Wearable bioartificial liver structure

Abstract

The utility model discloses a wearable bioartificial liver structure. The wearable bioartificial liver structure comprises a liquid circulation pipeline and a biological liver circulation pipeline, wherein the blood circulation pipeline comprises a blood input pipe, a first flexible driving part, a membrane type plasma separator and a blood return pipe which are connected in sequence; the biological liver circulation pipeline comprises a second flexible driving part, a membrane type plasma component separator, a cell canning device and a third flexible driving part which are connected in sequence. Wherein the blood circulation pipeline is used for extracting blood out of a body for plasma separation, and the biological liver circulation pipeline is connected with the blood circulation pipeline so as to provide human hepatocyte-like cells required by a human body, and the human hepatocyte-like cells and the separated blood are jointly transfused back into the human body; moreover, the first flexible driving part, the second flexible driving part and the third flexible driving part are all provided with wearing parts so as to be directly worn on a human body. Therefore, the problem that the patient needs to lie in bed for a long time in the treatment period is effectively solved, and the patient can carry the equipment for long-time treatment.

Description

TECHNICAL FIELD

[0001] The utility model relates to a wearable bioartificial liver structure belongs to medical instrument technical field. BACKGROUND

[0002] Liver failure is a serious disease with a very high mortality rate, and medical conservative treatment often has poor effect. Artificial liver support therapy, especially biological and hybrid artificial liver, has become one of the effective means for treating severe hepatitis and liver failure, and has been recognized worldwide. The bioartificial liver support system mainly consists of blood (or plasma) return circulation and biological liver circulation, and the biological liver circulation is the core, which provides secretion, metabolism, biological transformation and detoxification functions based on cultured hepatocytes and biological reactors.

[0003] However, the existing bioartificial liver support system has some limitations. For patients who need continuous treatment, the existing biological reactor is difficult to update or replace. In addition, the whole artificial liver system is large in size and weight, which is not convenient to move and carry, resulting in that the patient can only be in bed for a long time during treatment, which seriously affects the patient's quality of life.

[0004] Therefore, it is a technical challenge to be solved at present to develop a new type of wearable bioartificial liver support system to solve the above problems. SUMMARY

[0005] The technical problem to be solved by the utility model lies in providing a wearable bioartificial liver structure.

[0006] To achieve the above technical purpose, the utility model adopts the following technical scheme:

[0007] A wearable bioartificial liver structure, comprising a blood circulation pipeline and a biological liver circulation pipeline;

[0008] The blood circulation pipeline comprises a blood input pipe, a first flexible driving part, a membrane type plasma separator and a blood return pipe connected in sequence;

[0009] The biological liver circulation pipeline comprises a second flexible driving part, a membrane type plasma component separator, a cell tank loader and a third flexible driving part connected in sequence; wherein the inlet of the second flexible driving part is connected with the outer wall outlet of the membrane type plasma separator, the outlet of the second flexible driving part is connected with the inner cavity inlet of the membrane type plasma component separator, and the inner cavity outlet of the membrane type plasma component separator is connected with the blood return pipe through a transfusion pipeline; the inlet of the cell tank loader is connected with the outer wall outlet of the membrane type plasma component separator, and the outlet of the cell tank loader is connected with the outer wall inlet of the membrane type plasma component separator through the third flexible driving part, so as to jointly form the biological liver circulation pipeline.

[0010] The first flexible driving part, the second flexible driving part and the third flexible driving part each have a wearing part for being directly worn on the human body.

[0011] Preferably, the wearing part comprises two magic tapes which are arranged on two sides of the first flexible driving part, the second flexible driving part and the third flexible driving part respectively, and the first flexible driving part, the second flexible driving part and the third flexible driving part are worn on the human body by being wrapped around the patient's body and adhered to each other.

[0012] Preferably, the wearing part is an adhesive plate having an adhesive surface, and a non-adhesive surface of the adhesive plate is fixed on the first flexible driving part, the second flexible driving part and the third flexible driving part, so that the first flexible driving part, the second flexible driving part and the third flexible driving part are directly adhered to the human skin by the adhesive surface of the adhesive plate.

[0013] Preferably, the wearable bioartificial liver structure further comprises:

[0014] A heater arranged on the blood return pipe for heating the blood plasma to a preset temperature.

[0015] Preferably, the wearable bioartificial liver structure further comprises:

[0016] A heparin pump connected between the first flexible driving part and the membrane type plasma separator for injecting heparin into the blood.

[0017] Preferably, the first flexible driving part and the second flexible driving part are both flexible magnetic suspension centrifugal pumps.

[0018] Preferably, the blood input pipe, the blood return pipe and the infusion pipeline are all made of medical PVC.

[0019] Preferably, the cell tank device has a plurality of cell tank layers, the plurality of cell tank layers are arranged at equal intervals in the vertical direction, and each of the cell tank layers is provided with a plurality of human liver-like cells.

[0020] Preferably, the wearable bioartificial liver structure further comprises:

[0021] A constant temperature incubator for providing a constant temperature environment for the culture of human liver-like cells.

[0022] Preferably, the constant temperature incubator has a hollow inner cavity, and the cell tank device containing human liver-like cells is placed in the hollow inner cavity for the culture of human liver-like cells.

[0023] Preferably, the wearable bioartificial liver structure further comprises a transfusion part; the transfusion part comprises a liquid storage bag and a transfusion pump, an inlet of the transfusion pump is connected with the liquid storage bag, and an outlet of the transfusion pump is connected with the inner cavity inlet of the membrane type plasma separator.

[0024] Compared with the prior art, the wearable bioartificial liver structure provided by the utility model adopts a flexible driving part to replace the original large rigid peristaltic pump, and the wearing part arranged on the flexible driving part can directly wear the bioartificial liver structure on the human body. Moreover, the flexible driving part is preferably a flexible magnetic suspension centrifugal pump which is compatible with body tissues and organs, can adapt to the movement of the human body to deform to a certain extent, and has pump flow capacity at different operating angles, thereby optimizing the use experience of the patient and being suitable for long-term wearing and use. Thus, the problem that the patient needs to be in bed for a long time during treatment is effectively solved, and the patient can carry the equipment and be treated for a long time. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 The structure schematic view of the wearable bioartificial liver structure provided by the utility model embodiment is shown. DETAILED DESCRIPTION

[0026] The technical content of the utility model will be described in detail below in combination with the drawings and specific embodiments.

[0027] The utility model embodiment provides a wearable bioartificial liver structure, and a large rigid peristaltic pump in an existing bioartificial liver support system is replaced by a flexible magnetic suspension centrifugal pump based on a folded permanent magnetic film and magnetic suspension technology. The flexible magnetic suspension centrifugal pump is developed by a team of Professor Huang Xian of Tianjin University (for details, see a paper published on October 29, 2021 in Science Advances, the link of which is: https: / / doi.org / 10.1126 / sciadv.abi7203). For different application scenarios, the volume can be as low as 0.3-11.7 cm 3 , and the mass can be as light as 0.3-12.8 g. The flexible magnetic suspension centrifugal pump is compatible with body tissues and organs, can adapt to the movement of the human body to deform to a certain extent, and has pump flow capacity at different operating angles, thereby optimizing the use experience of the patient and being suitable for long-term wearing and use. Thus, the problem that the patient needs to be in bed for a long time during treatment is effectively solved, and the patient can carry the equipment and be treated for a long time.

[0028] As Figure 1As shown in the illustration, this utility model provides a wearable bioartificial liver structure, including a blood circulation tubing 10 and a bioartificial liver circulation tubing 20. The blood circulation tubing 10 is used to draw blood out of the body for plasma separation. Based on a special membrane structure and filtration technology, different components in the plasma can be selectively separated, thereby rapidly removing pathogenic substances. The bioartificial liver circulation tubing 20 is connected to the blood circulation tubing 10 to provide the body with the necessary human liver-like cells, which are then combined with the separated blood and reinfused into the body to improve the patient's symptoms and prognosis.

[0029] In one embodiment of this invention, the blood circulation pipeline 10 includes a blood input tube 1, a first flexible drive unit 2, a membrane plasma separator 3, and a blood return tube 4 connected in sequence. Specifically, one end of the blood input tube 1 is connected to the human body, and the other end is connected to the inlet of the first flexible drive unit 2, so as to draw blood out of the human body through the first flexible drive unit 2. The outlet of the first flexible drive unit 2 is connected to the inner cavity inlet 31 of the membrane plasma separator 3, so that the blood drawn from the body is input into the membrane plasma separator 3, and then plasma is separated by the membrane plasma separator 3. The inner cavity outlet 32 ​​of the membrane plasma separator 3 is connected to the blood return tube 4, and the outer wall outlet 33 is connected to the biological liver circulation pipeline 20, so that after plasma separation, the plasma is transported to the biological liver circulation pipeline 20, and other beneficial components in the blood are returned to the human body through the blood return tube 4.

[0030] like Figure 1 As shown, the bio-liver circulation pipeline 20 includes a second flexible drive unit 5, a membrane-type plasma component separator 6, a cell filling device 7, and a third flexible drive unit 8 connected in sequence. Specifically, the inlet of the second flexible drive unit 5 is connected to the outer wall outlet 31 of the membrane-type plasma separator 3, and the outlet of the second flexible drive unit 5 is connected to the inner cavity inlet 61 of the membrane-type plasma component separator. The inner cavity outlet 62 of the membrane-type plasma component separator is connected to the blood return pipe 4 through the infusion pipe 9. The inlet of the cell filling device 7 is connected to the outer wall outlet 63 of the membrane-type plasma component separator, and the outlet of the cell filling device 7 is connected to the outer wall inlet 64 of the membrane-type plasma component separator through the third flexible drive unit 8, thereby forming the bio-liver circulation pipeline.

[0031] The cell container 7 contains multiple cell container layers 71 arranged at equal intervals along a vertical direction, and each cell container layer 71 contains multiple human liver-like cells. Furthermore, this wearable bioartificial liver structure includes a thermostatic incubator 30 to provide a constant temperature environment for culturing human liver-like cells. The thermostatic incubator 30 has a hollow inner cavity, allowing the cell container 7 containing human liver-like cells to be placed within this cavity for cell culture.

[0032] In an embodiment of the present application, the first flexible driving part 2, the second flexible driving part 5 and the third flexible driving part 8 are all flexible magnetic suspension centrifugal pumps. Moreover, each flexible driving part is provided with a wearing part for being directly worn on the human body. In a preferred embodiment, the wearing part can be two mutually cooperating magic tapes arranged on both sides of each flexible driving part, so that each flexible driving part is worn on the human body by means of the two mutually cooperating magic tapes being wrapped around the patient's body and being mutually adhered. In another preferred embodiment, the wearing part can also be an adhesive plate provided with adhesive, and the non-adhesive side of the adhesive plate is fixed to each flexible driving part, so that each driving part is directly adhered to the human skin by means of the adhesive side of the adhesive plate. It can be understood that the specific structure of the wearing part is not limited to the above two embodiments, and in other embodiments, adaptive adjustment can be made according to the needs, as long as the wearing needs of the patient can be met.

[0033] It can be understood that, by replacing the traditional large rigid peristaltic pump with the flexible magnetic suspension centrifugal pump based on the folded permanent magnetic film and the magnetic suspension technology, the bioartificial liver can be directly worn on the human body, so that the patient does not need to be in bed for a long time during treatment and can have a certain freedom of movement (for example, using the toilet or walking normally). Therefore, the convenience of treatment is greatly improved, and the compliance of the patient in treatment is also improved.

[0034] In actual work, the blood of the patient is led out of the body by the first flexible driving part 2 and pumped into the membrane type plasma separator 3 for plasma separation, so as to separate the blood into plasma and blood cells. Among them, the plasma enters the bio-liver circulation pipeline 20, and the blood cells are recombined with the plasma after completing the bio-liver circulation, and then are returned to the patient's body.

[0035] The plasma separated by the membrane type plasma separator 3 is pumped into the membrane type plasma component separator 6 by the second flexible driving part 5, for separating the normal components and the components needing purification in the plasma. Subsequently, the plasma enters the cell tank device 7 from the outer wall outlet 63 of the membrane type plasma component separator 6, so as to be combined with the human liver-like cells in the cell tank device 7. The plasma combined with the human liver-like cells is pumped into the membrane type plasma component separator 6 by the third flexible driving part 8, and then is combined with the blood cells separated by the membrane type plasma separator 3 through the infusion pipeline 9, so as to complete the whole bio-liver circulation process.

[0036] In the above embodiment, optionally, the wearable bioartificial liver structure further comprises a heater 11. The heater 11 is arranged on the blood return pipe 4, for heating the plasma to a preset temperature (close to the temperature of the human body, for example: 36-37℃).

[0037] In the above embodiment, the wearable bioartificial liver structure optionally further comprises a heparin pump 12. The heparin pump 12 is connected between the first flexible driving part 2 and the membrane type plasma separator 3, and is used to inject heparin into the blood.

[0038] In the above embodiment, the blood input pipe 1, the blood return pipe 4 and the infusion pipe 9 are all made of medical PVC.

[0039] In the above embodiment, the wearable bioartificial liver structure optionally further comprises an infusion part (not shown in the figure). Specifically, the infusion part comprises a liquid storage bag and an infusion pump, the inlet of the infusion pump is connected with the liquid storage bag, and the outlet of the infusion pump is connected with the inner cavity inlet 31 of the membrane type plasma separator 3, so as to deliver the liquid in the liquid storage bag into the membrane type plasma separator 3 and then into the patient's body.

[0040] It should be noted that the above embodiments are only illustrative. The technical solutions of the embodiments can be combined, and all are within the protection scope of the present application.

[0041] It should be understood that the terms "upper", "lower", "horizontal" and the like indicate the orientation or positional relationship shown in the drawings, and are only used for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0042] In addition, the terms "first" and "second" are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features referred to. Therefore, the features defined as "first" and "second" can explicitly or implicitly include one or more of the features. In the description of the present application, the meaning of "multiple" is two or more, unless otherwise specifically limited.

[0043] The wearable bioartificial liver structure provided by the present application has been described in detail above. Any obvious modification made by a person skilled in the art without departing from the essential content of the present application will constitute an infringement of the patent right of the present application and will bear the corresponding legal responsibility.

Claims

1. A wearable bioartificial liver structure, characterized in that The blood circulation pipeline and the biological liver circulation pipeline; The blood circulation pipeline comprises a blood input pipeline, a first flexible driving part, a membrane type plasma separator and a blood return pipeline connected in sequence; The biological liver circulation pipeline comprises a second flexible driving part, a membrane type plasma component separator, a cell tank loader and a third flexible driving part connected in sequence; the inlet of the second flexible driving part is connected with the outer wall outlet of the membrane type plasma separator, the outlet of the second flexible driving part is connected with the inner cavity inlet of the membrane type plasma component separator, the inner cavity outlet of the membrane type plasma component separator is connected with the blood return pipeline through a transfusion pipeline; the inlet of the cell tank loader is connected with the outer wall outlet of the membrane type plasma component separator, and the outlet of the cell tank loader is connected with the outer wall inlet of the membrane type plasma component separator through the third flexible driving part, thereby forming the biological liver circulation pipeline together. The first flexible driving part, the second flexible driving part and the third flexible driving part each have a wearing part to be directly worn on the human body.

2. The wearable biological artificial liver structure according to claim 1, wherein: The wearing part comprises two magic tapes matched with each other, and the magic tapes are arranged on both sides of the first flexible driving part, the second flexible driving part and the third flexible driving part respectively, so as to wear the first flexible driving part, the second flexible driving part and the third flexible driving part on the human body by surrounding the patient's body and adhering to each other.

3. The wearable biological artificial liver structure according to claim 1, wherein: The wearing part is an adhesive plate with adhesive, and the non-adhesive side of the adhesive plate is fixed on the first flexible driving part, the second flexible driving part and the third flexible driving part, so as to directly paste the first flexible driving part, the second flexible driving part and the third flexible driving part on the human skin through the adhesive side of the adhesive plate.

4. The wearable bioartificial liver structure of claim 1, wherein Further comprising: A heater arranged on the blood return pipeline for heating the plasma to a preset temperature.

5. The wearable bioartificial liver structure of claim 1, wherein Further comprising: A heparin pump connected between the first flexible driving part and the membrane type plasma separator for injecting heparin into the blood.

6. The wearable biological artificial liver structure according to claim 1, wherein: The first flexible driving part and the second flexible driving part are both flexible magnetic suspension centrifugal pumps.

7. The wearable biological artificial liver structure according to claim 1, wherein: The blood input pipeline, the blood return pipeline and the transfusion pipeline are all made of medical PVC.

8. The wearable biological artificial liver structure according to claim 1, wherein: The cell tank loader has a plurality of cell tank layers, and the plurality of cell tank layers are arranged at equal intervals in the vertical direction, and each of the cell tank layers is provided with a plurality of human liver-like cells.

9. The wearable bioartificial liver structure of claim 1, wherein Further comprising: A constant temperature incubator for providing a constant temperature environment for the culture of human liver-like cells; The constant temperature incubator has a hollow inner cavity, and the cell tank loader containing human liver-like cells is placed in the hollow inner cavity for the culture of human liver-like cells.

10. The wearable bioartificial liver structure of claim 1, wherein Further comprising: The infusion unit comprises a liquid storage bag and an infusion pump, the inlet of the infusion pump is connected with the liquid storage bag, and the outlet of the infusion pump is connected with the inner cavity inlet of the membrane type plasma separator.

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