Modularized three-dimensional fluorescent drug sensitivity detection device

Abstract

The utility model discloses a modularized three-dimensional fluorescent drug sensitivity detection device, relates to the technical field of fluorescent drug sensitivity detection, and solves the problems that the modularized three-dimensional fluorescent drug sensitivity detection device in the prior art is poor in cultivation effect, difficult to meet the multi-group cultivation requirement and low in cultivation efficiency. Comprising a test box; a partition plate is arranged in the test box and divides the test box into a first test area and a second test area, bearing plates are arranged in the first test area and the second test area, and culture dishes are arranged on the bearing plates; the bearing platform plate is provided with a placing groove; according to the design, a user can conveniently and flexibly adjust the distance between the upper bearing platform plate and the lower bearing platform plate so as to meet the placing requirements of culture dishes of different specifications, and the multiple test areas arranged in the device can meet the culture requirements of various microorganism varieties at the same time, so that the application range of the device is remarkably widened, and the practicability is high. And the overall working efficiency is effectively improved.

Description

TECHNICAL FIELD

[0001] The utility model belongs to fluorescent drug sensitivity detection technical field, especially related to a modular three-dimensional fluorescent drug sensitivity detection device. BACKGROUND

[0002] Modular three-dimensional fluorescent drug sensitivity detection is a kind of combined three-dimensional fluorescence spectroscopy technology and modular detection system, realizes fast, accurate drug sensitivity evaluation by analyzing the metabolic product, enzyme activity and cell membrane permeability change of microorganism under the action of drug, it is especially suitable for clinical, research and development and public health field.The main components include: sample processing module, for completing sample dilution, fluorescent probe marking, temperature control incubation;Among them, the key components of sample processing module are (automatic pipetting workstation, temperature control incubator (37 DEG C±0.5 DEG C), fluorescent probe storage and distribution system).

[0003] At present, the existing modular three-dimensional fluorescent drug sensitivity detection device has certain limitation.In the detection process, its temperature control incubator is only equipped with an independent incubation area, and this design can only meet the culture demand of single variety of microorganism in the microorganism culture stage, thereby greatly limiting the application range of the device and reducing the overall working efficiency.

[0004] In summary, the modular three-dimensional fluorescent drug sensitivity detection device in the prior art has the problems of poor cultivation effect, difficulty in meeting the multi-group cultivation demand and low cultivation efficiency. UTILITY MODEL CONTENT

[0005] The utility model provides a kind of modular three-dimensional fluorescent drug sensitivity detection device, can solve the problems of poor cultivation effect, difficulty in meeting the multi-group cultivation demand and low cultivation efficiency of modular three-dimensional fluorescent drug sensitivity detection device in prior art.

[0006] To achieve the above object, according to the first aspect of the utility model embodiment proposes a kind of modular three-dimensional fluorescent drug sensitivity detection device, including test box;

[0007] The test box is provided with a partition plate, the partition plate divides the test box into test area one and test area two, the test area one and test area two are provided with bearing slab, and the bearing slab is provided with petri dish;

[0008] Further comprising: placing connecting assembly, the bearing slab is provided with a placing groove, and the placing connecting assembly includes a circle of adsorption magnetic ring fixedly arranged on the inner wall of placing groove and adsorption magnetic ring fixedly sleeved on the outside of petri dish.

[0009] Further improvement lies in that the placing connecting assembly further includes positioning column fixedly installed at four corners of the inner wall of placing groove.

[0010] Further improvement lies in that the bottom surface of the culture dish is fixedly installed on the connecting plate, and the connecting plate is provided with a positioning socket installed in cooperation with a positioning column.

[0011] Further improvement lies in that the number of the bearing platform plates is provided with several.

[0012] Further improvement lies in that the two side inner walls of the test area one and the test area two are fixedly installed with several clamping rods.

[0013] Further improvement lies in that the clamping groove is formed through the clamping rod.

[0014] Further improvement lies in that the bottom surface of the bearing platform plate is fixedly installed with clamping rods on both sides.

[0015] Further improvement lies in that the bearing platform plate is installed in the test area one and the test area two through the clamping rods on both sides.

[0016] Further improvement lies in that the test box is slidably provided with a storage box, and the storage box is provided with several storage grids.

[0017] Further improvement lies in that the bottom surface of the test box is provided with rubber blocks at four corners, and the rubber blocks are threadedly connected to the bottom surface of the test box.

[0018] Compared with the prior art, the beneficial effects of the utility model are:

[0019] (1) The clamping rods on both sides of the bottom surface of the bearing platform plate are clamped into the clamping grooves on each pair of clamping rods, so that the assembly and disassembly of the bearing platform plate can be easily completed. This design not only facilitates the user to flexibly adjust the distance between the adjacent bearing platform plates to adapt to the placement requirements of different specifications of culture dishes, but also simultaneously meets the culture requirements of various microorganisms, thereby significantly widening the application range of the device and effectively improving the overall work efficiency.

[0020] (2) When the bearing platform plate is installed, the selected culture dish is placed in the placing groove on the bearing platform plate. At this time, the adsorption magnetic ring on the outer periphery of the culture dish is attracted to and tightly fitted with the adsorption magnetic ring in the placing groove, and the positioning column in the placing groove is inserted into the positioning socket of the connecting plate at the bottom of the culture dish. This design realizes the stable positioning and fixation of the culture dish, ensures the firm and reliable connection of the adsorbed culture dish, and facilitates the subsequent convenient disassembly and replacement operation. BRIEF DESCRIPTION OF DRAWINGS

[0021] Fig. 1 is the overall structure schematic view of the utility model;

[0022] Fig. 2 is the test box cross-section structure schematic view of the utility model;

[0023] Fig. 3 Figure is the culture dish structure schematic diagram on single bearing platform plate of the utility model.

[0024] Markings in the figure:

[0025] 1, storage box;11, storage grid;

[0026] 2, test box;21, rubber block;22, box door;23, partition plate;201, test area one;202, test area two;203, bearing platform plate;204, placing groove;205, connecting rod;206, connecting groove;207, clamping rod;

[0027] 3, culture dish;

[0028] 4, place connecting assembly;41, adsorption magnetic ring;42, adsorption magnetic ring;43, positioning column;44, connecting plate;45, positioning socket. DETAILED DESCRIPTION

[0029] The technical solutions of the utility model will be described clearly and completely below in combination with embodiments. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the utility model.

[0030] As shown in Figs. 1-3 A modular three-dimensional fluorescent drug sensitivity detection device, comprising a test box 2, a partition plate 23 is arranged in the test box 2, the test box 2 is divided into a test area one 201 and a test area two 202 by the partition plate 23, a bearing platform plate 203 is arranged in the test area one 201 and the test area two 202, and a culture dish 3 is arranged on the bearing platform plate 203;

[0031] It needs to be pointed out that the number of bearing platform plates 203 of the test area one 201 and the test area two 202 is selected according to the demand, and two groups are taken as an example in the embodiment;

[0032] The connecting assembly 4 is placed on the support plate 203, and the support plate 203 is provided with a placing groove 204. The connecting assembly 4 comprises a ring of adsorbing magnetic rings 41 fixedly arranged on the inner wall of the placing groove 204, an adsorbing magnetic ring 42 fixedly sleeved on the outside of the culture dish 3, and positioning columns 43 fixedly installed at four corners of the inner wall of the placing groove 204. The bottom surface of the culture dish 3 is fixedly installed on a connecting plate 44, and the connecting plate 44 is provided with a positioning socket 45 matched with the positioning columns 43. The selected culture dish 3 is placed in the placing groove 204 on the support plate 203. At this time, the adsorbing magnetic ring 42 on the outer periphery of the culture dish 3 is attracted to and tightly combined with the adsorbing magnetic ring 41 in the placing groove 204, and the positioning columns 43 in the placing groove 204 are inserted into the positioning socket 45 of the connecting plate 44 at the bottom of the culture dish 3. This design realizes stable positioning and fixing of the culture dish 3, ensures firm and reliable connection of the adsorbed culture dish 3, and facilitates subsequent convenient disassembly and replacement operation.

[0033] Specifically, the inner walls on both sides of the test area one 201 and the test area two 202 are fixedly installed with a plurality of clamping rods 205, each clamping rod 205 is arranged at the same height, and a clamping groove 206 is formed through each clamping rod 205. The bottom surface of the support plate 203 is fixedly installed with clamping rods 207 on both sides, and the support plate 203 is installed in the test area one 201 and the test area two 202 through the clamping rods 207 on both sides. By clamping the clamping rods 207 on both sides of the bottom surface of the support plate 203 into the clamping grooves 206 pre-installed on each pair of clamping rods 205, the assembly and disassembly of the support plate 203 can be easily completed. This design not only facilitates users to flexibly adjust the distance between adjacent support plates 203 to adapt to the placement requirements of different specifications of culture dishes 3, but also enables the multiple test areas in the device to simultaneously meet the culture requirements of multiple microorganism varieties, thereby significantly expanding the application range of the device and effectively improving the overall working efficiency.

[0034] As a preferred embodiment, the test box 2 is slidably provided with a storage box 1, and the storage box 1 is provided with a plurality of storage compartments 11 for storing a plurality of test items and matched instruments.

[0035] As a preferred embodiment, the bottom surface of the test box 2 is provided with rubber blocks 21 at four corners, which are threadedly connected to the bottom surface of the test box 2 to improve the stability of the test box 2 after placement.

[0036] As shown in Figs. 1-3 It should be noted that the modular three-dimensional fluorescence drug sensitivity detection device in the application file further comprises:

[0037] ①Optical detection module; function is to collect three-dimensional fluorescence spectral data (excitation wavelength 400-700 nm, emission wavelength 450-750 nm). Key components include: high-sensitivity CCD camera (quantum efficiency ≥ 85%), pulsed xenon lamp light source (service life ≥ 10^9 flashes), motorized filter wheel (supports 10 nm step adjustment) and microfluidic chip interface (optional, for single-cell detection)

[0038] ②Data analysis module; function is to process three-dimensional spectral data in real time, output drug sensitivity parameters (MIC, killing curve). Key components include: GPU-accelerated computing card (NVIDIA A100 or similar), pre-trained AI model (based on ResNet-50 architecture), user interaction interface (supports Web / mobile access)

[0039] ③Automatic control module; function is to coordinate the work of each module, realize unattended detection. Key components include: industrial-grade PLC controller (response time ≤ 1 ms), mechanical arm system (repeat positioning accuracy ± 0.05 mm) and sensor array (monitoring temperature, humidity, light intensity), the above modules are used together and installed on the test box 2, which is the prior art and the working principle is disclosed. In addition, it should be noted that this application file only improves the shortcomings of the prior art modular three-dimensional fluorescence drug sensitivity detection device, such as poor cultivation effect and difficulty in meeting the needs of multiple cultivation, and low cultivation efficiency, and does not involve other improvements. The size and specification are installed according to the actual demand on site; the working principle of the modular three-dimensional fluorescence drug sensitivity detection device is introduced as follows:

[0040] When the new scheme is used, the test personnel can select the appropriate number of bearing plates 203 according to the actual demand. During installation, the clamping rods 207 on the bottom surface of the bearing plate 203 are respectively clamped into the pre-designed clamping grooves 206 on each pair of clamping rods 205, so that the assembly and disassembly of the bearing plate 203 can be easily completed. This design not only facilitates users to flexibly adjust the distance between adjacent bearing plates 203 to adapt to the placement requirements of different specifications of culture dishes 3, but also enables the multiple test areas in the device to simultaneously meet the cultivation requirements of multiple microorganism varieties, thereby significantly expanding the application range of the device and effectively improving the overall work efficiency.

[0041] When the support plate 203 is installed, the selected culture dish 3 is placed in the placing groove 204 on the support plate 203. At this time, the adsorbing magnetic ring 42 on the outer periphery of the culture dish 3 is attracted to and closely combined with the adsorbing magnetic ring 41 in the placing groove 204, and the positioning column 43 in the placing groove 204 is correspondingly inserted into the positioning flange 45 of the connecting plate 44 at the bottom of the culture dish 3. This design realizes the stable positioning and fixing of the culture dish 3, ensures that the connected culture dish 3 after adsorption is firm and reliable, and facilitates the subsequent convenient disassembly and replacement operation.

[0042] The above examples are only used to illustrate the technical method of the utility model and are not limited. Although the utility model is described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical method of the utility model can be modified or replaced equivalently without departing from the spirit and scope of the technical method of the utility model.

Claims

1. A modular three-dimensional fluorescent drug sensitivity detection device, comprising a test box (2); characterized in that A partition plate (23) is arranged in the test box (2), the test box (2) is divided into a test area one (201) and a test area two (202) by the partition plate (23), a bearing platform (203) is arranged in the test area one (201) and the test area two (202), and a culture dish (3) is arranged on the bearing platform (203). Further comprising: a placing connecting assembly (4), a placing groove (204) is formed in the bearing platform (203), the placing connecting assembly (4) comprises a ring of adsorbing magnetic rings (41) fixedly arranged on the inner wall of the placing groove (204) and an adsorbing magnetic ring (42) fixedly sleeved on the outside of the culture dish (3).

2. The modular three-dimensional fluorescent drug sensitivity detection device according to claim 1, characterized in that, The placing connecting assembly (4) further comprises positioning columns (43) fixedly installed at four corners of the inner wall of the placing groove (204).

3. The modular three-dimensional fluorescent drug sensitivity detection device according to claim 1, wherein, The bottom surface of the culture dish (3) is fixedly installed on a connecting plate (44), and the connecting plate (44) is provided with a positioning bayonet (45) installed in cooperation with the positioning column (43).

4. The modular three-dimensional fluorescent drug sensitivity detection device according to claim 1, characterized in that, The number of the bearing platforms (203) is several.

5. The modular three-dimensional fluorescent drug sensitivity detection device according to claim 1, wherein, A plurality of clamping rods (207) are fixedly installed on the bottom surface of the bearing platform (203).

6. The modular three-dimensional fluorescent drug sensitivity test device according to claim 5, wherein, A clamping groove (206) is formed through the clamping rod (207).

7. The modular three-dimensional fluorescent drug sensitivity test device according to claim 1, wherein, The clamping rod (207) is installed in the test area one (201) and the test area two (202) through the clamping rod (207) on the two sides of the bearing platform (203).

8. The modular three-dimensional fluorescent drug sensitivity test device according to claim 7, wherein, The test box (2) is provided with a storage box (1) slidingly arranged thereon, and a plurality of storage compartments (11) are arranged in the storage box (1).

9. The modular three-dimensional fluorescent drug sensitivity test device according to claim 1, wherein, Rubber stoppers (21) are arranged at four corners of the bottom surface of the test box (2), and the rubber stoppers (21) are threadedly connected to the bottom surface of the test box (2).

10. The modular three-dimensional fluorescent drug sensitivity test device according to claim 1, wherein, ​

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