Microbubble generating device with medicine carrying function
By setting a drug carrier and a bubble-splitting mesh on the microbubble generator, the problems of unstable ultrasound contrast agent bubbles and the inability to inject drugs simultaneously were solved, achieving more stable and safer microbubble generation and improving detection results.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-12
- Publication Date
- 2026-03-31
AI Technical Summary
In existing technologies, ultrasound contrast agents have poor bubble stability, are cumbersome to operate and have adverse reactions, and cannot be injected simultaneously for detection, affecting detection results and safety.
Design a microbubble generator with drug-carrying function. By setting a drug carrier on the foaming device, pre-mixing the drug with physiological saline, using the drug-carrying chamber and bubble splitting net to improve bubble stability, and controlling the mixing process by a booster motor or cylinder to ensure uniform drug dissolution.
It improves the stability and detection effect of microbubbles, reduces operational errors, and enhances the safety and convenience of detection.
Smart Images
Figure CN224056004U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model belongs to the technical field of medical apparatus and instruments, and particularly relates to a microbubble generating device with a drug loading function. BACKGROUND
[0002] PFO (patent foramen ovale) is a kind of congenital heart disease, which refers to that the foramen ovale between left and right atrium fails to close completely during the development of infants, resulting in an abnormal channel between the left and right atrium. PFO exists in 1 / 4 of the general population and is related to various diseases, especially closely related to the occurrence of migraine and cryptogenic stroke. At present, the patent foramen ovale is usually diagnosed by transthoracic echocardiography or transcranial Doppler ultrasound contrast. The ultrasound contrast agent is injected into the body through the vein and circulates to the right atrium with the blood. When PFO exists, the ultrasound contrast agent (microbubbles) will enter the left atrium, left ventricle, aorta and intracranial arteries through the unclosed foramen ovale. These microbubbles will strongly reflect the ultrasound waves, so as to be detected by the probe of echocardiography or transcranial Doppler to confirm the existence and size of PFO.
[0003] At present, the ultrasound contrast agent for diagnosing PFO is mainly a mixture of air and physiological saline, and the microbubbles are generated by manual oscillation method. The stability of the bubbles is poor, and a surfactant is usually added to the mixture to reduce the merging rate of the microbubbles in the liquid and increase the stability during use. The surfactants used include polysorbate, propylene glycol, polyethylene glycol, lecithin, poloxamer, glycerol, hypertonic saline, etc. The amount of the above surfactants injected into the human blood is strictly limited, and too much injection often causes other adverse reactions. Too little addition of the surfactant will result in no effect of the generated bubbles. The on-site proportioning by the operator will cause tediousness and great error, and finally result in poor mixing effect of the contrast agent or cause new complications. In addition, some patients may have other diseases, and in order to ensure the safety of detection, specific drugs will also be injected into the patients, which is generally injected separately in the prior art.
[0004] Therefore, in view of the problems in the prior art, there is an urgent need for a microbubble generating device with a drug loading function. UTILITY MODEL CONTENT
[0005] Therefore, the utility model provides a microbubble generating device with a drug loading function, which can be configured in advance according to the predetermined drug proportioning or according to the specific condition of the patient, so as to save the preparation time during the foaming experiment. The drug is dissolved in the physiological saline during the bubble generating process, which can achieve sufficient mixing, make the bubbles more stable, and improve the contrast effect and safety.
[0006] The technical scheme adopted by the utility model is as follows:
[0007] The microbubble generating device with a drug loading function comprises a first mixer, a second mixer and a needle head which are connected with each other, and a drug loading device is connected between the first mixer and the needle head; and a drug loading cavity is arranged in the drug loading device.
[0008] In the further optimization of the technical scheme of the utility model, the first mixer, the second mixer and the needle head are connected through a three-way valve, and the drug loading device is arranged between the three-way valve and the needle head.
[0009] In the further optimization of the technical scheme of the utility model, the inner surface of the drug loading cavity is an abrasive surface, or a groove structure is arranged on the inner surface of the drug loading cavity.
[0010] In the further optimization of the technical scheme of the utility model, the inner diameter of the drug loading cavity gradually decreases from the end close to the needle head to the end close to the first mixer.
[0011] In the further optimization of the technical scheme of the utility model, the drug loading cavity comprises a first chamber and a second chamber, an isolation plate is arranged between the first chamber and the second chamber, and the first chamber and the second chamber are both connected with a fluid channel of the microbubble generating device.
[0012] In the further optimization of the technical scheme of the utility model, a dialysis membrane is arranged on the communication port between the first chamber and the needle head.
[0013] In the further optimization of the technical scheme of the utility model, at least one layer of bubble splitting nets is arranged in the second chamber, and all the bubble splitting nets are arranged at intervals.
[0014] In the further optimization of the technical scheme of the utility model, the pore diameters of all the bubble splitting nets gradually decrease from the first mixer to the needle head, and the pore diameters are 1-15 um.
[0015] In the further optimization of the technical scheme of the utility model, a bubble splitting net is arranged between the first mixer and the drug loading device and / or between the drug loading device and the needle head.
[0016] In the further optimization of the technical scheme of the utility model, a boosting motor or a boosting air cylinder is further arranged on the first mixer and / or the second mixer.
[0017] The utility model has the beneficial effects that:
[0018] By arranging the drug loading device between the first mixer and the needle head, the drug in the drug loading device can be mixed into the liquid when physiological saline is extracted, and the drug and the liquid are fully mixed in the process of repeatedly pushing and pulling the bubble generating device between the first mixer and the second mixer. By designing the inner wall of the drug loading cavity, the adhesion of the drug can be improved.
[0019] The drug loading cavity is arranged in a split structure, and a dialysis membrane is arranged in the first cavity, so that the drug can be prevented from flowing away due to gravity when physiological saline is extracted; in addition, by arranging a bubble cutting net in the second cavity, the bubbles can be cut, so that the bubbles in the liquid are smaller; and a boosting motor or a boosting cylinder is arranged on the mixer for the structure, so that the stability and safety of the foam laboratory bolus can be improved. BRIEF DESCRIPTION OF DRAWINGS
[0020] The above and other objects, features and advantages of the present application will become more apparent from the following description of embodiments of the present application, taken in conjunction with the accompanying drawings, in which:
[0021] Figure 1 is a schematic diagram of the overall structure of the microbubble generating device of the present application;
[0022] Figure 2 is a schematic diagram of the structure of one of the embodiments of the drug carrier of the present application;
[0023] Figure 3 is a schematic diagram of the structure of one of the embodiments of the drug carrier of the present application;
[0024] Figure 4 is a schematic diagram of the structure of one of the embodiments of the drug carrier of the present application;
[0025] Figure 5 is a schematic diagram of the structure of one of the embodiments of the drug carrier of the present application.
[0026] In the figure: 1, first mixer; 2, second mixer; 3, needle; 4, three-way valve; 5, drug carrier;
[0027] 51, drug loading cavity; 511, isolation plate; 512, first cavity; 513, second cavity; 514, dialysis membrane; 515, bubble cutting net; 52, outer luer connector; 53, inner luer connector. DETAILED DESCRIPTION
[0028] The present application is described below based on the embodiments, but the present application is not limited to only these embodiments. In the following detailed description of the present application, some specific details are described in detail in order to avoid confusion of the essence of the present application, and the well-known methods, processes, procedures, elements are not described in detail.
[0029] In addition, those of ordinary skill in the art should understand that the drawings provided herein are for illustrative purposes only, and the drawings are not necessarily drawn to scale.
[0030] Unless the context clearly requires otherwise, throughout the description and the claims, the words "comprise," "comprising," and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in the sense of "including, but not limited to." The word "couple" and variations thereof, such as, for example, "couples," "coupling," and "coupled," means to join, attach, connect, or link.
[0031] In the description of the utility model, it is understood that the terms "first", "second" and the like are only for the purpose of description, and cannot be understood as indicating or implying relative importance. In addition, in the description of the utility model, unless otherwise stated, the meaning of "multiple" is two or more.
[0032] The following will be described in combination with Figures 1-5 The technical scheme of the present application is described in detail.
[0033] The utility model provides a kind of microbubble generating device with drug loading function, as shown in Figure 1 It can be mixed with gas and liquid by the cooperation of first mixer 1 and second mixer 2, and the effect of fully dissolving preset gas into liquid can be achieved by multiple push-pull. In the foaming experiment, 1ml of gas is usually mixed into 9ml of liquid. Due to the properties of gas and liquid, the gas-liquid mixture after mixing will be unstable, and small bubbles in the liquid will merge to form large bubbles or separate from the liquid. Therefore, the technical solution is connected between the first mixer 1 and the needle 3 with a drug carrier 5. The drug carrier 5 is connected with the first mixer 1 through an outer luer connector 52 and connected with the needle 3 through an inner luer connector 53. Figure 2 As shown in the figure, the drug carrier 5 is provided with a drug loading cavity 51, which can be used to set a specified amount of surfactant in advance. When the first mixer 1 extracts liquid, the surfactant will be dissolved in the liquid, and then mixed with gas. The mixed gas will be relatively stable. Of course, the surfactant in the drug loading cavity 51 is only one of the use methods. In addition, when performing patent ductus arteriosus foaming experiment for infants, a certain amount of tranquilizer will be injected, and the medicine can also be placed in the drug loading cavity 51 for mixing. Other common medicines can be preset in the drug loading cavity 51 according to the clinical situation to increase the convenience of operation and reduce the preparation time of foaming experiment medicine.
[0034] The first mixer 1, the second mixer 2 and the needle 3 are connected by the three-way valve 4 when the device is in use. Preferably, the medicine carrier 5 is arranged between the three-way valve 4 and the needle 3. When the first mixer 1 starts to suck liquid, the channel between the first mixer 1 and the needle 3 is connected, and the liquid is sucked through the needle 3. When gas is sucked, the channel between the second mixer 2 and the needle 3 is connected. When the first mixer 1 and the second mixer 2 are both ready, the two mixers are connected, and the liquid in the first mixer 1 is mixed with the liquid in the second mixer 2 by repeatedly pushing and pulling, so as to produce liquid containing a large number of microbubbles for detecting patent foramen ovale. The medicine carrier 5 arranged between the three-way valve 4 and the needle 3 can mix the preset medicine into the liquid when the first mixer 1 sucks the liquid.
[0035] In order to control the amount of medicine carried by the medicine carrier 5 and facilitate the attachment of the medicine to the medicine carrying cavity 51, the inner surface of the medicine carrying cavity 51 is frosted, or a groove structure is arranged on the inner surface of the medicine carrying cavity 51. In this way, the solid medicine can be made into powder and sprayed or smeared on the inner wall of the medicine carrying cavity 51, so that the medicine can be washed away when the liquid flows, so as to mix the medicine with the liquid. Preferably, as shown in Figure 3 The inner diameter of the medicine carrying cavity 51 gradually decreases from the end close to the needle 3 to the end close to the first mixer 1, so that the medicine on the inner wall of the medicine carrying cavity 51 can be fully mixed into the liquid by changing the flow rate of the liquid when the liquid is sucked.
[0036] Another preferred embodiment of the medicine carrying cavity 51 is shown in Figure 4 The medicine carrying cavity 51 includes a first cavity 512 and a second cavity 513, and a partition plate 511 is arranged between the first cavity 512 and the second cavity 513, and the first cavity 512 and the second cavity 513 are both connected to the fluid channel of the microbubble generating device. That is, the partition plate 511 divides the medicine carrying cavity 51 into two parallel cavities, and the upper parts of the two cavities are both connected to the three-way valve 4, and the lower parts of the two cavities are both connected to the needle 3. In this way, two kinds of medicine can be placed in the same medicine carrier 5. Similarly, three or more cavities can also be arranged.
[0037] On the basis of the above preferred embodiments, as shown in Figure 5As shown, a dialysis membrane 514 is arranged on the communication port between the first chamber 512 and the needle 3. The dialysis membrane 514 is a homogeneous membrane of organic polymer, which can pass small molecules (normal saline) and block large molecules, so that the drug (surfactant) in the first chamber 512 will not flow out due to gravity when normal saline is sucked. The normal saline flushes the drug (surfactant) into the syringe for mixing after passing through the dialysis membrane 514. When the contrast agent is mixed, the microbubbles enter the blood vessels through the second chamber 513, thereby achieving the detection effect. In order to increase the number of microbubbles in the liquid and reduce the volume of the microbubbles, at least one bubble fragmentation net 515 is arranged in the second chamber 513, and all the bubble fragmentation nets 515 are arranged at intervals, so that the fragmentation can be performed step by step to generate more microbubbles with smaller volume. The bubble fragmentation net 515 is arranged in the second chamber 513 so that the mixed phase of gas and liquid after fragmentation can directly enter the blood through the needle 3 and then enter the detection site, thereby improving the detection effect. Preferably, the pore size of all the bubble fragmentation nets 515 gradually decreases from the first mixer 1 to the needle 3, and the pore size is 1-15 um. In this embodiment, in order to facilitate the installation of the gas permeable membrane and the bubble fragmentation net 515, the drug carrier 5 is arranged in a split structure, and the dialysis membrane 514 and the bubble fragmentation net 515 are arranged at the connection. In this embodiment, the surfactant can be arranged in a capsule shape and placed in the first chamber 512. When the liquid drawn into the first chamber 512, the surfactant will be dissolved in the liquid.
[0038] Alternatively, a bubble fragmentation net 515 is arranged between the first mixer 1 and the drug carrier 5 and / or between the drug carrier 5 and the needle 3. That is, the bubble fragmentation net 515 is arranged at the connection joint of the first mixer 1 and the three-way valve 4 or the connection joint of the three-way valve 4 and the drug carrier 5, and at the connection joint of the needle 3 and the drug carrier 5, because the structure of the bubble fragmentation net 515 piece is convenient to clamp at the connection joint.
[0039] In the above embodiment, the structure of the drug carrier 5 is added, so that the resistance of the syringe in the mixer during the injection process is increased, and manual injection is more laborious. Therefore, a boost motor or a boost cylinder is further arranged on the first mixer 1 and / or the second mixer 2. The boost motor or the boost cylinder can control the advancing speed and can release the labor of manual injection and reduce the error of manual injection.
[0040] It should be understood that the above embodiments are only exemplary and not limiting, and those skilled in the art can make various obvious or equivalent modifications or replacements to the above details without departing from the basic principles of the present application, which will be included in the scope of the claims of the present application.
Claims
1. A microbubble generating device having a drug loading function, comprising a first mixer, a second mixer and a needle which are in communication with each other, characterized in that, A drug loading device is connected between the first mixer and the needle; the drug loading device is provided with a drug loading cavity; the first mixer, the second mixer and the needle are connected through a three-way valve, and the drug loading device is arranged between the three-way valve and the needle.
2. The microbubble generating device with drug loading function according to claim 1, wherein, The inner surface of the drug loading cavity is a frosted surface, or a groove structure is arranged on the inner surface of the drug loading cavity.
3. The microbubble generating device with drug loading function according to any one of claims 1-2, wherein, The inner diameter of the drug loading cavity gradually decreases from the end close to the needle to the end close to the first mixer.
4. The microbubble generating device with drug loading function according to any one of claims 1-2, wherein, The drug loading cavity comprises a first chamber and a second chamber, a separation plate is arranged between the first chamber and the second chamber, and the first chamber and the second chamber are both connected with a fluid channel of the microbubble generating device.
5. The microbubble generating device with drug loading function according to claim 4, wherein, A dialysis membrane is arranged on the communication port between the first chamber and the needle.
6. The microbubble generating device with drug loading function according to claim 4, wherein, At least one layer of bubble splitting net is arranged in the second chamber, and all the bubble splitting nets are arranged at intervals.
7. The microbubble generating device with drug loading function according to claim 6, wherein, The pore size of all the bubble splitting nets gradually decreases from the first mixer to the needle, and the pore size is 1-15 um.
8. The microbubble generating device with drug loading function according to any one of claims 1-2 or 5-7, wherein, A bubble splitting net is arranged between the first mixer and the drug loading device and / or between the drug loading device and the needle.
9. The microbubble generating device with drug loading function according to claim 8, wherein, A boost motor or a boost air cylinder is further arranged on the first mixer and / or the second mixer.