Suspension high-shear dispersion preparation mixing equipment
By designing a multi-stage stirring impeller structure, the problems of uneven mixing and excessively long mixing time in single-impeller shear dispersers are solved, achieving efficient dispersion and rapid mixing of suspensions, thereby improving drug quality and production efficiency.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-23
- Publication Date
- 2026-04-14
AI Technical Summary
When existing shear dispersers use a single impeller for mixing, the quality stability of the suspension is easily affected, and the stirring time is too long, resulting in low production efficiency and increased costs.
The multi-stage stirring impeller structure includes a first dispersion disk, a second dispersion disk, and an intermediate guide paddle. It improves mixing efficiency through multiple shearing and cyclic movements. Specifically, the first and second dispersion disks are combined and an intermediate guide paddle is set between them to form multiple stirring modes.
It significantly improves the uniformity of component dispersion and mixing efficiency of suspensions, shortens stirring time, enhances drug particle size refinement and dissolution rate, and ensures drug quality and production efficiency.
Smart Images
Figure CN224113785U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of mixing equipment technology, specifically to a high-shear dispersion preparation and mixing equipment for suspensions. Background Technology
[0002] In the pharmaceutical industry, ibuprofen suspension is a commonly used over-the-counter drug. Its preparation process involves first separately stirring and mixing to prepare a slurry and a mixture. Then, the prepared slurry and mixture are combined with flavoring and coloring agents and raw water. High-speed shear dispersers are required for mixing to ensure that all components are uniformly mixed to form a stable suspension system.
[0003] Existing shear dispersers use a single rectangular toothed impeller. When this impeller rotates, the mixed liquid in the raw water is agitated and moves circumferentially up and down. Its mixing efficiency depends on its high rotational speed. In actual production, during the stirring process, the circumferential up and down movement of the liquid may lead to over-mixing in some areas and under-mixing in others, thus affecting the overall quality stability of the ibuprofen suspension. Furthermore, each stirring session typically exceeds 15 minutes, which significantly extends the processing time for ibuprofen suspension, a drug requiring multiple stirring steps. This longer processing time reduces production efficiency, increases production costs, and may also have a potential impact on drug quality. Utility Model Content
[0004] To address the shortcomings of existing technologies, this invention provides a high-shear dispersion preparation and mixing device for suspensions, which solves the problems of existing shear dispersers using a single impeller which easily affects the quality of the suspension and the excessively long stirring time.
[0005] To achieve the above objectives, the present invention provides the following technical solution: a high-shear dispersion preparation and mixing device for suspensions, comprising a disperser, wherein a main shaft is provided on the power mechanism of the disperser, and a stirring plate is provided at the bottom of the main shaft, the stirring plate comprising a second dispersion plate located at the bottom end of the main shaft and an intermediate guide paddle and a first dispersion plate located above the second dispersion plate, the intermediate guide paddle being located between the first dispersion plate and the second dispersion plate.
[0006] Preferably, the first dispersing disk, the intermediate guide paddle, and the second dispersing disk are arranged at intervals from top to bottom, the distance between the first dispersing disk and the intermediate guide paddle is a, and the distance between the intermediate guide paddle and the second dispersing disk is b, where b > a.
[0007] Preferably, the diameter of the first dispersion disk is A, and the diameter of the second dispersion disk is B, where A > B.
[0008] Preferably, the surface of the first dispersing disk has multiple openings circumferentially, and the multiple openings are strip-shaped and arranged in a circular array with the main axis as the center.
[0009] Preferably, each of the openings includes a first side and a second side, and the two ends of the first side and the second side are connected to form a first angle and a second angle.
[0010] Preferably, each of the openings is inclined, such that the first corner is close to the main shaft and the second corner is close to the outer edge of the first dispersing disk.
[0011] Preferably, both the first and second sides are arc-shaped, such that the width of the opening at the center is greater than the width of the opening at the first and second corners.
[0012] Preferably, the top of the intermediate guide propeller is closed, and the interior is a hollow cavity that extends downwards; the wall of the intermediate guide propeller has several slots that extend downwards to form multiple blades.
[0013] Preferably, each of the blades is bent outwards.
[0014] Beneficial effects
[0015] By using the high-shear dispersion and mixing device for suspensions provided by this invention, a multi-stage stirring impeller is employed, combining a first and second dispersion disc with an intermediate guide paddle between them. This changes the traditional stirring mode of a single rectangular toothed dispersion impeller. When the main shaft rotates at high speed, the solution is drawn upwards by the second dispersion disc and comes into contact with the first dispersion disc for secondary shearing. Compared to the traditional single impeller, which can only perform a relatively simple stirring and mixing once, this secondary shearing process allows the solution to be processed multiple times in one rotation, resulting in more thorough dispersion and mixing of various components in the solution. For example, for ibuprofen suspension particles, after secondary shearing, the particle size can be further refined and the distribution more uniform, thereby improving the drug's dissolution rate and bioavailability, and ensuring the drug's efficacy.
[0016] Furthermore, after the solution undergoes secondary shearing through the first dispersion disk, the intermediate guide paddle rotates and forcibly transports the solution to the second dispersion disk, allowing the solution to continuously blend with the original liquid during the repeated motion of the first dispersion disk, the intermediate guide paddle, and the second dispersion disk. This cyclical motion pattern significantly improves mixing efficiency. Compared to traditional equipment where a single stirring time is over 15 minutes, this equipment can significantly reduce the stirring time per cycle. Attached Figure Description
[0017] Figure 1 This is an isometric drawing of the disperser of this utility model;
[0018] Figure 2This is a three-dimensional structural diagram of the mixing plate and main shaft of this utility model;
[0019] Figure 3 This utility model Figure 2 Top view;
[0020] Figure 4 This utility model Figure 2 Main view;
[0021] Figure 5 This is a schematic diagram of the intermediate guide propeller structure of this utility model.
[0022] Explanation of symbols in the diagram:
[0023] 1. Disperser, 2. Main shaft, 3. First dispersing disc, 4. Intermediate guide paddle, 5. Second dispersing disc, 6. Opening, 7. First corner, 8. Second corner, 9. First side, 10. Second side, 11. Grooved, 12. Paddle blade. Detailed Implementation
[0024] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Various changes can be made to the implementation scheme as long as the effects of the present invention can be achieved.
[0025] Those skilled in the art can connect the components in this case sequentially. The specific connection and operation sequence should refer to the working principle described below. The detailed connection methods are well-known technologies in the art. The following mainly introduces the working principle and process.
[0026] This embodiment provides a suspension high-shear dispersion preparation and mixing device, referring to... Figure 1 As shown, it includes a disperser 1, on which a stirring container can be placed. The stirring container contains the original liquid. A main shaft 2 is provided on the power mechanism of the disperser 1. A stirring plate is provided at the bottom of the main shaft 2. The main shaft 2 and the stirring plate are inserted into the stirring container.
[0027] Reference Figure 2 As shown, the mixing disc includes a second dispersion disc 5 located at the bottom of the main shaft 2, an intermediate guide paddle 4 located above the second dispersion disc 5, and a first dispersion disc 3. The intermediate guide paddle 4 is located between the first dispersion disc 3 and the second dispersion disc 5. When the main shaft 2 descends to its lowest point, the second dispersion disc 5 is 5 cm from the bottom, and the first dispersion disc 3 is 15 cm from the bottom.
[0028] like Figure 5 As shown, the top of the intermediate guide propeller 4 is closed, and the interior is a hollow cavity that runs downwards; the wall of the intermediate guide propeller 4 has several slots 11 that run downwards to form multiple blades 12.
[0029] Furthermore, each blade 12 is bent outwards, and the angle between the bent blade 12 and the longitudinal vertical line is b, wherein the angle b is preferably 10°.
[0030] For example, during implementation, the first dispersion disk 3, the intermediate guide paddle 4, and the second dispersion disk 5 rotate synchronously. The second dispersion disk 5 shears and rolls the slurry or mixture or a mixture of slurry and mixture in a circumferential direction. Some of the solution moves downward and is drawn back to the second dispersion disk 5, while some of the solution hits the container wall and rises, and is sheared a second time by the first dispersion disk 3. The first dispersion disk 3 rolls the solution in a circumferential direction, with some of the solution moving upward and being drawn back to the first dispersion disk 3. When some of the solution moves downward, it is forcibly transported to the second dispersion disk 5 by the rotation of the intermediate guide paddle 4. The solution repeats the above motion trajectory when the main shaft 2 rotates at a speed of 1400 rpm or more, so that the solution continuously merges with the original liquid during the repeated motion of the first dispersion disk 3, the intermediate guide paddle 4, and the second dispersion disk 5.
[0031] For example, the first dispersing disk 3, the intermediate guide paddle 4, and the second dispersing disk 5 are arranged at intervals from top to bottom at the bottom of the main shaft 2. The distance between the first dispersing disk 3 and the intermediate guide paddle 4 is 'a', and the distance between the intermediate guide paddle 4 and the second dispersing disk 5 is 'b', where b > a. This allows the intermediate guide paddle 4 to preferentially contact the solution dispersed downwards by the first dispersing disk 3 and increases the distance the solution travels towards the second dispersing disk 5, ensuring the solution contacts the second dispersing disk 5 in a dispersed manner, thus improving the dispersion effect of the second dispersing disk 5 on the returning solution.
[0032] Furthermore, the diameter of the first dispersion disk 3 is A, and the diameter of the second dispersion disk 5 is B, where A > B. That is, in the top view projection, the first dispersion disk 3 is larger than the second dispersion disk 5. During the shearing operation, the original solution forms a vortex in the container, with an inverted hollow cone at the center. The larger diameter of the first dispersion disk 3 allows for better contact with the circumferential solution of the vortex.
[0033] Furthermore, such as Figure 2 and Figure 3As shown, the surface of the first dispersion disk 3 has multiple openings 6 circumferentially. These openings 6 are strip-shaped and arranged in a circular array around the main shaft 2. Each opening 6 includes a first side 9 and a second side 10, with the two ends of the first side 9 and the second side 10 connecting to form a first angle 7 and a second angle 8. When the first dispersion disk 3 rotates, causing some of the solution to move upwards and be drawn back to the first dispersion disk 3, the solution can pass through the openings 6 and move directly downwards to the intermediate guide paddle 4. Simultaneously, as the solution passes through the openings 6, it can also come into contact with the first angle 7 and the second angle 8, generating collision and shearing. This allows the solution and the original liquid to collide and fuse at high speed within a small space, further enhancing the shearing and fusion effect. In addition, the design of the openings 6 reduces the weight of the large-diameter first dispersion disk 3, making the weight of the first dispersion disk 3 similar to that of the second dispersion disk 5, ensuring the stability of the main shaft 2's operation.
[0034] It should be noted that the first angle 7 and the second angle 8 mentioned above are arc-shaped angles, which are easier to process and prevent the problem of incomplete cleaning caused by dead corners.
[0035] Furthermore, such as Figure 3 As shown, each opening 6 is inclined, so that the first corner 7 is close to the main shaft 2 and the second corner 8 is close to the outer edge of the first dispersion disk 3. This design can ensure the structural strength of the first dispersion disk 3 when it rotates at high speed, and can make the solution and the original liquid come into contact with one of the corners when rotating forward or backward.
[0036] In addition, both the first side 9 and the second side 10 are curved, making the width of the opening in the middle of the opening 6 greater than the width of the opening at the first corner 7 and the second corner 8, which is more conducive to the passage of the solution and the original liquid.
[0037] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A high shear dispersion preparation mixing device for suspension, comprising a dispersion machine, a main shaft is arranged on a power mechanism of the dispersion machine, a stirring disc is arranged at the bottom of the main shaft, characterized in that: The stirring disc comprises a second dispersion disc at the bottom end of the main shaft and an intermediate guide paddle and a first dispersion disc above the second dispersion disc, and the intermediate guide paddle is between the first dispersion disc and the second dispersion disc.
2. A high shear dispersion compounding apparatus for suspensions according to claim 1, characterized in that: The first dispersion disc, the intermediate guide paddle and the second dispersion disc are spaced from top to bottom, the spacing between the first dispersion disc and the intermediate guide paddle is a, and the spacing between the intermediate guide paddle and the second dispersion disc is b, wherein b>a.
3. A high shear dispersion compounding device for suspensions according to claim 1, characterized in that: The diameter of the first dispersion disc is A, and the diameter of the second dispersion disc is B, wherein A>B.
4. A high shear dispersion compounding apparatus for suspensions according to any one of claims 1 to 3, characterized in that: The first dispersion disc surface is circumferentially provided with a plurality of openings, and the plurality of openings are strip-shaped and arranged in a circular array with the main shaft as the center.
5. A high shear dispersion compounding apparatus for suspensions according to claim 4, characterized in that: Each of the openings comprises a first side and a second side, and the two ends of the first side and the second side are connected to form a first corner and a second corner.
6. A high shear dispersion compounding apparatus for suspensions according to claim 5 wherein: Each of the openings is inclined, so that the first corner is close to the main shaft, and the second corner is close to the outer edge of the first dispersion disc.
7. A high shear dispersion compounding device for suspensions according to claim 5, characterized in that: The first side and the second side are arc-shaped, so that the opening width of the middle part of the opening is greater than the opening width at the first corner and the second corner.
8. A high shear dispersion compounding apparatus for suspensions according to claim 1 or 2, characterized in that: The top of the intermediate guide paddle is closed, and the inside is a downwardly penetrating hollow cavity; the wall of the intermediate guide paddle is provided with a plurality of slots penetrating downwardly to form a plurality of paddle blades.
9. A high shear dispersion compounding apparatus for suspensions according to claim 8, characterized in that: Each of the paddle blades is outwardly inclined and bent.