model.

[0021] Figure 6 It is a three-dimensional structure schematic diagram of the inflation encryption device in open state of the utility model.

[0022] Figure 7 It is a three-dimensional structure schematic diagram of the inflation encryption device in open state of the utility model.

[0023] In the figure: 1, collecting and culturing box; 2, perspective glass; 3, box cover; 4, inflation encryption device; 5, culture main machine; 6, control button; 7, display screen; 8, collecting and culturing mechanism; 9, sealing gasket; 10, heat insulation base; 11, anti-dropping sleeve; 12, collecting and culturing base; 13, collecting and culturing test tube; 14, test tube fixing jack; 15, U-shaped fixed top plate; 16, U-shaped cover plate; 17, sealing fixed sleeve; 18, booster air cylinder; 19, U-shaped inflation air bag; 20, rubber plunger; 21, push-pull screw; 22, internal thread adjusting sleeve; 23, screw knob. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the utility model.

[0025] The utility model provides a kind of collecting and culturing mechanism, which comprises collecting and culturing box, inflation encryption device, culture main machine, control button, display screen and collecting and culturing mechanism. Figures 1-7The exosome culture and collection device shown includes a collection incubator 1 and a culture main machine 5 arranged at the rear end of the collection incubator 1, and the culture main machine 5 is communicated with the inside of the collection incubator 1 through a plurality of air strip holes. The collection incubator 1 and the culture main machine 5 are two core parts of the device and are communicated through the air strip holes. This communication mode ensures that the suitable culture conditions such as temperature and gas composition generated by the culture main machine 5 can be stably transmitted to the inside of the collection incubator 1, providing a stable environmental basis for exosome culture. The collection incubator 1 is provided with a box cover 3 at the top end. The left rear corner and the right rear corner of the box cover 3 are rotatably connected to the collection incubator 1 through hinges. The bottom ends of the collection incubator 1 and the culture main machine 5 are provided with a plurality of placing feet. The bottom end outer wall of the box cover 3 is also pasted and fixed with a sealing pad 9. The bottom end of the sealing pad 9 can be completely attached to the top end outer wall of the collection incubator 1. The hinges can facilitate the opening and closing of the box cover 3. The sealing pad 9 pasted at the bottom end of the box cover 3 can completely attach to the top end outer wall of the collection incubator 1 when the box cover 3 is closed, preliminarily forming a sealed protection for the inside environment of the collection incubator 1. On this basis, the expansion encryption device 4 arranged at the front end and the left and right ends of the box cover 3 further enhances the sealing effect, preventing external air, dust, microorganisms and other pollutants from entering, ensuring the purity and stability of the exosome culture environment. The front end outer wall of the upper half of the culture main machine 5 is designed with a slope. The front end outer wall of the upper half of the culture main machine 5 is provided with a display screen 7 inside. A plurality of control buttons 6 are arranged on the left and right sides of the display screen 7. The slope design conforms to ergonomics, facilitating the observation of the display screen 7 information and the operation of the control buttons 6 by the operator, realizing the setting and adjustment of the culture parameters such as temperature, time and gas flow, so as to meet the needs of different exosome culture stages. The inside of the front end of the collection incubator 1 and the inside of the top end of the box cover 3 are both reserved with a rectangular viewing window. The rectangular viewing window is fixed with a perspective glass 2. The connection between the perspective glass 2 and the collection incubator 1 and the box cover 3 is also treated with glass glue for encryption. The perspective glass 2 facilitates the operator to observe the inside situation of the collection incubator 1 at any time, such as the exosome culture state in the collection culture test tube 13 and the culture medium liquid level. At the same time, the glass glue encryption treatment further ensures the sealing property.

[0026] As Figure 1 , Figure 2 , Figure 3 and Figure 4As shown, the collection incubator 1 is internally provided with a collection culture mechanism 8, which is composed of a heat insulation base 10, a anti-off sleeve 11, a collection culture base 12, a collection culture test tube 13 and a test tube fixing jack 14. The heat insulation base 10 is fixed to the inner wall of the bottom end of the collection incubator 1. The anti-off sleeve 11 is fixed to the top end of the heat insulation base 10 and is flush with the outer wall of the heat insulation base 10. The collection culture base 12 is inserted into the anti-off sleeve 11. A plurality of test tube fixing jacks 14 are equidistantly arranged in the collection culture base 12 and are all upwardly open. The collection culture base 12 is inserted into the test tube fixing jacks 14. The heat insulation base 10 in the collection culture mechanism 8 is fixed to the inner wall of the bottom end of the collection incubator 1, which reduces the heat exchange between the bottom of the collection incubator 1 and the external environment and maintains the stability of the temperature around the collection culture test tube 13. The anti-off sleeve 11 is fixed to the top end of the heat insulation base 10 and is flush with the outer wall of the heat insulation base 10, which ensures that the collection culture base 12 can be stably inserted therein and prevents the collection culture base 12 from shaking or falling off during the operation of the equipment. The plurality of test tube fixing jacks 14 equidistantly arranged in the collection culture base 12 provide stable placement positions for the collection culture test tube 13. The upwardly open design facilitates the accurate addition of samples or culture medium containing exosomes into the collection culture test tube 13, thereby achieving the effective collection and culture of exosomes.

[0027] As Figure 1 , Figure 2 , Figure 5 , Figure 6 and Figure 7As shown, the front end and both ends of the box cover 3 are connected with the expansion encryption device 4, which comprises a U-shaped fixed top plate 15, a U-shaped cover plate 16, a sealing fixed sleeve 17, a pressure cylinder 18 and a U-shaped expansion air bag 19. The U-shaped fixed top plate 15 is fixedly connected to the outer wall of the front end and both ends of the box cover 3. The U-shaped cover plate 16 is fixed to the bottom end of the U-shaped fixed top plate 15, and the front end and both ends of the U-shaped cover plate 16 are flush with the outer wall of the U-shaped fixed top plate 15. The U-shaped expansion air bag 19 is fixedly attached to the U-shaped inner wall of the U-shaped cover plate 16. When the inside of the U-shaped expansion air bag 19 is not pressurized, the box cover 3 can be normally rotated and closed to the top end of the collection incubator 1. After the box cover 3 is closed to the top end of the collection incubator 1, the U-shaped expansion air bag 19 can be completely sleeved on the outside of the front end and both ends of the closure of the box cover 3 and the collection incubator 1. The sealing fixed sleeve 17 is arranged at the rear side of the right end center of the U-shaped cover plate 16, and the pressure cylinder 18 is inserted and fixed in the sealing fixed sleeve 17. The U-shaped fixed top plate 15 is fixed to the outer wall of the front end and both ends of the box cover 3, providing a mounting base for the entire expansion encryption device 4. The U-shaped cover plate 16 is fixed to the bottom end of the U-shaped fixed top plate 15, and the front end and both ends of the U-shaped cover plate 16 are flush with the outer wall of the U-shaped fixed top plate 15. This structural design ensures the regularity and overall coordination of the appearance of the device. The U-shaped expansion air bag 19 is fixedly attached to the U-shaped inner wall of the U-shaped cover plate 16. When the inside of the U-shaped expansion air bag 19 is not pressurized, it will not hinder the normal rotation and closure of the box cover 3. The box cover 3 can be smoothly rotated and closed to the top end of the collection incubator 1, facilitating the daily opening and closing operation of the equipment. The U-shaped expansion air bag 19 and the right end center of the rear side of the U-shaped cover plate 16 are connected with the air hole inside. The sealing fixed sleeve 17 is sleeved on the right end outside of the air hole. The pressure cylinder 18 communicates with the inside of the U-shaped expansion air bag 19 through the air hole. The sealing fixed sleeve 17 is sleeved on the right end outside of the air hole, and the pressure cylinder 18 is inserted and fixed in the sealing fixed sleeve 17. This forms a complete gas transmission channel, so that the pressure cylinder 18 can communicate with the inside of the U-shaped expansion air bag 19 through the air hole, providing a necessary passage for subsequent pressurization of the U-shaped expansion air bag 19.

[0028] As Figure 1 , Figure 2 , Figure 5 , Figure 6 and Figure 7As shown, the inflation encryption device 4 further comprises a rubber plunger 20, a push-pull screw 21, an internally threaded adjusting sleeve 22 and a screw knob 23, the internally threaded adjusting sleeve 22 is fixed to the right end of the pressure cylinder 18, the right end of the pressure cylinder 18 is internally provided with a through hole, the push-pull screw 21 is inserted into the through hole, the right end of the push-pull screw 21 is provided with the screw knob 23, the screw knob 23 is located to the right of the internally threaded adjusting sleeve 22, the left end of the push-pull screw 21 is rotatably connected with the rubber plunger 20, the rubber plunger 20 is located in the interior of the pressure cylinder 18, the screw knob 23, the push-pull screw 21, the internally threaded adjusting sleeve 22 and the rubber plunger 20 jointly constitute a pressure boosting operating mechanism, the screw knob 23 is located to the right of the internally threaded adjusting sleeve 22, when the operator rotates the screw knob 23, since the screw knob 23 is fixedly connected with the push-pull screw 21, the rotation of the screw knob 23 can drive the push-pull screw 21 to synchronously rotate clockwise and counterclockwise, the right end of the push-pull screw 21 passes through the through hole at the center of the right end of the pressure cylinder 18 and cooperates with the internally threaded adjusting sleeve 22, when the push-pull screw 21 rotates, according to the screw transmission principle, the push-pull screw 21 will move left and right under the action of the internally threaded adjusting sleeve 22, the rubber plunger 20 is rotatably connected to the left end of the push-pull screw 21 and is located in the interior of the pressure cylinder 18, since the rubber plunger 20 is made of elastic soft rubber and is in interference fit with the pressure cylinder 18, this ensures that the rubber plunger 20 can tightly adhere to the cylinder wall in the pressure cylinder 18, preventing gas leakage, when the push-pull screw 21 moves left, it will push the rubber plunger 20 to synchronously move left in the pressure cylinder 18, thereby compressing the air in the pressure cylinder 18 into the U-shaped inflation bag 19 through the air hole.

[0029] As Figure 1 , Figure 2 , Figure 5 , Figure 6 and Figure 7 Figure 1 Figure 2 Figure 5 Figure 6 Figure 7As shown, the screw knob 23 can drive the push-pull screw 21 to rotate clockwise or counterclockwise, and the push-pull screw 21 can move left and right through the thread action with the inner threaded adjusting sleeve 22. The rubber plunger 20 is made of elastic soft rubber, and the rubber plunger 20 is in interference fit with the pressure cylinder 18. When the box cover 3 is closed to the top end of the collection incubator 1, the U-shaped inflatable air bag 19 is located at the front end and the left and right ends outside the closed part of the box cover 3 and the collection incubator 1. At this time, through the above-mentioned pressurization operation, the internal pressure of the U-shaped inflatable air bag 19 is increased, and the air bag starts to expand. The expanded U-shaped inflatable air bag 19 will tightly extrude and fit at the closed part of the box cover 3 and the collection incubator 1, filling the possible gap and forming a tight sealing line. Compared with the traditional static sealing structure, this sealing method achieved by air bag expansion can better adapt to the possible slight size difference and assembly error between the box cover 3 and the collection incubator 1, thereby significantly improving the overall sealing performance of the equipment and effectively preventing external air, dust, moisture and microorganisms and other pollutants from entering the inside of the collection incubator 1, providing a relatively stable and pure environment for the culture and collection of exosomes.

[0030] Finally, it should be noted that: the above only for the preferred embodiments of the present application, and not for limiting the present application, although the foregoing detailed description of the present application, for those skilled in the art, it can still be modified, or part of the technical features of the equivalent replacement, within the spirit and principles of the present application, any modification, equivalent replacement, improvement, etc., should be included within the scope of the present application.

Claims

1. An exosome culture and collection device, comprising a collection culture box (1) and a culture main machine (5) arranged at the rear end of the collection culture box (1), the culture main machine (5) is communicated with the inside of the collection culture box (1) through a plurality of ventilation strip holes, the top end of the collection culture box (1) is provided with a box cover (3), the left rear corner and the right rear corner of the box cover (3) are rotatably connected with the collection culture box (1) through hinges, the bottom end of the collection culture box (1) and the culture main machine (5) are provided with a plurality of placing feet, the bottom end outer wall of the box cover (3) is further pasted and fixed with a sealing gasket (9), the bottom end of the sealing gasket (9) can be completely attached to the top end outer wall of the collection culture box (1), characterized in that: The front end and both ends of the box cover (3) are connected with expansion encryption devices (4); The expansion encryption devices (4) comprise a U-shaped fixed top plate (15), a U-shaped cover plate (16), a sealing fixed sleeve (17), a pressurized air cylinder (18) and a U-shaped expansion air bag (19), the outer walls of the front end and both ends of the box cover (3) are fixedly connected with the U-shaped fixed top plate (15), the bottom end of the U-shaped fixed top plate (15) is fixedly connected with the U-shaped cover plate (16), the U-shaped cover plate (16) is flush with the outer walls of the front end and both ends of the U-shaped fixed top plate (15), the U-shaped inner wall of the U-shaped cover plate (16) is fixedly attached with the U-shaped expansion air bag (19), when the inside of the U-shaped expansion air bag (19) is not pressurized, the box cover (3) can be normally rotated and closed to the top end of the collecting incubator (1), after the box cover (3) is closed to the top end of the collecting incubator (1), the U-shaped expansion air bag (19) can be completely sleeved on the outside of the front end and both ends of the closed part of the box cover (3) and the collecting incubator (1), the rear side of the right end center of the U-shaped cover plate (16) is provided with the sealing fixed sleeve (17), the sealing fixed sleeve (17) is fixedly inserted with the pressurized air cylinder (18).

2. The exosome culture and collection device of claim 1, wherein: The right end of the U-shaped expansion air bag (19) is connected with the rear side inside of the right end center of the U-shaped cover plate (16) through a gas hole, the sealing fixed sleeve (17) is sleeved on the outside of the right end of the gas hole, and the inside of the U-shaped expansion air bag (19) is communicated with the pressurized air cylinder (18) through the gas hole.

3. The exosome culture and collection device of claim 2, wherein: The expansion encryption devices (4) further comprise a rubber plunger (20), a push-pull screw (21), an internally-threaded adjusting sleeve (22) and a screw knob (23), the right end of the pressurized air cylinder (18) is fixedly connected with the internally-threaded adjusting sleeve (22), the right end center of the pressurized air cylinder (18) is provided with a perforation in the inside, the push-pull screw (21) is inserted in the perforation, the right end of the push-pull screw (21) is provided with the screw knob (23), the screw knob (23) is located on the right side of the internally-threaded adjusting sleeve (22), and the left end of the push-pull screw (21) is rotationally connected with the rubber plunger (20), and the rubber plunger (20) is located in the inside of the pressurized air cylinder (18).

4. The exosome culture and collection device of claim 3, wherein: The screw knob (23) can drive the push-pull screw (21) to rotate clockwise and counterclockwise, the push-pull screw (21) can move left and right through the thread action with the internally-threaded adjusting sleeve (22), the rubber plunger (20) is made of elastic soft rubber, and the rubber plunger (20) is in interference fit with the pressurized air cylinder (18).

5. The exosome culture and collection device of claim 1, wherein: The front end outer wall of the upper half of the culture main machine (5) is provided with an inclined surface, the front end outer wall of the upper half of the culture main machine (5) is provided with a display screen (7) in the inside, and a plurality of control buttons (6) are arranged on the left and right sides of the display screen (7).

6. The exosome culture and collection device of claim 1, wherein: The inside of the front end of the collecting incubator (1) and the inside of the top end of the box cover (3) are both reserved with a rectangular window, the rectangular window is fixedly connected with a perspective glass (2), and the connection part of the perspective glass (2) and the collecting incubator (1) and the box cover (3) is further processed by using glass glue.

7. The exosome culture and collection device of claim 6, wherein: The collection incubator (1) is internally provided with a collection culture mechanism (8), which is composed of a heat insulation base (10), a anti-off sleeve (11), a collection culture base (12), a collection culture test tube (13) and a test tube fixing jack (14), the heat insulation base (10) is fixed to the inner wall of the bottom end of the collection incubator (1), the top end of the heat insulation base (10) is fixed with the anti-off sleeve (11), the anti-off sleeve (11) is flush with the outer wall of the heat insulation base (10) respectively, and the collection culture base (12) is inserted into the anti-off sleeve (11).

8. The exosome culture and collection device of claim 7, wherein: A plurality of test tube fixing jacks (14) are equidistantly arranged in the collection culture base (12), the plurality of test tube fixing jacks (14) are all upwardly opened, and the collection culture base (12) is inserted into the test tube fixing jack (14).

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