Multi-mode stimulation device for promoting cerebral circulation

Abstract

The utility model provides a multi-mode stimulation device for promoting cerebral circulation, and aims to solve the problem of poor cerebral circulation improvement effect caused by single stimulation mode of equipment for promoting cerebral circulation in the prior art. A multi-mode stimulation device for promoting cerebral circulation comprises a glasses assembly which comprises a glasses frame and two glasses legs located on the left side and the right side of the glasses frame respectively, and the glasses frame is provided with two sets of LED lamp assemblies which correspond to the left eye and the right eye of a person respectively and emit light at the frequency of 40 HZ; the nose plug assembly comprises a mounting seat electrically connected with the glasses legs and two nose plugs arranged on the mounting seat, and a near-infrared lamp emitting light at the frequency of 40HZ is arranged in each nose plug; the earplug assembly comprises two earplugs capable of producing sound at the frequency of 40HZ, and the two earplugs are respectively arranged on the two glasses legs. According to the invention, through photoacoustic multi-mode synergistic stimulation, the effect of better improving the cerebral blood perfusion function can be achieved, so that the cerebral function is improved.

Description

Technical Field

[0001] This invention belongs to the technical field of devices for promoting brain circulation, and specifically relates to a multimodal stimulation device for promoting brain circulation. Background Technology

[0002] With increasing life expectancy, the challenges posed by aging are growing, particularly neurological diseases, which can damage brain structure and function, leading to a range of brain functional impairments, including cognitive impairment. To prevent or improve brain function, devices have emerged that stimulate the brain using methods such as 40Hz light or sound. These devices aim to improve brain circulation, thereby repairing brain function and alleviating sleep disorders.

[0003] For example, the patent with publication number CN212491164U includes a light-emitting mechanism, which includes a light source unit, a switch unit, and a drive unit. The light source unit is used to emit 40Hz white light. The treatment device emits 40Hz white light through the light-emitting mechanism to irradiate the affected area, improve anxiety, repair spatial cognition damage, and improve the patient's neurological function.

[0004] For example, patent CN115364330B discloses a gamma brainwave eyeglass for the prevention and treatment of organic diseases of the central nervous system, including a frame, composite lenses, a light source array, a control unit, and a power supply unit; the light source array can emit light waves at a frequency of 40 Hz for stimulation under the control of the control unit. Furthermore, the device's audio module can also emit audio at a frequency of 40 Hz for sound stimulation.

[0005] However, existing devices suffer from a limited range of stimulation modes, resulting in limited effectiveness in improving cerebral circulation. Summary of the Invention

[0006] This invention provides a multimodal stimulation device for promoting cerebral circulation, aiming to solve the problem that existing devices for promoting cerebral circulation have relatively simple stimulation modes, resulting in poor effects on improving cerebral circulation.

[0007] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows:

[0008] A multimodal stimulation device for promoting brain circulation includes:

[0009] The eyeglasses assembly includes a frame and two temples located on the left and right sides of the frame, respectively. The frame is provided with two sets of LED light assemblies that correspond to the left and right eyes of a person and emit light at a frequency of 40HZ.

[0010] A nose plug assembly, comprising a mounting base electrically connected to the temple of the endoscope and two nose plugs disposed on the mounting base, each nose plug containing a near-infrared lamp emitting light at a frequency of 40 Hz; and,

[0011] An earplug assembly comprising two earplugs that emit sound at a frequency of 40 Hz, the two earplugs being respectively mounted on two temples of the glasses.

[0012] A further embodiment: Each LED light assembly includes an upper LED light on the upper side and a lower LED light on the lower side, with a visible area for human eye observation between the upper LED light and the lower LED light, and both the upper LED light and the lower LED light are tilted and illuminating the corresponding eyes.

[0013] Based on the above technical solution: by setting a visible area for human eye observation between the upper LED light and the lower LED light, while the human eye receives light prevention and relief, the field of vision directly in front of the eyes will not be blocked by the LED light component, and the user can see things in front of them normally without experiencing dizziness or other discomfort during the wearing process.

[0014] A further embodiment: Each of the nasal plugs has an internal cavity, one end of the nasal plug is mounted on the mounting base, and the other end of the nasal plug has a light-transmitting hole for the near-infrared light emitted by the near-infrared lamp to pass through.

[0015] A further embodiment: The near-infrared lamp is a lamp that emits near-infrared light with a wavelength of 800-850nm.

[0016] Based on the above technical solution: the nasal plug is inserted into the nasal cavity, and the near-infrared light emitted by the near-infrared lamp inside the nasal plug at 40Hz with a wavelength of 800-8500nm can better penetrate tissues and bones to reach brain cells, thereby achieving better prevention and relief effects.

[0017] A further embodiment: The frame is provided with a nose pad, which is located on the lower side of the middle of the frame.

[0018] A further embodiment: The temple of the glasses is provided with a power supply component for supplying power to the LED light assembly, earplug assembly and nose plug assembly.

[0019] A further embodiment: The temple is provided with an interface for charging the power supply assembly.

[0020] Based on the above technical solution, by setting up a power supply component, the prevention and mitigation device of the present invention can be used in more places, expanding the application scenarios.

[0021] The beneficial effects of this invention are as follows:

[0022] The device of the present invention can be used for different groups of people. It can use a single stimulation mode, such as light stimulation, sound stimulation or near-infrared light stimulation through the nasal cavity, or it can combine multiple stimulation modes in a coordinated manner. This can provide customized stimulation programs for individual differences, further improve the effects of improving brain circulation and cerebral blood perfusion, thereby improving brain function and sleep disorders. Attached Figure Description

[0023] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic diagram of the structure of a multimodal stimulation device for promoting brain circulation according to the present invention.

[0025] Figure 2 This is a schematic diagram of the nasal plug assembly.

[0026] Figure 3 This is a schematic diagram illustrating the entire process of participants in the trial at the hospital.

[0027] Figure 4 This is a schematic diagram of the EEG responses of the subjects participating in the trial.

[0028] Figure 5 This is a schematic diagram showing an increasing trend in neural connectivity between various brain regions and the hippocampus in the subjects participating in the experiment.

[0029] Figure 6 This is a schematic diagram of FC-right brain-3-month baseline reduction.

[0030] Explanation of the labels in the diagram:

[0031] 1-Frame; 11-Upper LED light; 12-Lower LED light; 2-Temperature; 3-Nose pad; 4-Earplug; 5-Mounting base; 6-Nose plug. Detailed Implementation

[0032] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the protection scope of the present invention.

[0033] like Figure 1 and Figure 2 As shown, this embodiment provides a multimodal stimulation device for promoting cerebral circulation, comprising:

[0034] The eyeglasses assembly includes a frame 1 and two temples 2 located on the left and right sides of the frame 1, respectively. The frame 1 is provided with two sets of LED light assemblies that correspond to the left and right eyes of a person and emit light at a frequency of 40HZ.

[0035] A nasal plug assembly, comprising a mounting base 5 electrically connected to the temple 2 and two nasal plugs 6 disposed on the mounting base 5, each nasal plug 6 containing a near-infrared lamp emitting light at a frequency of 40 Hz; and,

[0036] The earplug assembly 4 includes two earplugs 4 that emit sound at a frequency of 40Hz, and the two earplugs 4 are respectively disposed on the two temples 2.

[0037] Among them, the 40Hz light stimulation emitted by the glasses component, the 40Hz sound stimulation emitted by the earplug component, and the 40Hz near-infrared light stimulation emitted by the nasal plug component can all be transmitted to the brain and generate gamma oscillations in the brain, thereby preventing and alleviating cognitive dysfunction.

[0038] The LED light assembly that stimulates the human eye can be positioned directly in front of the eye. In this embodiment, to facilitate the patient's observation of the surrounding environment while receiving light stimulation, each LED light assembly includes an upper LED 11 on the upper side and a lower LED 12 on the lower side. A visible area for human observation is provided between the upper LED 11 and the lower LED 12. Both the upper LED 11 and the lower LED 12 are tilted and irradiate towards their corresponding eyes.

[0039] In one specific embodiment, each nasal plug 6 has an internal cavity. One end of the nasal plug 6 is mounted on the mounting base 5, and the other end of the nasal plug 6 has a light-transmitting hole for near-infrared light emitted by a near-infrared lamp to pass through. The near-infrared lamp emits near-infrared light with a wavelength of 800-850nm. Specifically, near-infrared light can stimulate mitochondria to enhance ATP production, regulate cell signal transduction, activate glial-lymphatic circulation in the brain, accelerate the clearance of pathological proteins, especially P-tau, and reduce neural tangles. Furthermore, near-infrared light can also stimulate glial-lymphatic circulation in the brain, promote lymphatic system stability, and accelerate the clearance of harmful waste such as pathological proteins in the brain. Currently, local near-infrared light intervention aimed at improving neurological diseases mainly stimulates specific areas of the brain or the nasal cavity.

[0040] In this embodiment, to make the user more comfortable when wearing the glasses, the frame 1 is provided with a nose pad 3 and the nose pad 3 is located on the lower side of the middle of the frame 1.

[0041] In this embodiment, the temple 2 is provided with a power supply component for supplying power to the LED light assembly, earplug 4 assembly, and nose plug assembly. Both the power supply component and the circuit board are housed within the temple 2. The temple 2 is also provided with an interface for charging the power supply component, a power switch, parameter adjustment buttons, etc.

[0042] For ease of storage, the temple 2 can be designed as a folding temple 2.

[0043] The following explanation, combined with experimental results, further illustrates this embodiment:

[0044] I. Experimental Objective:

[0045] This is a prospective clinical study that included 6 participants. Eligible participants underwent a 12-week intervention. The effectiveness and safety of the device in clinical application were ultimately determined based on pre- and post-intervention results. It should be noted that this trial was conducted at the Second Affiliated Hospital of Zhejiang University School of Medicine. Figure 3 (The entire process of subjects participating in the trial in the hospital).

[0046] II. Test Equipment:

[0047] Experimental product: Sound and light therapy device

[0048] Manufacturer: Hangzhou Shudan Medical Technology Co., Ltd.

[0049] Brainwave Device: Life1ines R40

[0050] Manufacturing unit: Lifeline Neuro Company, LLC

[0051] Nuclear magnetic resonance imaging (NMR) equipment: uMR790-3.0T

[0052] Manufacturer: Shanghai United Imaging Healthcare Co., Ltd.

[0053] III. Experimental Methods:

[0054] The participation period for each trial participant is defined as the time from agreeing to enroll in the trial to the end of the final follow-up. According to the trial design, the expected participation duration for each participant is: screening period: 1-2 weeks; treatment period: 12 weeks.

[0055] IV. Subject Selection:

[0056] 1. Selection criteria:

[0057] (1) Age 55 (inclusive) to 75 (inclusive);

[0058] (2) The CDR score is 0.5;

[0059] (3) Mini-Mental State Examination (MMSE) score between 17 and 22;

[0060] (4) Hachinski score < 5 points;

[0061] (5) Mini-Geriatric Depression Scale (GDS-15) score ≤ 5;

[0062] (6) No visual or auditory abnormalities, and the scale monitoring can be completed;

[0063] (7) Students with ≥5 years of education are able to communicate normally;

[0064] (8) Understand the product usage process and plan, and sign a written informed consent form.

[0065] 2. Exclusion criteria:

[0066] (1) Make a clear diagnosis of neurological diseases other than AD, such as Parkinson's disease, Huntington's disease, frontotemporal dementia, epilepsy, multiple sclerosis, stroke, etc.

[0067] (2) History of head injury or being unconscious for more than 30 minutes;

[0068] (3) Suffering from mental illnesses, such as schizophrenia, bipolar disorder, etc.;

[0069] (4) History of glaucoma or severe cataracts;

[0070] (5) Serious physical illnesses that affect cognitive function;

[0071] (6) A history of substance dependence or behavioral disorder (such as alcohol dependence or abuse) that affects cognitive function within the past two years;

[0072] (7) Other circumstances that prevent daily intervention on time;

[0073] (8) Those who have participated in other scientific research projects or clinical trials within the past 3 months;

[0074] (9) Had received other cognitive training (including memory clinics, online cognitive games, etc.) in the three months prior to the consultation;

[0075] (10) Currently taking or having taken non-AD treatment drugs that may affect brain function within the past 3 months, such as nerve blockers or antidepressants, analgesics, etc. containing anticholinergic components;

[0076] (11) Contraindications to MRI examination exist, such as the presence of metal implants in the body, such as pacemakers, artificial valves, cochlear implants, aneurysm clips, etc.; more than 2 metal dentures or porcelain crowns (>2) must also be excluded;

[0077] (12) The Edinburgh Hand-Dominant Scale determines whether the person is left-handed or bi-handed.

[0078] 3. Elimination criteria:

[0079] (1) Those who are found to have contraindications after entering clinical observation;

[0080] (2) Those who did not use the product according to the research plan and whose effectiveness cannot be determined.

[0081] 4. Shedding criteria:

[0082] (1) Among the research participants who signed the informed consent form and were randomly selected to be enrolled, those who were lost to follow-up or who voluntarily withdrew their informed consent form or requested to withdraw from the study were all considered dropout cases.

[0083] (2) For cases of detachment, researchers must fill in the reasons for detachment in detail in the case report form.

[0084] 5. Termination Criteria:

[0085] (1) A serious adverse reaction event related to the use of the product occurs, and the user of the product is deemed to be discontinued;

[0086] (2) If a serious adverse event occurs that is unrelated to the use of the product, the test shall be stopped after judgment;

[0087] (3) Those who refuse to use the product in accordance with the research protocol;

[0088] (4) Those who, according to the researchers’ assessment, may cause harm to the research participants if they continue to use the product.

[0089] In summary, this trial included 6 participants, and the trial content included:

[0090] (1) Active intervention with 40Hz white light, sound and near-infrared light through the nose for 1 hour every day, 5 days a week for a total of 12 weeks. Subjects were given 40Hz photoacoustic combined with near-infrared light through the nose by using an intervention device at a fixed location.

[0091] V. Experimental Results and Analysis:

[0092] The results of this experiment showed that, under the same intensity of photoacoustic stimulation, the EEG response of healthy individuals was stronger than that of patients. Except for one patient who did not reach the response threshold due to taking memantine, after adding transnasal near-infrared light intervention, the EEG response of patients was similar to that of healthy individuals. (See results below.) Figure 4 .

[0093] Functional magnetic resonance imaging (fMRI) data showed that, compared with baseline, patients who reached the response threshold exhibited an increasing trend in neural connectivity between various brain regions and the hippocampus after 12 weeks of intervention. Furthermore, cerebral blood perfusion improved. The results are shown in the attached figures. Figure 5 and Figure 6 .

[0094] In conclusion, when 40 Hz photoacoustic stimulation is delivered to the brain, it can improve brain circulation and improve cerebral blood perfusion.

[0095] This invention is not limited to the above-mentioned optional embodiments. Under the premise of non-contradiction, the various solutions can be combined arbitrarily. Anyone can derive other forms of products under the guidance of this invention. However, no matter what changes are made in their shape or structure, all technical solutions that fall within the scope of the claims of this invention are within the protection scope of this invention.

Claims

1. A multi-modal stimulation device for promoting cerebral circulation, characterized in that, include: The eyeglasses assembly includes a frame and two temples located on the left and right sides of the frame, respectively. The frame is provided with two sets of LED light assemblies that correspond to the left and right eyes of a person and emit light at a frequency of 40HZ. A nose plug assembly, comprising a mounting base electrically connected to the temple of the endoscope and two nose plugs disposed on the mounting base, each nose plug containing a near-infrared lamp emitting light at a frequency of 40 Hz; and, An earplug assembly comprising two earplugs that emit sound at a frequency of 40 Hz, the two earplugs being respectively mounted on two temples of the glasses.

2. A multi-modal stimulation device for promoting cerebral circulation according to claim 1, wherein, Each LED light assembly includes an upper LED light on the upper side and a lower LED light on the lower side. A visible area for human eye observation is provided between the upper LED light and the lower LED light. The upper LED light and the lower LED light are both tilted and illuminate the corresponding eyes.

3. A multi-modal stimulation device for promoting cerebral circulation according to claim 1, wherein, Each of the nose plugs has an internal cavity, one end of the nose plug is mounted on the mounting base, and the other end of the nose plug has a light-transmitting hole for the near-infrared light emitted by the near-infrared lamp to pass through.

4. A multi-modal stimulation device for facilitating cerebral circulation according to claim 3, wherein, The near-infrared lamp is a lamp that emits near-infrared light with a wavelength of 800-850nm.

5. The multi-modal stimulation device for facilitating cerebral circulation of claim 1, wherein, The frame is equipped with a nose pad, which is located on the lower middle part of the frame.

6. The multi-modal stimulation device for facilitating cerebral circulation of claim 1, wherein, The temple of the glasses is provided with a power supply component for supplying power to the LED light assembly, earplug assembly and nose plug assembly.

7. A multi-modal stimulation device for facilitating cerebral circulation according to claim 6, wherein, The temple is provided with an interface for charging the power supply assembly.

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