Urinalysis instrument and micro-fluidic chip thereof

Abstract

The utility model discloses a urinalysis instrument and a micro-fluidic chip thereof, the micro-fluidic chip is used for the urinalysis instrument, the urinalysis instrument comprises a plurality of reagent capsules and a test board, and the test board is provided with a test cavity. The micro-fluidic chip is provided with a main flow channel, a plurality of reagent flow channels, a sample flow channel, an air flow channel and a uniform mixing cavity, the main flow channel extends in the first direction, one end of the main flow channel is located on the outer side of the main flow channel, and the other end of the main flow channel is located in the middle of the main flow channel. One end of each reagent runner is communicated with the main runner, and the other end of each reagent runner is communicated with a reagent capsule. One end of the sample runner is communicated with the main runner, and the other end of the sample runner is used for receiving samples. One end of the air flow channel communicates with the main flow channel, and the other end of the air flow channel is used for receiving air. The uniform mixing cavity is connected with one end, positioned in the middle part, of the main flow channel, and the other end of the main flow channel is communicated with a test cavity. The blending cavity is arranged in the vertical direction, and the width of the blending cavity is gradually increased from the two ends of the blending cavity to the middle of the blending cavity.

Description

TECHNICAL FIELD

[0001] The utility model relates to urine test appearance technical field, especially urine test appearance and micro -fluidic chip thereof. BACKGROUND

[0002] With the growth of human life, the importance of health care and maintenance has been paid more and more attention. Urine can reflect a person's health condition to a certain extent, and through quantitative analysis of urine composition, diseases such as pancreas and kidney can be understood. Urine detection has become one of the indispensable items of routine detection of medical institutions, and dry chemical urine detection analyzer has become an important instrument for medical institutions to detect.

[0003] The urine test appearance on the market currently produces air bubbles in the sample transportation process, and the sample and reagent cannot be completely mixed in the micro -fluidic chip, which affects the accuracy of the test. UTILITY MODEL CONTENT

[0004] The utility model aims at providing a kind of micro -fluidic chip to solve the problems of prior art.

[0005] To solve the above technical problems, the embodiment of the utility model provides a kind of micro -fluidic chip, the micro -fluidic chip is used in urine test appearance, the urine test appearance includes multiple reagent capsules and test plate, and the test plate is equipped with test cavity;The micro -fluidic chip includes:

[0006] Flow channel plate, the surface of the flow channel plate is equipped with recessed:

[0007] Main flow channel, the main flow channel extends along the first direction and one end is located at the middle part of the micro -fluidic chip;

[0008] Multiple reagent flow channels, one end of multiple reagent flow channels is communicated with the main flow channel respectively, and the other end is used to communicate with reagent capsule;

[0009] Sample flow channel, one end of the sample flow channel is communicated with the main flow channel, and the other end is used to receive sample;

[0010] Air flow channel, one end of the air flow channel is communicated with the main flow channel, and the other end is used to receive air;

[0011] Mixing cavity, the mixing cavity is connected with one end of the main flow channel located at the middle part, and the other end is used to communicate with test cavity;The mixing cavity is along vertical direction, and the width size of the mixing cavity gradually increases from both ends to middle of the mixing cavity;And

[0012] Cover plate, the cover plate is connected with the surface of the flow channel plate and covers the main flow channel, the reagent flow channel, the sample flow channel, the air flow channel and the mixing cavity.

[0013] In one embodiment, the mixing cavity comprises:

[0014] a first section, a bottom end of the first section being in communication with the main flow channel;

[0015] a mixing chamber, a top end of the mixing chamber being connected with a top end of the main flow channel, the mixing chamber comprising a first curved surface and a second curved surface, the first curved surface and the second curved surface being oppositely arranged, the first curved surface being a curved surface concaved towards away from the second curved surface, and the second curved surface being a curved surface concaved towards away from the first curved surface; and

[0016] a tail section, one end of the tail section being connected with a bottom end of the mixing chamber, and the other end being in communication with the test chamber.

[0017] In one embodiment, the mixing chamber further comprises a third curved surface, a top end of the third curved surface being connected with the first section, and a bottom end of the third curved surface being connected with the second curved surface, the third curved surface being a curved surface concaved towards the first curved surface.

[0018] In one embodiment, a radius of the first curved surface ranges from 5mm to 8mm, and an arc length of the first curved surface ranges from 7mm to 10mm;

[0019] a radius of the second curved surface ranges from 5mm to 8mm, and an arc length of the second curved surface ranges from 7mm to 10mm;

[0020] a radius of the third curved surface ranges from 0.75mm to 2mm, and an arc length of the third curved surface ranges from 1.5mm to 3mm.

[0021] In one embodiment, a height of the mixing chamber along a vertical direction ranges from 8mm to 12mm, and a width of the mixing chamber along a first direction ranges from 8mm to 12mm.

[0022] In one embodiment, the mixing cavity extends along the first direction, and one end of the mixing cavity is in communication with the main flow channel, and the other end of the mixing cavity is in communication with the test chamber;

[0023] a top wall of the mixing cavity gradually increases from both ends to a middle of the mixing cavity along the first direction.

[0024] In one embodiment, the top wall of the mixing cavity is a curved surface.

[0025] In one embodiment, a width of the mixing cavity along the first direction ranges from 20mm to 24mm, and a height of the mixing cavity along a vertical direction ranges from 3mm to 4mm.

[0026] In one embodiment, the main flow channel has a radius ranging from 0.5mm to 1mm, the inner side wall of the mixing cavity comprises a first section and a second section connected to each other, the first section is an arc surface protruding towards the outside, the second section is located on top of the first section and is an arc surface recessed towards the inside, the first section has a radius ranging from 3mm to 5mm, and the second section has a recessed depth ranging from 1mm to 2.2mm.

[0027] In one embodiment, the flow channel plate is further provided with a mixing elbow, which is a curved pipe shape and communicates with the mixing cavity at one end and with the test cavity at the other end.

[0028] The utility model also relates to a urine test instrument, the urine test instrument includes the micro -fluidic chip of above. BRIEF DESCRIPTION OF DRAWINGS

[0029] Figures 1-3 Respectively be the perspective drawing of urine test instrument of an embodiment of the utility model.

[0030] Figures 4-7 Is Figure 1 The exploded view of urine test instrument in the embodiment shown.

[0031] Figure 8 And Figure 9 Is Figure 1 The perspective drawing of rear shell in the embodiment shown.

[0032] Figure 10 Is Figure 4 The perspective drawing of micro -fluidic chip of the embodiment shown.

[0033] Figure 11 Is Figure 10 The mixing cavity diagram of micro -fluidic chip of the embodiment shown.

[0034] Figure 12 Is Figure 1 The assembly drawing of support, fresh water container, sample container, battery, detection component, circuit board and multiple pumps in the embodiment shown.

[0035] Figure 13 And Figure 14 The perspective drawing of micro -fluidic chip of another embodiment of the utility model.

[0036] Figure 15 Is Figure 14 The sectional view of micro -fluidic chip of the embodiment shown along A-A line.

[0037] Figure 16 The control method flow chart of urine test instrument of one embodiment of the utility model.

[0038] Figure 17A liquid path diagram of a urine test instrument which is an embodiment of the present application.

[0039] Reference numerals: 100, urine test instrument; 11, front shell; 12, rear shell; 121, connecting part; 122, cover; 123, collection cavity; 124, groove; 125, pipe hole; 126, sewage outlet; 127, rail; 128, first air outlet; 129, second air outlet; 2, flow channel plate; 21, main flow channel; 22, sample flow channel; 23, air flow channel; 24, clean water flow channel; 25, mixing cavity; 251, first section; 252, mixing chamber; 253, tail section; 254, first arc surface; 255, second arc surface; 256, third arc surface; 257, second mixing cavity; 2571, first section; 2572, second section; 26, mixing bend; 27, washing flow channel; 28, reagent flow channel; 3, detection mechanism; 31, detection component; 4, clean water container; 401, first clean water pump; 402, first clean water pipe; 403, second clean water pipe; 41, second clean water pump; 42, first air pipe; 5, sample container; 501, first sample pump; 502, first sample pipe; 503, second sample pipe; 51, second sample pump; 52, second air pipe; 6, bracket; 7, reagent capsule; 8, battery; 9, circuit board; 101, air pump; 102, reagent pump; 103, washing pump; DETAILED DESCRIPTION

[0040] In order to make the objects, technical solutions and advantages of the present application clearer, the embodiments of the present application will be described in detail below with reference to the drawings. However, those skilled in the art can understand that, in the embodiments of the present application, many technical details are presented in order to make the readers better understand the present application. However, the technical solutions claimed in the claims of the present application can be realized even without these technical details and various changes and modifications based on the following embodiments.

[0041] Unless otherwise required by the context, the words “comprise” and variations such as “comprising”, “contain” and “containing” will be understood to imply the inclusion of a stated integer or group of integers but not the exclusion of any other integer or group of integers.

[0042] The embodiments of the present application will be described in detail below with reference to the drawings in order to make the objects, features and advantages of the present application clearer. It should be understood that the embodiments shown in the drawings are not a limitation on the scope of the present application but are only used to illustrate the essential spirit of the technical solutions of the present application.

[0043] Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrase "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics can be combined in any suitable manner in one or more embodiments.

[0044] As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. It should be noted that the term "comprising" as used in this specification is used in the sense of "including", and thus should be interpreted to cover also "consisting of" and "consisting essentially of".

[0045] In the following description, for purposes of clarity, directional terms are used to describe the orientation of the various structures and components of the present application. It should be noted that the terms "front," "back," "left," "right," "outer," "inner," "outward," "inward," "upper," "lower," and the like as can be understood based on the drawings are used for convenience only to describe the orientation of the components and are not intended to be limiting.

[0046] The present application relates to a urine test instrument 100 which is small in size and high in efficiency, and can remove bubbles in a sample or water, and can be applied to routine urine tests, such as 14 items of ascorbic acid tests, including vitamin (C, VC), white blood cell (WBC), urobilinogen (URO), bilirubin (BIL), occult blood (BLD), nitrite (NIT), pH, protein (PRO), specific gravity (SG), ketone (KET), glucose (GLU), creatinine (CR), calcium (CA), and microalbumin (MA) + UACR (urinary microalbumin / creatinine ratio) + UPCR (urinary protein / creatinine ratio) + urinary uric acid comprehensive value (based on CKD-EPI algorithm). Hereinafter, a urine test instrument 100 according to one embodiment of the present application will be described in detail with reference to the accompanying drawings.

[0047] As shown in Figures 1-5 The urine test instrument 100 includes a housing, a detection mechanism 3 located in the housing, a microfluidic chip, a sample driving module, a clean water driving module, a reagent driving module, a plurality of pipes, a battery 8, a sensor, a control module, and a support 6. The housing is provided with a collection cavity 123 for collecting a sample or water. The sample driving module includes a sample container 5, a pipe connecting the sample container 5 and the collection cavity 123, a pump connected to the pipe, and a pipe connecting the sample container 5 and a sample flow channel of the microfluidic chip, and a pump connected to the pipe.

[0048] As shown in Figure 7The clean water driving module comprises a clean water container 4, a pipeline connecting the clean water container 4 and the collecting cavity 123, a pump connected with the pipeline, a pipeline connecting the clean water container 4 and the clean water flow channel of the micro-fluidic chip, and a pump connected with the pipeline.

[0049] The reagent driving module comprises a plurality of reagent capsules 7, a plurality of reagent pipelines respectively connecting the plurality of reagent capsules 7 and the plurality of reagent flow channels of the micro-fluidic chip, and a plurality of reagent pumps connected with the plurality of reagent pipelines.

[0050] As Figure 6 , Figure 7 The clean water container 4 and the sample container 5 are respectively used for storing water and a sample. The reagent capsule 7 is used for containing a reagent for testing. The micro-fluidic chip is connected with the reagent capsule 7, the sample container 5 and the clean water container 4, and is used for mixing the reagent and the sample. The detection mechanism 3 comprises a test plate and a detection component. The test plate is provided with a test cavity, and the test cavity is connected with the micro-fluidic chip and can receive mixed liquid after the reagent and the sample are mixed. The detection component is used for detecting the mixed liquid. The sensor is installed in the shell and is used for detecting the liquid in the collecting cavity 123. The control module can control the plurality of pumps to move or control the detection component 31 to detect according to the signal of the sensor. The battery 8 is used for supplying power for the plurality of pumps or the detection component 31. The bracket 6 is located in the shell and is used for fixing the detection mechanism 3, the battery 8, the control module, the reagent capsule 7, the sample container 5, the clean water container 4 and the micro-fluidic chip.

[0051] Specifically, the shell is used for accommodating the detection mechanism 3, the micro-fluidic chip, the sample driving module, the clean water driving module, the reagent driving module, the battery 8, the control module and the bracket 6, and the shell can be attached to the inner wall of the barrel of the closestool.

[0052] In one embodiment, the shell comprises a front shell 11 and a rear shell 12 connected with the front shell 11. The rear shell 12 is used for being attached to the inner wall of the barrel of the closestool, and the front shell 11 can prevent foreign matters from entering the urine test instrument 100. The front shell 11 and the rear shell 12 both have smooth arc surfaces protruding towards the outside. After the rear shell 12 is attached to the inner wall of the barrel of the closestool, the shell of the urine test instrument 100 is smooth as a whole and will not be jammed by foreign matters. The entire front shell 11 and rear shell 12 can be connected by screws or clamping, and the specific connection mode of the front shell 11 and the rear shell 12 is not limited.

[0053] The top end of the rear shell 12 is provided with a recessed collecting cavity 123. The collecting cavity 123 is used for collecting a sample and water. The sample is urine.

[0054] In Figures 1-9In the shown embodiment, the rear shell 12 comprises a connecting portion 121 and a cover 122. The connecting portion 121 is substantially conical ring-shaped and has a smooth outer surface, i.e. the diameter of the connecting portion 121 gradually decreases from the front end to the rear end, the front end is fixedly connected to the front shell 11 and matches the outer surface of the front shell 11, and the outer surface appears to be a smooth arc surface. The cover 122 is connected to the rear end of the connecting portion 121, and the rear end of the cover 122 is an arc surface protruding outward.

[0055] The collection cavity 123 is formed by recessing the top end of the cover 122 and is open at the top end. The inner wall of the collection cavity 123 is sized to be larger at the top end to facilitate collection of the sample and is sized to be smaller at the bottom end to facilitate transport of the sample. Since a portion of the foam mixed in the sample is eliminated when the sample flows to the bottom end during the sample collection process, the interference with the test caused by the foam transported to the test cavity can be avoided.

[0056] As shown in Figure 5 and Figure 9 , the inner wall of the cover 122 is also recessed to form two grooves 124 for accommodating the clean water container 4 and the sample container 5. The two grooves 124 are distributed on both sides of the collection cavity 123, and the two grooves 124 and the collection cavity 123 share a side wall along the first direction, so that the grooves 124 are adjacent to the collection cavity 123, and the outer side of the grooves 124 is close to the radial outer side of the cover 122, i.e. the arrangement of the two grooves 124 and the collection cavity 123 maximizes the volume of the cover 122, and the volume of the entire urine test instrument 100 can be reduced.

[0057] The inner wall of the collection cavity 123 is sized to gradually decrease from the top end to the bottom end to facilitate collection of the sample. In Figure 5 and Figure 6 the shown embodiment, the collection cavity 123 has a front wall, a rear wall, and two inner walls along the first direction. The rear wall is located on a side wall close to the inner wall of the barrel of the closest toilet, and the rear wall is an arc surface slightly protruding toward the rear end to facilitate receiving more sample. The front wall is oppositely arranged to the rear wall. The two inner walls of the collection cavity 123 along the first direction are arc surfaces protruding toward each other, i.e. the width of the collection cavity 123 along the first direction gradually decreases from top to bottom.

[0058] As shown in Figure 5 , Figure 7 , Figure 8 , Figure 9In the sampling chamber 123, five pipe holes 125 are provided on the two inner walls along the first direction. One pipe hole 125 is located at the top of one of the inner walls, near the top opening of the sampling chamber 123. This pipe hole 125 is used to communicate with the clean water container 4 to expel air bubbles from the clean water container 4. This pipe hole 125 is defined as the first vent hole 128. The other four pipe holes 125 are located at the bottom of the sampling chamber 123 and on both sides of the sampling chamber 123 along the first direction. Two of the four pipe holes 125 are used to communicate with the sample container 5 and the clean water container 4 through pipes. The other pipe hole 125 is connected to the test chamber through a drain pipe. The last pipe hole 125 is used to communicate with the sample container 5 to facilitate the expulsion of air bubbles. This pipe hole 125 is defined as the second vent hole 129, and the second vent hole 129 is located at the bottom of the sampling chamber 123. Of the five pipe holes 125 provided inside the collection cavity 123, four pipe holes 125 are close to the bottom of the collection cavity 123, and one pipe hole 125 is close to the top of the collection cavity 123.

[0059] like Figure 3 As shown, the bottom of the collection chamber 123 is also provided with a drain port 126. The drain port 126 is very small, and during the process of receiving samples and clean water, the collection chamber 123 will not lose water quickly, but will only discharge it slowly, which will not affect the collection of samples. The operation of the pipe hole 125 and the drain port 126 will be described in detail below.

[0060] like Figure 3 As shown, the top opening of the collection chamber 123 is relatively large, and a filter section is also provided at the top opening. The filter section includes multiple rails 127 and a filter screen. The multiple rails 127 are arranged at intervals along the first direction and connected to the top of the collection chamber 123 to block larger foreign objects. The filter screen is located below the multiple rails 127 and connected to the inner wall of the collection chamber 123, covering the entire top opening of the collection chamber 123 for fine filtration.

[0061] A sensor is also installed inside the collection chamber 123. This sensor is connected to the control module and can sense whether the liquid collected in the collection chamber 123 is a sample or water, and transmit the collected signal to the control module.

[0062] The bracket 6 is installed inside the housing and supports the water container 4, sample driving module, reagent driving module, water driving module, microfluidic chip, and battery 8. The bracket 6 can be fixedly connected to the front housing 11 or the rear housing 12 by bolts, and the specific shape of the bracket 6 is not limited.

[0063] like Figure 10As shown, the microfluidic chip comprises a flow channel plate 2 and a cover plate connected to the flow channel plate 2, wherein the flow channel plate 2 is a plate-shaped member extending along a first direction, and is used for mixing reagents and samples. Specifically, a front surface or a rear surface of the flow channel plate 2 is provided with a recessed main flow channel 21, a sample flow channel 22, a water flow channel 24, an air flow channel 23, a plurality of reagent flow channels 28, and a mixing cavity 25, wherein the main flow channel 21 extends along the first direction, and the first direction is perpendicular to a vertical direction.

[0064] The cover plate covers and is connected to the front surface or the rear surface of the flow channel plate 2, and covers the main flow channel 21, the sample flow channel 22, the water flow channel 24, the air flow channel 23, the plurality of reagent flow channels 28, and the mixing cavity 25. The cover plate and the main flow channel 21 cooperate to prevent liquid in the main flow channel 21, the sample flow channel 22, the water flow channel 24, the air flow channel 23, the plurality of reagent flow channels 28, and the mixing cavity 25 from overflowing.

[0065] One end of the main flow channel 21 extends to an outer end of the microfluidic chip along the first direction, and the other end extends to a substantially middle part of the microfluidic chip.

[0066] One end of the sample flow channel 22, the water flow channel 24, the air flow channel 23, and the plurality of reagent flow channels 28 is connected to the main flow channel 21, and the other end extends to a top side or a bottom side of the microfluidic chip, and is used for communicating with the sample container 5, the water container 4, or the reagent capsule 7 through a pipeline. Figure 6 And Figure 10 In the embodiment shown, the sample flow channel 22, the water flow channel 24, the air flow channel 23, and the plurality of reagent flow channels 28 are spaced apart like branches on the top and bottom of the main flow channel 21, and in other embodiments, other arrangement modes can also be used.

[0067] Specifically, as shown in Figure 12 The sample container 5 communicates with the sample flow channel 22 through a pipeline, which is defined as a first sample pipeline 502, and the sample container 5 communicates with the collection cavity 123 through another pipeline, which is defined as a second sample pipeline 503.

[0068] As shown in Figure 12 The first sample pipeline 502 is connected to one pump, which is defined as a first sample pump 501, and the first sample pump 501 is used to drive the sample in the sample container 5 to flow into the sample flow channel 22 and then into the main flow channel 21 through the sample flow channel 22.

[0069] As shown in Figure 12 The second sample pipeline 503 is connected to another pump, which is defined as a second sample pump 51, and the second sample pump 51 is used to drive the sample in the collection cavity 123 to enter the sample container 5.

[0070] Similarly to the sample container 5, as shown in Figure 12In the embodiment, the fresh water container 4 is also connected with the fresh water flow channel 24 and the collection cavity 123 through two pipes respectively. The pipe connecting the fresh water container 4 with the fresh water flow channel 24 is the first fresh water pipe 402, and the pipe connecting the fresh water container 4 with the collection cavity 123 is the second fresh water pipe 403.

[0071] The first fresh water pipe 402 is connected with a pump, which is the first fresh water pump 401. The first fresh water pump is used to drive the water in the fresh water container 4 to flow from the first fresh water pipe into the fresh water flow channel 24, and then into the main flow channel 21.

[0072] The second fresh water pipe 403 is connected with another pump, which is the second fresh water pump 41. The second fresh water pump 41 is used to drive the water in the collection cavity 123 to flow from the second fresh water pipe into the fresh water container 4.

[0073] In addition, as shown in Figure 4 and Figure 8 , the top of the fresh water container 4 and the top of the sample container 5 are respectively provided with an air outlet. The air outlet of the fresh water container 4 is connected with a pipe, which is the first exhaust pipe 42. The two ends of the first exhaust pipe 42 are respectively connected with the air outlet of the fresh water container 4 and the first exhaust hole 128 of the collection cavity 123.

[0074] As shown in Figure 4 and Figure 5 , the air outlet of the sample container 5 is connected with another pipe, which is defined as the second exhaust pipe 52. The two ends of the second exhaust pipe 52 are respectively connected with the air outlet of the sample container 5 and the second exhaust hole 129 of the collection cavity 123.

[0075] As shown in Figures 4-10 , the flow rate of the second sample pump 51 is greater than that of the first sample pump 501, and the flow rate of the second fresh water pump 41 is greater than that of the first fresh water pump 401. In use, when the sensor senses that the sample is collected in the collection cavity 123, the control module can drive the second sample pump 51 to work after receiving the sensor signal. The second sample pump 51 has a large flow rate and can extract a large amount of samples in the collection cavity 123 into the sample container 5. During the rapid extraction process, air bubbles will be generated. The air bubbles and part of the samples enter the sample container 5, then pass through the second exhaust pipe 52 and the second exhaust hole 129 at the bottom end of the collection cavity 123 into the collection cavity 123, and then are discharged from the bottom end of the collection cavity 123. The flow rate of the first sample pump 501 is small, which can quantitatively extract the samples in the sample container 5 from the sample pipe into the sample flow channel 22, and then into the main flow channel 21. This arrangement can discharge the air bubbles in the sample, so that no air bubbles are generated in the sample extracted by the first sample pump 501, thereby avoiding affecting the detection.

[0076] Similarly, as shown in Figures 4-10As shown, when it is necessary to extract the water in the collection cavity 123 to clean the microfluidic chip and the test cavity, the second clean water pump 41 is also used to extract a large amount of water in the collection cavity 123 into the clean water container 4, and then the first clean water pump 401 is used to extract the water in the clean water container 4 to the clean water flow channel 24 and the main flow channel 21. The bubbles in the clean water container 4 can enter the first exhaust hole 128 at the top end of the collection cavity 123 through the exhaust hole and the first exhaust pipeline 42. Since the clean water has a washing effect, the bubbles and water in the first exhaust hole 128 can flow into the collection cavity 123 after entering the top end of the collection cavity 123, thereby cleaning the collection cavity 123 again. Therefore, the first exhaust hole 128 is arranged at the top end of the collection cavity 123. Since the bubbles and samples in the sample container 5 can contaminate the collection cavity 123, the second exhaust hole 129 needs to be arranged at the bottom end of the collection cavity 123 to avoid contaminating the collection cavity 123.

[0077] When there are a large number of bubbles in the clean water used for washing, the cleaning effect will also be affected. Therefore, after the clean water container 4 is exhausted, the bubbles entering the main flow channel 21 can also be reduced.

[0078] Of course, in other embodiments, if it is ensured that there are no bubbles in the samples and water collected in the collection cavity 123, the clean water container 4 or the sample container 5 can also not be arranged. That is, the first clean water pipeline 402 or the first sample pipeline 502 is directly connected to the collection cavity 123, and the water or samples in the collection cavity 123 is directly extracted to the main flow channel 21 by the corresponding pump.

[0079] In addition, in order to maximize the capacity of the samples and water and not to occupy too much internal space, the sample container 5 and the clean water container 4 are matched with the shape of the groove 124 as much as possible.

[0080] The first sample pump 501, the second sample pump 51, the first clean water pump 401, and the second clean water pump 41 are preferably peristaltic pumps. The second sample pump 51 has a small flow rate, and can realize precise and quantitative extraction of samples to the main flow channel 21.

[0081] In Figure 10 In the embodiment shown, the clean water flow channel 24 is located at the outer end of the main flow channel 21, that is, the clean water flow channel 24 and the main flow channel 21 both extend in the first direction, and the clean water flow channel 24 can also be regarded as part of the outer end of the main flow channel 21. It can be ensured that the entire main flow channel 21 is clear and clean.

[0082] The reagent driving module is mounted on the bracket, a plurality of reagent capsules 7 are fixed on the bracket 6, and the plurality of reagent capsules 7 are respectively connected to a plurality of reagent flow channels 28 on the microfluidic chip through a plurality of reagent pipelines. Both ends of each reagent pipeline are respectively connected to one reagent flow channel 28 and one reagent capsule 7, and each reagent pipeline is respectively connected to one reagent pump 102.

[0083] AsFigure 17 As shown, the reagent pump 102 can draw the reagent in the reagent capsule 7 to the reagent flow channel 28 and then to the main flow channel 21. According to the detection requirement, the reagent pump 102 can quantitatively draw the reagent in the reagent capsule 7 to the main flow channel 21, and the quantification is more accurate. The reagent pump 102 is preferably a peristaltic pump.

[0084] The air flow channel 23 is connected with another pipeline, which is defined as an air pipeline, and the air pipeline is further connected with a pump, which is defined as an air pump 101.

[0085] The air pump 101 can draw the external air from the air pipeline to the main flow channel 21 through the air flow channel 23, and of course, the air in the main flow channel 21 can be drawn to the outside through the air pipeline. The air pump 101 is connected with the support 6, and is preferably a peristaltic pump.

[0086] The air flow channel 23 is close to the clean water flow channel 24, that is, closer to the outer end of the sample flow channel. The air from the air flow channel 23 can drive all the reagents or samples in the main flow channel 21 to flow into the mixing chamber 25 from the main flow channel 21.

[0087] The above-mentioned pumps are peristaltic pumps. In order to be connected with the peristaltic pump, the pipelines need to be divided into two sections, and the two ends of the two sections are respectively connected with the two ends of the hose of the peristaltic pump.

[0088] Specifically, the mixing chamber 25 is connected with one end of the main flow channel 21 in the middle part of the microfluidic chip. The mixing chamber 25 has a certain accommodation space, which can be used for mixing the sample and the reagent.

[0089] After the second sample pump 51 draws the sample to the sample container 5, the first sample pump 501 can draw the sample in the sample container 5 to the sample flow channel 22, and then to the main flow channel 21. Then, the air pump 101 drives the air pipeline to draw the external air into the main flow channel 21, and pushes the sample in the main flow channel 21 to flow to the mixing chamber 25.

[0090] After the sample flows into the mixing chamber 25, the first sample pump 501 needs to draw a part of the air in the main flow channel 21 to the sample flow channel 22 in reverse, so as to prevent the reagent from flowing into the sample flow channel 22 during the flow in the main flow channel 21.

[0091] The reagent also flows into the mixing chamber 25 in the same way. Specifically, the reagent pump 102 draws the reagent in the reagent capsule 7 to the main flow channel 21 through the reagent pipeline, and then the air pump 101 draws the external air into the main flow channel 21, pushes the reagent in the main flow channel 21 to enter the mixing chamber 25. Then, the reagent pump needs to operate in reverse, and draws a part of the air in the main flow channel 21 to the reagent flow channel 28.

[0092] The mixing chamber 25 is connected to the test chamber. After the reagent and sample enter the mixing chamber 25, the air pump 101 can draw air into the mixing chamber 25 to drive the reagent and sample to tumble and mix in the mixing chamber 25 to obtain a mixed liquid. The air pump 101 can drive the mixed liquid in the mixing chamber 25 to the test chamber.

[0093] In a preferred embodiment, the microfluidic chip also includes a mixing bend 26, the two ends of which are connected to the test chamber and the mixing chamber 25, respectively. The mixing bend 26 is a curved pipe.

[0094] After the reagents and samples enter the mixing chamber 25, the air pump can drive the reagents and samples in the mixing chamber 25 from the mixing chamber 25 into the mixing bend 26, and then return from the mixing bend 26 to the mixing chamber 25. After going back and forth two or three times, the reagents and samples are fully mixed, and then the mixed liquid is driven from the mixing chamber 25 and the mixing bend 26 into the test chamber.

[0095] The sample or reagent needs to be propelled towards the mixing chamber 25 by gas to mix, and the gas also needs to separate the sample and reagent as they enter the mixing chamber 25. Therefore, bubbles will be generated during the flow of the sample or reagent. However, after the sample and reagent are mixed multiple times in the mixing chamber 25, the bubbles will be broken and will not flow into the test chamber to interfere with the detection.

[0096] exist Figure 10 In the illustrated embodiment, the mixing chamber 25 and the main channel 21 extend along a first direction, which is perpendicular to the vertical direction. The mixing chamber 25 includes a first segment 251, a mixing chamber 252, and a tail segment 253 that are connected to each other. The first segment 251 extends along the vertical direction, with its bottom end connected to the main channel 21 and its top end connected to the mixing chamber 252. The tail segment extends along the first direction and is slightly lower than the main channel 21. Both ends of the tail segment 253 are connected to the mixing chamber 252 and the mixing bend 26, respectively.

[0097] The mixing chamber 252 is roughly baseball-shaped, with its top end connected to the first segment 251 and its bottom end connected to the tail segment. Of the two side walls of the mixing chamber 252 arranged opposite each other along a first direction, one side wall includes a first arc surface 254, and the other side wall includes a second arc surface 255 and a third arc surface 256 connected to each other.

[0098] The first arc surface 254 is concavely curved towards the second arc surface 255, and has one end tangent to a horizontal plane and the other end tangent to a vertical plane. Preferably, the radius of the first arc surface 254 is in the range of 5mm to 8mm, and the arc length is in the range of 7mm to 10mm. More preferably, the radius of the first arc surface 254 is 5mm, and the arc length is 7.85mm. The top end of the first arc surface 254 is connected to the first section 251 by a horizontal inner wall, and the bottom end is connected to a vertical inner wall which extends to the tail section.

[0099] The second arc surface 255 is concavely curved towards the first arc surface 254, i.e. both the first arc surface 254 and the second arc surface 255 are concavely curved towards the outside. The bottom end of the second arc surface 255 is tangent to a horizontal plane, and the top end is tangent to a vertical plane. The bottom end of the second arc surface 255 is connected to the tail section by a horizontal inner wall.

[0100] Preferably, the radius of the second arc surface 255 is in the range of 5mm to 8mm, and the arc length is in the range of 7mm to 10mm. More preferably, the radius of the second arc surface 255 is 5mm, and the arc length is 7.85mm.

[0101] The third arc surface 256 is concavely curved towards the inside of the mixing cavity 25. The third arc surface 256 is located on the top of the second arc surface 255, and the bottom end of the third arc surface 256 is tangent to a vertical plane which overlaps with the vertical plane tangent to the top end of the second arc surface 255. The top end of the third arc surface 256 is tangent to a horizontal plane which is below the horizontal plane tangent to the top end of the first arc surface 254.

[0102] Preferably, the radius of the third arc surface 256 is in the range of 0.75mm to 2mm, and the arc length is in the range of 1.5mm to 3mm. More preferably, the radius of the third arc surface 256 is 2mm, and the arc length is 3mm.

[0103] The bottom end of the third arc surface 256 can be directly connected to the top end of the second arc surface 255, or can be spaced apart by a vertical inner wall. The height of the mixing cavity 25 in the vertical direction is in the range of 8mm to 12mm, and the width in the first direction is in the range of 7mm to 9mm. Preferably, the height hi of the mixing cavity 252 in the vertical direction is 9.75mm, and the width wi in the first direction is 8mm. Figure 11

[0104] The diameter of the mixing bend 26 is in the range of 1mm to 2mm, and more preferably is 1.5mm.

[0105] ​Experiments show that the mixing effect is best after the sample and the reagent flow back and forth in the mixing cavity 25 and the mixing bend 26 once, that is, the sample and the reagent flow from the mixing cavity 25 into the mixing bend 26 and then return to the mixing cavity 25 to complete the mixing effect.

[0106] The mixing liquid capacity required for detection is about 55 um, and experiments show that the above-mentioned size of the mixing cavity 25 and the mixing bend 26 not only ensures that the mixing liquid does not return to the main flow channel 21 during the mixing process, but also can be fully mixed.

[0107] In another embodiment, as shown in Figures 13-15 , the flow channel plate is provided with another mixing cavity, which is defined as a second mixing cavity 257. The second mixing cavity 257 also extends in the first direction and one end is in communication with the main flow channel 21 and the other end is in communication with the test cavity. In addition, the top wall of the second mixing cavity 257 gradually increases from both ends to the middle of the second mixing cavity 257 in the first direction, and the top wall of the second mixing cavity 257 is arc-shaped. Of course, in this embodiment, the microfluidic chip is also provided with a water flow channel, a reagent flow channel, and an air flow channel in communication with the main flow channel, and the operation is the same as the previous embodiment, Figure 12 and Figure 14 The flow channels are not shown.

[0108] Of course, the rear end of the second mixing cavity 257 can also be provided with a mixing bend (not shown in the figure), and the two ends of the mixing bend are in communication with the second mixing cavity 257 and the test cavity, respectively. Similar to the previous embodiment, after the reagent and the sample flow into the second mixing cavity 257, the air pump drives the reagent and the sample to flow from the second mixing cavity 257 into the mixing bend, and repeatedly flows back to mix the reagent and the sample, and then drives the mixed liquid into the test cavity.

[0109] Preferably, as shown in Figure 14 , the width range w2 of the second mixing cavity 257 in the first direction is 20-24 mm. The height range h2 of the second mixing cavity 257 in the vertical direction is 3-4 mm.

[0110] Preferably, as shown in Figure 14 , the radius range r of the main flow channel is 0.5-1 mm, and the inner wall of the second mixing cavity 257 includes a first section 2571 protruding towards the outside and a second section 2572 recessed towards the inside. The first section 2571 and the second section 2572 are preferably arc-shaped, the bottom end of the first section is connected to the inner wall of the main flow channel, and the top section is connected to the bottom end of the second section.

[0111] The first segment and the second segment are preferably circular arc surfaces, and the radius of the first segment is preferably in the range of 3mm-5mm. The depth of the second segment recessed towards the interior is greater than the depth of the first segment recessed towards the interior, and the depth of the second segment recessed towards the interior is in the range of 1.0mm-2.2mm.

[0112] The size of the mixing cavity determines the mixing effect and the backflow of the liquid, so the mixing cavity size and the main flow channel size of the above data are obtained through many experiments, which can guarantee the mixing effect.

[0113] As Figure 15 In the second mixing cavity 257, the liquid in the flow process will not rise to the top wall of the second mixing cavity 257, that is, the liquid will not contact the second segment 2572 of the second mixing cavity 257. The liquid has an angular flow effect, that is, the liquid will adhere to the inner wall of the second mixing cavity 257 during the flow process. When the liquid flows from the main flow channel 21 into the second mixing cavity 257, the surface of the liquid will form an arc surface curved towards the outside at one end of the second mixing cavity 257 close to the main flow channel 21. When the liquid flows out of the second mixing cavity 257 to the mixing elbow or the test cavity, that is, when the liquid flows from the second mixing cavity 257 to the outside, the surface of the liquid will also form an arc surface recessed towards the outside at the other end of the second mixing cavity 257 away from the main flow channel 21. The two arc surfaces formed during the liquid entering and flowing out of the second mixing cavity 257 enclose a roughly spherical space that accommodates bubbles, and the bubbles will be broken in this space, thereby reducing the bubbles flowing into the test cavity from the second mixing cavity 257.

[0114] After the sample and the reagent are mixed, the mixed liquid enters the test cavity from the second mixing cavity 257 and the mixing elbow, Figure 4 In the embodiment shown, a section of pipeline is connected between the test cavity and the mixing elbow. In other embodiments, the test cavity can be directly provided on the microfluidic chip, or the test plate can be arranged adjacent to the microfluidic chip, and the test cavity can be directly communicated with the mixing elbow.

[0115] The test cavity is a cavity extending in the first direction, and the width of the test cavity in the vertical direction gradually increases from both ends to the middle. The top wall of the test cavity gradually rises from both ends to the middle, and the bottom wall of the test cavity gradually decreases from both ends to the middle. The bottom wall of the test cavity forms a pit to facilitate the placement of the mixed liquid for detection.

[0116] The detection component 31 includes a light source device and a photosensitive sensor, which are respectively arranged at corresponding positions of the test plate. The test plate is made of transparent material. The light source device is an LED light for irradiating the mixed liquid in the test cavity, and the photosensitive sensor is used to sense the light after the light source device irradiates the mixed liquid to detect the composition of the sample.

[0117] When enough sample is collected in the collection cavity 123, the excess sample is discharged from the drain 126 at the bottom end of the collection cavity 123. When the operator flushes the bowl of the toilet, water is collected in the collection cavity 123. When the sensor detects the water, it sends a signal to the control module. The control module controls the second clean water pump 41 to draw the water in the collection cavity 123 into the clean water container 4.

[0118] Of course, the test cavity can be connected to one of the holes 125 at the bottom end of the collection cavity 123 through a drain pipe. The air pump can pump the mixed liquid in the test cavity to the drain pipe, and then to the collection cavity 123, and finally to the bowl of the toilet through the drain 126 at the bottom end of the collection cavity 123.

[0119] In another embodiment, the test plate is arranged adjacent to the rear shell 12, and the test cavity can also be provided with a drain 126 that extends directly to the outside of the rear shell 12. After detection, the mixed liquid in the test cavity can also be directly discharged from the drain 126.

[0120] As a preferred solution, as shown in Figure 10 The microfluidic chip is also provided with a washing flow channel 27 that is connected to the main flow channel 21 at one end and to a container containing a washing agent at the other end through a washing pipe. The container is defined as a washing container. The washing pipe is also connected to a washing pump 103.

[0121] After detection, before the control module drives the second clean water pump 41 to draw the water in the clean water container 4, it first controls the washing pump 103 to draw the washing liquid in the washing container into the main flow channel 21, and then controls the second clean water pump 41 to draw the water in the clean water container 4 into the main flow channel 21. The air pump drives the water and the washing liquid in the main flow channel 21 into the mixing cavity 25, and the water and the washing liquid repeatedly flow in the mixing cavity 25 and the mixing bend 26 to mix the water and the washing liquid. After mixing, the control module controls the air pump to push the mixed washing liquid into the test cavity in sequence from the mixing cavity, the mixing bend, and then out of the test cavity.

[0122] Alternatively, the washing pump 103 drives the washing agent in the container to enter the main flow channel 21 from the washing flow channel 27 to obtain mixed washing liquid. The air pump continues to push the mixed washing liquid into the test cavity in sequence via the mixing cavity 25 and the mixing bend 26, and then flows into the collection cavity 123 from the test cavity and the drain pipe, and finally is discharged into the bowl of the toilet from the drain 126 of the collection cavity 123.

[0123] The present application also relates to a control method of the urine testing device 100. In one embodiment, the urine testing device 100 comprises a housing, a detection mechanism 3, a sensor, a microfluidic chip, a first sample pump 501, a reagent pump, an air pump and a control module, wherein the top end of the housing is provided with a collection cavity 123. The sensor is used to sense the sample and water in the collection cavity 123, and the sensor can be an infrared sensor or other sensors. The microfluidic chip is provided with a main flow channel 21, a mixing cavity 25, a sample flow channel 22, an air flow channel 23 and a plurality of reagent flow channels 28. The first sample pump 501 is connected with a first sample pipeline 502. The plurality of reagent pumps are connected with a plurality of reagent pipelines. The air pump is connected with an air pipeline.

[0124] As shown in Figure 16 the control method comprises the following steps:

[0125] S1, after the sensor senses the information that the sample is collected in the collection cavity 123, the information is transmitted to the control module, and the control module controls the first sample pump 501 to control the sample in the collection cavity 123 to flow from the sample flow channel 22 to the main flow channel 21 according to the information of the sensor, and then controls the air pump to push the sample in the main flow channel 21 to flow into the mixing cavity 25, and then controls the first sample pump 501 to suck a part of the air in the main flow channel 21 into the sample flow channel 22;

[0126] S2, the sensor senses that the water is collected in the collection cavity 123 and transmits the information to the control module, and the control module controls the reagent pump to drive the reagent in the reagent capsule 7 to flow from the reagent flow channel 28 to the main flow channel 21, and then controls the air pump to push and suck the air into the main flow channel 21, so as to push the reagent in the main flow channel 21 to flow into the mixing cavity 25, and then controls the reagent pump to suck a part of the air in the main flow channel 21 into the reagent flow channel 28;

[0127] S3, the control module controls the air pump to repeatedly push the sample and the reagent in the mixing cavity 25 to flow in the mixing cavity 25, and then controls the air pump to push the mixed liquid to flow from the mixing cavity 25 to the test cavity after the mixed liquid is obtained;

[0128] S4, the control module controls the detection component 31 to detect the mixed liquid in the test cavity.

[0129] In one preferred embodiment, the housing is provided with a sample container 5, a second sample pipeline 503 and a second sample pump 51, and the sample container 5, the second sample pump 51 and the second sample pipeline 503 have been described above and will not be described in detail.

[0130] In this case, in step S1, the control module first controls the second sample pump 51 to drive the sample in the collection cavity 123 to flow into the sample container 5, and then controls the first sample pump to drive the sample in the sample container 5 to flow from the sample flow channel 22 to the main flow channel 21.

[0131] In another preferred embodiment, the microfluidic chip comprises a mixing elbow 26 arranged in a curve, and the mixing chamber 25 is in communication with the main flow channel 21 and the mixing elbow 26 at two ends thereof, and the mixing elbow 26 is in communication with the mixing chamber 25 and the test chamber at two ends thereof;

[0132] In step S3, after the sample and the reagent enter the mixing chamber 25 from the main flow channel 21, the control module controls the air pump to repeatedly push the sample and the reagent in the mixing chamber 25 to enter the mixing elbow 26 from the mixing chamber 25 and then return to the mixing chamber 25, so as to obtain the mixed liquid, and then the control module controls the air pump to push the mixed liquid to pass through the mixing chamber 25 and the mixing elbow 26 to the test chamber in sequence.

[0133] Preferably, the microfluidic chip is further provided with a clean water flow channel 24, one end of the clean water flow channel 24 is in communication with the main flow channel 21, and the other end is in communication with the collection chamber 123 through a first clean water pipeline, and the clean water pipeline is connected with a first clean water pump 401.

[0134] After the detection is completed, that is, after step S4, there is still step S5, after the detection component 31 detects the mixed liquid in the test chamber, the detection information is transmitted to the control module, the control module controls the first clean water pump 401 to drive the water in the collection chamber 123 to enter the main flow channel 21, the control module controls the air pump to suck air into the main flow channel 21, and drives the water in the main flow channel 21 to pass through the mixing chamber 25, the mixing elbow 26 and the test chamber in sequence from the main flow channel 21, and finally discharged from the test chamber.

[0135] Further, the shell is further provided with a clean water container 4, and a second clean water pipeline 403 and a second clean water pump 41. The two ends of the second clean water pipeline 403 are in communication with the collection chamber 123 and the clean water container 4 respectively. The two ends of the first clean water pipeline 402 are in communication with the clean water container 4 and the clean water flow channel 24 respectively. The second clean water pump 41 is connected with the second clean water pipeline 403.

[0136] In step S5, after the detection component 31 detects the mixed liquid in the test chamber, the control module first controls the second clean water pump 41 to drive the water in the collection chamber 123 to flow into the clean water container 4, and then controls the first clean water pump 401 to drive the water in the clean water container 4 to enter the main flow channel 21 from the clean water flow channel 24, and the air pump drives the water in the main flow channel 21 to pass through the mixing chamber 25, the mixing elbow 26 and the test chamber in sequence, and finally discharged from the test chamber.

[0137] Further, the microfluidic chip is further provided with a washing flow channel 27, which is in communication with the main flow channel 21 and is in communication with a container containing a washing agent through a washing pipeline;

[0138] The urine test instrument 100 further comprises a washing pump connected with the washing pipeline;

[0139] In step S5, after the detection component 31 detects the mixed liquid in the test chamber, the control module controls the washing pump to drive the washing agent in the container to enter the main flow channel 21 from the washing flow channel 27, the second clean water pump 41 drives the water in the collection chamber 123 to flow into the clean water container 4, the first clean water pump 401 drives the water in the clean water container 4 to flow into the main flow channel 21 from the clean water flow channel 24, the air pump sucks air into the main flow channel 21, and drives the water and the washing agent in the main flow channel 21 to flow into the mixing chamber 25 and the mixing bend 26 from the main flow channel 21, and then flow into the test chamber, and finally flow out of the test chamber.

[0140] Further, in step S5, the control module controls the air pump to suck air into the main flow channel 21, and drives the water and the washing agent in the main flow channel 21 to flow into the mixing chamber 25 from the main flow channel 21, and then controls the air pump to repeatedly push the water and the washing agent in the mixing chamber 25 to flow into the mixing bend 26 from the mixing chamber 25 and then return to the mixing chamber 25, so as to obtain the mixed washing liquid, and then controls the air pump to push the mixed washing liquid to flow into the test chamber in sequence via the mixing chamber 25 and the mixing bend 26, and finally flow out of the test chamber.

[0141] Further, the test chamber is communicated with the collection chamber 123 through a sewage pipeline, and the collection chamber 123 is provided with a sewage outlet 126 at the bottom end.

[0142] In step S5, the control module controls the air pump to suck air into the main flow channel 21, and drives the water and the reagent in the main flow channel 21 to flow into the test chamber in sequence via the mixing chamber 25 and the mixing bend 26, and then flow into the collection chamber 123 through the sewage pipeline and flow out of the sewage outlet 126.

[0143] The above-mentioned plurality of pumps are preferably peristaltic pumps, and in particular, the pump driving the reagent, which can improve the accuracy by using the peristaltic pump.

[0144] The control module is installed on the circuit board 9, and the circuit board 9 is fixed on the support 6. The control module and the detection mechanism 3 are fixed to the substantially middle part of the support 6, which is located at the rear end of the microfluidic chip.

[0145] After the urine test instrument 100 detects, the detected spectral data is sent to the computing device, and the computing device analyzes the urine detection data of the current user to be tested based on the spectral data of the urine of the current user to be tested.

[0146] As a preferred solution, a wireless communication module (WIFI, 4G, 5G, etc.) is further arranged in the shell, and the control module can send the spectral data or urine detection data to the cloud server through the wireless communication module. After the collected sample information of the current user to be tested reaches the required number of the current configured user state prediction model, the computing device automatically inputs the sample information of the current user to be tested within the first set time period to the user state prediction model, and the user state prediction model outputs the user physiological index data of the current user to be tested within the second set time period in the future under the current environmental condition, thereby forming a continuous time period (first set time period + second set time period) of user physiological index data. Of course, the user state prediction model can also be triggered by the user through the user terminal (mobile phone, tablet computer and other electronic devices) to make a prediction. The specific scenario is that the user sends a prediction request to the computing device through the user terminal, and the computing device determines the sample information of the user within the first set time period required for prediction according to the identity information of the current user when receiving the prediction request of the user, and inputs the sample information into the user state prediction model to obtain the user physiological index data of the user within the second set time period.

[0147] After the health classification model predicts the health type of the user to be tested, the user state prediction result in the region can be analyzed, and the physiological indicators, living habits, environmental factors and other information of the user to be tested are comprehensively evaluated. Based on the prediction result of the health classification and the physiological indicators of the user to be tested, the overall health status of the user to be tested can be determined, and whether the user to be tested has a potential health problem can be judged.

[0148] The collection cavity 123 is arranged to have a larger top end opening and a smaller bottom end, and the sample flows into the sample container 5 from the bottom end of the collection cavity 123. During the process of flowing from the top end to the bottom end, a part of the air bubbles can be reduced.

[0149] Moreover, the sample container 5 is used in the collection process, and the sample container 5 is provided with an air outlet hole. The sample in the collection cavity 123 is extracted to the sample container 5 by the second sample pump 51, and the sample container 5 is extracted into the microfluidic chip by the first sample pump. The air bubbles in the sample during the collection process can be reduced to be transported into the microfluidic chip, and the detection accuracy is improved.

[0150] In addition, the microfluidic chip is provided with a mixing cavity 25 and a mixing bend 26. The shape of the mixing cavity 25 is improved, which not only facilitates the mixing of the reagent and the sample, but also ensures the mixing of the reagent and the sample, reduces the flow of air bubbles into the test cavity, and improves the detection accuracy.

[0151] The urine analyzer 100 of the present invention drives multiple reagents, samples, water and air respectively by multiple pumps, which can improve the driving efficiency. Moreover, by using the mixing chamber 25 and the mixing bend 26, the mixing effect of reagents and samples, as well as water and reagents, can be improved.

[0152] The present invention also relates to a toilet, which includes a toilet body and the aforementioned urine analyzer. The urine analyzer is attached to the inner wall of the toilet body and is located near the front end. The rear shell 12 of the housing is adhered to the inner wall of the toilet body, and the top opening of the collection chamber 123 is used to collect samples and water.

[0153] The preferred embodiments of the present invention have been described in detail above, but it should be understood that, if necessary, aspects of the embodiments can be modified to utilize aspects, features, and concepts from various patents, applications, and publications to provide other embodiments.

[0154] In light of the detailed description above, these and other changes can be made to the embodiments. Generally, the terminology used in the claims should not be considered limited to the specific embodiments disclosed in the specification and claims, but should be understood to include all possible embodiments together with the full scope of equivalents enjoyed by these claims.

[0155] Those skilled in the art will understand that the above embodiments are specific examples of implementing the present invention, and in practical applications, various changes in form and detail may be made without departing from the spirit and scope of the present invention.

Claims

1. A microfluidic chip for a urine test instrument, the urine test instrument comprising a plurality of reagent capsules and a test plate, the test plate being provided with a test cavity; characterized in that, The microfluidic chip comprises: a flow channel plate, a surface of the flow channel plate being provided with recesses: a main flow channel, the main flow channel extending along a first direction and having one end located at a middle part of the microfluidic chip; a plurality of reagent flow channels, one end of each of the plurality of reagent flow channels being in communication with the main flow channel, and the other end being configured to be in communication with a reagent capsule; a sample flow channel, one end of the sample flow channel being in communication with the main flow channel, and the other end being configured to receive a sample; an air flow channel, one end of the air flow channel being in communication with the main flow channel, and the other end being configured to receive air; a mixing cavity, the mixing cavity being connected to one end of the main flow channel at the middle part and being configured to be in communication with a test cavity, the mixing cavity extending along a vertical direction, and a width dimension of the mixing cavity gradually increasing from both ends to a middle of the mixing cavity; and a cover plate, the cover plate being connected to the surface of the flow channel plate and covering the main flow channel, the reagent flow channels, the sample flow channel, the air flow channel, and the mixing cavity.

2. The microfluidic chip of claim 1, wherein, The mixing cavity comprises: a first section, a bottom end of the first section being in communication with the main flow channel; a mixing chamber, a top end of the mixing chamber being connected to a top end of the main flow channel, the mixing chamber comprising a first curved surface and a second curved surface, the first curved surface and the second curved surface being oppositely arranged, the first curved surface being a curved surface recessed towards away from the second curved surface, and the second curved surface being a curved surface formed towards away from the first curved surface; and a second section, one end of the second section being connected to a bottom end of the mixing chamber, and the other end being in communication with the test cavity.

3. The microfluidic chip of claim 2, wherein, The mixing chamber further comprises a third curved surface, a top end of the third curved surface being connected to the first section, and a bottom end of the third curved surface being connected to the second curved surface, the third curved surface being a curved surface recessed towards the first curved surface.

4. The microfluidic chip of claim 3, wherein, A radius of the first curved surface ranges from 5 mm to 8 mm, and an arc length of the first curved surface ranges from 7 mm to 10 mm; A radius of the second curved surface ranges from 5 mm to 8 mm, and an arc length of the second curved surface ranges from 7 mm to 10 mm; A radius of the third curved surface ranges from 0.75 mm to 2 mm, and an arc length of the third curved surface ranges from 1.5 mm to 3 mm.

5. The microfluidic chip of claim 3, wherein, A height of the mixing chamber along the vertical direction ranges from 8 mm to 12 mm, and a width of the mixing chamber along the first direction ranges from 8 mm to 12 mm.

6. The microfluidic chip of claim 1, wherein, The mixing cavity extends along the first direction, and one end of the mixing cavity is in communication with the main flow channel, and the other end of the mixing cavity is in communication with the test cavity. A top wall of the mixing cavity gradually increases from both ends to a middle of the mixing cavity along the first direction.

7. The microfluidic chip of claim 6, wherein, The top wall of the mixing cavity is a curved surface.

8. The microfluidic chip of claim 7, wherein, A width of the mixing cavity along the first direction ranges from 20 mm to 24 mm, and a height of the mixing cavity along the vertical direction ranges from 3 mm to 4 mm.

9. The microfluidic chip of claim 7, wherein, A radius of the main flow channel ranges from 0.5 mm to 1 mm, an inner side wall of the mixing cavity comprises a first section and a second section connected to each other, the first section is a curved surface protruding towards the outside, the second section is located at a top of the first section, the second section is a curved surface recessed towards the inside, a radius of the first section ranges from 3 mm to 5 mm, and a recessed depth of the second section ranges from 1 mm to 2.2 mm.

10. The microfluidic chip of claim 1, wherein, The flow channel plate is further provided with a mixing elbow, which is in the shape of a curved pipe and has one end communicated with the mixing cavity and the other end communicated with the testing cavity.

11. A urine test meter, characterized by, The urine testing instrument comprises the micro-fluidic chip of claim 1.

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