Imidacloprid raw medicine synthesizing device

Abstract

The utility model discloses an imidacloprid raw medicine synthesis device, relates to the technical field of medicine production equipment, and comprises a base and a stirring kettle, a stirring component is arranged in the stirring kettle, a sealing cover is arranged on the top surface of the stirring kettle, a feeding hole is formed in the top surface of the sealing cover, a controller is fixedly arranged on the side wall of the stirring kettle, and the controller is connected with the stirring kettle. A temperature control mechanism is arranged in the stirring kettle, and the temperature control mechanism which is integrated in the stirring kettle and is internally provided with a movable temperature sensor is arranged, so that the fixing frame, the flow guide groove, the heating plates and the cooling plates which are alternately arranged, and the reciprocating motion detection assembly driven by the driving motor are matched with one another. Continuous scanning monitoring and independent precise regulation and control of the temperatures of the reaction materials in different intervals in the vertical direction are achieved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical production equipment technology, specifically to an apparatus for synthesizing imidacloprid technical. Background Technology

[0002] In the cyclopentadiene synthesis route of imidacloprid, the final condensation step (reaction of intermediate CCMP with imidazolidine) is crucial. This reaction requires the highly dispersed addition of one component to another, and demands that the reaction system be homogeneously mixed, at a constant temperature, and with a stable pH. In existing technologies, this reaction is typically carried out in a stirred tank.

[0003] A search revealed Chinese patent CN215540808U, which discloses a device for synthesizing terbutaline technical grade. The device includes: a housing with a sealed lid at the top; a support and discharge pipe at the bottom; a drive motor mounted on the lid via a bracket; a rotating rod connected below the drive motor; stirring rods extending into the housing at both ends of the rotating rod; an air pump, a radar level gauge, and a temperature sensor extending into the housing; liquid inlet pipes on both sides of the housing, each connected to a liquid inlet pump; a guide pipe connected to one end of each liquid inlet pipe located inside the housing; heating wires installed inside the side walls of the housing; a cooling water pipe installed inside the bottom wall of the housing; and a control box installed on the outer wall of the housing. This device solves the problem of complex operation and inability to meet production needs in existing technologies.

[0004] However, conventional stirred tank reactors in the existing technology have significant shortcomings when applied to condensation reactions such as imidacloprid, which are highly sensitive to temperature. The existing technology cannot achieve precise, zoned real-time temperature monitoring and dynamic control within the reaction system, which leads to the formation of temperature gradients and local overheating or undercooling points within the reactor. This uneven temperature environment will exacerbate the formation of side reactions such as "double pyridine" impurities, resulting in a decrease in the yield of the target product, difficulty in ensuring purity, and poor batch-to-batch product quality stability.

[0005] Therefore, based on the above-mentioned search and combined with existing technologies, an imidacloprid technical material synthesis device is proposed to solve the above problems. Utility Model Content

[0006] The purpose of this invention is to provide an apparatus for synthesizing imidacloprid technical grade, so as to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, this utility model provides the following technical solution:

[0008] An apparatus for synthesizing imidacloprid technical grade includes a base and a stirred tank. The stirred tank contains a stirring assembly, a sealing cover on its top surface, and a feed inlet on the top surface of the sealing cover. A controller is fixedly mounted on the side wall of the stirred tank, and a temperature control mechanism is installed within the stirred tank. The temperature control mechanism includes a fixed frame, which is fixedly installed in the inner wall of the stirred tank. A flow guide groove is formed on the side wall of the fixed frame, and an installation groove is formed inside the fixed frame. The temperature control mechanism also includes multiple heating and cooling plates, which are alternately installed on the side wall of the installation groove. The temperature control mechanism further includes a detection assembly. The detection assembly includes a temperature sensor, which is located on one side of the fixed frame. A movable groove is formed on the side wall of the fixed frame located on one side of the flow guide groove. A reciprocating screw is rotatably connected to the movable groove, and a movable block is provided on the outer surface of the reciprocating screw. The side wall of the movable block is fixedly connected to the side wall of the temperature sensor.

[0009] Preferably, the detection component further includes: a protective shell, which is fixedly installed on the top surface of the mounting frame, and a drive motor is disposed in the protective shell, the output shaft of which is connected to the top surface of the reciprocating lead screw.

[0010] Preferably, the stirring assembly includes: a stirring blade rotatably connected to the center inside the stirring vessel, and a servo motor fixedly mounted on the top surface of the sealing cover, the output shaft of the servo motor being connected to the top surface of the stirring blade.

[0011] Compared with the prior art, the beneficial effects of this utility model are:

[0012] 1. In this utility model, by setting a temperature control mechanism integrated inside the stirred tank with a built-in movable temperature sensor, the fixed frame, the guide channel, the alternating heating plate and cooling plate, and the reciprocating moving detection component driven by the drive motor cooperate with each other to realize continuous scanning monitoring and independent and precise control of the temperature of the reactants in different intervals in the vertical direction. This creates a highly uniform and stable reaction temperature field inside the stirred tank, effectively suppressing side reactions and improving the reaction efficiency, product yield and purity of imidacloprid synthesis.

[0013] 2. In this utility model, by setting the temperature sensor on a movable block that can move back and forth along the fixed frame, a single detection element can cover and dynamically monitor the temperature changes of the entire main reaction zone, realizing the function of comprehensive temperature monitoring with a more streamlined hardware configuration, reducing system complexity and manufacturing costs, and improving the timeliness of temperature feedback. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0015] Figure 2 This is a schematic diagram of the disassembled structure of the sealing cap of this utility model;

[0016] Figure 3 This is a schematic diagram of the overall structure of the temperature control mechanism of this utility model;

[0017] Figure 4 This is a schematic diagram of the internal structure of the temperature control mechanism of this utility model;

[0018] Figure 5 This utility model Figure 3 Enlarged structural diagram at point A in the middle.

[0019] In the diagram: 1. Base; 2. Mixing vessel; 3. Sealing cover; 4. Feed inlet; 5. Controller; 6. Fixing frame; 7. Guide channel; 8. Mounting slot; 9. Heating plate; 10. Cooling plate; 11. Temperature sensor; 12. Moving channel; 13. Reciprocating screw; 14. Moving block; 15. Protective shell; 16. Drive motor; 17. Stirring blade; 18. Servo motor. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] In the description of this utility model, it should be noted that the terms "upper", "lower", "inner", "outer", "top", "bottom", "side", "front", "rear", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0022] In one typical implementation of this application, please refer to Figures 1-5 As shown, an apparatus for synthesizing imidacloprid technical grade includes a base 1, and a stirred tank 2 is fixedly mounted on the top surface of the base 1 by welding or bolts. The stirred tank 2 constitutes the main reaction vessel for carrying out the imidacloprid condensation reaction.

[0023] The stirring assembly is located inside the stirring vessel 2. Specifically, the stirring assembly includes a stirring blade 17 rotatably connected to the center of the stirring vessel 2. The rotatable connection is usually achieved through a bearing seat located at the bottom of the stirring vessel 2 and on the sealing cover 3 to support the stirring shaft and allow it to rotate freely. A servo motor 18 is fixedly mounted on the top surface of the sealing cover 3 by bolts. The output shaft of the servo motor 18 is connected to the top end of the stirring shaft of the stirring blade 17 through a coupling to drive the stirring blade 17 to rotate and stir and mix the reaction materials.

[0024] The sealing cover 3 is installed on the top surface of the mixing vessel 2 by means of flange and bolts. The top surface of the sealing cover 3 has a feed port 4 for adding various raw materials required for the synthesis of imidacloprid, such as intermediate CCMP, imidazoline and solvent, into the mixing vessel 2.

[0025] The controller 5 is fixedly installed on the side wall of the mixing vessel 2 by a bracket. The controller 5 is preferably a PLC programmable logic controller, which has a temperature control program pre-set inside, used to receive temperature signals and output control commands.

[0026] The temperature control mechanism is integrated inside the stirred tank 2 to achieve high-precision temperature control of the reaction system in multiple zones.

[0027] The temperature control mechanism includes: a fixing frame 6, which is fixedly installed on the inner wall of the stirring vessel 2 by welding or fasteners. The side wall of the fixing frame 6 has multiple guide grooves 7 longitudinally opened to guide the flow of reactants. The fixing frame 6 has an installation groove 8 inside.

[0028] The temperature control mechanism also includes: multiple heating plates 9 and multiple cooling plates 10, which are alternately and side by side installed on the side wall of the mounting groove 8. The heating plates 9 are embedded with heating wires, and their power lines pass through the fixing frame 6 and are connected to the external power supply and controller 5. The cooling plates 10 are provided with cooling medium flow channels, and their inlet and outlet pipes pass through the fixing frame 6 and are connected to the external cooling medium circulation system and the regulating valve controlled by the controller 5. The heating plates 9 and cooling plates 10 together constitute a plate heat exchange unit for heating or cooling the reaction material flowing through the guide groove 7.

[0029] The temperature control mechanism also includes a detection component, which includes a temperature sensor 11, preferably a platinum resistance thermometer (PT100), which is connected to the analog input module of the controller 5 via a signal line to collect temperature data in real time and transmit it to the controller 5. A movable groove 12 is provided on the side wall of the fixed frame 6 on one side of the guide groove 7. A reciprocating screw 13 is rotatably connected to the movable groove 12 through bearing seats at both ends. A movable block 14 is threadedly connected to the outer surface of the reciprocating screw 13. The side wall of the movable block 14 is fixedly connected to the side wall of the temperature sensor 11 by a clamp or bracket, so that the temperature sensor 11 can move together with the movable block 14.

[0030] The detection assembly also includes: a protective housing 15, which is fixedly mounted on the top surface of the mounting bracket 6 by bolts for dust and splash protection. A drive motor 16 is fixedly mounted in the protective housing 15 by a mounting base. The output shaft of the drive motor 16 is connected to the top end of the reciprocating lead screw 13 by a coupling for driving the reciprocating lead screw 13 to rotate in both directions.

[0031] During the imidacloprid condensation reaction, the reactants are first added to the stirred tank 2 through the feed inlet 4. Then, the servo motor 18 is activated by the controller 5, driving the stirring blades 17 to rotate and mix the materials. Simultaneously, the controller 5 activates the drive motor 16, driving the reciprocating screw 13 to rotate periodically in both directions, causing the moving block 14 and the temperature sensor 11 fixed thereon to move up and down along the moving groove 12. The temperature sensor 11 can thus continuously scan and detect the material temperature at different heights within the stirred tank 2.

[0032] It is worth mentioning that the temperature sensor 11 continuously transmits the detected real-time temperature data to the controller 5 via its connected electrical signal line. The control program inside the controller 5 compares the received temperature data for each interval with the preset optimal reaction temperature curve. Based on the comparison result, the controller 5 independently controls the energization and de-energization of the heating wires in the corresponding interval heating plate 9 through its digital output module, or controls the opening of the regulating valve on the cooling medium pipeline of the corresponding cooling plate 10 through its analog output module, thereby precisely adjusting the heat exchange power of each heating plate 9 or cooling plate 10. For example, when the temperature of a certain interval is lower than the set value, the controller 5 will increase the power of the heating plate 9 in that interval or reduce the cooling capacity of the cooling plate 10; conversely, it will reduce the heating power or increase the cooling capacity.

[0033] Subsequently, under the action of stirring, when the reactants flow through the guide channel 7 on the fixed frame 6, they are heated or cooled by the heating plates 9 or cooling plates 10 arranged alternately on both sides of the channel and in a precise temperature control state, so that the temperature of each zone in the reaction system can be quickly and independently adjusted and stabilized within the specified temperature range required by the process.

[0034] Working principle:

[0035] In operation, after the raw material is added through the feed inlet 4, the controller 5 starts the servo motor 18 to drive the stirring blades 17 for stirring. Simultaneously, the controller 5 starts the drive motor 16 to rotate the reciprocating screw 13, causing the moving block 14 carrying the temperature sensor 11 to reciprocate along the moving groove 12, continuously detecting the material temperature at different heights within the stirred tank 2. The temperature sensor 11 transmits real-time temperature data to the controller 5, which, according to preset process parameters, independently adjusts the power of the heating plate 9 or cooling plate 10 at corresponding positions to precisely heat or cool the material flowing through the guide groove 7. This design aims to eliminate temperature gradients and localized overheating within the reactor, creating a uniform and stable temperature environment for the imidacloprid condensation reaction, thereby suppressing side reactions and improving product yield and purity.

[0036] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. An apparatus for synthesizing imidacloprid technical grade, comprising a base (1) and a stirred tank (2), wherein a stirring assembly is provided inside the stirred tank (2), a sealing cover (3) is provided on the top surface of the stirred tank (2), and a feed inlet (4) is provided on the top surface of the sealing cover (3), characterized in that: A controller (5) is fixedly installed on the side wall of the stirring vessel (2), and a temperature control mechanism is provided in the stirring vessel (2); The temperature control mechanism includes: a fixed frame (6), which is fixedly installed in the inner wall of the stirring vessel (2), and the side wall of the fixed frame (6) is provided with a flow guide groove (7), and the interior of the fixed frame (6) is provided with an installation groove (8). The temperature control mechanism also includes a heating plate (9) and a cooling plate (10), wherein multiple heating plates (9) and cooling plates (10) are provided and alternately installed on the side wall of the mounting groove (8). The temperature control mechanism also includes a detection component. The detection component includes a temperature sensor (11), which is disposed on one side of a fixed frame (6). A movable groove (12) is provided on the side wall of the fixed frame (6) on one side of the guide groove (7). A reciprocating screw (13) is rotatably connected in the movable groove (12). A movable block (14) is provided on the outer surface of the reciprocating screw (13). The side wall of the movable block (14) is fixedly connected to the side wall of the temperature sensor (11).

2. The apparatus for synthesizing imidacloprid technical grade according to claim 1, characterized in that: The detection components also include: A protective shell (15) is fixedly installed on the top surface of a fixed frame (6). A drive motor (16) is provided in the protective shell (15). The output shaft of the drive motor (16) is connected to the top surface of a reciprocating lead screw (13).

3. The apparatus for synthesizing imidacloprid technical grade according to claim 1, characterized in that: The stirring assembly includes: The stirring blade (17) is rotatably connected to the center inside the stirring vessel (2). A servo motor (18) is fixedly installed on the top surface of the sealing cover (3). The output shaft of the servo motor (18) is connected to the top surface of the stirring blade (17).

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