DPMAS plasma backflow device
By designing the DPMAS plasma return device, which uses the power of a second blood pump to return plasma to the human body, the problems of unsafe and wasteful plasma return in existing technologies are solved, and safe and effective plasma return is achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- QUAN ZHOU SHI DI YI YI YUAN
- Filing Date
- 2025-02-07
- Publication Date
- 2026-05-05
AI Technical Summary
Existing DPMAS plasma refluxing methods pose risks of excessive pressure leading to blood cell damage, air embolism, and plasma waste. They also have high operational requirements and are not safe.
A DPMAS plasma reflux device was designed, comprising a first blood pump, a plasma separator, a second blood pump, and an adsorption column. It is connected to a saline container via a reflux pipe and uses the power of the second blood pump to return plasma to the human body, avoiding excessive pressure. A detachable plug and a union end are used to achieve a safe connection.
This method enables safe and effective plasma reinfusion, reduces operational difficulty, avoids blood cell damage and plasma waste, and improves operational safety and efficiency.
Smart Images
Figure CN224193849U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to a DPMAS plasma reflux device. Background Technology
[0002] Dual Plasma Molecular Adsorption (DPMAS) involves drawing blood outside the body and passing it through a plasma separator. The separated plasma then passes sequentially through an anion exchange resin plasma bilirubin adsorption column and a neutral macroporous resin adsorption column. Some of the bilirubin and other toxins in the plasma are adsorbed, and the adsorbed plasma then combines with blood cells and other formed elements before returning to the body. The combined adsorption of the plasma through two columns (models HA330-Ⅱ and BS330) increases the clearance of inflammatory mediators and toxins such as bilirubin. After treatment, 600-800ml of plasma remains in the two columns. Clinically, the following methods are commonly used for plasma return: 1. After flushing with 500ml of saline, the pressure monitoring device is removed. The original three-way connector is connected to the flushed saline via an infusion set, and the bag is changed. The plasma is then returned to the adsorber under pressure through the pressure bag. This method carries the risk of excessive pressure leading to blood cell damage and may result in insufficient plasma return. It requires a high level of operator skill. 2. Air reinfusion: This involves using a 50ml syringe connected to a three-way valve to push the plasma back into the adsorbent. This method carries risks of contamination and air embolism, requires highly skilled operators, and is rarely used clinically. 3. Direct disposal: While safe, this method results in plasma waste.
[0003] Based on the above issues, the applicant conducted research drawing on their daily work experience, which led to this case. Utility Model Content
[0004] The purpose of this invention is to provide a DPMAS plasma reflux device that is simple in structure and easy to operate.
[0005] To achieve the above objectives, the present invention adopts the following technical solution:
[0006] A DPMAS plasma reflux device includes a first blood pump, a plasma separator, a second plasma pump, and an adsorption column for adsorbing toxins. The outlet end of the first blood pump is connected to the input end of the plasma separator via an inlet tube. The plasma separator has a first outlet end and a second outlet end. The first outlet end is connected to the input end of the second plasma pump, and the second outlet end is connected to an outlet tube. The output end of the second plasma pump is connected to the input end of the adsorption column, and the output end of the adsorption column is connected to the outlet tube. The device also includes a reflux tube. One end of the reflux tube has a plug for connecting to a saline container, and the other end of the reflux tube has a connector. The connector has a removable plug for sealing the connector. The input end of the second plasma pump has a union that mates with the connector. The union is detachably disposed at the first outlet end. The union is matched with the connector, and the plug is matched with the first outlet end and can seal the first outlet end.
[0007] As a preferred embodiment of this utility model, a first switching valve is provided on the inlet blood vessel, and a second switching valve is provided on the outlet blood vessel.
[0008] In a preferred embodiment of this invention, the plug-in end is in the shape of a pointed tube.
[0009] As a preferred embodiment of this utility model, the plug-in end is provided with an exhaust check valve.
[0010] As a preferred embodiment of the present invention, the outlet end of the exhaust check valve is provided with a cap for sealing the outlet end of the exhaust check valve, and the cap is detachably provided at the outlet end of the exhaust check valve.
[0011] In a preferred embodiment of this utility model, the plug is a cap, with a first external thread on the connecting end and a first internal thread matching the first external thread inside the cap.
[0012] As a preferred embodiment of this utility model, a second external thread is provided on the outer wall of the first outlet end, the union end is a union sleeve, the union sleeve is screwed onto the second external thread, and the inner wall of the union sleeve is provided with a second internal thread that matches the first external thread.
[0013] In a preferred embodiment of this invention, the adsorption column comprises a plasma bilirubin adsorption column and a neutral macroporous resin adsorption column connected in series.
[0014] In a preferred embodiment of the present invention, a first blood storage device is provided between the first blood pump and the plasma separator, a second blood storage device is provided between the outlet blood vessel and the second outlet end, a second switching valve is provided between the second blood storage device and the second outlet end, and the outlet end of the adsorption column is connected to the second blood storage device.
[0015] As a preferred embodiment of this utility model, an anticoagulant injection line is provided between the first blood temporary storage device and the first blood pump.
[0016] After adopting the technical solution of this utility model, when it is necessary to recover the plasma in the adsorption column, the plug is removed from the connecting end and the union end is removed from the first outlet end. The first outlet end is sealed by the plug. At this time, under the action of the first blood pump, the blood can still circulate in the human body through the plasma separator. The connecting end is connected to the union end, and the plug end is inserted into the saline. The second plasma pump is started. The saline is transported by the second plasma pump carried by the reflux device itself. Its transport is stable, safe and effective, and it is not easy to have excessive pressure. The recovered plasma is transported to the outlet blood vessel and can be reinfused into the human body. It can effectively return the plasma in the adsorption column to the patient's body and avoid plasma waste. Attached Figure Description
[0017] Figure 1 This is a schematic diagram of the structure of this utility model.
[0018] Figure 2 for Figure 1 Enlarged view of point A in the middle.
[0019] In the picture:
[0020] Plasma separator 10 First outlet end 11
[0021] Second outlet end 12 Return connector 13
[0022] First blood pump 20; Second plasma pump 30
[0023] 31 live connector
[0024] 40 saline container, 41 reflux tube
[0025] Connector 42 Plug-in 43
[0026] Exhaust check valve 44, cover 45
[0027] Cap 46
[0028] Inlet vessel 51, Outlet vessel 52
[0029] First blood temporary storage device 53 Second blood temporary storage device 54
[0030] First switching valve 55 Second switching valve 56
[0031] Plasma bilirubin adsorption column 61; Neutral macroporous resin adsorption column 62
[0032] Anticoagulant injection tubing 70 Detailed Implementation
[0033] To better understand the technical solution of this utility model, the following description is provided in more detail with reference to the embodiments.
[0034] Reference Figures 1 to 2 A DPMAS plasma reflux device includes a first blood pump 20, a plasma separator 10, a second plasma pump 30, and an adsorption column for adsorbing toxins. The outlet end of the first blood pump 20 is connected to the input end of the plasma separator 10 via an inlet tube 51. The plasma separator 10 has a first outlet end 11 and a second outlet end 12. The first outlet end 11 is connected to the input end of the second plasma pump 30 and is used to transport the preliminarily separated plasma to the adsorption column for toxin adsorption. The second outlet end 12 is connected to an outlet tube 52, through which another portion of the blood flows directly back into the human body after passing through the plasma separator. The output end of the second plasma pump 30 is connected to the input end of the adsorption column, and the output end of the adsorption column is connected to the outlet tube 52. In a preferred embodiment, the adsorption column includes a plasma bilirubin adsorption column 61 and a neutral macroporous resin adsorption column 62 connected in series. The plasma bilirubin adsorption column uses a BS330 bilirubin adsorber, and the neutral macroporous resin adsorption column is model HA330-II. In this invention, the plasma separator 10, the first blood pump 20, and the second plasma pump 30 can be the corresponding structures in Fresenius hemodialysis machines, which are existing structures and will not be described in detail here.
[0035] This invention also includes a reflux pipe 41. One end of the reflux pipe 41 is provided with a plug end 43 for connecting to a saline container, and the other end of the reflux pipe 41 is provided with a connecting end 42. The connecting end 42 is provided with a removable plug for sealing the connecting end 42. The input end of the second plasma pump 30 is provided with a union end 31 that can mate with the connecting end 42. The union end 31 is detachably provided at the first outlet end 11. During plasma separation, the union end 31 is installed at the first outlet end 11. The plasma after passing through the plasma separator 10 enters the second plasma pump 30 through the first outlet end 11 and the union end 31. The union end is matched with the connecting end. After the union end 31 is removed from the first outlet end 11, the union end 31 can mate with the connecting end to achieve communication. The plug of this invention is matched with the first outlet end 11 and can seal the first outlet end 11. After the union end 31 is removed, the first outlet end 11 is sealed by the plug.
[0036] As a preferred embodiment of this utility model, one end of the insertion end 43 is connected to the reflux tube 41, and the other end is in the shape of a pointed tube, so as to facilitate direct insertion into the saline container 40.
[0037] In a preferred embodiment of this invention, a one-way exhaust valve 44 is provided in the middle of the return pipe 41. Specifically, the one-way exhaust valve 44 is located at the plug-in end 43. In another preferred embodiment, the outlet end of the one-way exhaust valve 44 is provided with a cap 45 for sealing the outlet end of the one-way exhaust valve 44. The cap 45 is detachably provided at the outlet end of the one-way exhaust valve 44. When venting is required, the cap 45 is opened. The one-way exhaust valve 44 is a valve capable of unidirectionally discharging gas without discharging liquid; this is a structure in the prior art and will not be described in detail here.
[0038] As a preferred embodiment of this utility model, the plug is a cap 46, which has a first external thread on the connecting end 42 and a first internal thread matching the first external thread inside the cap 46. When the return pipe is not in use, the cap 46 is screwed into the first external thread position to prevent the connecting end 42 from being contaminated.
[0039] As a preferred embodiment of this utility model, a second external thread is provided on the outer wall of the first outlet end 11, and the union end 31 is a union sleeve. The union sleeve is screwed onto the second external thread, and the inner wall of the union sleeve is provided with a second internal thread that matches the first external thread. When it is necessary to connect the connecting end 42 and the union end 31, the second internal thread is screwed onto the position of the first external thread to achieve the connection between the connecting end 42 and the union end 31.
[0040] In a preferred embodiment of this invention, a first blood reservoir 53 is provided between the first blood pump 20 and the plasma separator 10, a second blood reservoir 54 is provided between the outlet blood vessel 52 and the second outlet end 12, a second switching valve 56 is disposed between the second blood reservoir 54 and the second outlet end 12, and the outlet end of the adsorption column is connected to the second blood reservoir 54. In another preferred embodiment, an anticoagulant injection line 70 is provided between the first blood reservoir 53 and the first blood pump 20, through which anticoagulant is injected during hemodialysis.
[0041] In this invention, during plasma reflux, the plug is removed from the connecting end 42, and the union end 31 is removed from the first outlet end 11. The first outlet end 11 is then sealed with the plug. At this time, under the action of the first blood pump 20, blood can still circulate in the human body through the plasma separator 10. The connecting end 42 is then connected to the union end 31, and the plug end 43 is inserted into the saline container 40. The second plasma pump 30 is then started, and the saline is slowly transported to the bilirubin adsorption column 6 and the neutral macroporous resin adsorption column 62, pushing the residual plasma in the adsorption column back into the human body.
[0042] The scope of protection of this utility model is not limited to this embodiment. Any similar modifications made to it are considered to be within the scope of protection of this utility model.
Claims
1. A DPMAS plasma reflux device, comprising a first blood pump, a plasma separator, a second plasma pump, and an adsorption column for adsorbing toxins, wherein the outlet end of the first blood pump is connected to the input end of the plasma separator via an inlet tube, the plasma separator has a first outlet end and a second outlet end, the first outlet end is connected to the input end of the second plasma pump, the second outlet end is connected to an outlet tube, the output end of the second plasma pump is connected to the input end of the adsorption column, and the output end of the adsorption column is connected to the outlet tube, characterized in that: It also includes a reflux tube, one end of which is provided with a plug for connecting to a saline container, and the other end of which is provided with a connection end. The connection end is provided with a removable plug for sealing the connection end. The input end of the second plasma pump is provided with a union end that can be mated with the connection end. The union end is detachably provided at the first outlet end. The union end is matched with the connection end, and the plug is matched with the first outlet end and can seal the first outlet end.
2. The DPMAS plasma reflux device as described in claim 1, characterized in that: A first switching valve is provided on the inlet blood vessel, and a second switching valve is provided on the outlet blood vessel.
3. The DPMAS plasma reflux device as described in claim 2, characterized in that: The connector is in the shape of a pointed tube.
4. The DPMAS plasma reflux device as described in claim 3, characterized in that: The plug end is equipped with an exhaust check valve.
5. The DPMAS plasma reflux device as described in claim 4, characterized in that: The outlet end of the exhaust check valve is provided with a cap for sealing the outlet end of the exhaust check valve, and the cap is detachably provided at the outlet end of the exhaust check valve.
6. The DPMAS plasma reflux device as described in claim 5, characterized in that: The plug is a cap, and a first external thread is provided on the connecting end, and a first internal thread matching the first external thread is provided inside the cap.
7. A DPMAS plasma reflux device as described in claim 6, characterized in that: The outer wall of the first outlet end is provided with a second external thread, the union end is a union sleeve, the union sleeve is screwed onto the second external thread, and the inner wall of the union sleeve is provided with a second internal thread that matches the first external thread.
8. A DPMAS plasma reflux device as described in claim 7, characterized in that: The adsorption column comprises a plasma bilirubin adsorption column and a neutral macroporous resin adsorption column connected in series.
9. A DPMAS plasma reflux device as described in claim 8, characterized in that: A first blood storage device is provided between the first blood pump and the plasma separator, a second blood storage device is provided between the outlet blood vessel and the second outlet end, a second switching valve is provided between the second blood storage device and the second outlet end, and the outlet end of the adsorption column is connected to the second blood storage device.
10. A DPMAS plasma reflux device as described in claim 9, characterized in that: An anticoagulant injection line is provided between the first blood temporary storage device and the first blood pump.