A distillation apparatus for producing gemcitabine

Abstract

This utility model discloses a distillation apparatus for producing gemcitabine. Upon opening the valve, the apparatus begins a reaction. An evaporation chamber is fixedly connected to the end of a first conduit. A reboiler is fixedly connected to the left side of the evaporation chamber via a pipe. A reflux conduit is located at the lower end of the reboiler, and a bottom liquid pump is fixedly connected to its rear surface. A column bottom receiving device is fixedly connected to the right side of the bottom liquid pump. The liquid enters the reboiler through the bottom reflux conduit for further heating. Sediment forms at the bottom of the evaporation chamber; this sediment is pumped out by the bottom liquid pump and enters the column bottom receiving device. A third conduit is fixedly connected to the upper right end of the evaporation chamber. A condenser is located at the upper end of the second conduit. A reflux tank is fixedly connected to the rear side of the condenser. A buffer tank is fixedly connected to the inlet of the reflux tank, and a finished product storage tank is fixedly connected to the other side of the filter screen. A reflux vessel is located at the lower end of the reflux tank, allowing for cyclical and repeated evaporation, thus improving utilization.

Description

Technical Field

[0001] This utility model relates to the field of distillation apparatus for producing gemcitabine, and particularly to a distillation apparatus for producing gemcitabine. Background Technology

[0002] A distillation unit for producing gemcitabine is used in cancer treatment, showing significant efficacy against various tumors, and market demand continues to grow. This has driven the research and development of its efficient production technology. As a key piece of equipment for improving product purity, the technological development of distillation units has attracted much attention. The synthesis of gemcitabine involves multiple steps, generating various impurities such as unreacted raw materials and byproducts, which need to be removed through separation methods such as distillation to obtain a high-purity product. Furthermore, the chemical properties of gemcitabine and its intermediates are quite complex, requiring stringent distillation conditions. Parameters such as temperature, pressure, and reflux ratio need to be precisely controlled to prevent product decomposition or deterioration. During the distillation process of gemcitabine production, a large amount of precipitation and incomplete distillation occur. Distillation units, in addition to their role in gemcitabine production, are also used in high-end chemical industries and similar production and processing fields such as drug synthesis.

[0003] The Chinese Patent Website published patent "CN207671960U" for a distillation apparatus for producing gemcitabine. The apparatus includes a gemcitabine feedstock tank fixedly connected to a pressure pump via a conduit. A finished gemcitabine storage tank is fixedly connected to the lower right side of the feedstock tank. A condenser is installed above the finished gemcitabine storage tank. A gas filter is fixedly connected to the right end of the condenser via a conduit. The gas filter is fixedly connected to an evaporation chamber, which is surrounded by a shell. A waste gas tank is installed at the lower right corner of the evaporation chamber. A reboiler is fixedly connected to the right side of the waste gas tank via a conduit. An ultrasonic vibrator is installed at the bottom of the reboiler, and a gas filter is installed inside the reboiler. This distillation apparatus for producing gemcitabine can fully and effectively utilize thermal energy, resulting in higher safety. It also effectively improves distillation efficiency and ensures distillation results. Utility Model Content

[0004] The purpose of this invention is to at least solve one of the technical problems existing in the prior art, and to provide a distillation apparatus for producing gemcitabine. This apparatus, in conjunction with a gas filter, slag removal port, thermometer, pressure gauge, first flow meter, second flow meter, reaction protection device, level gauge, pressure stabilizing valve, buffer tank, spring filter plate, spray tower, drain outlet, first conduit, valve, pressure valve, evaporation chamber, heating tube, reboiler, reflux conduit, bottom liquid pump, column bottom receiving device, second conduit, third conduit, condenser, reflux tank, filter screen, finished product storage tank, reflux vessel, and waste gas absorption device, initiates the reaction upon opening the valve. The liquid enters the reboiler through the bottom reflux conduit for further heating. Sediment forms at the bottom of the evaporation chamber, which is pumped out by the bottom liquid pump and enters the column bottom receiving device. A reflux tank is connected to the top of the evaporation chamber via a conduit, and a reflux vessel is located after the reflux tank. The reflux vessel then pumps the liquid back into the evaporation chamber, allowing for circulation and repeated evaporation, thus improving utilization. Dynamic adjustment of the reflux ratio ensures efficient and stable operation of the distillation column.

[0005] This utility model also provides a distillation apparatus for producing gemcitabine, comprising: a gemcitabine feed tank, a first conduit disposed on the upper surface of the gemcitabine feed tank, a valve fixedly connected to the outer surface of the first conduit, a pressure valve disposed at the rear end of the valve, an evaporation chamber fixedly connected to the end of the first conduit, a heating tube fixedly connected to the bottom surface of the evaporation chamber, a reboiler fixedly connected to the left side of the evaporation chamber via a pipe, a reflux conduit disposed at the lower end of the reboiler, a bottom liquid pump fixedly connected to the rear surface of the reflux conduit, and a reboiler housing fixedly connected to the right side of the bottom liquid pump; through the reflux conduit and the bottom liquid pump, unreacted liquid can be discharged into the evaporation chamber to continue the reaction, thereby improving utilization rate.

[0006] An evaporation chamber is included, with a second conduit fixedly connected to its upper end and a third conduit fixedly connected to its upper right end. A condenser is installed at the upper end of the second conduit, and a reflux tank is fixedly connected to the rear end of the condenser. A filter screen is fixedly connected to the other side of the reflux tank, and a finished product storage tank is fixedly connected to the other side of the filter screen. A reflux vessel is installed at the lower end of the reflux tank, and the evaporation chamber is fixedly connected to the other side of the reflux vessel. A waste gas absorption device is fixedly installed on the right side of the evaporation chamber. This design addresses the potential for sediment buildup at the bottom of the evaporation chamber, preventing sediment from affecting the distillation process within the evaporation chamber.

[0007] According to this utility model, a distillation apparatus for producing gemcitabine is provided, wherein a gas filter screen is disposed in the middle of the inner surface of the waste gas absorption device, and a slag removal port is disposed on the right side of the gas filter screen. These components can separate minute particles present in the gas, which are then discharged from the device through the slag removal port.

[0008] According to this utility model, a distillation apparatus for producing gemcitabine is provided, wherein a thermometer is fixedly connected to the upper left surface of the evaporation chamber, and a pressure gauge is fixedly connected to the upper right surface of the evaporation chamber. These components allow for monitoring of the temperature and pressure within the evaporation chamber, ensuring the normal operation of the apparatus.

[0009] According to the present invention, a distillation apparatus for producing gemcitabine is provided, wherein a first flow meter is installed at the upper end of the second conduit and a second flow meter is installed at the upper end of the third conduit. These components allow for the detection of flow rates in both conduits, preventing excessively rapid flow and potential irreversible damage to subsequent equipment.

[0010] According to the present invention, a distillation apparatus for producing gemcitabine is provided, wherein a reaction protection device is provided at the rear end of the pressure valve. Through these components, the generating apparatus can be shut down immediately in the event of a problem, ensuring the safety of operators.

[0011] According to the present invention, a distillation apparatus for producing gemcitabine is provided, wherein a level gauge is installed at the front end of the bottom liquid pump, and a pressure stabilizing valve is fixedly connected to the outlet of the bottom liquid pump. These components prevent the pump from cavitating due to excessively low bottom liquid level, or prevent the distillation efficiency from being affected by excessively high liquid level.

[0012] According to the present invention, a distillation apparatus for producing gemcitabine is provided, wherein a buffer tank is fixedly connected to the inlet of the reflux tank, and a spring filter plate is provided on the inner surface of the buffer tank. These components can reduce the impact of flow rate fluctuations on the liquid level.

[0013] According to this utility model, a distillation apparatus for producing gemcitabine is provided, wherein a spray tower is fixedly connected to the top of the waste gas absorption device, and a right drain outlet is provided on the right side of the waste gas absorption device. These components allow for the liquefaction of waste, increasing the product recovery rate.

[0014] Beneficial effects:

[0015] 1. Compared with the prior art, a distillation apparatus for producing gemcitabine, through the cooperation of a gas filter, a slag removal port, a thermometer, a pressure gauge, a first flow meter, a second flow meter, a reaction protection device, a level gauge, a pressure stabilizing valve, a buffer tank, a spring filter plate, a spray tower, and a drain outlet, solves the problem of possible material precipitation at the bottom of the evaporation chamber and avoids the precipitation affecting the distillation process in the evaporation chamber.

[0016] 2. Compared with existing technologies, this distillation unit for producing gemcitabine, through its coordination with a first conduit, valves, pressure valve, evaporation chamber, heating tube, reboiler, reflux conduit, bottom liquid pump, column bottom housing, second conduit, third conduit, condenser, reflux tank, filter screen, finished product storage tank, reflux vessel, and waste gas absorption device, allows for cyclic and repeated evaporation, improving utilization efficiency. Dynamic adjustment of the reflux ratio ensures efficient and stable operation of the distillation column. Attached Figure Description

[0017] The present invention will be further described below with reference to the accompanying drawings and embodiments;

[0018] Figure 1 This is a top view of the overall structure of the distillation unit used for the production of gemcitabine.

[0019] Figure 2 This is an overall front view of the distillation unit used for the production of gemcitabine;

[0020] Figure 3 This is a structural diagram of the right side of the overall structure of the distillation unit used for the production of gemcitabine;

[0021] Figure 4 This is a diagram showing the internal structure of the exhaust gas absorption device in the heat dissipation system for a single-tube IGBT.

[0022] Legend:

[0023] 1. Gemcitabine raw material tank; 2. First conduit; 3. Valve; 4. Pressure valve; 5. Evaporation chamber; 6. Heating tube; 7. Reboiler; 8. Reflux conduit; 9. Kettle liquid pump; 10. Tower kettle containment device; 11. Second conduit; 12. Third conduit; 13. Condenser; 14. Reflux tank; 15. Filter screen; 16. Finished product storage tank; 17. Reflux kettle; 18. Waste gas absorption device; 19. Gas filter screen; 20. Slag removal port; 21. Thermometer; 22. Pressure gauge; 23. First flow meter; 24. Second flow meter; 25. Reaction protection device; 26. Level gauge; 27. Pressure regulating valve; 28. Buffer tank; 29. ​​Spring filter plate; 30. Spray tower; 31. Drain outlet. Detailed Implementation

[0024] This section will describe in detail the specific embodiments of the present utility model. The preferred embodiments of the present utility model are shown in the accompanying drawings. The purpose of the drawings is to supplement the textual description with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present utility model, but they should not be construed as limiting the scope of protection of the present utility model.

[0025] Reference Figure 1This utility model discloses a distillation apparatus for producing gemcitabine, comprising: a gemcitabine feed tank 1, a first conduit 2 disposed on the upper surface of the gemcitabine feed tank 1, a valve 3 fixedly connected to the outer surface of the first conduit 2, a pressure valve 4 disposed at the rear end of the valve 3, and a reaction protection device 25 disposed at the rear end of the pressure valve 4. An evaporation chamber 5 is fixedly connected to the end of the first conduit 2, a thermometer 21 is fixedly connected to the upper left surface of the evaporation chamber 5, and a pressure gauge 22 is fixedly connected to the upper right surface of the evaporation chamber 5. A heating tube 6 is fixedly connected to the bottom surface of the evaporation chamber 5, a reboiler 7 is fixedly connected to the left side of the evaporation chamber 5 via a pipe, a reflux conduit 8 is disposed at the lower end of the reboiler 7, a bottom liquid pump 9 is fixedly connected to the rear surface of the reflux conduit 8, a column bottom receiving device 10 is fixedly connected to the right side of the bottom liquid pump 9, a level gauge 26 is disposed at the front end of the bottom liquid pump 9, and a pressure regulating valve 27 is fixedly connected to the outlet of the bottom liquid pump 9.

[0026] Specifically, when the valve is opened, the device begins to react. An evaporation chamber 5 is fixedly connected to the end of the first conduit 2. A thermometer 21 is fixedly connected to the upper left surface of the evaporation chamber 5, and a pressure gauge 22 is fixedly connected to the upper right surface of the evaporation chamber 5. A heating tube 6 is fixedly connected to the bottom surface of the evaporation chamber 5. A reboiler 7 is fixedly connected to the left side of the evaporation chamber 5 via a pipe. A reflux conduit 8 is installed at the lower end of the reboiler 7. A bottom liquid pump 9 is fixedly connected to the rear surface of the reflux conduit 8. A column bottom receiving device 10 is fixedly connected to the right side of the bottom liquid pump 9. The liquid enters the reboiler through the bottom reflux conduit for further heating. Sediment appears at the bottom of the evaporation chamber. The bottom sediment is extracted by the bottom liquid pump and enters the column bottom receiving device.

[0027] An evaporation chamber 5 is fixedly connected to a second conduit 11 at its upper end and a third conduit 12 at its upper right end. A condenser tube 13 is installed at the upper end of the second conduit 11, and a first flow meter 23 is installed at the upper end of the second conduit 11. A second flow meter 24 is installed at the upper end of the third conduit 12. A reflux tank 14 is fixedly connected to the rear end of the condenser tube 13. A filter screen 15 is fixedly connected to the other side of the reflux tank 14. A buffer tank 28 is fixedly connected to the inlet of the reflux tank 14, and a spring filter plate 29 is installed on the inner surface of the buffer tank 28. A finished product storage tank 16 is fixedly connected to the other side of the filter screen 15. A reflux vessel 17 is installed at the lower end of the reflux tank 14, and the evaporation chamber 5 is fixedly connected to the other side of the reflux vessel 17. A waste gas absorption device 18 is fixedly installed on the right side of the evaporation chamber 5. A gas filter screen 19 is installed in the middle of the inner surface of the waste gas absorption device 18, and a slag removal port 20 is installed on the right side of the gas filter screen 19.

[0028] Specifically, a second conduit 11 is fixedly connected to the upper end of the evaporation chamber 5, and a third conduit 12 is fixedly connected to the upper right end of the evaporation chamber 5. A condenser 13 is installed at the upper end of the second conduit 11, and a first flow meter 23 is installed at the upper end of the second conduit 11. A second flow meter 24 is installed at the upper end of the third conduit 12. A reflux tank 14 is fixedly connected to the rear end of the condenser 13. A filter screen 15 is fixedly connected to the other side of the reflux tank 14. A buffer tank 28 is fixedly connected to the inlet of the reflux tank 14, and a spring filter plate 29 is installed on the inner surface of the buffer tank 28. A finished product storage tank 16 is fixedly connected to the other side of the filter screen 15. A reflux vessel 17 is installed at the lower end of the reflux tank 14, and the evaporation chamber 5 is fixedly connected to the other side of the reflux vessel 17. This allows for reflux and repeated evaporation, improving utilization. Dynamic adjustment of the reflux ratio ensures efficient and stable operation of the distillation column.

[0029] Working principle: When the valve is opened, the device begins to react. The first conduit 2 is fixedly connected to the end of the evaporation chamber 5. A thermometer 21 is fixedly connected to the upper left surface of the evaporation chamber 5, and a pressure gauge 22 is fixedly connected to the upper right surface of the evaporation chamber 5. A heating tube 6 is fixedly connected to the bottom surface of the evaporation chamber 5. A reboiler 7 is fixedly connected to the left side of the evaporation chamber 5 through a pipe. A reflux conduit 8 is installed at the lower end of the reboiler 7. A bottom liquid pump 9 is fixedly connected to the rear surface of the reflux conduit 8. A column bottom receiving device 10 is fixedly connected to the right side of the bottom liquid pump 9. The liquid enters the reboiler through the bottom reflux conduit for further heating. A precipitate appears at the bottom of the evaporation chamber. The bottom precipitate is extracted by the bottom liquid pump and enters the column bottom receiving device.

[0030] A second conduit 11 is fixedly connected to the upper end of the evaporation chamber 5, and a third conduit 12 is fixedly connected to the upper right end of the evaporation chamber 5. A condenser 13 is installed at the upper end of the second conduit 11, and a first flow meter 23 is installed at the upper end of the second conduit 11. A second flow meter 24 is installed at the upper end of the third conduit 12. A reflux tank 14 is fixedly connected to the rear end of the condenser 13. A filter screen 15 is fixedly connected to the other side of the reflux tank 14. A buffer tank 28 is fixedly connected to the inlet of the reflux tank 14, and a spring filter plate 29 is installed on the inner surface of the buffer tank 28. A finished product storage tank 16 is fixedly connected to the other side of the filter screen 15. A reflux vessel 17 is installed at the lower end of the reflux tank 14, and the evaporation chamber 5 is fixedly connected to the other side of the reflux vessel 17. This allows for reflux and repeated evaporation, improving utilization. Dynamic adjustment of the reflux ratio ensures efficient and stable operation of the distillation column.

[0031] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. A distillation apparatus for producing gemcitabine, characterized in that, include: Gemcitabine raw material tank (1), a first conduit (2) is provided on the upper surface of the gemcitabine raw material tank (1), a valve (3) is fixedly connected to the outer surface of the first conduit (2), a pressure valve (4) is provided at the rear end of the valve (3), an evaporation chamber (5) is fixedly connected to the end of the first conduit (2), a heating tube (6) is fixedly connected to the bottom surface of the evaporation chamber (5), a reboiler (7) is fixedly connected to the left side of the evaporation chamber (5) through a pipe, a reflux conduit (8) is provided at the lower end of the reboiler (7), a kettle liquid pump (9) is fixedly connected to the rear surface of the reflux conduit (8), and a tower kettle housing device (10) is fixedly connected to the right side of the kettle liquid pump (9); An evaporation chamber (5) is provided with a second conduit (11) fixedly connected to its upper end and a third conduit (12) fixedly connected to its upper right end. A condenser (13) is provided at the upper end of the second conduit (11). A reflux tank (14) is fixedly connected to the rear end of the condenser (13). A filter screen (15) is fixedly connected to the other side of the reflux tank (14). A finished product storage tank (16) is fixedly connected to the other side of the filter screen (15). A reflux vessel (17) is provided at the lower end of the reflux tank (14). An evaporation chamber (5) is fixedly connected to the other side of the reflux vessel (17). A waste gas absorption device (18) is fixedly provided on the right side of the evaporation chamber (5).

2. A distillation apparatus for producing gemcitabine according to claim 1, characterized in that, A gas filter screen (19) is provided in the middle of the inner surface of the waste gas absorption device (18), and a slag removal port (20) is provided on the right side of the gas filter screen (19).

3. A distillation apparatus for producing gemcitabine according to claim 1, characterized in that, A thermometer (21) is fixedly connected to the upper left surface of the evaporation chamber (5), and a pressure gauge (22) is fixedly connected to the upper right surface of the evaporation chamber (5).

4. A distillation apparatus for producing gemcitabine according to claim 1, characterized in that, The upper end of the second conduit (11) is provided with a first flow meter (23), and the upper end of the third conduit (12) is provided with a second flow meter (24).

5. A distillation apparatus for producing gemcitabine according to claim 1, characterized in that, The rear end of the pressure valve (4) is equipped with a reaction protection device (25).

6. A distillation apparatus for producing gemcitabine according to claim 1, characterized in that, A level gauge (26) is provided at the front end of the reactor liquid pump (9), and a pressure stabilizing valve (27) is fixedly connected at the outlet of the reactor liquid pump (9).

7. A distillation apparatus for producing gemcitabine according to claim 1, characterized in that, The inlet of the reflux tank (14) is fixedly connected to a buffer tank (28), and a spring filter plate (29) is provided on the inner surface of the buffer tank (28).

8. A distillation apparatus for producing gemcitabine according to claim 1, characterized in that, The top of the waste gas absorption device (18) is fixedly connected to the spray tower (30), and a right drain outlet (31) is provided on the right side of the waste gas absorption device (18).

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