Triphosgene solid feeding device in lopinavir intermediate TPA production process
By designing a feeding device with components such as a guide cylinder, guide block, sealing groove, and adjusting plate, the problems of gas leakage and inconvenient feeding in the phosgene solid feeding device were solved, realizing flexible feeding port adjustment and a safe solid feeding process.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- XIAMEN SICHONG BIOPHARMACEUTICAL TECHNOLOGY CO LTD
- Filing Date
- 2025-05-13
- Publication Date
- 2026-04-14
AI Technical Summary
Existing phosgene solid feeding devices pose risks of gas pollution or inconvenience in feeding, especially when the device is set with a full opening, which can easily cause gas leakage, while a small opening setting makes feeding inconvenient.
A feeding device including a feeding unit and an adjustment unit was designed. Through the combination of a guide cylinder, a guide block, a sealing groove, an adjustment plate, a sealing plate and a return spring, the feeding port can be flexibly adjusted and sealed, ensuring the stable input of solid phosgene and reducing gas leakage.
It enables automatic adjustment of the feeding port status according to changes in the material state during the solid feeding process of phosgene, reducing gas leakage and improving the safety and convenience of feeding.
Smart Images
Figure CN224113916U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of feeding device technology, specifically a triphosgene solid feeding device for the production process of lopinavir intermediate TPA. Background Technology
[0002] Lopinavir is a novel protease inhibitor for HIV that works primarily by blocking the cleavage of Gag-Pol protein, producing immature, non-infectious viral particles.
[0003] Triphosgene is a useful reagent in the synthesis of many organic intermediates because it has been found to react with nucleophiles (such as carbon, nitrogen, and oxygen) in the synthesis of these organic compounds. These reactions are not only mild but also provide fairly high yields. There are two ways to add solid triphosgene: 1. Dissolve it in a dissolving vessel with toluene or chloroform and then add it dropwise to the reaction vessel; 2. Add the solid triphosgene directly to the reaction vessel.
[0004] However, there are many problems with the current method of directly feeding solid light into the device. Either it is a fully open design, which can easily cause gas pollution, or it is a small open design, which is inconvenient for feeding.
[0005] Therefore, it is necessary to propose a feeding device that facilitates the addition of solid triphosgene. Utility Model Content
[0006] The purpose of this invention is to provide a triphosgene solid feeding device for the production process of lopinavir intermediate TPA, so as to solve the above-mentioned technical problems to a certain extent, and to change the feeding port according to the feeding state.
[0007] To achieve the above objectives, the present invention provides the following technical solution: including a feeding unit and an adjustment unit, wherein the adjustment unit includes a guide cylinder, a platform-shaped feeding cylinder is fixedly installed on the top of the guide cylinder, a guide block with a rounded upper surface is fixedly installed on the inner wall of the feeding cylinder, and an collecting cylinder is fixedly installed below the guide block on the inner wall of the guide cylinder and does not contact the adjustment unit;
[0008] The adjustment unit includes a sealing groove formed on the inner wall of the guide cylinder, an adjustment plate fixedly installed on the outer wall of the guide cylinder parallel to the sealing groove, the side of the adjustment plate being open and passing through the guide cylinder, a circular sealing plate being slidably installed inside the adjustment plate, a return spring being fixedly installed on the inner wall of the adjustment plate, the other end of the return spring being fixedly connected to the inner wall of the sealing plate, a through slot being formed at the end of the adjustment plate away from the sealing plate, a positioning groove being formed on the outer wall of the through slot, an insertion rod being inserted into the through slot, positioning blocks being symmetrically installed on the outer wall of the insertion rod, the insertion rod being fixedly connected to the sealing plate by a connecting rod, and the insertion rod being rotatably connected to the connecting rod.
[0009] Furthermore, the gathering cylinder is positioned above the sealing groove, and the inner diameter of the gathering cylinder is larger than the inner diameter of the guide block, while the inner diameter of the gathering cylinder is smaller than the inner diameter of the sealing groove.
[0010] Furthermore, the inner diameter of the adjusting plate is larger than the inner diameter of the sealing groove, the inner diameter of the sealing plate is smaller than the inner diameter of the sealing groove, and the sealing plate is parallel to the sealing groove.
[0011] Furthermore, a sealing ring is provided on the outer wall of the sealing plate, and the sealing plate contacts the inner wall of the sealing groove after the sealing ring is installed.
[0012] Furthermore, there are several return springs, which are symmetrically installed inside the adjustment plate with the through slot as the center.
[0013] Furthermore, the side area of the insert rod is smaller than the side area of the slot, and the side area of the connecting rod is larger than the side area of the slot.
[0014] Furthermore, the lateral area of the positioning block is smaller than the lateral area of the positioning groove.
[0015] Furthermore, the insertion rod is fixedly connected to a handle at its outer end of the adjustment plate.
[0016] Compared with the prior art, the beneficial effects of this utility model are as follows:
[0017] In use, the insert rod is pulled towards the handle until the positioning block extends out of the positioning groove. The return spring retracts, and the sealing plate moves into the adjusting plate along with the insert rod, thereby opening the internal space of the guide cylinder. Since the insert rod is rotatably connected to the connecting rod, the insert rod can be rotated to make the positioning block and the positioning groove form a cross shape, ensuring that the positioning block contacts the outer wall of the adjusting plate and cannot fall off. At this point, solid material can enter from the feed cylinder and pass through the guide cylinder for feeding. After feeding is complete, the insert rod is rotated to align the positioning block with the positioning groove. The insert rod is then released, and the return spring releases its elastic potential energy, pushing the sealing plate into the sealing groove. This seals the guide cylinder, reducing gas leakage and facilitating the adjustment of the feed port state, further changing the channel state according to changes in the material state. Attached Figure Description
[0018] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0019] Figure 1 This is a top view of the overall structure of this embodiment;
[0020] Figure 2 This is a front sectional view of the overall structure of this embodiment;
[0021] Figure 3 This is an enlarged schematic diagram of the structure at point A in this embodiment;
[0022] Figure 4 This is a top sectional view of the overall structure of this embodiment;
[0023] Figure 5 This is a side view of the overall structure of this embodiment;
[0024] Figure 6 This is a schematic diagram of the structure at point B in this embodiment.
[0025] The attached diagram lists the components represented by each number as follows:
[0026] 100. Feeding unit; 110. Guide cylinder; 111. Gathering cylinder; 112. Sealing groove; 120. Feeding cylinder; 121. Guide block;
[0027] 200. Adjustment unit; 210. Adjustment plate; 211. Through slot; 212. Positioning slot; 220. Through rod; 221. Handle; 230. Positioning block; 240. Connecting rod; 250. Sealing plate; 260. Return spring. Detailed Implementation
[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.
[0029] Please see Figure 1-6 This utility model provides a technical solution: a triphosgene solid feeding device for the production process of lopinavir intermediate TPA, including a feeding unit 100 and an adjustment unit 200. The adjustment unit 200 includes a guide cylinder 110, a platform-shaped feed cylinder 120 fixedly installed on the top of the guide cylinder 110, a guide block 121 with rounded corners on its upper surface fixedly installed on the inner wall of the feed cylinder 120, and an agglomeration cylinder 111 fixedly installed below the guide block 121, which is located on the inner wall of the guide cylinder 110 and does not contact the adjustment unit 200. The platform-shaped feed cylinder 120 facilitates the injection of solid material, and the guide block 121 provides buffering, allowing the solid material to fall stably downward into the agglomeration cylinder 111. At the same time, the rounded corners of the guide block 121 prevent the solid material from accumulating in the guide block 121, keeping the solid material moving stably downward. When the solid material enters the agglomeration cylinder 111, it can continue to move downward.
[0030] The adjustment unit 200 includes a sealing groove 112 formed on the inner wall of the guide cylinder 110. The gathering cylinder 111 is located above the sealing groove 112. The inner diameter of the gathering cylinder 111 is larger than the inner diameter of the guide block 121, and the inner diameter of the gathering cylinder 111 is smaller than the inner diameter of the sealing groove 112. Since the gathering cylinder 111 is located above the sealing groove 112, and its inner diameter and depth are both larger than the sealing groove 112, the solid material can only fall under the action of gravity after entering the gathering cylinder 111, without any extra angle to enter the sealing groove 112. This prevents the solid material from entering the sealing groove 112 and affecting the use of the adjustment unit 200, thus maintaining the stable feeding of the solid material.
[0031] See Figure 2 , Figure 4 In a preferred embodiment, an adjusting plate 210 is fixedly installed on the outer wall of the guide cylinder 110, parallel to the sealing groove 112. The side of the adjusting plate 210 is open and passes through the guide cylinder 110. A circular sealing plate 250 is slidably installed inside the adjusting plate 210. The inner diameter of the adjusting plate 210 is larger than the inner diameter of the sealing groove 112, and the inner diameter of the sealing plate 250 is smaller than the inner diameter of the sealing groove 112. The sealing plate 250 is parallel to the sealing groove 112, and a sealing ring is provided on the outer wall of the sealing plate 250. After the sealing ring is installed, the sealing plate 250 contacts the inner wall of the sealing groove 112.
[0032] The sealing plate 250 can be moved into the sealing groove 112 and is located within the sealing groove 112. The inner diameter of the sealing plate 250 is larger than the inner diameter of the guide cylinder 110. The sealing plate 250 can seal the guide cylinder 110 to the maximum extent. The sealing ring can contact the sealing groove 112 to the maximum extent and block it, further preventing gas from moving upward from the bottom of the guide cylinder 110.
[0033] See Figure 2 , Figure 3 , Figure 4 and Figure 6 In a further preferred embodiment, a reset spring 260 is fixedly installed on the inner wall of the adjusting plate 210. There are several reset springs 260, which are symmetrically installed inside the adjusting plate 210 with the through slot 211 as the center. The other end of the reset spring 260 is fixedly connected to the inner wall of the sealing plate 250.
[0034] Several return springs 260 allow the sealing plate 250 to be moved open and moved out of the sealing groove 112. When the sealing plate 250 needs to be sealed in the sealing groove 112, the return springs 260 release their elastic potential energy to push the sealing plate 250 into the sealing groove 112. When the return springs 260 release their elastic potential energy to their maximum stretched state, the sealing plate 250 is completely inside the sealing groove 112. Then, the sealing plate 250 is moved slightly into the sealing groove 112 by the inserting rod 220 to make the connection tighter. At this time, the sealing plate 250 is more tightly connected in the sealing groove 112.
[0035] See Figure 3 , Figure 4 , Figure 5 and Figure 6 In a further preferred embodiment, the end of the adjusting plate 210 away from the sealing plate 250 has a through slot 211 that passes through the adjusting plate 210. The outer wall of the through slot 211 has a positioning groove 212. A through rod 220 is inserted into the through slot 211. The side area of the through rod 220 is smaller than the side area of the through slot 211. Positioning blocks 230 are symmetrically installed on the outer wall of the through rod 220. The side area of the positioning blocks 230 is smaller than the side area of the positioning groove 212. The through rod 220 is fixedly connected to the sealing plate 250 by a connecting rod 240. The through rod 220 and the connecting rod 240 are rotatably connected. A handle 221 is fixedly connected to the outer end of the through rod 220 of the adjusting plate 210.
[0036] In the first embodiment, grasp the handle 221 and pull the insertion rod 220 toward the handle 221 until the positioning block 230 extends out of the positioning groove 212. The return spring 260 retracts, and the sealing plate 250 moves into the adjustment plate 210 along with the insertion rod 220, thereby opening the internal space of the guide cylinder 110. Since the insertion rod 220 is rotatably connected to the connecting rod 240, the insertion rod 220 can be rotated at this time so that the positioning block 230 and the positioning groove 212 form a cross shape, so that the positioning block 230 contacts the outer wall of the adjustment plate 210 and cannot fall off.
[0037] In the second embodiment, the insertion rod 220 is rotated so that the positioning block 230 is aligned with the positioning groove 212. The insertion rod 220 is released, and the reset spring 260 releases its elastic potential energy. At this time, the positioning block 230 moves along the positioning groove 212 into the adjusting plate 210, pushing the sealing plate 250 into the sealing groove 112.
[0038] In the description of this utility model, it should be understood that the terms "coaxial", "bottom", "one end", "top", "middle", "other end", "upper", "side", "top", "inner", "front", "center", "both ends", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.
[0039] In this utility model, unless otherwise explicitly specified and limited, the terms "installation", "setting", "connection", "fixing", "screw connection", etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.
[0040] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A triphosgene solid feeding device for the production process of lopinavir intermediate TPA, comprising a feeding unit (100) and an adjusting unit (200), characterized in that: The adjustment unit (200) includes a guide cylinder (110), a table-shaped feed cylinder (120) is fixedly installed on the top of the guide cylinder (110), a guide block (121) with a rounded upper surface is fixedly installed on the inner wall of the feed cylinder (120), and an collecting cylinder (111) is fixedly installed below the guide block (121) and is disposed on the inner wall of the guide cylinder (110) and does not contact the adjustment unit (200). The adjusting unit (200) includes a sealing groove (112) formed on the inner wall of the guide cylinder (110). An adjusting plate (210) is fixedly installed on the outer wall of the guide cylinder (110) parallel to the sealing groove (112). The side of the adjusting plate (210) is open and passes through the guide cylinder (110). A circular sealing plate (250) is slidably installed inside the adjusting plate (210). A return spring (260) is fixedly installed on the inner wall of the adjusting plate (210). The other end of the return spring (260) is connected to the inner wall of the sealing plate (250). The wall is fixedly connected, and the end of the adjusting plate (210) away from the sealing plate (250) is provided with a through slot (211) that passes through the adjusting plate (210). The outer wall of the through slot (211) is provided with a positioning groove (212). A through rod (220) is inserted into the through slot (211). Positioning blocks (230) are symmetrically installed on the outer wall of the through rod (220). The through rod (220) and the sealing plate (250) are fixedly connected by a connecting rod (240). The through rod (220) and the connecting rod (240) are rotatably connected.
2. The triphosgene solid feeding device for the production process of lopinavir intermediate TPA according to claim 1, characterized in that: The gathering cylinder (111) is located above the sealing groove (112). The inner diameter of the gathering cylinder (111) is larger than the inner diameter of the guide block (121), and the inner diameter of the gathering cylinder (111) is smaller than the inner diameter of the sealing groove (112).
3. The triphosgene solid feeding device for the production process of lopinavir intermediate TPA according to claim 1, characterized in that: The inner diameter of the adjusting plate (210) is larger than the inner diameter of the sealing groove (112), the inner diameter of the sealing plate (250) is smaller than the inner diameter of the sealing groove (112), and the sealing plate (250) is parallel to the sealing groove (112).
4. The triphosgene solid feeding device for the production process of lopinavir intermediate TPA according to claim 3, characterized in that: The sealing plate (250) is provided with a sealing ring on its outer wall. After the sealing plate (250) is installed with the sealing ring, it contacts the inner wall of the sealing groove (112).
5. The triphosgene solid feeding device for the production process of lopinavir intermediate TPA according to claim 1, characterized in that: There are several return springs (260), and several return springs (260) are symmetrically installed inside the adjustment plate (210) with the through slot (211) as the center.
6. The triphosgene solid feeding device for the production process of lopinavir intermediate TPA according to claim 1, characterized in that: The side area of the insertion rod (220) is smaller than the side area of the insertion slot (211), and the side area of the connecting rod (240) is larger than the side area of the insertion slot (211).
7. The triphosgene solid feeding device for the production process of lopinavir intermediate TPA according to claim 1, characterized in that: The side area of the positioning block (230) is smaller than the side area of the positioning groove (212).
8. The triphosgene solid feeding device for the production process of lopinavir intermediate TPA according to claim 6, characterized in that: The insertion rod (220) is fixedly connected to a handle (221) at the outer end of the adjusting plate (210).