Vacuum purification device

Abstract

The utility model relates to a vacuum purification device which comprises a base, a tank body and a stirring assembly, the tank body is cylindrical and transversely arranged on the base, the stirring assembly comprises a motor, a rotating shaft and a spiral piece, the two ends of the rotating shaft are movably connected with the two ends of the tank body through sealing bearings, and the output end of the motor is connected with the rotating shaft through a coupler to drive the rotating shaft to rotate in the tank body. The spiral pieces are arranged around the rotating shaft and abut against the inner wall of the tank body, exhaust pipes are arranged at the two ends of the upper portion of the tank body, a feeding pipe is arranged between the two exhaust pipes, a discharging pipe is arranged in the middle of the lower end of the tank body, inflation pipes are further arranged at the left end and the right end of the tank body, the rotating shaft is movably sleeved with stop pieces, and the spiral pieces are located between the two stop pieces. The stop piece abuts against the inner wall of the tank body. By means of the design of the exhaust pipe and the inflation pipe, the stop piece is driven to move along the rotating shaft in the tank body under the action of air pressure, residual medicine liquid and separated crystal substances at the bottom of the tank body are scraped through displacement of the stop piece, accumulation in the tank body is avoided, and follow-up manual cleaning is not needed.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical preparation technology, and in particular to a vacuum purification device. Background Technology

[0002] Under negative pressure, the boiling point of the drug solution can be lowered, achieving low-temperature, high-efficiency evaporation and concentration, reducing the damage to the active ingredients of heat-sensitive drugs. The vacuum inside the tank is typically achieved by using a vacuum pump to evacuate the equipment cavity to a negative pressure state (usually -0.05 to -0.08 MPa), significantly lowering the boiling point of the drug solution. For example, water can evaporate below 80°C under vacuum, avoiding high-temperature damage to heat-sensitive drug components and accelerating solvent evaporation or byproduct removal. Simultaneously, stirring enhances mass transfer efficiency, making it suitable for purification processes such as crystallization and extraction.7 For example, controlling the vacuum degree at 0.08-0.09 MPa during antibiotic crystallization can increase purity to 99.5%. Current vacuum purification equipment involves directly adding the drug solution into the tank, evacuating the tank, and heating the solution. During heating, crystals precipitated from the solution easily adhere to the inner wall of the tank, making them difficult to remove later. Therefore, improvements are needed. Utility Model Content

[0003] Therefore, it is necessary to provide a vacuum purification device to address the above problems.

[0004] A vacuum purification device includes a base, a tank, and a stirring assembly. The tank is cylindrical and placed horizontally on the base. The stirring assembly includes a motor, a rotating shaft, and a spiral blade. The two ends of the rotating shaft are movably connected to the two ends of the tank via sealed bearings. The output end of the motor is connected to the rotating shaft via a coupling, driving the rotating shaft to rotate within the tank. The spiral blade is arranged around the rotating shaft and abuts against the inner wall of the tank. Suction pipes are provided at both ends of the upper part of the tank, and a feed pipe is provided between the two suction pipes. A discharge pipe is provided at the middle of the lower end of the tank. Air filling pipes are also provided at the left and right ends of the tank. Stop plates are movably sleeved on the rotating shaft, and the spiral blade is located between the two stop plates, with the stop plates abutting against the inner wall of the tank.

[0005] Preferably, the inner wall of the tank is provided with a guide strip along the axial direction, and the edge of the stop plate is movably engaged with the guide strip.

[0006] Preferably, a stop ring is provided on the upper inner wall of the tank, and the stop ring is in movable contact with the upper edge of the stop plate.

[0007] Preferably, the tank body is made of 316 stainless steel.

[0008] The advantages of this invention are: by utilizing the design of the suction pipe and the inflation pipe, the baffle plate is driven to move along the rotating shaft inside the tank under the action of air pressure. The movement of the baffle plate scrapes the residual medicine and precipitated crystals at the bottom of the tank, preventing them from accumulating inside the tank. This eliminates the need for subsequent manual cleaning, reduces the workload of laboratory personnel, and improves efficiency. Attached Figure Description

[0009] Figure 1 This is a three-dimensional schematic diagram of a vacuum purification device according to one embodiment;

[0010] Figure 2 This is a schematic cross-sectional view of a vacuum purification device. Detailed Implementation

[0011] To make the above-mentioned objects, features, and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a full understanding of this utility model. However, this utility model can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this utility model. Therefore, this utility model is not limited to the specific embodiments disclosed below.

[0012] It should be noted that when an element is referred to as being "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. When an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.

[0013] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0014] like Figures 1-2As shown, a vacuum purification device includes a base 1, a tank 2, and a stirring assembly 3. The tank 2 is cylindrical and horizontally placed on the base 1. The stirring assembly 3 includes a motor 31, a rotating shaft 32, and a spiral blade 33. The two ends of the rotating shaft 32 are movably connected to the two ends of the tank 2 through sealed bearings. The output end of the motor 31 is connected to the rotating shaft 32 through a coupling, driving the rotating shaft 32 to rotate inside the tank 2. The spiral blade 33 is arranged around the rotating shaft 32 and abuts against the inner wall of the tank 2. The upper two ends of the tank 2 are provided with suction pipes 21, and a feed pipe 22 is arranged between the two suction pipes 21. The lower middle part of the tank 2 is provided with a discharge pipe 23. The left and right ends of the tank 2 are also provided with air filling pipes 24. A stop plate 4 is movably sleeved on the rotating shaft 32, and the spiral blade 33 is located between the two stop plates 4. The stop plate 4 abuts against the inner wall of the tank 2. Specifically, the base 1 serves as a support, allowing the tank 2 to be placed horizontally, and also acts as a support component for the motor 31. The output end of the motor 31 is connected to the rotating shaft 32 via a coupling. The two ends of the rotating shaft 32 are movably connected to the ends of the tank 2 via sealed bearings. The sealed bearings can adopt a non-contact labyrinth seal structure, which reduces gas permeability through a multi-stage gap structure, suitable for vacuum environments in the range of 10^-1 to 10^-2 Pa. A spiral blade 33 is provided on the rotating shaft 32. When the motor 31 drives the rotating shaft 32 to rotate inside the tank 2, the spiral blade 33 rotates, stirring the liquid medicine inside the tank 2, preventing the liquid medicine at the bottom of the tank 2 from solidifying and adhering to the inner wall of the tank 2 during heating. The tank 2 is made of metal, which is thermally conductive, and a heating wire is embedded in the semi-circle at the bottom of the tank 2 for heating the liquid medicine on the inner wall of the tank 2. The liquid medicine can be added through the feed pipe 22 at the top of the tank 2. After the liquid medicine is added, the vacuum pump uses the suction pipe 21 to evacuate the tank 2 to the set pressure. The vacuum pump can be a Roots vacuum pump with a booster system, which has both suction and pressurization capabilities. Pressurization can reset the stop plate 4, that is, the suction pipe 21 is inflated, and the solenoid valve at the inflation pipe 24 is opened, which drives the stop plate to reset under the pressure. At the same time, a pressure sensor can be installed in the tank 2 to detect the pressure inside the tank 2 in real time and feed the detection information back to the backend controller, which then controls the operation of the vacuum pump. We have set two suction pipes 21 on the tank 2, located on both sides of the feed pipe 22, and inflation pipes 24 are also set at both ends of the tank 2. We have installed electric valves on the suction pipe 21, feed pipe 22, discharge pipe 23 and inflation pipe 24 for the controller to control the opening and closing of the pipes. When it is necessary to evacuate the tank 2, the vacuum pump draws air through the evacuation pipe 21. At this time, the solenoid valve on the evacuation pipe 21 is opened, while the solenoid valves on the feed pipe 22, the discharge pipe 23 and the inflation pipe 24 are closed.When vacuum purification is complete and discharge is required, the solenoid valves on the suction pipe 21 and the feed pipe 22 are closed, while the solenoid valves on the discharge pipe 23 and the inflation pipe 24 are opened. The external inflation equipment inflates the tank through the inflation pipe 24. Driven by the air pressure, the two baffle plates 4 move towards each other and gather the liquid at the bottom of the tank 2, making it easier for the purified liquid to be discharged from the discharge pipe 23. In addition, the baffle plates 4 also act as a scraper during the displacement process, scraping away the crystals precipitated from the liquid at the bottom of the tank 2 to prevent them from accumulating inside the tank 2. No subsequent manual cleaning is required, reducing the workload of laboratory personnel and improving efficiency.

[0015] like Figure 2 As shown, a guide strip 25 is provided on the inner wall of the tank body 2 along the axial direction, and the edge of the stop plate 4 is movably engaged with the guide strip 25. Specifically, the guide strip 25 guides the linearly displaced stop plate 4 to prevent it from deviating during displacement.

[0016] like Figure 2 As shown, a stop ring 26 is provided on the upper inner wall of the tank 2, and the stop ring 26 movably abuts against the upper edge of the stop plate 4. Specifically, the stop ring 26 serves as a limiting function, restricting the displacement of the stop plate 4. The stop ring 26 is semi-circular and is located between the feed pipe 22 and the exhaust pipe 21. The stop plate 4, which can move linearly along the rotating shaft 32, scrapes away the crystals accumulated at the bottom of the tank 2, allowing them to mix with the medicine and flow out from the discharge pipe 23, thus preventing them from accumulating inside the tank 2, which can easily solidify over time and become extremely difficult to clean.

[0017] Specifically, the tank 2 is made of 316 stainless steel, which has excellent thermal conductivity, enabling low-temperature and high-efficiency evaporation and concentration, and reducing the damage to the active ingredients of heat-sensitive drugs.

[0018] The embodiments described above are merely illustrative of several implementations of this utility model, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. A vacuum purification apparatus, characterized in that: The device includes a base, a tank, and a stirring assembly. The tank is cylindrical and placed horizontally on the base. The stirring assembly includes a motor, a rotating shaft, and a spiral blade. The two ends of the rotating shaft are movably connected to the two ends of the tank via sealed bearings. The output end of the motor is connected to the rotating shaft via a coupling, driving the rotating shaft to rotate within the tank. The spiral blade is arranged around the rotating shaft and abuts against the inner wall of the tank. The upper two ends of the tank are provided with suction pipes, and a feed pipe is arranged between the two suction pipes. The lower middle part of the tank is provided with a discharge pipe. Air inlet pipes are also provided at the left and right ends of the tank. A stop plate is movably sleeved on the rotating shaft, and the spiral blade is located between the two stop plates, with the stop plates abutting against the inner wall of the tank.

2. The vacuum purification apparatus as described in claim 1, characterized in that: The inner wall of the tank is provided with a guide bar along the axial direction, and the edge of the stop plate is movably engaged with the guide bar.

3. The vacuum purification apparatus as described in claim 1, characterized in that: A stop ring is provided on the upper inner wall of the tank, and the stop ring is in movable contact with the upper edge of the stop plate.

4. The vacuum purification apparatus as described in claim 1, characterized in that: The tank is made of 316 stainless steel.

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