Analyzing and sampling device for pharmaceutical preparation

Abstract

The application provides an analytical sampling device for pharmaceutical preparations, comprising: an operation box, a partition plate arranged in the operation box and used for dividing the operation box into a sampling area and a cleaning area distributed along a first direction, the top end of the partition plate having a preset distance from the inner top surface of the operation box; a bearing plate is arranged in the sampling area, and a sample bottle and a sampling bottle are sequentially arranged on the bearing plate in the first direction; the sampling assembly is arranged in the operation box, can move back and forth in the first direction, can vertically move up and down, and is used for extracting a sample in the sample bottle into the sampling bottle; a cleaning assembly used for cleaning the sampling assembly is arranged in the cleaning area. Manual sampling is avoided, and the whole sampling process is completed in the operation box, so that the whole sampling process is relatively good in sealing performance, the external environment is isolated, the external environment is prevented from polluting a medicinal preparation in the sampling process, and the accuracy of a detection result of the extracted medicinal preparation is ensured.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pharmaceutical preparation, in particular to an analysis sampling device for pharmaceutical preparation. BACKGROUND

[0002] Pharmaceutical preparation refers to mixing active ingredients with excipients to prepare a dosage form suitable for a specific purpose for clinical use. There are various types of pharmaceutical preparations, including tablets, capsules, injections, oral liquids, suppositories, etc. The design and preparation of pharmaceutical preparations need to consider safety, effectiveness, controllability, stability and compliance principles. Therefore, pharmaceutical preparations need to be sampled and analyzed during the production stage. For example, the analysis of liquid pharmaceutical preparations (injections, oral liquids, etc.) is usually quantitative analysis, so precise sampling of liquid pharmaceutical preparations is required.

[0003] However, the existing sampling of liquid pharmaceutical preparations is usually manually sampled by an operator. Specifically, the operator immerses the sampling inlet of the sampler below the liquid level of the pharmaceutical preparation, and moves the plug rod vertically up and down in the plug barrel by pulling the plug rod to achieve sampling. During the entire operation, the sampler, pharmaceutical preparation, etc. are exposed to the air, so that the pharmaceutical preparation is easily contaminated during the entire sampling process, thereby affecting the accuracy of the test results of the obtained pharmaceutical preparation. After the sampling process is completed, the sampler needs to be taken away for cleaning before another sample is sampled, making the entire sampling process more cumbersome and affecting the sampling efficiency. CONTENT OF THE UTILITY MODEL

[0004] The present application provides an analysis sampling device for pharmaceutical preparation to solve the technical problems described in the background.

[0005] To solve the above technical problems, the present application adopts the following technical solutions:

[0006] The present application provides an analysis sampling device for pharmaceutical preparation, comprising:

[0007] An operation box is provided with a partition plate for separating the operation box into a sampling area and a cleaning area distributed along a first direction, and the top end of the partition plate is a predetermined distance from the inner top surface of the operation box;

[0008] A bearing plate is provided in the sampling area, and a test sample bottle and a sampling bottle are sequentially arranged on the bearing plate along the first direction;

[0009] A sampling assembly is arranged in the operation box and can move back and forth along the first direction and vertically up and down, for extracting the test sample in the test sample bottle into the sampling bottle;

[0010] The cleaning area is provided with a cleaning assembly for cleaning the sampling assembly.

[0011] Optionally, a first lead screw and a guide rod located directly below the first lead screw are arranged in the operation box and rotate along the first direction, a first connecting block is threadedly sleeved on the first lead screw, a lower section of the first connecting block is sleeved on the guide rod, and the first lead screw is driven by a first driving motor arranged on the outer sidewall of the operation box.

[0012] A vertical moving assembly is arranged on the first connecting block, and the sampling assembly is arranged on the vertical moving assembly and vertically moves up and down through the vertical moving assembly.

[0013] Optionally, a vertical sliding slot is formed in the first connecting block along the height direction of the first connecting block.

[0014] The vertical moving assembly comprises a second lead screw, a second connecting block and a clamping assembly.

[0015] The second lead screw is arranged to rotate in the vertical sliding slot, the second connecting block is threadedly sleeved on the second lead screw, the clamping assembly is arranged on the second connecting block and is used for clamping the sampling assembly, and the second lead screw is driven by a second driving motor arranged on the top surface of the second connecting block.

[0016] Optionally, vertical clamping slots are formed in the opposite inner sidewalls of the vertical sliding slot, clamping plates are respectively arranged on the opposite sidewalls of the second connecting block, the clamping plates are clamped in the vertical clamping slots and can vertically move up and down along the vertical clamping slots.

[0017] Optionally, the clamping assembly comprises a fixing ring, two adjusting bolts and two clamping plates.

[0018] The fixing ring is arranged on the second connecting block, the two adjusting bolts are threadedly penetrated through the fixing ring, and one end of each adjusting bolt located in the fixing ring is provided with the clamping plate used for clamping the sampling assembly.

[0019] Optionally, the sampling assembly comprises a sampling cylinder and a sampling rod.

[0020] The sampling rod is arranged in the sampling cylinder and the top end of the sampling rod is connected with the telescopic end of a telescopic piece arranged on the inner top surface of the operation box, the telescopic piece is used for driving the sampling rod to vertically move up and down in the sampling cylinder to realize sampling or lofting.

[0021] The clamping plate abuts against the outer surface of the sampling cylinder.

[0022] Optionally, the bearing plate is sequentially provided with a first fixing groove for fixing the sample bottle containing the pharmaceutical preparation and a second fixing groove for fixing the sampling bottle along the first direction.

[0023] The second fixing groove is at least three, and each second fixing groove corresponds to one sampling bottle.

[0024] Optionally, the cleaning assembly comprises a flushing groove, a cleaning barrel and a waste water tank sequentially arranged in the cleaning area along the first direction.

[0025] The flushing groove is provided with a plurality of high-pressure nozzles on the outer wall near the top thereof in a circumferential direction, the water inlets of the plurality of high-pressure nozzles are communicated with a water inlet pipe, one end of the water inlet pipe away from the high-pressure nozzles is used for communicating with a water source arranged in the cleaning area, the cleaning barrel is filled with cleaning liquid, and the waste water tank is used for collecting waste liquid after cleaning the sampling assembly.

[0026] Optionally, the cleaning assembly further comprises

[0027] An infrared lamp arranged in the cleaning area.

[0028] Optionally, the door of the operation box is provided with a visual observation area.

[0029] The pharmaceutical preparation sampling device provided by the application separates the operation box into a sampling area and a cleaning area through a partition plate, and then vertically moves up and down through the sampling assembly to realize the sampling of the pharmaceutical preparation in the sample bottle into the sampling bottle, thereby avoiding manual sampling and making the whole sampling process completed in the operation box, so that the whole sampling process has better sealing performance, thereby isolating the external environment and avoiding the pollution of the external environment to the pharmaceutical preparation in the sampling process, and ensuring the accuracy of the detection result of the sampled pharmaceutical preparation. In addition, after the sampling process is completed, the sampling assembly is moved to the cleaning area in the operation box along the first direction, the sampling assembly is cleaned through the cleaning assembly, and the sampling assembly after cleaning is moved to the sampling area along the first direction again for the next sampling, thereby avoiding the possibility of pollution of the pharmaceutical preparation in the next sampling process, and the sampling process and the cleaning process of the sampling assembly are continuous, thereby improving the sampling efficiency of the pharmaceutical preparation, and the sampling area and the cleaning area are separated, so that the sampling and the cleaning process of the sampling assembly do not affect each other, thereby further ensuring the accuracy of the detection result of the sampled pharmaceutical preparation. BRIEF DESCRIPTION OF DRAWINGS

[0030] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are some embodiments of the present application, and other drawings can be obtained by those skilled in the art without any creative effort based on these drawings.

[0031] Figure 1 The structural schematic diagram of the analytical sampling device for the pharmaceutical preparation provided by an embodiment of the present application is shown in the figure.

[0032] Figure 2 The structural schematic diagram of the analytical sampling device for the pharmaceutical preparation provided by another embodiment of the present application is shown in the figure.

[0033] Figure 3 The structural schematic diagram of the analytical sampling device for the pharmaceutical preparation provided by another embodiment of the present application is shown in the figure.

[0034] Figure 4 The structural schematic diagram of the analytical sampling device for the pharmaceutical preparation provided by another embodiment of the present application is shown in the figure.

[0035] Figure 5 The structural schematic diagram of the upper and lower moving assembly provided with the clamping assembly and the sampling assembly clamped by the clamping assembly is shown in the figure.

[0036] Figure 6 The structural schematic diagram of the upper and lower moving assembly provided with the clamping assembly is shown in the figure.

[0037] In the figure: 100, operation box; 101, sampling area; 102, cleaning area; 103, partition; 104, first screw rod; 1041, first connecting block; 105, guide rod; 1041, first connecting block; 106, first driving motor; 107, telescopic part; 108, box door; 1081, visual observation window; 200, bearing plate; 201, sample bottle; 202, sampling bottle; 300, sampling assembly; 301, sampling cylinder; 302, sampling rod; 400, cleaning assembly; 401, flushing groove; 4011, high-pressure spray head; 402, cleaning barrel; 403, waste water tank; 404, infrared lamp; 500, upper and lower moving assembly; 501, second screw rod; 502, second connecting block; 5021, second driving motor; 5022, clamping plate; 503, clamping assembly; 5031, fixing ring; 5032, adjusting bolt; 5033, clamping plate; 600, vertical sliding slot; 601, vertical clamping slot; 700, water inlet pipe. DETAILED DESCRIPTION

[0038] In order to make the purposes, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of the present application.

[0039] Reference Figures 1 to 6 The present application provides an analysis sampling device for pharmaceutical preparations, comprising:

[0040] The operation box 100 is provided with a partition plate 103 for separating the operation box 100 into a sampling area 101 and a cleaning area 102 distributed along a first direction. The top end of the partition plate 103 is at a preset distance from the inner top surface of the operation box 100 (which can be set according to actual needs, and the present application does not make a specific limitation here). A box door 108 is arranged on the side wall of the operation box 100. The arrangement of the box door 108 facilitates opening the box door 108 to put samples into the operation box 100 or take samples out of the operation box 100, and then closing the box door 108 to make the operation box 100 in a closed state.

[0041] The sampling area 101 is provided with a bearing plate 200. The bearing plate 200 is provided with a test sample bottle 201 and a sampling bottle 202 in sequence along the first direction. The test sample bottle 201 contains the pharmaceutical preparation to be analyzed, and the sampling bottle 202 contains a certain amount of the pharmaceutical preparation to be analyzed taken from the test sample bottle 201. In addition, the bearing plate 200 is placed on the inner bottom surface of the sampling area 101. When putting samples, the test sample bottle 201 containing the pharmaceutical preparation to be analyzed and the sampling bottle 202 for containing a certain amount of the pharmaceutical preparation to be analyzed can be placed on the bearing plate 200. The bearing plate 200 provided with the test sample bottle 201 and the sampling bottle 202 can be taken out of the operation box 100 after the sampling process is completed. The test sample bottle 201 containing the pharmaceutical preparation to be analyzed can be taken out for analysis, which realizes overall sampling and putting, thereby improving the convenience of the pharmaceutical preparation sampling process.

[0042] Further, in order to ensure the stability of the test sample bottle 201 and the sampling bottle 202 on the bearing plate 200, the bearing plate 200 in the present application is provided with a first fixing groove for fixing the test sample bottle 201 containing the pharmaceutical preparation and a second fixing groove for fixing the sampling bottle 202. In addition, in order to ensure the accuracy of the detection results, at least three parallel samples are required when analyzing the pharmaceutical preparation. Therefore, the second fixing groove has at least three, and each second fixing groove corresponds to a sampling bottle 202. Through the detection of at least three samples of the pharmaceutical preparation obtained, the accuracy of the measurement results is improved.

[0043] The sampling assembly 300 is arranged in the operation box 100 and can move back and forth along the first direction and vertically up and down, and is used to draw the sample in the sample bottle 201 into the sample bottle 202; wherein the top end of the partition plate 103 is at a preset distance from the inner top surface of the operation box 100, so as to ensure that the sampling assembly 300 can move back and forth between the sampling area 101 and the cleaning area 102 during the movement of the sampling assembly 300 along the first direction in the operation box 100, that is, the sampling assembly 300 is cleaned after sampling, and then returns to the sampling area 101 for the next round of sampling after the cleaning process is completed.

[0044] The cleaning assembly 400 for cleaning the sampling assembly 300 is arranged in the cleaning area 102. Since the operation box 100 is divided into the sampling area 101 and the cleaning area 102 by the partition plate 103, the sampling assembly 300 can be cleaned after sampling, and the sampling process and the cleaning process of the sampling assembly 300 do not affect each other, further ensuring the accuracy of the detection result of the extracted pharmaceutical preparation.

[0045] The analysis sampling device of the pharmaceutical preparation provided in the application is used in actual use. The sample bottle 201 containing the pharmaceutical preparation and the sampling bottle 202 for containing the pharmaceutical preparation to be detected are placed on the bearing plate 200. The box door 108 of the operation box 100 is opened. The bearing plate 200 is placed on the inner bottom surface of the sampling area 101 in the operation box 100. The pharmaceutical preparation in the sample bottle 201 is drawn into the sampling bottle 202 by the sampling assembly 300 moving in the operation box 100 in the first direction and vertically moving up and down. After the sampling is completed, the sampling assembly 300 moves in the first direction again to the cleaning area 102 and is cleaned by the cleaning assembly 400. The cleaned sampling assembly 300 is used for the next sampling. Then the box door 108 is opened. The bearing plate 200 is taken out. The sampling bottle 202 is taken away to detect and analyze the pharmaceutical preparation in it. In the above sampling process, the pharmaceutical preparation in the sample bottle 201 is drawn into the sampling bottle 202 by the vertical up-and-down movement of the sampling assembly 300, avoiding manual sampling. The whole sampling process is completed in the operation box 100, so that the sealing property of the whole sampling process is good, thereby isolating the external environment and avoiding the pollution of the external environment to the pharmaceutical preparation in the sampling process, ensuring the accuracy of the detection result of the extracted pharmaceutical preparation. In addition, after the sampling process is completed, the sampling assembly 300 moves in the first direction to the cleaning area 102 in the operation box 100. The sampling assembly 300 is cleaned by the cleaning assembly 400. The cleaned sampling assembly 300 moves in the first direction again to the sampling area 101 for the next sampling, avoiding the possibility of pollution of the pharmaceutical preparation in the next sampling process. The sampling process and the cleaning process of the sampling assembly 300 are continuous, thereby improving the sampling efficiency of the pharmaceutical preparation. The sampling area 101 and the cleaning area 102 are separated, so that the sampling and the cleaning process of the sampling assembly 300 do not affect each other, further ensuring the accuracy of the detection result of the extracted pharmaceutical preparation.

[0046] In some embodiments, with reference to Figure 2 and Figure 4 , the first lead screw 104 is rotationally arranged in the first direction in the operation box 100, and the guide rod 105 is arranged below the first lead screw 104. The first connecting block 1041 is threadedly sleeved on the first lead screw 104. The lower section of the first connecting block 1041 is sleeved on the guide rod 105. The first lead screw 104 is driven by the first driving motor 106 arranged on the outer side wall of the operation box 100. The first direction is parallel to the length direction of the operation box 100. The two ends of the first lead screw 104 are rotationally arranged on the two inner side walls of the operation box 100. One end of the guide rod 105 is arranged on the inner side wall of the operation box 100, and the other end of the guide rod 105 is arranged on the partition plate 103.

[0047] In addition, the first connecting block 1041 is provided with an up-down moving assembly 500, and the sampling assembly 300 is arranged on the up-down moving assembly 500 and moves vertically up and down through the up-down moving assembly 500. The up-down moving assembly 500 is fixedly arranged on the first connecting block 1041, and the sampling assembly 300 is fixedly arranged on the up-down moving assembly 500.

[0048] In the above embodiment, in the process of forward rotation or reverse rotation of the first driving motor 106, the first connecting block 1041 threaded on the first lead screw 104 is driven to move back and forth along the first lead screw 104, and in the process of moving back and forth along the first lead screw 104, the first connecting block 1041 moves back and forth along the length direction of the guide rod 105, and the guide rod 105 is arranged to limit the first connecting block 1041, avoiding the first connecting block 1041 rotating around the first lead screw 104 by a certain amplitude, so that the first connecting block 1041 moves linearly along the first lead screw 104, thereby improving the stability of the linear movement of the first connecting block 1041. Since the up-down moving assembly 500 is fixedly arranged on the first connecting block 1041, that is, the first connecting block 1041 drives the up-down moving assembly 500 to move back and forth along the first direction parallel to the first lead screw 104 in the process of moving back and forth along the first lead screw 104, and since the sampling assembly 300 is fixedly arranged on the up-down moving assembly 500, that is, in the process of moving back and forth along the first lead screw 104, the sampling assembly 300 moves back and forth along the first direction between the sampling area 101 and the cleaning area 102, realizing cleaning of the sampling assembly 300 after sampling, and ensuring the sampling efficiency.

[0049] In some embodiments, referring to Figure 2 and Figure 5 the first connecting block 1041 in the present application is provided with a vertical sliding groove 600 in the height direction thereof; the arrangement of the vertical sliding groove 600 facilitates the installation of the up-down moving assembly 500.

[0050] In addition, the up-down moving assembly 500 includes a second lead screw 501, a second connecting block 502, and a clamping assembly 503; specifically, the second lead screw 501 is rotationally arranged in the vertical sliding groove 600, the second connecting block 502 is threaded on the second lead screw 501, the clamping assembly 503 is arranged on the second connecting block 502 and is used for clamping the sampling assembly 300, and the second lead screw 501 is driven by a second driving motor 5021 arranged on the top surface of the second connecting block 502; the clamping assembly 503 is fixedly arranged on the second connecting block 502.

[0051] In the above embodiment, the second driving motor 5021 is rotated forward or reversely to drive the second connecting block 502 on the second screw rod 501 to move vertically up and down along the second screw rod 501, and the clamping assembly 503 on the second connecting block 502 moves vertically up and down synchronously with the second connecting block 502, and the sampling assembly 300 is clamped by the clamping assembly 503, so that the sampling assembly 300 moves vertically up and down with the clamping assembly 503, thereby adjusting the distance between the bottom end of the sampling assembly 300 and the sample bottle 201, the sampling bottle 202 and the cleaning assembly 400, and facilitating sampling.

[0052] In some embodiments, with reference to Figure 6 The vertical clamping groove 601 is formed in the opposite two inner side walls of the vertical sliding groove 600, and the clamping plate 5022 is arranged on the opposite two side walls of the second connecting block 502 and clamped in the vertical clamping groove 601 and can move vertically up and down along the vertical clamping groove 601.

[0053] In the above embodiment, the vertical clamping groove 601 and the clamping plate 5022 are arranged to limit the vertical up and down movement of the second connecting block 502, so that the second connecting block 502 does not rotate around the second screw rod 501 during the vertical up and down movement, and the stability of the vertical up and down movement of the second connecting block 502 is ensured.

[0054] In some embodiments, with reference to Figure 5 and Figure 6 The clamping assembly 503 in the application includes a fixed ring 5031, two adjusting bolts 5032 and two clamping plates 5033. Specifically, the fixed ring 5031 is arranged on the second connecting block 502, the two adjusting bolts 5032 are threaded through the fixed ring 5031, and one end of each adjusting bolt 5032 in the fixed ring 5031 is provided with a clamping plate 5033 for clamping the sampling assembly 300.

[0055] In the above embodiment, the sampling assembly 300 is placed in the fixed ring 5031, and the adjusting bolt 5032 on the fixed ring 5031 is screwed to make the clamping plate 5033 on the adjusting bolt 5032 abut against the outer wall of the sampling assembly 300, so as to clamp and fix the outer wall of the sampling assembly 300 by the clamping plate 5033, thereby ensuring the stability of the sampling assembly 300 during sampling.

[0056] In some embodiments, with reference to Figure 1 , Figure 2 , Figure 4 and Figure 5The sampling assembly 300 in the application comprises a sampling cylinder 301 and a sampling rod 302; wherein the outer wall of the sampling cylinder 301 is provided with scale lines, and the bottom end of the sampling rod 302 is provided with a rubber piston, which is specifically referred to a medical syringe, and the application does not elaborate on it in detail.

[0057] In addition, the sampling rod 302 is arranged in the sampling cylinder 301 and the top end thereof is connected with the telescopic end of the telescopic piece 107 arranged on the inner top surface of the operation box 100, and the telescopic piece 107 is used to drive the sampling rod 302 to vertically move up and down in the sampling cylinder 301 to realize sampling or sampling; wherein the telescopic piece 107 can be an electric push rod, etc., and the arrangement of the telescopic piece 107 avoids manual sampling and improves the accuracy of sampling.

[0058] In addition, the sampling rod 302 is arranged in the sampling cylinder 301 and the top end thereof is connected with the telescopic end of the telescopic piece 107 arranged on the inner top surface of the operation box 100, and the telescopic piece 107 is used to drive the sampling rod 302 to vertically move up and down in the sampling cylinder 301 to realize sampling or sampling; wherein the telescopic piece 107 can be an electric push rod, etc., and the arrangement of the telescopic piece 107 avoids manual sampling and improves the accuracy of sampling.

[0059] In some embodiments, with reference to Figure 2 and Figure 3 The cleaning assembly 400 in the application comprises a flushing tank 401, a cleaning barrel 402 and a waste tank 403 arranged in the cleaning area 102 in sequence in the first direction; wherein the outer wall of the sampling assembly 300 is first flushed through the flushing tank 401, the inside of the sampling assembly 300 is cleaned by drawing the cleaning liquid in the cleaning barrel 402 through the sampling assembly 300, and the waste liquid after cleaning is injected into the waste tank 403 for storage, so that the cleaning process of the sampling assembly 300 can be continuously carried out by opening the door 108 of the operation box 100 to timely add cleaning liquid into the cleaning barrel 402 or to timely clean the waste liquid in the waste tank 403.

[0060] In addition, the outer wall of the flushing tank 401 near the top thereof is circumferentially provided with a plurality of high-pressure nozzles 4011, the water inlets of the plurality of high-pressure nozzles 4011 are communicated with water inlet pipes 700, one end of the water inlet pipe 700 away from the high-pressure nozzle 4011 is used to communicate with the cleaning barrel 402, the cleaning barrel 402 is filled with cleaning liquid, and the waste tank 403 is used to collect the waste liquid after cleaning the sampling assembly 300. Wherein, a small booster pump is arranged on each water inlet pipe 700.

[0061] In the above embodiment, when the sampling assembly 300 moves to the position directly above the flushing tank 401 in the first direction, the sampling assembly 300 moves vertically downward and enters the flushing tank 401, the cleaning liquid in the cleaning barrel 402 is pumped into the corresponding high-pressure nozzle 4011 through the small booster pump on each water inlet pipe 700, the outer wall of the sampling assembly 300 is flushed by the cleaning liquid sprayed by the high-pressure nozzle 4011, after the flushing is completed, the sampling assembly 300 moves to the position directly above the cleaning barrel 402 and the sampling port of the sampling assembly 300 is immersed below the liquid level of the cleaning barrel 402, the inside of the sampling assembly 300 is cleaned by the cleaning liquid in the cleaning barrel 402, and the cleaned cleaning liquid is discharged into the waste tank 403.

[0062] It is explained here that the flushing tank 401 is connected with a waste liquid pipe, when there is a large amount of waste liquid in the flushing tank 401, the cabinet door 108 of the operation box 100 is opened to discharge the waste liquid in the flushing tank 401, and the waste tank 403 collects the waste liquid discharged after the sampling assembly 300 extracts the cleaning liquid in the cleaning barrel 402 and flushes the sampling assembly 300.

[0063] In some embodiments, with reference to Figures 2 to 4 The cleaning assembly 400 in the application further includes an infrared lamp 404 arranged in the cleaning area 102. In order to ensure that the cleaning process of the sampling assembly 300 is not affected, the infrared lamp 404 is arranged close to the waste tank 403.

[0064] In the above embodiment, the sampling assembly 300 after cleaning is dried by the radiant heat generated by the infrared lamp 404, which avoids the influence of the sampling assembly 300 on the next extracted pharmaceutical preparation, and ensures the accuracy of the detection result of the pharmaceutical preparation.

[0065] In some embodiments, with reference to Figure 1 The cabinet door 108 of the operation box 100 in the application is provided with a visual observation area 1081. The visual observation area 1081 facilitates the observation of the sampling situation in the operation box 100 and the cleaning situation of the sampling assembly by the cleaning assembly 400, and facilitates the timely removal or arrangement of the sampling bottle 202 in the cleaning area 102 and other operations.

[0066] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the application, but not to limit them; although the application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that they can modify the technical solutions described in the foregoing embodiments, or make equivalent replacement for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the application.

Claims

1. An analytical sampling device for pharmaceutical preparations, characterized in that, The utility model relates to a kind of sampling and cleaning device, including: Operation box (100), the partition (103) for separating the operation box (100) into sampling area (101) and washing area (102) distributed along the first direction is provided in the operation box (100), the top end of the partition (103) is at a preset distance from the inner top surface of the operation box (100); Sampling area (101) is provided with bearing plate (200), sample bottle (201) and sampling bottle (202) are sequentially provided on the bearing plate (200) along the first direction; Sampling assembly (300) is arranged in the operation box (100) and can move back and forth along the first direction and can move vertically up and down, for extracting sample in the sample bottle (201) into the sampling bottle (202); Washing assembly (400) for washing the sampling assembly (300) is provided in the washing area (102).

2. The analytical sampling device for pharmaceutical preparations according to claim 1, characterized in that, First lead screw (104) is rotationally arranged in the operation box (100) along the first direction, and guide rod (105) is located directly below the first lead screw (104), first connecting block (1041) is threadedly sleeved on the first lead screw (104), the lower section of the first connecting block (1041) is sleeved on the guide rod (105), and the first lead screw (104) is driven by the first driving motor (106) arranged on the outer side wall of the operation box (100). Up-and-down moving assembly (500) is arranged on the first connecting block (1041), and the sampling assembly (300) is arranged on the up-and-down moving assembly (500) and moves vertically up and down through the up-and-down moving assembly (500).

3. The analytical sampling device for pharmaceutical preparations according to claim 2, characterized in that, A vertical sliding groove (600) is formed in the height direction of the first connecting block (1041). The up-and-down moving assembly (500) includes second lead screw (501), second connecting block (502) and clamping assembly (503). The second lead screw (501) is rotationally arranged in the vertical sliding groove (600), the second connecting block (502) is threadedly sleeved on the second lead screw (501), the clamping assembly (503) is arranged on the second connecting block (502) and used for clamping the sampling assembly (300), and the second lead screw (501) is driven by the second driving motor (5021) arranged on the top surface of the second connecting block (502).

4. The analytical sampling device for pharmaceutical preparations according to claim 3, characterized in that Vertical clamping grooves (601) are formed in the opposite inner side walls of the vertical sliding groove (600), clamping plates (5022) are respectively arranged on the opposite side walls of the second connecting block (502), the clamping plates (5022) are clamped in the vertical clamping grooves (601) and can move vertically up and down along the vertical clamping grooves (601).

5. The analytical sampling device for pharmaceutical preparations according to claim 3, characterized in that, The clamping assembly (503) includes fixing ring (5031), two adjusting bolts (5032) and two clamping plates (5033). The fixing ring (5031) is arranged on the second connecting block (502), two adjusting bolts (5032) are threaded through the fixing ring (5031), and one end of each adjusting bolt (5032) in the fixing ring (5031) is provided with the clamping plate (5033) for clamping the sampling assembly (300).

6. The analytical sampling device for pharmaceutical preparations according to claim 5, characterized in that, The sampling assembly (300) comprises a sampling cylinder (301) and a sampling rod (302). The sampling rod (302) is arranged in the sampling cylinder (301) and the top end of the sampling rod (302) is connected with the telescopic end of the telescopic piece (107) arranged on the inner top surface of the operation box (100), and the telescopic piece (107) is used to drive the sampling rod (302) to vertically move up and down in the sampling cylinder (301) to realize sampling or lofting. The clamping plate (5033) is in abutment with the outer surface of the sampling cylinder (301).

7. The analytical sampling device for pharmaceutical preparations according to claim 1, characterized in that, The cleaning assembly (400) comprises, in sequence along the first direction, a flushing tank (401), a cleaning barrel (402) and a waste water tank (403) arranged in the cleaning area (102). A plurality of high-pressure nozzles (4011) are circumferentially arranged on the outer wall near the top of the flushing tank (401), the water inlets of the plurality of high-pressure nozzles (4011) are communicated with a water inlet pipe (700), one end of the water inlet pipe (700) away from the high-pressure nozzles (4011) is used to communicate with the cleaning barrel (402), the cleaning barrel (402) is filled with cleaning liquid, and the waste water tank (403) is used to collect waste liquid after cleaning the sampling assembly (300).

8. The analytical sampling device for pharmaceutical preparations according to claim 7, characterized in that The cleaning assembly (400) further comprises an infrared lamp (404) arranged in the cleaning area (102).

9. The analytical sampling device for pharmaceutical preparations according to any one of claims 1 to 8, characterized in that A visual observation area (1081) is arranged on the box door (108) of the operation box (100).

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