Microwave synthesis reaction instrument with rapid cooling function

Abstract

The utility model provides a microwave synthesis reaction instrument with fast cooling function, including casing, three-necked flask, temperature sensor, bottle stopper, socket, backing plate, furnace door and controller, the controller is fixed in the casing, the casing is provided with the placing cavity, backing plate is located on the bottom wall of placing cavity, socket is fixed on the side wall of placing cavity, the temperature sensor is fixed on the bottom wall of placing cavity, and the temperature sensor is fixed on the bottom wall of placing cavity. The bottle plug is embedded in an opening of the three-neck flask, the temperature sensor penetrates through the bottle plug and is immersed in the reagent, the temperature sensor is connected with the socket through the connecting wire, the furnace door is hinged to the machine shell and used for blocking the opening of the containing cavity, a heat conduction plate is connected to the base plate, and a containing groove used for supporting the three-neck flask is formed in the heat conduction plate. The side, back to the containing groove, of the heat conduction plate is connected with a semiconductor chilling plate, heat dissipation holes are formed in the bottom wall of the machine shell and correspond to the semiconductor chilling plate, the semiconductor chilling plate and the temperature sensor are electrically connected with the controller, and the purpose of improving practicability is achieved.

Description

Technical Field

[0001] This utility model relates to experimental instruments, and in particular, to a microwave synthesis reactor with a rapid cooling function. Background Technology

[0002] Microwave chemical synthesis instruments can catalyze many types of organic, pharmaceutical, and biochemical reactions, such as addition, substitution, esterification, hydrolysis, and polymerization, as well as physical processes such as solvent extraction of food, natural products, and minerals.

[0003] Currently, Chinese patent CN204544169U discloses a multi-purpose microwave chemical synthesizer, including a housing, a three-necked flask installed inside the housing with a temperature sensor inside the flask; the temperature sensor is connected to a temperature sensor socket installed inside the housing; a magnetic stir bar is placed inside the three-necked flask, and a fixed base is provided between the three-necked flask and the housing; a rear column is fixed to the top of the housing, and a reflux condenser tube installed at the top of the housing is fixed by a test tube clamp on the rear column; a glass tee tube is installed at the bottom of the reflux condenser tube, and the glass tee tube is connected to the three-necked flask through a waveguide cutoff tube embedded at the top of the housing; an inner reaction vessel and an outer reaction vessel are installed on the top of the base; the inner reaction vessel cover is connected to a pressure sensor installed inside the housing through a pressure measuring tube sleeve; this device is reasonably designed, suitable for microwave synthesis reactions under both atmospheric and high pressure, and has a wide range of applications.

[0004] However, in drug development, different crystal forms of the same drug can affect its solubility and bioavailability. After rapidly heating the reagent to its dissolution temperature using microwaves, it is necessary to quickly cool it down to a specific temperature to induce the formation of metastable crystal forms. Existing multi-purpose microwave chemical synthesizers obviously do not have the function of rapid cooling, and therefore their practicality is not high. Utility Model Content

[0005] In view of this, the purpose of this utility model is to provide a microwave synthesis reactor with rapid cooling function. By setting a semiconductor cooling chip, rapid cooling can be achieved to adapt to different experimental scenarios and improve practicality.

[0006] To solve the above-mentioned technical problems, the technical solution of this utility model is: a microwave synthesis reactor with rapid cooling function, including a housing, a three-necked flask, a temperature sensor, a stopper, a socket, a pad, a furnace door, and a controller. The controller is fixed inside the housing. The housing has a placement cavity. The pad is located on the bottom wall of the placement cavity. The socket is fixed on the side wall of the placement cavity. The stopper is embedded in the opening of the three-necked flask. The temperature sensor passes through the stopper and is immersed in the reagent. The temperature sensor is connected to the socket via a connecting wire. The furnace door is hinged to the housing and is used to seal the opening of the placement cavity. A heat-conducting plate is connected to the pad. The heat-conducting plate has a receiving groove for supporting the three-necked flask. A thermoelectric cooler is connected to the side of the heat-conducting plate opposite to the receiving groove. A heat dissipation hole is provided on the bottom wall of the housing. The heat dissipation hole corresponds to the thermoelectric cooler. The thermoelectric cooler and the temperature sensor are both electrically connected to the controller.

[0007] To achieve the above technical solution, a three-necked flask is placed on a pad, the furnace door is closed, and the microwave generator inside the outer shell operates, heating the reagent inside the three-necked flask. A temperature sensor monitors the temperature of the reagent inside the three-necked flask in real time. After heating to a certain temperature, the microwave generator stops operating, and then the thermoelectric cooler operates. The cold end of the thermoelectric cooler rapidly cools the three-necked flask through a heat-conducting plate, while the high temperature generated by the hot end of the thermoelectric cooler is dissipated through heat dissipation holes, ensuring stable operation of the thermoelectric cooler and improving its practicality. Because the heat-conducting plate has a receiving groove, the three-necked flask can be placed stably on the heat-conducting plate.

[0008] In a preferred embodiment of this utility model, a support ring is fixedly connected to the lower surface of the housing, the heat dissipation hole is located inside the support ring, a support plate is fixedly connected inside the support ring, a power motor is connected to the support plate, a fan blade is connected to the power shaft of the power motor, the fan blade corresponds to the semiconductor cooling chip, the power motor is electrically connected to the controller, and an air outlet is provided at one end of the support ring near the housing.

[0009] To achieve the above technical solution, the power motor starts, the power shaft drives the fan blades to rotate, and the air generated by the fan blades enters the support ring from the end of the support ring and blows onto the thermoelectric cooler. The heat on the thermoelectric cooler is blown away by the air, and the hot air is discharged from the air outlet, so that the thermoelectric cooler has a better heat dissipation effect, so that the thermoelectric cooler can operate at a higher power, thereby enabling the thermoelectric cooler to cool down at a faster speed and further improving its practicality.

[0010] In a preferred embodiment of this utility model, the support ring is connected to a filter screen via a magnet, and the power motor is located inside the filter screen.

[0011] By implementing the above technical solution, after the power motor starts, the end of the support ring will generate a suction effect. Through the filtering effect of the filter screen, the power motor is less likely to be damaged. Furthermore, since the filter screen is fixed to the support ring by magnetic attraction, it is easy to disassemble, thereby further improving practicality and ease of installation and removal.

[0012] In a preferred embodiment of this utility model, a heat sink is fixedly connected to the lower surface of the housing, a thermally conductive silicone grease layer is provided between the heat sink and the semiconductor cooling chip, the heat sink is located inside the support ring, a plurality of heat dissipation rods are fixedly connected to the heat sink, the plurality of heat dissipation rods are arranged along the axial direction of the heat sink, and the fan blades are located in the cavity surrounded by the plurality of heat dissipation rods.

[0013] To achieve the above technical solution, the heat generated at the hot end of the thermoelectric cooler is transferred to the heat sink and heat dissipation rod through the thermal grease layer. The air generated by the rotating fan blades blows towards the heat sink and then towards the heat dissipation rod in a divergent manner, thereby greatly improving the heat dissipation effect of the thermoelectric cooler. This allows the thermoelectric cooler to operate at higher power to achieve faster cooling and further improve its practicality.

[0014] As a preferred embodiment of this utility model, an installation hole is provided on the top wall of the housing, and a waveguide cut-off tube is inserted through the installation hole. One end of the waveguide cut-off tube is connected to a three-necked flask, and the other end of the waveguide cut-off tube is connected to a glass tee tube. A condenser tube and a dropping funnel are respectively connected to the two ends of the glass tee tube.

[0015] To achieve the above technical solution, in the heating or exothermic reaction of the three-necked flask, volatile substances will vaporize and rise, and after being cooled by the condenser, they will flow back to the reaction system to avoid material loss; the dropping funnel is used to add reactants or catalysts drop by drop to precisely control the reaction process; and it can be applied to different production processes to further improve practicality.

[0016] As a preferred embodiment of this utility model, a fixing block is fixedly connected to the side of the housing facing away from the placement cavity. The fixing block has a fixing hole, and a column is connected to the fixing hole through a positioning structure. The column is connected to a test tube clamp through a cross adapter clamp, and the test tube clamp holds the condenser tube.

[0017] To achieve the above technical solution, the positioning structure makes it difficult for the column to separate from the fixing block, and the test tube rack clamps the condenser tube, making the glass tee tube and the condenser tube more stable.

[0018] As a preferred embodiment of this utility model, the positioning structure includes a square sliding hole, an elastic element, a slider, and a V-shaped groove. The square sliding hole is opened on the inner wall of the fixing hole, the elastic element and the slider are placed in the fixing hole, and the V-shaped groove is opened on the outer wall of the column. The column passes through the fixing hole and the slider is embedded in the V-shaped groove due to the elastic force of the elastic element.

[0019] To achieve the above technical solution, the column is inserted into the fixing hole, and the end of the column abuts against the inclined surface on the slider. The slider slides completely into the square sliding hole along the inclined surface. As the column continues to move down, when the V-groove corresponds to the slider, the end of the slider is embedded in the V-groove by the elastic force of the elastic element. The resulting frictional force positions the column, thus facilitating the installation of the column. Applying an upward pulling force to the column to overcome the frictional force allows the column to be pulled out of the fixing hole.

[0020] As a preferred embodiment of this utility model, the housing is equipped with a display screen, a power adjustment knob, a time setting key, and a time adjustment key, all of which are electrically connected to the controller.

[0021] The above technical solution facilitates the adjustment of microwave generator parameters, and the display screen can show the temperature so that experimenters can view the information. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the structure of this utility model;

[0023] Figure 2 This diagram illustrates the location of the heatsink.

[0024] Figure 3 To illustrate the position of the fixed block;

[0025] Figure 4 This diagram illustrates the location of the thermal grease layer.

[0026] Figure 5 This is a cross-sectional diagram of the fixed block.

[0027] Reference numerals: 1. Housing; 2. Three-necked flask; 3. Temperature sensor; 4. Stopper; 5. Socket; 6. Pad; 7. Furnace door; 8. Heat-conducting plate; 9. Receiving groove; 10. Semiconductor cooling chip; 11. Heat dissipation hole; 12. Support ring; 13. Support plate; 14. Motor; 15. Fan blade; 16. Air outlet; 17. Heat sink; 18. Thermal grease layer; 19. Heat dissipation rod; 20. Filter screen; 21. Magnet; 22. Waveguide cutoff tube; 23. Glass tee tube; 24. 25. Condenser; 26. Dropping funnel; 27. Fixing block; 28. Fixing hole; 29. ​​Column; 30. Cross adapter; 31. Test tube clamp; 32. Positioning structure; 33. Square sliding hole; 34. Elastic element; 35. Slider; 36. V-groove; 37. Display screen; 38. Power adjustment knob; 39. Time setting key; 40. Time adjustment key; 41. On / off key; 42. Pause key; 43. Placement chamber; 44. Inclined surface; 45. Temperature adjustment key; 46. Temperature setting key. Detailed Implementation

[0028] The specific embodiments of this utility model will be further described in detail below with reference to the accompanying drawings, so that the technical solution of this utility model can be more easily understood and mastered.

[0029] A microwave synthesis reactor with rapid cooling function includes a housing 1, a three-necked flask 2, a temperature sensor 3, a stopper 4, a socket 5, a pad 6, a furnace door 7, and a controller. A microwave generator is installed inside the housing 1, and the controller, a PLC controller, is fixed inside the housing 1. A placement cavity 42 is formed on the housing 1, and the socket 5 is fixed to the side wall of the placement cavity 42. The stopper 4 is embedded in the opening of the three-necked flask 2. The temperature sensor 3 passes through the stopper 4 and is immersed in the reagent; the temperature sensor 3 is connected to the socket 5 via a connecting wire.

[0030] A copper heat-conducting plate 8 is fixedly connected to the pad 6. A receiving groove 9 for supporting the three-necked flask 2 is formed on the upper surface of the heat-conducting plate 8. A semiconductor cooling chip 10 is provided on the side of the heat-conducting plate 8 opposite to the receiving groove 9, and the cold end of the semiconductor cooling chip 10 is attached to the heat-conducting plate 8.

[0031] A circular heat dissipation hole 11 is provided on the bottom wall of the housing 1, and the semiconductor cooling chip 10 is fixed in the heat dissipation hole 11.

[0032] A support ring 12 is fixedly connected to the lower surface of the housing 1. A heat dissipation hole 11 is located inside the support ring 12. A support plate 13 is fixedly connected inside the support ring 12, and the support plate 13 is located in the middle of the support ring 12. A power motor 14 is fixedly connected to the support plate 13, and a fan blade 15 is fixedly connected to the power shaft of the power motor 14. The power motor 14 is a brushless motor to enable the fan blade 15 to have a high rotational speed.

[0033] The fan blade 15 corresponds to the hot end of the semiconductor cooling chip 10, the power motor 14 is electrically connected to the controller, and the support ring 12 has an air outlet 16 at one end near the housing 1. Multiple air outlets 16 are arranged along the axis of the support ring 12.

[0034] A copper heat sink 17 is fixedly connected to the lower surface of the housing 1. A thermally conductive silicone grease layer 18 is applied between the heat sink 17 and the semiconductor cooling chip 10. The heat sink 17 is located inside the support ring 12. Multiple heat dissipation rods 19 are fixedly connected to the heat sink 17, and the heat dissipation rods 19 are integrated with the heat sink 17. The multiple heat dissipation rods 19 are arranged along the axial direction of the heat sink 17, and the fan blades 15 are located within the cavity formed by the multiple heat dissipation rods 19.

[0035] The support ring 12 is connected to the filter screen 20 via a magnet 21, and the power motor 14 is located inside the filter screen 20.

[0036] A mounting hole is provided on the top wall of the housing 1, and a waveguide cutoff tube 22 is inserted through the mounting hole. One end of the waveguide cutoff tube 22 is connected to a three-necked flask 2, and the other end of the waveguide cutoff tube 22 is connected to a glass tee tube 23. A condenser tube 24 and a dropping funnel 25 are respectively connected to the two ends of the glass tee tube 23.

[0037] A fixing block 26 is fixedly connected to the side of the casing 1 opposite to the placement cavity 42. A fixing hole 27 is provided on the fixing block 26. A column 28 is connected to the fixing hole 27 through a positioning structure. A test tube clamp 30 is connected to the column 28 through a cross adapter 29. The test tube clamp 30 holds the condenser tube 24.

[0038] The positioning structure 31 includes a square sliding hole 310, an elastic element 32, a slider 33, and a V-groove 34. The square sliding hole 310 is formed on the inner wall of the fixing hole 27. The elastic element 32 is a spring. The end of the slider 33 away from the elastic element 32 has two opposing inclined surfaces 43. The V-groove 34 is formed on the outer wall of the column 28. The column 28 passes through the fixing hole 27, and the slider 33 is embedded in the V-groove 34 due to the elastic force of the elastic element 32.

[0039] The furnace door 7 is hinged to the housing 1 and is used to seal the opening of the placement cavity 42.

[0040] The housing 1 is equipped with a display screen 36, a power adjustment knob 37, a time setting key 38, a time adjustment key 39, a power switch 40, a pause key 41, a temperature adjustment key 44, and a temperature setting key 45. The display screen 36, power adjustment knob 37, time setting key 38, time adjustment key 39, microwave generator, semiconductor cooling chip 10, temperature sensor 3, temperature adjustment key 44, and temperature setting key 45 are all electrically connected to the controller.

[0041] The power adjustment knob 37 is used to adjust the power of the microwave generator. The display screen 36 shows the real-time temperature, preset temperature, and current time.

[0042] Of course, the above are just typical examples of this utility model. In addition, this utility model may have many other specific implementation methods. All technical solutions formed by equivalent substitution or equivalent transformation fall within the scope of protection claimed by this utility model.

Claims

1. A microwave synthesis reactor with rapid cooling function, comprising a housing (1), a three-necked flask (2), a temperature sensor (3), a stopper (4), a socket (5), a pad (6), a furnace door (7), and a controller, wherein the controller is fixed inside the housing (1), the housing (1) has a placement cavity (42), the pad (6) is located on the bottom wall of the placement cavity (42), the socket (5) is fixed on the side wall of the placement cavity (42), the stopper (4) is embedded in the opening of the three-necked flask (2), the temperature sensor (3) passes through the stopper (4) and is immersed in the reagent, the temperature sensor (3) is connected to the socket (5) through a connecting wire, and the furnace door (7) is hinged to the housing (1) and used to seal the opening of the placement cavity (42), characterized in that: The gusset plate (6) is connected with a heat-conducting plate (8), the heat-conducting plate (8) is provided with a containing groove (9) for supporting a three-neck flask (2), the side of the heat-conducting plate (8) opposite to the containing groove (9) is connected with a semiconductor refrigeration sheet (10), the bottom wall of the cabinet (1) is provided with a heat dissipation hole (11) corresponding to the semiconductor refrigeration sheet (10), and the semiconductor refrigeration sheet (10) and the temperature sensor (3) are electrically connected with the controller.

2. The microwave synthesis reactor with rapid cooling function according to claim 1, characterized in that: The lower surface of the cabinet (1) is fixedly connected with a supporting ring (12), the heat dissipation hole (11) is located in the supporting ring (12), the supporting ring (12) is fixedly connected with a supporting plate (13) inside, the supporting plate (13) is connected with a power motor (14), the power shaft of the power motor (14) is connected with a fan blade (15) corresponding to the semiconductor refrigeration sheet (10), the power motor (14) is electrically connected with the controller, and the supporting ring (12) is provided with an air outlet hole (16) at one end close to the cabinet (1).

3. The microwave synthesis reactor with rapid cooling function according to claim 2, characterized in that: The supporting ring (12) is connected with a filter screen (20) through a magnet (21), and the power motor (14) is located in the filter screen (20).

4. The microwave synthesis reactor with rapid cooling function according to claim 2, characterized in that: The lower surface of the cabinet (1) is fixedly connected with a heat dissipation fin (17), a heat-conducting silicone grease layer (18) is arranged between the heat dissipation fin (17) and the semiconductor refrigeration sheet (10), the heat dissipation fin (17) is located in the inside of the supporting ring (12), a plurality of heat dissipation rods (19) are fixedly connected to the heat dissipation fin (17), the plurality of heat dissipation rods (19) are arranged along the axial direction of the heat dissipation fin (17), and the fan blade (15) is located in a cavity surrounded by the plurality of heat dissipation rods (19).

5. The microwave synthesis reactor with rapid cooling function according to claim 1, characterized in that: The top wall of the cabinet (1) is provided with a mounting hole, a waveguide cutoff pipe (22) is arranged in the mounting hole, one end of the waveguide cutoff pipe (22) is connected with the three-neck flask (2), the other end of the waveguide cutoff pipe (22) is connected with a glass tee pipe (23), and the two ends of the glass tee pipe (23) are respectively connected with a condenser tube (24) and a dropping funnel (25).

6. The microwave synthesis reactor with rapid cooling function according to claim 5, characterized in that: The side of the cabinet (1) opposite to the placing cavity (42) is fixedly connected with a fixed block (26), the fixed block (26) is provided with a fixed hole (27), the fixed hole (27) is connected with a stand column (28) through a positioning structure (31), the stand column (28) is connected with a test tube clamp (30) through a cross adapter clamp (29), and the test tube clamp (30) clamps the condenser tube (24).

7. The microwave synthesis reactor with rapid cooling function according to claim 6, characterized in that: The positioning structure (31) comprises a square sliding hole (310), an elastic member (32), a sliding block (33) and a V-shaped groove (34), the square sliding hole (310) is arranged on the inner wall of the fixed hole (27), the elastic member (32) and the sliding block (33) are arranged in the fixed hole (27), the V-shaped groove (34) is arranged on the outer wall of the stand column (28), and the stand column (28) penetrates into the fixed hole (27) and makes the sliding block (33) embedded in the V-shaped groove (34) due to the elastic force of the elastic member (32).

8. The microwave synthesis reactor with rapid cooling function according to any one of claims 1-7, characterized in that: The shell (1) is connected with a display screen (36), a power adjusting knob (37), a time setting key (38) and a time adjusting key (39), and the display screen (36), the power adjusting knob (37), the time setting key (38) and the time adjusting key (39) are electrically connected with the controller.

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