Automatic sample subpackaging device for gene sequencing

Abstract

The utility model relates to the field of gene sequencing, and discloses an automatic sample subpackaging device for gene sequencing. According to the device, the protective cover is used for preventing cleaning liquid and sample liquid from splashing outwards during cleaning and split charging of the conveyed liquid, the sample spray head can convey the split charging liquid to the sample test tube, the cleaning liquid spray head internally comprises a water segregator, and the lower surface of the water segregator is provided with a plurality of spray head main bodies; the cleaning device is used for cleaning the outer surface of the sample nozzle, so that influence on normal use of the nozzle due to caking formed after floating dust on the outer surface of the nozzle is mixed with residual sample liquid is avoided, and normal operation of the device is guaranteed. The device is provided with the assembly for cleaning the outer surface of the spray head used for subpackaging the samples before subpackaging the samples, so that the problem that liquid left on the outer surface of the spray head can form cakes after being dried, and the cakes can influence subsequent normal use of the spray head is solved.

Description

Technical Field

[0001] This application belongs to the field of gene sequencing technology, specifically an automated sample dispensing device for gene sequencing. Background Technology

[0002] Gene sequencing is a technique for analyzing the genomic DNA sequence of an organism, aiming to determine the order of bases in the DNA molecule. This technique allows for deeper understanding of an organism's genetic information, including the structure and function of genes and their relationship to various biological phenomena and diseases.

[0003] However, the existing device does not have a component for cleaning the outer surface of the nozzle used for sample dispensing before sample dispensing. The liquid residue on the outer surface of the nozzle will form clumps after drying, which will affect the normal use of the nozzle. Utility Model Content

[0004] The purpose of this application is to provide an automated sample dispensing device for gene sequencing, in order to solve the problem that the device mentioned above does not have a component for cleaning the outer surface of the nozzle used for sample dispensing before sample dispensing, and that the outer surface of the nozzle will adsorb dust from the surrounding environment, and that the dust on the outer surface of the nozzle will mix with the residual sample liquid to form clumps that affect the normal use of the nozzle.

[0005] The technical solution adopted in this application is as follows: it includes a fixing block, a first electric slider is fixedly installed on the lower surface of the fixing block, a first slide rail is fitted to the outer surface of the first electric slider, a protective cover is fixedly installed inside the fixing block, a sample nozzle is fixedly installed in the middle of the inner side of the protective cover, a cleaning liquid nozzle is fixedly installed inside the protective cover, a plurality of delivery pipes are fixedly installed on the upper surface of the protective cover, a plurality of metal corrugated pipes are fixedly installed at the other end of the delivery pipes, and a plurality of support frames are fixedly installed on the outer surfaces of the front and rear sides of the metal corrugated pipes.

[0006] By adopting the above technical solution, a first electric slider is fixedly installed on the lower surface of the fixed block, a first slide rail is fitted to the outer surface of the first electric slider, a protective cover is fixedly installed inside the fixed block, a sample nozzle is fixedly installed in the middle of the protective cover, a cleaning fluid nozzle is fixedly installed inside the protective cover, multiple delivery pipes are fixedly installed on the upper surface of the protective cover, multiple metal corrugated pipes are fixedly installed at the other end of the delivery pipes, and multiple support frames are fixedly installed on the front and rear outer surfaces of the metal corrugated pipes. The fixed block serves as the mounting base for the nozzle assembly and is used to fix the nozzle assembly. The first electric slider is used to drive the nozzle assembly to move... The first slide rail allows the nozzle assembly to move within a defined range, enabling it to move to the cleaning area during cleaning. The first slide rail also provides a certain range of movement for the first electric slider, allowing the nozzle assembly to move between the cleaning and dispensing areas. When the first electric slider moves the first slide rail to the front, it reaches the dispensing area; when it moves the first electric slider moves the first slide rail to the rear, it reaches the cleaning area. The protective cover prevents cleaning fluid and sample liquid from splashing outwards during cleaning and dispensing. The sample nozzle contains a one-way valve; when the nozzle is pressurized, the valve core opens, spraying the sample liquid out. This allows the device to deliver liquid to sample tubes. The cleaning fluid nozzle contains a water separator, with multiple nozzle bodies on its lower surface for cleaning the outer surface of the sample nozzle. This prevents residual liquid from drying and forming clumps, which can affect the nozzle's subsequent use and ensure proper device operation. The delivery pipe contains two sections: a thicker pipe for sample liquid delivery and a thinner pipe for cleaning fluid delivery. The thicker and thinner pipes are fixedly connected to the upper surfaces of the sample nozzle and cleaning fluid nozzle, respectively, to deliver liquid to the corresponding nozzles. The metal bellows also contains thick and thin tubes, which are fixedly connected to the thick and thin tubes of the delivery pipe, respectively. It can extend and retract with the first electric slider driving the first slide rail, thereby ensuring the supply of the delivery pipe. The support frame is used to fix the metal bellows, and the support frame has multiple holes inside to provide conditions for the metal bellows to pass through its own interior. By installing a component in this device to clean the outer surface of the nozzle used for sample dispensing before sample dispensing, the problem of residual liquid on the outer surface of the nozzle forming clumps after drying is solved, and the clumps will affect the normal use of the nozzle in the future.

[0007] In a preferred embodiment, a water receiving pool is fixedly installed on the lower surface of the first slide rail, and a baffle is fixedly installed on the upper surface of the water receiving pool.

[0008] By adopting the above technical solution, a water receiving pool is fixedly installed on the lower surface of the first slide rail, and a baffle is fixedly installed on the upper surface of the water receiving pool. The water receiving pool, as the main part of the cleaning area, is used to provide a location for collecting the used cleaning liquid after the first electric slider drives the nozzle assembly to move above the water receiving pool, thereby preventing the cleaning liquid from flowing out to other places. The baffle is used to prevent the cleaning liquid from splashing outwards when it is discharged, which would require subsequent cleaning.

[0009] In a preferred embodiment, a workbench is fixedly installed on the lower surface of the water receiving pool, and a drain pipe is fixedly installed through the workbench on the lower surface of the water receiving pool.

[0010] By adopting the above technical solution, a workbench is fixedly installed on the lower surface of the water receiving tank, and a drain pipe is fixedly installed through the workbench on the lower surface of the water receiving tank. The workbench serves as the installation foundation for the entire device, used to bear and share the weight of the device itself, and to connect other components. The drain pipe is fixedly installed with the external pipe on the outside, used to discharge the used cleaning liquid collected in the water receiving tank into its interior to ensure its normal use.

[0011] In a preferred embodiment, a barrel placement groove is fixedly installed in the middle of the upper surface of the workbench, and multiple storage barrels are fitted inside the barrel placement groove.

[0012] By adopting the above technical solution, a barrel placement slot is fixedly installed in the middle of the upper surface of the workbench. Multiple storage barrels are fitted inside the barrel placement slot. The barrel placement slot provides a position for the storage barrels and can fix the storage barrels in the upper surface of the device. The left side of the storage barrel is used to store sample liquid, and the right side stores cleaning liquid. Its interior includes a threaded port, observation window, liquid replenishment port and handle, which facilitates the movement of the storage barrels and liquid replenishment operations.

[0013] In a preferred embodiment, a second slide rail is fixedly installed on the front side of the upper surface of the worktable, and a second electric slider is fitted inside the second slide rail.

[0014] By adopting the above technical solution, a second slide rail is fixedly installed on the front side of the upper surface of the workbench, and a second electric slider is fitted inside the second slide rail. The combination of the second slide rail and the second electric slider allows the second slide rail to limit the movement of the second electric slider on its own upper surface. The second electric slider moves within the range of the second slide rail, thereby driving the sample container to complete the automated dispensing process.

[0015] In a preferred embodiment, a sample placement slot is fixedly installed on the upper surface of the second electric slider, and a control console is fixedly installed on the front outer surface of the worktable.

[0016] By adopting the above technical solution, a sample placement slot is fixedly installed on the upper surface of the second electric slider, and a control console is fixedly installed on the front outer surface of the workbench. The interior of the sample placement slot is used to place sample tubes on the upper surface of the second electric slider, so that the second electric slider can drive the sample to carry out an automated dispensing process. The control console allows the staff to view and control the status and parameters of the device. The lower surface of the control console contains a junction box, which is electrically connected to the electrical equipment inside the device. The junction box in the control console is used to connect an external power cable to provide power to the entire device.

[0017] In a preferred embodiment, multiple robotic arms are fixedly installed on the left and right sides of the upper surface of the workbench, and multiple sample placement boxes are placed against the upper surface of the workbench.

[0018] By adopting the above technical solution, multiple robotic arms are fixedly installed on the left and right sides of the upper surface of the workbench. Multiple sample placement boxes are placed against the upper surface of the workbench. The robotic arms are located on the left and right sides of the device. The front outer surface of the robotic arms contains grippers that can be extended and retracted up and down by an electric telescopic rod. Driven by the robotic arms, the left robotic arm grips the sample tubes to be used in the left sample placement box and puts them into the sample placement slot. The right robotic arm grips the sample tubes that have been dispensed in the sample placement slot and puts them into the right sample placement box, thus achieving the purpose of automatic entry and exit of sample tubes into the filling area. The lower part of the sample placement box contains a counterweight to improve the stability of the robotic arm when placing and removing the grippers. Using multiple sample placement boxes can realize the dispensing of samples for different purposes.

[0019] In a preferred embodiment, a plurality of metal pipes are fixedly installed on the rear outer surface of the support frame, and a liquid pump is fixedly installed at the other end of the metal pipes. A screw cap is threaded onto the upper surface of the storage tank, and a liquid pumping pipe is fixedly installed inside the screw cap.

[0020] By adopting the above technical solution, multiple metal pipes are fixedly installed on the rear outer surface of the support frame, and a liquid pump is fixedly installed at the other end of the metal pipes. A screw cap is threaded onto the upper surface of the storage tank, and a liquid extraction tube is fixedly installed inside the screw cap. The multiple metal pipes are also fixedly connected to the thick and thin tubes of the metal corrugated pipe, respectively, so that the dispensing component can deliver sample liquid and cleaning liquid into the metal corrugated pipe. The liquid pump pressurizes the sample liquid and cleaning liquid that have passed through it to achieve the purpose of delivering liquid to the corresponding nozzle components. The screw cap can be rotated through the threaded opening in the storage tank to extend the liquid extraction tube into the corresponding storage tank. The inner side of the liquid extraction tube is fixedly installed with the liquid pump, and the outer side of the liquid extraction tube is fixedly installed with the screw cap and extends to the lower part of the storage tank, so that the liquid pump can extract the corresponding liquid from the storage tank.

[0021] In summary, due to the adoption of the above technical solution, the beneficial effects of this application are:

[0022] In this application, the protective cover is used to prevent cleaning fluid and sample liquid from splashing to the outside during cleaning and dispensing of liquid. The sample nozzle can dispense liquid into the sample tube. The cleaning fluid nozzle contains a water separator, and multiple nozzle bodies are provided on the lower surface of the water separator for cleaning the outer surface of the sample nozzle. This prevents dust on the outer surface of the nozzle from mixing with residual sample liquid and forming clumps that affect the normal use of the nozzle, thus ensuring the normal operation of the device. By installing a component in the device to clean the outer surface of the nozzle used for dispensing samples before sample dispensing, the problem of residual liquid on the outer surface of the nozzle forming clumps after drying, which affects the subsequent normal use of the nozzle, is solved. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the front three-dimensional structure in this application;

[0024] Figure 2 This is a schematic diagram of the rear three-dimensional structure in this application;

[0025] Figure 3 This is a schematic diagram of the internal structure of the nozzle assembly in this application;

[0026] Figure 4 This is a three-dimensional structural diagram of the nozzle assembly in this application;

[0027] Figure 5 This is a three-dimensional structural diagram of the packaging component in this application.

[0028] The diagram shows the following markings: 1. Fixed block; 2. First electric slider; 3. First slide rail; 4. Protective cover; 5. Sample nozzle; 6. Cleaning fluid nozzle; 7. Delivery pipe; 8. Corrugated metal pipe; 9. Support frame; 10. Water receiving pool; 11. Baffle; 12. Workbench; 13. Drain pipe; 14. Inner storage slot; 15. Storage bucket; 16. Second slide rail; 17. Second electric slider; 18. Sample placement slot; 19. Control console; 20. Robotic arm; 21. Sample placement box; 22. Metal pipe; 23. Liquid pump; 24. Cap; 25. Liquid extraction tube. Detailed Implementation

[0029] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions in the embodiments of this application will be clearly and completely described below in conjunction with the embodiments of this application. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application. Example

[0030] Reference Figures 1-5 The system includes a fixing block 1, which serves as the mounting base for the nozzle assembly and is used to fix the nozzle assembly. A first electric slider 2 moves the nozzle assembly within the range defined by a first slide rail 3, allowing the nozzle assembly to move to the cleaning area during cleaning. The first slide rail 3 provides a certain range of movement for the first electric slider 2, enabling the nozzle assembly to move between the cleaning and dispensing areas. When the first electric slider 2 moves the first slide rail 3 to the front, it reaches the dispensing area; when the first electric slider 2 moves the first slide rail 3 to the rear, it reaches the cleaning area. A protective cover 4 prevents cleaning fluid and sample liquid from splashing outwards during cleaning and dispensing. The sample nozzle 5 contains a one-way valve; when the nozzle is pressurized, the valve core opens, spraying the sample liquid out of its interior, allowing it to dispense liquid into sample tubes. The cleaning fluid nozzle 6 contains a water distributor; multiple nozzle bodies are arranged on the lower surface of the water distributor to clean the outer surface of the sample nozzle 5, thereby solving the problem of splashing. The residual liquid on the outer surface of the nozzle will form clumps after drying, which will affect the normal use of the nozzle. To ensure the normal operation of the device, the delivery pipe 7 contains two pipes: a thicker pipe for sample liquid delivery and a thinner pipe for cleaning liquid delivery. The thicker and thinner pipes in the delivery pipe 7 are fixedly connected to the upper surfaces of the sample nozzle 5 and the cleaning liquid nozzle 6, respectively, for delivering liquid to the corresponding nozzles. The metal corrugated pipe 8 also contains a thicker and a thinner pipe, which are fixedly connected to the thicker and thinner pipes of the delivery pipe 7, respectively. It can extend and retract with the first electric slider 2 when it drives the first slide rail 3, thereby ensuring the supply of the delivery pipe 7. The support frame 9 is used to fix the metal corrugated pipe 8, and the support frame 9 has multiple holes inside to provide conditions for the metal corrugated pipe 8 to pass through its own interior. By installing a component in the device to clean the outer surface of the nozzle used for sample dispensing before sample dispensing, the problem of residual liquid on the outer surface of the nozzle forming clumps after drying and affecting the normal use of the nozzle is solved.

[0031] Reference Figure 4The water receiving pool 10, as the main part of the cleaning area, is used to provide a location for collecting the used cleaning fluid after the first electric slider 2 moves the nozzle assembly above the water receiving pool 10, thereby preventing the cleaning fluid from flowing to other places. The baffle 11 is used to prevent the cleaning fluid from splashing outwards when it is discharged, which would require subsequent cleaning.

[0032] Reference Figure 2 The workbench 12 serves as the installation base for the entire device, bearing and sharing the weight of the device itself and connecting other components. The drain pipe 13 is fixedly installed with the external pipe on the outside, used to drain the used cleaning liquid collected in the water tank 10 to ensure its normal use.

[0033] Reference Figure 2 and Figure 5 The inner placement slot 14 provides a position for placing the storage container 15, and the inner placement slot 14 can fix the storage container 15 in the upper surface of the device. The left side of the storage container 15 is used to store sample liquid, and the right side stores cleaning liquid. Its interior includes a threaded port, observation window, liquid replenishment port and handle, which facilitates the movement of the storage container 15, liquid replenishment and other operations.

[0034] Reference Figure 1 The system employs a combination of a second slide rail 16 and a second electric slider 17. The second slide rail 16 is used to limit the movement of the second electric slider 17 on its upper surface within a certain range. The second electric slider 17 moves within the range of the second slide rail 16, thereby driving the sample container to complete the automated dispensing process.

[0035] Reference Figure 1 The interior of the sample placement slot 18 is used to place sample tubes on the upper surface of the second electric slider 17, providing a position so that the second electric slider 17 can drive the sample to carry out an automated dispensing process. The control console 19 allows the staff to view and control the status and parameters of the device. The lower surface of the control console 19 contains a junction box, which is electrically connected to the electrical equipment inside the device. The junction box in the control console 19 is used to connect an external power cable to provide power to the entire device.

[0036] Reference Figure 1The robotic arms 20 are located on the left and right sides of the device. The front outer surface of the robotic arms 20 is covered with grippers that can be extended and retracted up and down by an electric telescopic rod. Driven by the robotic arms 20, the left robotic arm 20 grips the sample tubes to be used in the left sample placement box 21 and puts them into the sample placement slot 18. The right robotic arm 20 grips the sample tubes that have been dispensed in the sample placement slot 18 and puts them into the right sample placement box 21, so as to achieve the purpose of automatic entry and exit of sample tubes into the filling area. The lower part of the sample placement box 21 includes a counterweight to improve the stability of the robotic arms 20 in placing and removing the grippers. Using multiple sample placement boxes 21 can realize the dispensing of samples for different purposes.

[0037] Reference Figure 5 Multiple metal pipes 22 are also fixedly connected to the thick and thin pipes of the metal bellows 8, respectively, so that the dispensing component can deliver sample liquid and cleaning liquid into the metal bellows 8. The pump 23 pressurizes the sample liquid and cleaning liquid passing through it to deliver liquid to the corresponding nozzle component. The cap 24 can be rotated through the threaded opening in the storage tank 15 to extend the suction pipe 25 into the corresponding storage tank 15. The inner side of the suction pipe 25 is fixedly installed with the pump 23, and the outer side of the suction pipe 25 is fixedly installed with the cap 24 and extends to the lower part of the storage tank 15, so that the pump 23 can extract the corresponding liquid from the storage tank 15.

[0038] The implementation principle of an automated sample dispensing device for gene sequencing according to this application is as follows: A fixed block 1 serves as the mounting base for the nozzle assembly, used to fix the nozzle assembly. A first electric slider 2 moves the nozzle assembly within the range defined by a first slide rail 3, allowing the nozzle assembly to move to the cleaning area during cleaning. The first slide rail 3 provides a certain range for the movement of the first electric slider 2, enabling the nozzle assembly to move between the cleaning and dispensing areas. When the first electric slider 2 moves the first slide rail 3 to the front, it reaches the dispensing area; when the first electric slider 2 moves the first slide rail 3 to the rear, it reaches the cleaning area. A protective cover 4 prevents cleaning fluid and sample liquid from splashing outwards during cleaning and dispensing. The sample nozzle 5 contains a one-way valve; when the nozzle is pressurized, the valve core opens, spraying the sample liquid out of its interior, allowing it to dispense liquid into the sample tubes. The cleaning fluid nozzle 6 contains a water distributor; multiple nozzle bodies are arranged on the lower surface of the water distributor for cleaning the outer surface of the sample nozzle 5. The cleaning process addresses the issue of residual liquid on the nozzle's outer surface forming clumps after drying, which can affect the nozzle's subsequent normal operation and ensure the device's proper functioning. The delivery pipe 7 contains two sections: a thicker pipe for sample liquid delivery and a thinner pipe for cleaning fluid delivery. The thicker and thinner pipes in delivery pipe 7 are fixedly connected to the upper surfaces of the sample nozzle 5 and cleaning fluid nozzle 6, respectively, to deliver liquid to the corresponding nozzles. The metal corrugated pipe 8 also contains a thicker and thinner pipe, fixedly connected to the thicker and thinner pipes of delivery pipe 7. It can extend and retract with the first electric slider 2 driving the first slide rail 3, ensuring the supply of liquid to delivery pipe 7. The support frame 9 is used to fix the metal corrugated pipe 8 and has multiple holes inside to allow the metal corrugated pipe 8 to pass through its interior. By installing this component to clean the outer surface of the nozzle used for sample dispensing before sample dispensing, the problem of residual liquid forming clumps on the nozzle's outer surface after drying, which can affect the nozzle's subsequent normal operation, is solved.

[0039] The above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application.

Claims

1. An automated sample dispensing device for gene sequencing, comprising a fixing block (1), characterized in that: The lower surface of the fixed block (1) is fixedly installed with a first electric slider (2), the outer surface of the first electric slider (2) is fitted with a first slide rail (3), the inside of the fixed block (1) is fixedly installed with a protective cover (4), the middle of the inside of the protective cover (4) is fixedly installed with a sample nozzle (5), the inside of the protective cover (4) is fixedly installed with a cleaning liquid nozzle (6), the upper surface of the protective cover (4) is fixedly installed with multiple delivery pipes (7), the other end of the delivery pipes (7) is fixedly installed with multiple metal corrugated pipes (8), and the front and rear outer surfaces of the metal corrugated pipes (8) are fixedly installed with multiple support frames (9).

2. The automated sample dispensing device for gene sequencing as described in claim 1, characterized in that: A water receiving pool (10) is fixedly installed on the lower surface of the first slide rail (3), and a baffle (11) is fixedly installed on the upper surface of the water receiving pool (10).

3. The automated sample dispensing device for gene sequencing as described in claim 2, characterized in that: A workbench (12) is fixedly installed on the lower surface of the water receiving pool (10), and a drain pipe (13) is fixedly installed through the workbench (12) on the lower surface of the water receiving pool (10).

4. The automated sample dispensing device for gene sequencing as described in claim 3, characterized in that: The upper surface of the workbench (12) is fixedly installed with a barrel placement groove (14), and multiple storage barrels (15) are fitted inside the barrel placement groove (14).

5. An automated sample dispensing device for gene sequencing as described in claim 3, characterized in that: The workbench (12) is fixedly mounted on the front side of the upper surface of the workbench (12), and a second electric slider (17) is fitted inside the second slide rail (16).

6. An automated sample dispensing device for gene sequencing as described in claim 5, characterized in that: The upper surface of the second electric slider (17) is fixedly equipped with a sample placement slot (18), and the front outer surface of the worktable (12) is fixedly equipped with a control console (19).

7. An automated sample dispensing device for gene sequencing as described in claim 3, characterized in that: Multiple robotic arms (20) are fixedly installed on the left and right sides of the upper surface of the workbench (12), and multiple sample placement boxes (21) are placed on the upper surface of the workbench (12).

8. An automated sample dispensing device for gene sequencing as described in claim 4, characterized in that: Multiple metal pipes (22) are fixedly installed on the rear outer surface of the support frame (9), and a liquid pump (23) is fixedly installed at the other end of the metal pipes (22). A screw cap (24) is threaded on the upper surface of the storage tank (15), and a liquid extraction pipe (25) is fixedly installed inside the screw cap (24).

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