Improved chromosome preparation platform

Abstract

The utility model discloses an improved chromosome preparation platform which comprises a device body, a clamping groove is formed in the top of the device body, a positioning blocking strip is arranged on the outer side of the clamping groove, a hinge is arranged on the other side of the positioning blocking strip, a sealing cover is arranged on the other side of the hinge, an opening is formed in the top of the sealing cover in a penetrating mode, and scale marks are arranged on the inner wall of the opening. An adjusting mechanism is arranged in the opening; according to the improved chromosome preparation platform, through the design of a sealing cover, a clamping groove, a positioning blocking strip, an adjusting mechanism and the like, the advantages of accurate dropwise adding, convenient operation, safety, environmental protection, low cost, high efficiency and the like are achieved, and the quality and efficiency of chromosome sample preparation are improved.

Description

Technical Field

[0001] This invention relates to the field of chromosome preparation, and in particular to an improved chromosome preparation platform. Background Technology

[0002] Currently, the substrate (hereinafter referred to as the "slide substrate") has its edge protruding about 1 cm above the inside of the groove, so that the slide forms a 10°-15° tilt angle with the horizontal plane. After the liquid sample is dropped onto the high end of the slide, it can flow along the inclined surface to achieve uniform distribution of chromosomes.

[0003] However, its use has the following four drawbacks: 1. Unstable chromosome dispersion quality: The evaporation rate of the fixative (a mixture of methanol and acetic acid in a 3:1 volume ratio) directly affects the chromosome dispersion effect. The airflow in the clean bench accelerates evaporation, leading to a decrease in dispersion quality; 2. Low sample drop precision: The sample needs to be dropped onto the slide from a height of approximately 15 cm, making it difficult to accurately locate the target area; 3. Safety hazards due to the open design: Volatile toxic gases can easily be inhaled by operators; 4. Inconvenient slide fixation: The lack of standardized slots makes installation time-consuming and prone to displacement. To address these issues, an improved chromosome preparation platform is provided. Utility Model Content

[0004] The technical problem this invention aims to solve is to overcome the following four defects in existing devices: 1. Unstable chromosome dispersion quality: The evaporation rate of the fixative (a mixture of methanol and acetic acid in a 3:1 volume ratio) directly affects the chromosome dispersion effect. The airflow in the clean bench accelerates evaporation, leading to a decrease in dispersion quality; 2. Low sample addition accuracy: The operation requires adding the sample to the slide from a height of approximately 15 cm, making it difficult to accurately locate the target area; 3. Safety hazards due to the open design: Volatile toxic gases are easily inhaled by operators; 4. Inconvenient slide fixation: The lack of standardized slots results in time-consuming installation and easy slip displacement. This invention provides an improved chromosome preparation platform.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: an improved chromosome preparation platform, comprising a device body, a slot provided on the top of the device body, a positioning bar provided on the outer side of the slot, a hinge provided on the other side of the positioning bar, a sealing cover provided on the other side of the hinge, an opening provided through the top of the sealing cover, graduation lines provided on the inner wall of the opening, and an adjustment mechanism provided inside the opening.

[0006] As a further description of the above technical solution:

[0007] The adjustment mechanism includes a top plate and a guide hole. The guide hole is provided through the interior of the top plate. Sliding blocks are symmetrically arranged on both sides of the top plate. A threaded rod is provided through the interior of each sliding block. A sliding groove is provided on the outer side of each sliding block. An idle wheel is provided on the outer side of each threaded rod. A transmission gear is provided at one end of the threaded rod. A drive gear is provided on one side of the transmission gear. A knob is provided through the other side of the drive gear.

[0008] As a further description of the above technical solution:

[0009] The connection between the sliding block and the threaded rod is provided with matching threads. Both the transmission gear and the drive gear are bevel gears, and the surface textures of the transmission gear and the drive gear match each other.

[0010] As a further description of the above technical solution:

[0011] The shape of the opening matches the top plate, and a sealing ring is provided at the connection between the opening and the top plate.

[0012] As a further description of the above technical solution:

[0013] The guide holes consist of four groups of eight holes in total. Each group of holes corresponds one-to-one with the position of the slot below. The diameter of each guide hole is five millimeters.

[0014] As a further description of the above technical solution:

[0015] The number of slots is four, and each slot is equipped with three positioning bars. The length of the sealing cover and the main body of the device is 204 mm, the width of the sealing cover and the main body of the device is 100 mm, the combined height of the sealing cover and the main body of the device is 160 mm, and the height of the main body of the device is 10 mm.

[0016] This utility model has the following beneficial effects:

[0017] In this invention, the improved chromosome preparation platform, through the design of a sealed cover, slots, positioning bars, and adjustment mechanisms, achieves advantages such as precise dispensing, convenient operation, safety and environmental protection, low cost and high efficiency, thereby improving the quality and efficiency of chromosome sample preparation. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of an improved chromosome preparation platform according to this utility model;

[0019] Figure 2 This is a perspective view of the overall structure of an improved chromosome preparation platform according to this utility model;

[0020] Figure 3 This is a schematic diagram showing the overall morphological changes of an improved chromosome preparation platform according to this utility model;

[0021] Figure 4 This is a schematic cross-sectional view of an improved chromosome preparation platform according to this utility model;

[0022] Legend:

[0023] 1. Main body of the device; 2. Slot; 3. Sealed cover; 4. Opening; 5. Adjustment mechanism; 51. Top plate; 52. Guide hole; 53. Sliding block; 54. Threaded rod; 55. Slide groove; 56. Idle wheel; 57. Transmission gear; 58. Drive gear; 59. Knob; 6. Positioning stop bar; 7. Hinge; 8. Scale line. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Referring to Figures 1-4, this utility model provides an improved chromosome preparation platform, including a device body 1. A slot 2 is provided on the top of the device body 1. A positioning bar 6 is provided on the outer side of the slot 2. A hinge 7 is provided on the other side of the positioning bar 6. A sealing cover 3 is provided on the other side of the hinge 7. An opening 4 is provided through the top of the sealing cover 3. A scale line 8 is provided on the inner wall of the opening 4. An adjustment mechanism 5 is provided inside the opening 4.

[0026] During use, the platform integrates components such as card slots, positioning bars, and sealing covers to achieve sealed operation, reduce volatilization and airflow interference, ensure operational safety, and improve dyeing quality.

[0027] The adjustment mechanism 5 includes a top plate 51 and a guide hole 52. The guide hole 52 is provided through the interior of the top plate 51. Sliding blocks 53 are symmetrically arranged on both sides of the top plate 51. A threaded rod 54 is provided through the interior of the sliding block 53. A sliding groove 55 is provided on the outer side of the sliding block 53. A freewheel 56 is provided on the outer side of the threaded rod 54. A transmission gear 57 is provided at one end of the threaded rod 54. A drive gear 58 is provided on one side of the transmission gear 57. A knob 59 is provided through the other side of the drive gear 58. The adjustment mechanism design enables the top plate height to be adjustable, the guide hole to accurately add samples, and the operation to be simple and adaptable to various experimental needs.

[0028] The connection between the sliding block 53 and the threaded rod 54 is provided with matching threads. Both the transmission gear 57 and the drive gear 58 are bevel gears, and the surface textures of the transmission gear 57 and the drive gear 58 match each other. The threaded connection and bevel gear transmission ensure stable and precise adjustment, improve the dripping accuracy, and guarantee the reliability of the experiment.

[0029] The shape of the opening 4 matches the top plate 51, and a sealing ring is provided at the connection between the opening 4 and the top plate 51; by matching the opening with the top plate, the sealing ring prevents leakage, ensures airtightness, and extends the service life of the equipment.

[0030] The guide holes 52 have four groups of eight guide holes in total, with two holes in each group. The guide holes 52 correspond one-to-one with the slots 2 below. The diameter of the guide holes 52 is five millimeters. By having multiple groups of guide holes correspond to the slots, multiple samples can be processed at the same time, improving experimental efficiency and making it highly applicable.

[0031] There are four card slots 2, and each card slot 2 is equipped with three positioning bars 6. The length of the sealing cover 3 and the main body 1 is 204 mm, the width of the sealing cover 3 and the main body 1 is 100 mm, the combined height of the sealing cover 3 and the main body 1 is 160 mm, and the height of the main body 1 is 10 mm. The platform is of moderate size, simple structure, low cost, suitable for a variety of laboratory scenarios, and has a high cost performance.

[0032] Working principle: Before use, wipe the device clean with a lint-free cloth or cleaning paper. Then, open the sealed cover 3 upwards using hinge 7, making it at a certain angle to the main body 1 for easy operation. Place the slide in the slot 2 at the top of the main body 1, and use the positioning bar 6 to position the slide, ensuring it is stable and accurately positioned in the slot 2 to prevent displacement during subsequent operations. According to the sample addition requirements, rotate the drive gear 58 by turning the knob 59. The drive gear 58 drives the transmission gear 57 to rotate, thereby causing the threaded rod 54 to rotate within the sliding block 53, realizing the up and down movement of the top plate 51 within the opening 4, adjusting the distance between the top plate 51 and the slide to meet different distance requirements. This ensures that the guide hole 52 is aligned with the target area on the slide. Then, the chromosome sample is dripped into the guide hole 52 through the opening 4 using a dropper or other dripping tool. The sample will precisely drip along the guide hole 52 onto the target area of ​​the slide. Since the diameter of the guide hole 52 is five millimeters, it ensures that the sample falls accurately into the target area, reducing errors. Simultaneously, the entire device has a closed structure, effectively preventing the inhalation of toxic gases and protecting the health of operators. After use, the modified chromosome preparation platform should be cleaned, wiping the main body 1, the sealing cover 3, and other components clean to remove residual samples, fixatives, and staining reagents. The platform should then be properly stored in a dry, clean environment for future use.

[0033] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. An improved chromosome preparation platform, comprising a main body (1), characterized in that, The device body (1) has a slot (2) on its top, a positioning bar (6) on the outside of the slot (2), a hinge (7) on the other side of the positioning bar (6), a sealing cover (3) on the other side of the hinge (7), an opening (4) through the top of the sealing cover (3), a scale line (8) on the inner wall of the opening (4), and an adjustment mechanism (5) inside the opening (4).

2. The improved chromosome preparation platform according to claim 1, characterized in that, The adjustment mechanism (5) includes a top plate (51) and a guide hole (52). The guide hole (52) is provided through the inside of the top plate (51). Sliding blocks (53) are symmetrically arranged on both sides of the top plate (51). A threaded rod (54) is provided through the inside of the sliding block (53). A sliding groove (55) is provided on the outside of the sliding block (53). An idle wheel (56) is provided on the outside of the threaded rod (54). A transmission gear (57) is provided at one end of the threaded rod (54). A drive gear (58) is provided on one side of the transmission gear (57). A knob (59) is provided through the other side of the drive gear (58).

3. The improved chromosome preparation platform according to claim 2, characterized in that, The connection between the sliding block (53) and the threaded rod (54) is provided with matching threads. The transmission gear (57) and the drive gear (58) are both bevel gears, and the surface texture of the transmission gear (57) and the surface texture of the drive gear (58) match each other.

4. The improved chromosome preparation platform according to claim 3, characterized in that, The shape of the opening (4) matches that of the top plate (51), and a sealing ring is provided at the connection between the opening (4) and the top plate (51).

5. The improved chromosome preparation platform according to claim 4, characterized in that, The guide hole (52) has four groups of eight guide holes in total. The guide hole (52) corresponds to the position of the slot (2) below. The diameter of the guide hole (52) is five millimeters.

6. The improved chromosome preparation platform according to claim 5, characterized in that, The number of slots (2) is four, and each slot (2) is equipped with three positioning bars (6). The length of the sealing cover (3) and the device body (1) is 204 mm, the width of the sealing cover (3) and the device body (1) is 100 mm, the combined height of the sealing cover (3) and the device body (1) is 160 mm, and the height of the device body (1) is 10 mm.

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