Device for detecting content of intermediate of sodium chloride injection

Abstract

The utility model discloses a device for detecting the content of a sodium chloride injection intermediate, and relates to the technical field of pharmacy. Comprising a detection cup, a Raman spectrum detector, a U-shaped pipe and a gas filtering device, an opening is formed in the lower portion of the detection cup, the opening is sealed through a cover plate, a liquid inlet pipe, a liquid outlet pipe and the Raman spectrum detector are installed on the cover plate, a Raman probe of the Raman spectrum detector upwards extends into the detection cup, and the U-shaped pipe is connected with the gas filtering device. A U-shaped pipe is further installed on the cover plate, one end of the U-shaped pipe extends to the upper portion in the detection cup, and the other end of the U-shaped pipe is located outside the detection cup and provided with a gas filtering device; the quantity of bubbles generated in the process that liquid enters the detection device can be reduced, the bubbles are prevented from being attached to the outer surface of a Raman probe of the Raman spectrum detector to influence the detection accuracy, meanwhile, the liquid inlet time is shortened, and the detection efficiency is improved.

Description

A device for detecting the content of intermediates in sodium chloride injection solution Technical Field

[0001] This utility model relates to the field of pharmaceutical technology, specifically to a device for detecting the content of intermediates in sodium chloride injection. Background Technology

[0002] The intermediate of sodium chloride injection requires online detection using a Raman system. The drug solution is quantitatively pumped into the detection container via a peristaltic pump. Existing detection containers typically use a detection cup with a Raman detector mounted on it. The detector probe is immersed in the internal liquid for detection. The following problems exist during the detection process: 1. The liquid in the detection container often does not fully immerse the probe surface, making accurate detection impossible. Ensuring the probe is fully immersed requires a large amount of sample, resulting in waste. 2. Because the detection container is sealed, the liquid enters slowly or in insufficient quantities, affecting detection time or accuracy. Furthermore, the sample cannot be completely emptied during discharge, leaving sample residue. 3. Due to its own pressure and the downward flow of the liquid into the detection container, the inverted drug solution generates numerous air bubbles. These bubbles adhere to the inner wall of the detection container and the surface of the probe, and their distribution is random. If air bubbles adhere to the surface of the Raman probe, it will affect the green light illumination and the capture of water peak changes, directly impacting the accuracy of the detection results. Summary of the Invention

[0003] This invention addresses the technical problem that existing Raman systems for detecting intermediate content in sodium chloride injections generate a large number of bubbles, resulting in slow or insufficient liquid inflow and affecting detection accuracy and efficiency. The aim is to provide a detection device for intermediate content in sodium chloride injections that reduces the amount of bubbles generated during liquid entry, preventing bubbles from adhering to the outer surface of the Raman probe and affecting detection accuracy. Simultaneously, it shortens the liquid inflow time and improves detection efficiency.

[0004] This utility model is achieved through the following technical solution:

[0005] A device for detecting the content of intermediates in sodium chloride injection solution includes a detection cup, a Raman spectroscopy detector, a U-tube, and a gas filter.

[0006] The detection cup has an opening at the bottom, which is sealed by a cover plate. The cover plate is equipped with an inlet pipe, an outlet pipe, and a Raman spectroscopy detector. The Raman probe of the Raman spectroscopy detector extends upward into the detection cup. A U-shaped tube is also installed on the cover plate. One end of the U-shaped tube extends into the upper part of the detection cup, and the other end of the U-shaped tube is located outside the detection cup and is equipped with a gas filter.

[0007] Furthermore, inside the detection cup, the top of the U-shaped tube is positioned higher than the top of the Raman probe.

[0008] Furthermore, the height of the end of the U-shaped tube located outside the detection cup is higher than the height of the other end located inside the detection cup.

[0009] Furthermore, the gas filtration device is a waterproof filter membrane.

[0010] Furthermore, the detection cup is fixedly connected to the cover plate via a fixing ring on its outer wall.

[0011] Furthermore, a first fixing hole is provided on the fixing ring, and a second fixing hole is provided on the cover plate. A fixing member is inserted between the first fixing hole and the second fixing hole to connect the detection cup and the cover plate.

[0012] Furthermore, a first temperature detector and a second temperature detector are also installed on the cover plate, and the temperature probes of the first temperature detector and the second temperature detector extend upward into the detection cup.

[0013] Furthermore, a pH detector is also installed on the cover plate, and the pH electrode probe of the pH detector extends upward into the detection cup.

[0014] Furthermore, the cover plate is also provided with instrument mounting holes.

[0015] Furthermore, the inlet pipe, outlet pipe, Raman spectroscopy detector, pH detector, first temperature detector, and second temperature detector are all fixed in the instrument mounting hole of the cover plate via connecting joints.

[0016] Compared with the prior art, this utility model has the following advantages and beneficial effects:

[0017] 1. In this invention, during testing, the sample gradually enters the test cup from bottom to top through the inlet tube. On the one hand, this allows the test cup to be partially sealed, facilitating liquid inflow and outflow, shortening the inlet time, and improving testing efficiency. On the other hand, because the liquid flows into the test cup from bottom to top, the amount of air bubbles during the liquid entry process is reduced, preventing air bubbles from adhering to the outer surface of the Raman probe of the Raman spectrometer, thereby avoiding them from adhering to the light path at the bottom of the Raman probe and ensuring the accuracy of the detection.

[0018] 2. This utility model uses a U-shaped tube, with one end connected to the inside of the detection cup and the other end located on the outside of the detection cup. When liquid enters, the gas inside the detection cup can be discharged through the U-shaped tube, and when liquid is discharged, external gas can enter the inside of the detection cup through the U-shaped tube. This avoids the situation where the liquid cannot flow or flows too slowly due to a completely sealed state. At the same time, in order to avoid the influence of unclean external air on the internal environment of the detection cup, a gas filter device is set at one end of the U-shaped tube to filter the external air and prevent unclean air from entering the detection cup and causing pollution to the internal environment. Attached Figure Description

[0019] The accompanying drawings, which are included to provide a further understanding of the embodiments of the present invention and form part of this application, do not constitute a limitation thereof. In the drawings:

[0020] Figure 1 is a schematic diagram of the overall structure of this utility model;

[0021] Figure 2 is a schematic diagram of the internal structure of this utility model;

[0022] Figure 3 is a schematic diagram of the connection structure between the detection cup and the cover plate;

[0023] Figure 4 is a schematic diagram of the detection cup.

[0024] The attached diagram shows the markings and corresponding component names:

[0025] 1-Detection cup, 2-Fixing ring, 201-First fixing hole, 3-Cover plate, 301-Instrument mounting hole, 302-Second fixing hole, 4-Inlet pipe, 5-First connecting connector, 6-Outlet pipe, 7-Second connecting connector, 8-Raman spectroscopy detector, 9-Third connecting connector, 10-pH detector, 11-Fourth connecting connector, 12-First temperature detector, 13-Fifth connecting connector, 14-Second temperature detector, 15-Sixth connecting connector, 16-U-shaped tube, 17-Gas filter device. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the embodiments and accompanying drawings. The illustrative embodiments and descriptions of this utility model are only used to explain this utility model and are not intended to limit this utility model.

[0027] In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, it will be apparent to those skilled in the art that these specific details are not necessary to implement the present invention. In other embodiments, well-known structures, circuits, materials, or methods are not specifically described in order to avoid obscuring the present invention.

[0028] Throughout this specification, references to "an embodiment," "an example," or "an example" mean that a particular feature, structure, or characteristic described in connection with that embodiment or example is included in at least one embodiment of the present invention. Therefore, the phrases "an embodiment," "an example," "an example," or "an example" appearing in various places throughout the specification do not necessarily refer to the same embodiment or example. Furthermore, specific features, structures, or characteristics can be combined in one or more embodiments or examples in any suitable combination and / or sub-combination. Moreover, those skilled in the art will understand that the illustrations provided herein are for illustrative purposes and are not necessarily drawn to scale. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0029] In the description of this utility model, the indicated orientation or positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship that the product of this application is usually placed in when in use, or the orientation or positional relationship that is commonly understood by those skilled in the art. It is only for the convenience of describing this application and simplifying the description, and is not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation of this application.

[0030] Meanwhile, the terms "set up," "assemble," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0031] Example

[0032] This embodiment provides a device for detecting the content of intermediates in sodium chloride injection, as shown in Figures 1-4, including a detection cup 1, a Raman spectroscopy detector 8, a U-shaped tube 16, and a gas filter 17;

[0033] The detection cup 1 has an opening at the bottom, which is sealed by a cover plate 3. An inlet pipe 4, an outlet pipe 6, and a Raman spectroscopy detector 8 are installed on the cover plate 3. The Raman probe of the Raman spectroscopy detector 8 extends upward into the detection cup 1. A U-shaped tube 16 is also installed on the cover plate 3. One end of the U-shaped tube 16 extends into the upper part of the detection cup 1, and the other end of the U-shaped tube 16 is located outside the detection cup 1 and is equipped with a gas filter device 17.

[0034] In this invention, during testing, the sample gradually enters the detection cup 1 from bottom to top through the liquid inlet pipe 4. On the one hand, this allows the detection cup 1 to be partially sealed, facilitating liquid inflow and outflow, shortening the liquid inlet time, and improving detection efficiency. On the other hand, since the liquid flows into the detection cup 1 from bottom to top, the amount of air bubbles during the liquid entry process is reduced, preventing air bubbles from adhering to the outer surface of the Raman probe of the Raman spectrometer detector 8, thereby preventing them from adhering to the light path at the bottom of the Raman probe and ensuring the accuracy of the detection.

[0035] This invention utilizes a U-shaped tube 16, with one end connected to the inside of the detection cup 1 and the other end located outside the detection cup 1. When liquid enters, the gas inside the detection cup 1 can be discharged through the U-shaped tube. When liquid is discharged, external gas enters the detection cup 1 through the U-shaped tube. This avoids the situation where the liquid cannot flow or flows slowly due to a completely sealed state. At the same time, to prevent unclean external air from affecting the internal environment of the detection cup 1, a gas filter device 17 is installed at one end of the U-shaped tube 16 to filter the external air, preventing unclean air from entering the detection cup 1 and polluting the internal environment.

[0036] The gas filtration device 17 is a waterproof filter membrane, preferably made of PTFE, which can serve as a waterproof and gas filtration device to prevent water from the external environment from entering the test cup 1 and affecting the accuracy of the test. At the same time, it filters the air entering the test cup 1 to prevent it from affecting the environment inside the test cup 1.

[0037] As shown in Figures 1 and 2, inside the detection cup 1, the top of the U-shaped tube 16 is higher than the top of the Raman probe, and the height of the end of the U-shaped tube 16 outside the detection cup 1 is higher than the height of the end inside the detection cup 1. Inside the detection cup 1, the top of the U-shaped tube 16 is almost close to the top inner wall of the detection cup 1, and its height is the highest compared to the probe positions of other instruments. This ensures that air inside the detection cup 1 is expelled even when the probes of other instruments are completely submerged in liquid. At the same time, the top of the outer U-shaped tube 16 is higher than the top of the inner wall to prevent liquid from flowing out from the outer end of the U-shaped tube 16 and contaminating the detection environment if liquid enters the U-shaped tube 16.

[0038] As shown in Figures 3 and 4, the detection cup 1 is fixedly connected to the cover plate 3 via a fixing ring 2 on its outer wall. To facilitate the connection between the detection cup 1 and the cover plate 3, a fixing ring 2 is provided on the outside of the detection cup 1. The fixing ring 2 has a first fixing hole 201, and the cover plate 3 has a second fixing hole 302. A fastener passes through the first fixing hole 201 and the second fixing hole 302 to connect the detection cup 1 and the cover plate 3. During installation, bolts are used to connect the detection cup 1 and the cover plate 3 through the first fixing hole 201 and the second fixing hole 302.

[0039] As shown in Figures 1 and 2, a first temperature detector 12 and a second temperature detector 14 are also installed on the cover plate 3. The temperature probes of the first temperature detector 12 and the second temperature detector 14 extend upward into the detection cup 1. Since temperature has a significant impact on the accuracy of the detection results (it affects the water seal), two temperature detectors are set to detect the internal liquid, thereby reducing the impact of temperature changes on the detection results.

[0040] A pH detector 10 is also installed on the cover plate 3. The pH electrode probe of the pH detector 10 extends upward into the detection cup 1. The pH value of the liquid inside can be detected by the pH electrode probe of the pH detector 10 to ensure that the pH value is within the required conditions.

[0041] As shown in Figures 1 and 3, the cover plate 3 is also provided with an instrument mounting hole 301. The liquid inlet pipe 4, liquid outlet pipe 6, Raman spectroscopy detector 8, pH detector 10, first temperature detector 12 and second temperature detector 14 are all fixed in the instrument mounting hole 301 of the cover plate 3 through connecting joints.

[0042] The inlet pipe 4 is fixed in the instrument mounting hole 301 of the cover plate 3 via the first connecting joint 5; the outlet pipe 6 is fixed in the instrument mounting hole 301 of the cover plate 3 via the second connecting joint 7; the Raman spectroscopy detector 8 is fixed in the instrument mounting hole 301 of the cover plate 3 via the third connecting joint 9; the pH detector 10 is fixed in the instrument mounting hole 301 of the cover plate 3 via the fourth connecting joint 11; the first temperature detector 12 is fixed in the instrument mounting hole 301 of the cover plate 3 via the fifth connecting joint 13; and the second temperature detector 14 is fixed in the instrument mounting hole 301 of the cover plate 3 via the sixth connecting joint 15.

[0043] Finally, it should be noted that the above specific embodiments are only used to describe the purpose, technical solution, and beneficial effects of this utility model in detail. It should be understood that the above description is only a specific implementation of this utility model and is not intended to limit the protection scope of this utility model. Although this utility model has been described in detail with reference to the foregoing specific embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions or improvements can be made to some or all of the technical features. These modifications, equivalent substitutions, and improvements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this utility model, and they should all be covered within the scope of the claims and specification of this utility model.

Claims

1. A device for detecting the content of intermediates in sodium chloride injection, characterized in that, The device includes a detection cup (1), a Raman spectroscopy detector (8), a U-tube (16), and a gas filter (17). The detection cup (1) has an opening at the bottom, which is sealed by a cover plate (3). The cover plate (3) is equipped with an inlet pipe (4), an outlet pipe (6), and a Raman spectroscopy detector (8). The Raman probe of the Raman spectroscopy detector (8) extends upward into the detection cup (1). The cover plate (3) is also equipped with a U-tube (16). One end of the U-tube (16) extends into the upper part of the detection cup (1), and the other end of the U-tube (16) is located outside the detection cup (1) and is equipped with a gas filter (17).

2. The device for detecting the content of intermediates in sodium chloride injection solution according to claim 1, characterized in that, Inside the detection cup (1), the top of the U-shaped tube (16) is higher than the top of the Raman probe.

3. The device for detecting the content of intermediates in sodium chloride injection solution according to claim 1, characterized in that, The height of the end of the U-shaped tube (16) located outside the detection cup (1) is higher than the height of the other end located inside the detection cup (1).

4. The device for detecting the content of intermediates in sodium chloride injection solution according to claim 1, characterized in that, The gas filtration device (17) is a waterproof filter membrane.

5. The device for detecting the content of intermediates in sodium chloride injection according to claim 1, characterized in that, The test cup (1) is fixedly connected to the cover plate (3) by a fixing ring (2) on the outer wall.

6. The device for detecting the content of intermediates in sodium chloride injection according to claim 5, characterized in that, The fixing ring (2) has a first fixing hole (201) and the cover plate (3) has a second fixing hole (302). A fixing member is inserted between the first fixing hole (201) and the second fixing hole (302) to connect the detection cup (1) and the cover plate (3).

7. A device for detecting the content of intermediates in sodium chloride injection solution according to any one of claims 1-6, characterized in that, The cover plate (3) is also equipped with a first temperature detector (12) and a second temperature detector (14), the temperature probes of the first temperature detector (12) and the second temperature detector (14) extending upward into the inside of the detection cup (1).

8. The device for detecting the content of intermediates in sodium chloride injection according to claim 7, characterized in that, A pH detector (10) is also installed on the cover plate (3), and the pH electrode probe of the pH detector (10) extends upward into the detection cup (1).

9. The device for detecting the content of intermediates in sodium chloride injection according to claim 8, characterized in that, The cover plate (3) is also provided with instrument mounting holes (301).

10. The device for detecting the content of intermediates in sodium chloride injection according to claim 9, characterized in that, The inlet pipe (4), outlet pipe (6), Raman spectroscopy detector (8), pH detector (10), first temperature detector (12) and second temperature detector (14) are all fixed in the instrument mounting hole (301) of the cover plate (3) through connecting joints.

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