Chromatographic device for glabridin production

Abstract

The utility model discloses a chromatographic device for glabridin production, which relates to the technical field of chromatography, and comprises a chromatographic column, the bottom of the chromatographic column is fixedly connected with a base, the top of the chromatographic column is provided with a screening mechanism, and the outer wall of the chromatographic column is provided with an extraction mechanism. In the chromatography process, a filler is needed to help separation of a glabridin mixture, firstly, the filler is placed above a sieve plate, then a motor is started to drive a rotating shaft to rotate, when the rotating shaft rotates, a convex block can be driven to rotate, when the convex block makes contact with the sieve plate, the sieve plate can be driven to slide in a sliding groove, and the filter screen can be separated. And when the contact between the convex block and the sieve plate is finished, the sieve plate can be extruded due to the counter-acting force of the spring, so that the mechanism can enable the small-particle filler to smoothly enter the chromatographic column, the contact between the filler and a mobile phase is increased, and finer separation can be realized.

Description

Technical Field

[0001] This utility model belongs to the field of chromatography technology, and in particular relates to a chromatography apparatus for the production of glycyrrhizin. Background Technology

[0002] Glycyrrhizin is a natural compound with various biological activities, mainly extracted from plants such as licorice. It has been widely studied and used in drug development, health products, cosmetics and other fields. Chromatography is an important separation and purification method for the production of glycyrrhizin. Chromatography can effectively separate glycyrrhizin from complex plant extracts, ensuring its high purity and high efficiency.

[0003] When separating complex plant extracts, packing materials are required. However, if the packing material particles are too large, the interaction between the packing material surface and different molecules may be uneven, thus affecting the separation effect. Therefore, we propose a chromatography device for the production of glycyrrhizin. Utility Model Content

[0004] The purpose of this invention is to provide a chromatography device for the production of glycyrrhizin. By starting the motor, the rotating shaft is driven to rotate. When the rotating shaft rotates, the sieve plate slides in the chute, which solves the problem of inconsistent packing size.

[0005] To solve the above-mentioned technical problems, this utility model is achieved through the following technical solution:

[0006] This utility model is a chromatography device for the determination of glycyrrhiza uralensis, including a chromatographic column, a base fixedly connected to the bottom of the chromatographic column, a sieving mechanism provided at the top of the chromatographic column, and an extraction mechanism provided on the outer wall of the chromatographic column;

[0007] The screening mechanism includes a screening housing, an internal groove, a screen plate slidably connected to the inner wall of the groove, a telescopic rod fixedly connected to the top of the screen plate, a spring fixedly connected to the outer wall of the screen plate, a fixing block fixedly connected to the outer wall of the screening housing, a motor fixedly connected to the outer wall of the fixing block, a rotating shaft fixedly connected to the output shaft of the motor via a coupling, and a protrusion fixedly connected to the side of the rotating shaft away from the motor.

[0008] Furthermore, the side of the telescopic rod away from the screen plate is fixedly connected to the inner wall of the chute, and the end of the spring away from the screen plate is fixedly connected to the outer wall of the chute.

[0009] Furthermore, the telescopic rod is located inside the spring, the outer wall of the rotating shaft is rotatably connected to the inner wall of the fixed block, and the outer wall of the rotating shaft is rotatably connected to the inner wall of the screening housing.

[0010] Furthermore, the extraction mechanism includes a fixed plate fixedly connected to the inner wall of the screening housing, and a connecting shaft is fixedly connected to the bottom of the fixed plate.

[0011] Furthermore, a second sieve plate is fixedly connected to the bottom of the connecting shaft, and the second sieve plate is located inside the chromatographic column.

[0012] Furthermore, a housing is fixedly connected to the top of the base, a gear rack is slidably connected to the inner wall of the housing, a gear meshes with the outer wall of the gear rack, the outer wall of the gear rack is fixedly connected to the outer wall of the screening housing, and a rotating shaft is fixedly connected to the inner wall of the gear.

[0013] Furthermore, the outer wall of the second rotating shaft is rotatably connected to the inner wall of the housing, a worm gear is fixedly connected to the outer wall of the second rotating shaft, a worm is meshed with the outer wall of the worm gear, and the outer wall of the worm is rotatably connected to the inner wall of the housing.

[0014] Furthermore, a collection housing one is snapped onto the outer wall of the chromatographic column, and a collection housing two is snapped onto the outer wall of the chromatographic column.

[0015] This utility model has the following beneficial effects:

[0016] 1. This utility model incorporates a sieve plate. During chromatography, packing material is needed to separate the glycyrrhizin mixture. First, the packing material is placed above the sieve plate. Then, the motor is started, driving the rotating shaft to rotate. As the rotating shaft rotates, it drives the protrusions to rotate. When the protrusions contact the sieve plate, the sieve plate slides in the groove, thus squeezing the telescopic rod and spring. When the contact between the protrusions and the sieve plate ends, the reaction force of the spring squeezes the sieve plate again, causing it to vibrate. At this time, some large particles of packing material are blocked by the sieve plate. This mechanism allows small particles of packing material to smoothly enter the chromatographic column, increasing the contact between the packing material and the mobile phase, and achieving finer separation.

[0017] 2. This utility model incorporates a second sieve plate. After separation, the packing material needs to be cleaned. First, the worm gear is manually rotated to drive the worm wheel. As the worm wheel rotates, the second rotating shaft rotates, which in turn drives the gear to rotate. As the gear rotates, the gear rack rises, causing the sieve housing to rise. As the sieve housing rises, the fixed plate moves, which in turn moves the connecting shaft, thus moving the second sieve plate. This mechanism can collect the packing material from the chromatographic column and clean it, ensuring consistent good separation efficiency while avoiding dead zones, reducing packing aging, and saving on packing replacement costs.

[0018] Of course, any product implementing this utility model does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0019] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0021] Figure 2 This is a schematic diagram of the protrusion structure of this utility model;

[0022] Figure 3 This is a schematic diagram of the sieve plate structure of this utility model;

[0023] Figure 4 This is a schematic diagram of the second structure of the sieve plate of this utility model;

[0024] Figure 5 This is a schematic diagram of the gear structure of this utility model.

[0025] The attached diagram lists the components represented by each number as follows:

[0026] 101. Chromatographic column; 102. Base; 2. Sieving mechanism; 201. Sieving shell; 202. Slide groove; 203. Sieve plate; 204. Telescopic rod; 205. Spring; 206. Fixing block; 207. Motor; 208. Rotating shaft; 209. Protrusion; 3. Extraction mechanism; 301. Fixing plate; 302. Connecting shaft; 303. Sieve plate two; 304. Shell; 305. Gear rack; 306. Gear; 307. Rotating shaft two; 308. Worm gear; 309. Worm; 310. Collection shell one; 311. Collection shell two. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0028] Please see Figure 1-5As shown, this utility model is a chromatography device for the determination of glycyrrhiza uralensis, including a chromatographic column 101, a base 102 fixedly connected to the bottom of the chromatographic column 101, and a sieving mechanism 2 provided at the top of the chromatographic column 101. The chromatographic column is a key device in chromatography for separating and analyzing sample mixtures. It is a tubular structure and is usually used to pack packing. An extraction mechanism 3 is provided on the outer wall of the chromatographic column 101. The sieving mechanism 2 includes a sieving shell 201, a groove 202 is opened inside the sieving shell 201, and a sieve plate 203 is slidably connected to the inner wall of the groove 202. By setting the sieve plate 203, excessive packing material is blocked. A telescopic rod 204 is fixedly connected to the top of the sieve plate 203, and a spring 205 is fixedly connected to the outer wall of the sieve plate 203. The outer wall of the sieve shell 201 is fixedly connected to... There is a fixed block 206, and a motor 207 is fixedly connected to the outer wall of the fixed block 206. A spring 205 is set to facilitate the compression of the screen plate 203. The output shaft of the motor 207 is fixedly connected to a rotating shaft 208 through a coupling. A protrusion 209 is fixedly connected to the side of the rotating shaft 208 away from the motor 207. The side of the telescopic rod 204 away from the screen plate 203 is fixedly connected to the inner wall of the slide groove 202. The end of the spring 205 away from the screen plate 203 is fixedly connected to the outer wall of the slide groove 202. By setting the slide groove 202, the screen plate 203 can slide inside the slide groove 202. The telescopic rod 204 is located inside the spring 205. The outer wall of the rotating shaft 208 is rotatably connected to the inner wall of the fixed block 206 and the outer wall of the rotating shaft 208 is rotatably connected to the inner wall of the screening housing 201.

[0029] The extraction mechanism 3 includes a fixed plate 301 fixedly connected to the inner wall of the sieve housing 201. A connecting shaft 302 is fixedly connected to the bottom of the fixed plate 301. A second sieve plate 303 is fixedly connected to the bottom of the connecting shaft 302. The second sieve plate 303 is located inside the chromatographic column 101. By setting the second sieve plate 303, the packing material is blocked, allowing the liquid phase to flow out. A housing 304 is fixedly connected to the top of the base 102. A gear rack 305 is slidably connected to the inner wall of the housing 304. A gear 306 meshes with the outer wall of the gear rack 305. The outer wall of the gear rack 305 is fixedly connected to the outer wall of the sieve housing 201. By setting the gear rack 305, the sieve housing 201 is moved. A second rotating shaft 307 is fixedly connected to the inner wall of the gear 306.

[0030] The outer wall of the rotating shaft 307 is rotatably connected to the inner wall of the housing 304. A worm gear 308 is fixedly connected to the outer wall of the rotating shaft 307. A worm 309 is meshed with the outer wall of the worm gear 308. The outer wall of the worm 309 is rotatably connected to the inner wall of the housing 304. By setting the worm 309, the worm gear 308 is driven to rotate. A collection housing 310 is snapped onto the outer wall of the chromatographic column 101. A collection housing 311 is snapped onto the outer wall of the chromatographic column 101.

[0031] One specific application of this embodiment is:

[0032] During chromatography, packing material is needed to help separate the glycyrrhizin mixture. First, the packing material is placed above the sieve plate 203. Then, the motor 207 is started, driving the rotating shaft 208 to rotate. As the rotating shaft 208 rotates, it drives the protrusion 209 to rotate. When the protrusion 209 contacts the sieve plate 203, it causes the sieve plate 203 to slide in the groove 202, thus squeezing the telescopic rod 204 and the spring 205. When the protrusion 209 stops contacting the sieve plate 203, the reaction force of the spring 205 will again squeeze the sieve plate 203, causing it to vibrate. At this time, some large packing particles will be blocked by the sieve plate 203. This mechanism allows small packing particles to smoothly enter the chromatographic column 101, increasing the contact between the packing material and the mobile phase, achieving finer separation. When separation is complete, the packing material needs to be cleaned. First, the worm gear 309 is manually rotated to drive the worm wheel 308 to rotate. As the worm wheel 308 rotates, it drives the telescopic rod 204 and the spring 205 to rotate. The rotating shaft 307 rotates, which in turn drives the gear 306 to rotate. As the gear 306 rotates, it causes the gear rack 305 to rise, which in turn causes the sieve housing 201 to rise. As the sieve housing 201 rises, it causes the fixed plate 301 to move, which in turn causes the connecting shaft 302 to move, thus moving the sieve plate 303. The sieve plate 303 allows the mobile phase to pass through but blocks the packing material. Therefore, as the sieve plate 303 moves, the packing material above it moves. During this upward movement, the packing material falls into the collection housing 310 and collection housing 311 due to gravity. Then, the collection housing 310 and collection housing 311 are removed, and the packing material inside is cleaned. This mechanism can collect the packing material from the chromatographic column 101 and clean it, ensuring consistent good separation efficiency, avoiding dead zones, reducing packing material aging, and saving on packing material replacement costs.

[0033] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0034] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A chromatographic device for producing glabridin, comprising a chromatographic column (101), a base (102) is fixedly connected to the bottom of the chromatographic column (101), characterized in that: The top of the chromatographic column (101) is provided with a screening mechanism (2), and the outer wall of the chromatographic column (101) is provided with an extraction mechanism (3); The screening mechanism (2) comprises a screening shell (201), a chute (202) is opened in the inside of the screening shell (201), a sieve plate (203) is slidably connected to the inner wall of the chute (202), a telescopic rod (204) is fixedly connected to the top of the sieve plate (203), a spring (205) is fixedly connected to the outer wall of the sieve plate (203), a fixed block (206) is fixedly connected to the outer wall of the screening shell (201), a motor (207) is fixedly connected to the outer wall of the fixed block (206), a rotating shaft (208) is fixedly connected to the output shaft of the motor (207) through a shaft coupling, and a protruding block (209) is fixedly connected to the side, away from the motor (207), of the rotating shaft (208).

2. A chromatographic device for producing glabridin according to claim 1, characterized by, The side, away from the sieve plate (203), of the telescopic rod (204) is fixedly connected to the inner wall of the chute (202), and one end, away from the sieve plate (203), of the spring (205) is fixedly connected to the outer wall of the chute (202).

3. A chromatographic device for producing glabridin according to claim 2, characterized in that, The telescopic rod (204) is located inside the spring (205), the outer wall of the rotating shaft (208) is rotatably connected to the inner wall of the fixed block (206), and the outer wall of the rotating shaft (208) is rotatably connected to the inner wall of the screening shell (201).

4. The chromatographic device for producing glabridin according to claim 1, wherein The extraction mechanism (3) comprises a fixed plate (301) fixedly connected to the inner wall of the screening shell (201), and the fixed plate (301) is fixedly connected with a connecting shaft (302) at the bottom.

5. A chromatographic device for producing glabridin according to claim 4, characterized by The connecting shaft (302) is fixedly connected with a second sieve plate (303) at the bottom, and the second sieve plate (303) is located inside the chromatographic column (101).

6. A chromatographic device for producing glabridin according to claim 5, characterized by The top of the base (102) is fixedly connected with a shell (304), the inner wall of the shell (304) is slidably connected with a gear strip (305), the outer wall of the gear strip (305) is engaged with a gear (306), the outer wall of the gear strip (305) is fixedly connected with the outer wall of the screening shell (201), and the inner wall of the gear (306) is fixedly connected with a second rotating shaft (307).

7. A chromatographic device for producing glabridin according to claim 6, characterized by The outer wall of the second rotating shaft (307) is rotatably connected with the inner wall of the shell (304), the outer wall of the second rotating shaft (307) is fixedly connected with a worm wheel (308), the outer wall of the worm wheel (308) is engaged with a worm (309), and the outer wall of the worm (309) is rotatably connected with the inner wall of the shell (304).

8. A chromatographic device for producing glabridin according to claim 7, characterized by The outer wall of the chromatographic column (101) is clamped with a collection shell one (310), and the outer wall of the chromatographic column (101) is clamped with a collection shell two (311).

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