Multi-stage circulating filtration device for polypeptide synthesis reaction liquid

Abstract

The utility model relates to the technical field of polypeptide processing, in particular to a multi-stage circulating filtering device for polypeptide synthesis reaction liquid, and aims to solve the problem that foreign matters easily enter filtering equipment when a filter element is replaced. The multi-stage circulating filtering device comprises a barrel, a through hole is formed in the upper surface of the barrel, and a lifting assembly is arranged above the barrel. Through cooperation of a hydraulic rod, a sealing cover and a first magnetic ring, the first magnetic ring applies pressure to a second magnetic ring, a filter cloth performs preliminary filtration on a reaction liquid, a filter membrane performs secondary filtration on the reaction liquid, and under the cooperation action of the hydraulic rod, the sealing cover and the first magnetic ring, the first magnetic ring drives the second magnetic ring to move out of the cylinder; after the second magnetic ring is detached, the through opening is sealed again, flowing of air inside and outside the cylinder is reduced, the filter membrane and the filter cloth which are replaced are installed and positioned through magnetic adsorption of the first magnetic ring and the second magnetic ring, the installation efficiency is improved, the contact time with the outside is shortened, and the safety of reaction liquid is improved.

Description

Technical Field

[0001] This utility model relates to the field of polypeptide processing technology, specifically a multi-stage circulating filtration device for polypeptide synthesis reaction liquid. Background Technology

[0002] Peptide processing refers to the synthesis, modification, or processing of peptide molecules through chemical, enzymatic, or biological methods. It is commonly used in research, pharmaceuticals, food, cosmetics, and other fields. Peptides are essentially short-chain proteins composed of amino acids linked by peptide bonds, and they play important roles in biological processes such as cell signal transduction, immune responses, and enzyme catalysis.

[0003] Currently, in the process of peptide processing, filtration devices are needed to filter the peptide synthesis reaction solution. Although the current filtration devices can filter the circulating liquid, they still have some shortcomings in actual use. For example, it is not convenient to quickly replace the filter element, which takes a lot of time. This also makes it easy for foreign objects to enter the filtration equipment when replacing the filter element, which poses a risk of contaminating the circulating liquid.

[0004] Based on this, this invention designs a multi-stage circulating filtration device for polypeptide synthesis reaction solution to solve the problem. Utility Model Content

[0005] The purpose of this invention is to provide a multi-stage circulating filtration device for polypeptide synthesis reaction liquid, so as to solve the problem in the above-mentioned background technology that foreign objects are easily introduced into the filtration equipment when the filter element is replaced.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a multi-stage circulating filtration device for polypeptide synthesis reaction liquid, comprising a cylinder, an opening on the upper surface of the cylinder, a lifting component above the cylinder, a filtration component inside the cylinder, and a guiding component inside the cylinder.

[0007] Furthermore, the lifting assembly includes a bracket mounted on the upper surface of the cylinder, a hydraulic rod fixedly mounted on the upper surface of the bracket, a sealing cap fixedly mounted on the telescopic end of the hydraulic rod, and the bottom end of the sealing cap extending into the interior of the opening.

[0008] Furthermore, the filter assembly includes a connecting seat installed on the top wall of the inner cylinder, a first magnetic ring fixedly installed on the inner top wall of the sealing cover, two sets of through holes opened on the bottom surface of the first magnetic ring, a second magnetic ring slidably installed on the inner wall of the connecting seat, a filter cloth fixedly installed on the inner wall of the second magnetic ring, a support ring fixedly installed on the bottom surface of the second magnetic ring, and a filter membrane fixedly installed on the inner wall of the support ring.

[0009] Furthermore, the guiding assembly includes a set of tension springs and a guide tube mounted on the bottom surface of the connecting seat. The bottom ends of the set of tension springs are jointly fixedly mounted with a guide ring. A top tube is fixedly mounted on the upper surface of the guide ring, and a conical cover is fixedly mounted on the bottom surface of the guide tube.

[0010] Furthermore, a feed pipe is fixedly connected to the upper surface of the cylinder, the right end of the feed pipe passes through the connecting seat and extends into the interior of the connecting seat, and a fixing ring is fixedly installed on the bottom surface of the cylinder, with two sets of mounting holes opened on the upper surface of the fixing ring.

[0011] Furthermore, a discharge pipe is fixedly connected to the outer surface of the cylinder, and the top end of the discharge pipe is fixedly connected to the bottom end of the conical cover.

[0012] Preferably, two fixing seats are fixedly installed on the upper surface of the cylinder, and the two fixing seats are fixedly installed on the front and back sides of the support respectively. A set of support blocks are fixedly installed on the outer surface of the telescopic end of the hydraulic rod, and the bottom surface of each support block is fixedly installed on the upper surface of the sealing cover.

[0013] Furthermore, a top ring is fixedly installed on the outer surface of the conduit, and a set of top rods is fixedly installed on the bottom surface of the top ring, with the bottom end of each top rod being fixedly installed to the inner bottom wall of the cylinder.

[0014] Compared with the prior art, the beneficial effects of this utility model are as follows: By using a hydraulic rod, a sealing cover, and a first magnetic ring in combination, the first magnetic ring applies pressure to the second magnetic ring, causing the filter cloth to perform preliminary filtration of the reaction liquid, and the filter membrane to perform secondary filtration of the reaction liquid. Under the combined action of the hydraulic rod, the sealing cover, and the first magnetic ring, the first magnetic ring drives the second magnetic ring to move out of the cylinder. After the second magnetic ring is disassembled, the opening is sealed again to reduce the flow of air between the inside and outside of the cylinder. The magnetic attraction of the first and second magnetic rings is used to install and position the replaced filter membrane and filter cloth, improving installation efficiency, reducing contact time with the outside, and improving the safety of the reaction liquid. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0016] Figure 2 This is a three-dimensional structural schematic diagram of the side view of this utility model;

[0017] Figure 3 This is a three-dimensional structural schematic diagram of the orthographic section of this utility model;

[0018] Figure 4 This utility model Figure 3 Enlarged structural diagram of the structure at point A.

[0019] The attached diagram lists the components represented by each number as follows:

[0020] 1. Cylinder; 101. Feed pipe; 102. Fixed seat; 103. Fixed ring; 104. Mounting hole; 105. Discharge pipe; 106. Through port; 2. Lifting assembly; 201. Bracket; 202. Hydraulic rod; 203. Sealing cover; 204. Support block; 3. Filter assembly; 301. Connecting seat; 302. First magnetic ring; 303. Through hole; 304. Second magnetic ring; 305. Filter cloth; 306. Filter membrane; 307. Support ring; 4. Guide assembly; 401. Guide ring; 402. Guide tube; 403. Top tube; 404. Tension spring; 405. Conical cover; 5. Top ring; 501. Top rod.

[0021] The realization of the purpose, functional features and advantages of this utility model will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0022] It should be understood that the specific embodiments described herein are merely illustrative of the present invention and are not intended to limit the present invention.

[0023] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of the stated features. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly and specifically defined.

[0024] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection, a direct connection, or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0025] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0026] Please refer to Figures 1 to 4 This utility model provides a technical solution: a multi-stage circulating filtration device for polypeptide synthesis reaction solution, including a cylinder 1, an opening 106 on the upper surface of the cylinder 1, a lifting assembly 2 above the cylinder 1, a filtration assembly 3 inside the cylinder 1, and a guiding assembly 4 inside the cylinder 1. The cylinder 1 is the main container, and the opening 106 on its upper surface facilitates the entry of the reaction solution and the installation and maintenance of the internal components. The lifting assembly 2 includes a bracket 201 fixed to the upper surface of the cylinder, a hydraulic rod 202 mounted on the bracket, and a sealing cap 203 connected to the telescopic end of the hydraulic rod. The sealing cap can move up and down through the telescopic movement of the hydraulic rod to precisely close or open the opening 106. The filtration assembly 3 is located inside the cylinder and is responsible for multi-stage filtration of the reaction solution to ensure its purity. The guiding assembly 4 assists in the flow of the reaction solution and the positioning of the filtration assembly, improving operating efficiency. In use, the reaction solution is injected into the cylinder through the feed pipe, and after multi-stage filtration by the filtration assembly, it is guided by the guiding assembly to the discharge pipe for discharge. A hydraulic rod drives the sealing cap to close the opening, reducing internal and external air contact and ensuring the safety of the reaction solution. The filter assembly, through magnetic adsorption and mechanical structure, enables rapid replacement and precise positioning of the filter media, reducing the risk of external contamination. The entire device is compact and easy to operate, suitable for the continuous filtration needs of high-purity reaction solutions in peptide synthesis. Efficient filtration and sealing are achieved through the coordinated work of the hydraulic rod, sealing cap, and filter assembly. After entering the cylinder, the reaction solution undergoes multi-stage filtration, effectively removing impurities. The filtered liquid is then smoothly discharged through the guide assembly. The hydraulic rod controls the opening and closing of the sealing cap, reducing airflow time and protecting the reaction solution from external contamination. The magnetic positioning design of the filter assembly simplifies the filter media replacement process, improves installation efficiency, and ensures stable filtration performance. The overall design of the device optimizes the purification efficiency of the reaction solution during peptide synthesis, reduces operation time, and improves production safety.

[0027] In one embodiment, please refer to Figure 2The lifting assembly 2 includes a bracket 201 mounted on the upper surface of the cylinder 1. A hydraulic rod 202 is fixedly mounted on the upper surface of the bracket 201. A sealing cover 203 is fixedly mounted on the telescopic end of the hydraulic rod 202. The bottom end of the sealing cover 203 extends into the interior of the opening 106. The sealing cover 203 can be moved up and down by the hydraulic rod 202, so that the sealing cover 203 can open and close the opening 106.

[0028] In one embodiment, please refer to Figure 4 The filter assembly 3 includes a connecting seat 301 installed on the inner top wall of the cylinder 1, a first magnetic ring 302 fixedly installed on the inner top wall of the sealing cover 203, two sets of through holes 303 opened on the bottom surface of the first magnetic ring 302, a second magnetic ring 304 slidably installed on the inner wall of the connecting seat 301, a filter cloth 305 fixedly installed on the inner wall of the second magnetic ring 304, a support ring 307 fixedly installed on the bottom surface of the second magnetic ring 304, and a filter membrane 306 fixedly installed on the inner wall of the support ring 307. By providing the first magnetic ring 302, pressure can be applied to the second magnetic ring 304 to position the second magnetic ring 304. The filter cloth 305 can be used to perform preliminary filtration of the reaction liquid, and the filter membrane 306 can be used to perform secondary filtration of the reaction liquid to improve the quality of the reaction liquid.

[0029] In one embodiment, please refer to Figure 3 and Figure 4 The guide assembly 4 includes a set of tension springs 404 and a guide tube 402 installed on the bottom surface of the connecting seat 301. The bottom ends of the set of tension springs 404 are fixedly installed with a guide ring 401. A top tube 403 is fixedly installed on the upper surface of the guide ring 401. A conical cover 405 is fixedly installed on the bottom surface of the guide tube 402. The top tube 403 can apply a thrust to the support ring 307, so that the support ring 307 can cooperate more stably with the pressure applied by the first magnetic ring 302, effectively preventing the first magnetic ring 302 from sliding.

[0030] In one embodiment, please refer to Figure 1 The upper surface of the cylinder 1 is fixedly connected to a feed pipe 101. The right end of the feed pipe 101 passes through the connecting seat 301 and extends into the interior of the connecting seat 301. A fixing ring 103 is fixedly installed on the bottom surface of the cylinder 1. Two sets of mounting holes 104 are opened on the upper surface of the fixing ring 103. The feed pipe 101 allows the reaction liquid to enter the interior of the device, enabling the device to filter the reaction liquid. The fixing ring 103 and the mounting holes 104 can fix the device to prevent it from sliding.

[0031] In one embodiment, please refer to Figure 2 The outer surface of the cylinder 1 is fixedly connected to the discharge pipe 105. The top end of the discharge pipe 105 is fixedly connected to the bottom end of the conical cover 405. The filtered reaction liquid can be guided through the discharge pipe 105 so that the reaction liquid can be discharged from the device.

[0032] In one embodiment, two fixing seats 102 are fixedly installed on the upper surface of the cylinder 1. The two fixing seats 102 are fixedly installed on the side facing each other and respectively on the front and back of the support 201. A set of support blocks 204 are fixedly installed on the outer surface of the telescopic end of the hydraulic rod 202. The bottom surface of each support block 204 is fixedly installed on the upper surface of the sealing cover 203. The fixing seats 102 can reinforce the support 201 and improve the stability of the support 201. The support blocks 204 can apply a pushing force to the sealing cover 203, so that the sealing cover 203 can maintain a more uniform force.

[0033] In one embodiment, please refer to Figure 3 A top ring 5 is fixedly installed on the outer surface of the conduit 402. A set of top rods 501 are fixedly installed on the bottom surface of the top ring 5. The bottom end of each top rod 501 is fixedly installed to the inner bottom wall of the cylinder 1. The top ring 5 and the top rods 501 can support the conduit 402, making the conduit 402 more stable.

[0034] In one specific embodiment, during use, the reaction solution is injected into the connecting seat 301 through the feed pipe 101. The reaction solution enters above the filter cloth 305 through the through hole 303, allowing the filter cloth 305 to perform preliminary filtration of the reaction solution. The filtered reaction solution falls onto the filter membrane 306, allowing the filter membrane 306 to perform secondary filtration of the reaction solution. The filtered reaction solution is discharged through the conical cover 405, which collects the reaction solution, allowing it to be discharged through the discharge pipe 105. When it is necessary to replace the filter cloth 305, the hydraulic rod 202 is activated to retract. The hydraulic rod 202 drives the first magnetic ring 302 to move upward, causing the first magnetic ring 302 to drive the second magnetic ring 304 to move upward through magnetic force. This causes the second magnetic ring 304 to move out of the cylinder 1. Then, the operator pulls the second magnetic ring 304 to disassemble the filter cloth 305 and the support ring 307. Subsequently, the hydraulic rod 202 is reset, causing it to push the sealing cover 203 downwards, closing the opening 106. After cleaning and replacing the filter cloth 305, the hydraulic rod 202 is moved upwards again, opening the sealing cover 203. Then, the magnetic attraction of the first magnetic ring 302 and the second magnetic ring 304 is used to position the second magnetic ring 304. The hydraulic rod 202 is then activated, pushing the second magnetic ring 304 downwards through the first magnetic ring 302 to install and position the second magnetic ring 304. Simultaneously, the support ring 307 pushes the top tube 403 downwards, causing the top tube 403 to apply a thrust to the support ring 307 through the cooperation of the tension spring 404 and the guide ring 401, thus completing the positioning of the second magnetic ring 304.

[0035] The above description is only a preferred embodiment of the present utility model and does not limit the patent scope of the present utility model. Any equivalent structural or procedural transformations made based on the content of the present utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present utility model.

Claims

1. A multi-stage circulating filtration device for polypeptide synthesis reaction solution, characterized in that, Includes a cylinder (1), the upper surface of the cylinder (1) is provided with an opening (106), a lifting assembly (2) is provided above the cylinder (1), a filter assembly (3) is provided inside the cylinder (1), and a guide assembly (4) is provided inside the cylinder (1). The lifting assembly (2) includes a bracket (201) installed on the upper surface of the cylinder (1). A hydraulic rod (202) is fixedly installed on the upper surface of the bracket (201). A sealing cover (203) is fixedly installed on the telescopic end of the hydraulic rod (202). The bottom end of the sealing cover (203) extends into the interior of the opening (106).

2. The multi-stage circulating filtration device for polypeptide synthesis reaction solution according to claim 1, characterized in that, The filter assembly (3) includes a connecting seat (301) installed on the inner top wall of the cylinder (1), a first magnetic ring (302) is fixedly installed on the inner top wall of the sealing cover (203), the bottom surface of the first magnetic ring (302) has two sets of through holes (303), and a second magnetic ring (304) is slidably installed on the inner wall of the connecting seat (301).

3. The multi-stage circulating filtration device for polypeptide synthesis reaction solution according to claim 2, characterized in that, A filter cloth (305) is fixedly installed on the inner wall of the second magnetic ring (304), a support ring (307) is fixedly installed on the bottom surface of the second magnetic ring (304), and a filter membrane (306) is fixedly installed on the inner wall of the support ring (307).

4. The multi-stage circulating filtration device for polypeptide synthesis reaction solution according to claim 1, characterized in that, The guide assembly (4) includes a set of tension springs (404) and a conduit (402) installed on the bottom surface of the connecting seat (301). A guide ring (401) is fixedly installed at the bottom end of the tension spring (404), a top pipe (403) is fixedly installed on the upper surface of the guide ring (401), and a conical cover (405) is fixedly installed on the bottom surface of the conduit (402).

5. The multi-stage circulating filtration device for polypeptide synthesis reaction solution according to claim 2, characterized in that, The upper surface of the cylinder (1) is fixedly connected to a feed pipe (101). The right end of the feed pipe (101) passes through the connecting seat (301) and extends into the interior of the connecting seat (301). A fixing ring (103) is fixedly installed on the bottom surface of the cylinder (1). Two sets of mounting holes (104) are opened on the upper surface of the fixing ring (103).

6. The multi-stage circulating filtration device for polypeptide synthesis reaction solution according to claim 4, characterized in that, The outer surface of the cylinder (1) is fixedly connected to a discharge pipe (105), and the top end of the discharge pipe (105) is fixedly connected to the bottom end of the conical cover (405).

7. The multi-stage circulating filtration device for polypeptide synthesis reaction solution according to claim 1, characterized in that, Two fixed seats (102) are fixedly installed on the upper surface of the cylinder (1). The two fixed seats (102) are fixedly installed on the side of each other, respectively, on the front and back of the bracket (201). A set of support blocks (204) are fixedly installed on the outer surface of the telescopic end of the hydraulic rod (202). The bottom surface of each support block (204) is fixedly installed on the upper surface of the sealing cover (203).

8. The multi-stage circulating filtration device for polypeptide synthesis reaction solution according to claim 4, characterized in that, A top ring (5) is fixedly installed on the outer surface of the conduit (402), and a set of top rods (501) is fixedly installed on the bottom surface of the top ring (5). The bottom end of each top rod (501) is fixedly installed to the inner bottom wall of the cylinder (1).

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