A rotary evaporator for medical and pharmaceutical synthesis experiments

Abstract

The utility model discloses a kind of rotary evaporators for medical synthetic experiment, including body and sleeve, the inside of sleeve is equipped with flow guide pipe, the outer wall of flow guide pipe is fixedly connected with the inner wall of sleeve by multiple connecting beams, through hole is equipped between multiple connecting beams, one end of sleeve is equipped with frosted external interface and the opening connection of flask on body, the other end of sleeve is equipped with frosted internal interface and the connecting pipe connection on body, one end of flow guide pipe is inserted into flask, the other end of flow guide pipe extends to the vicinity of pressure relief valve mounting hole of condenser tube on body, flow guide valve can be inserted into pressure relief valve mounting hole, flow guide valve is inserted into one side of condenser tube and is connected with flow guide pipe.The utility model provides a kind of rotary evaporators for medical synthetic experiment, can be in without taking down flask case through flow guide pipe to flask in negative pressure suction to supplement product, hinged movable rod is arranged, movable rod is clamped in flask mouth position by the hoop of tail end, avoid flask to slip.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical synthesis equipment technology, specifically to a rotary evaporator for pharmaceutical synthesis experiments. Background Technology

[0002] A rotary evaporator is a device that removes solvent by heating under vacuum conditions. It is frequently used in pharmaceutical synthesis experiments. Its main working principle is to create a vacuum environment using a vacuum pump, thereby lowering the boiling point of the solvent. The solvent in the product is then evaporated into a gaseous phase by heating the product. This gaseous solvent is then condensed and collected through a condenser. Finally, the product precipitates from the solvent, and the remaining product may be a solid or an oily liquid, depending on its properties.

[0003] Existing rotary evaporators generally include a base, a water bath, a condenser, and a flask. The water bath is mounted on the base, and a lifting and adjusting mechanism is provided on one side of the water bath. The top of the lifting and adjusting mechanism is equipped with an annular shell, one side of which is fixedly connected to the condenser. A rotating mechanism is provided inside the shell, and an inclined connecting pipe is provided on the side of the shell near the water bath. The rotating mechanism can control the rotation of the connecting pipe, and the connecting pipe and the condenser are kept in communication. A collection bottle is connected to the bottom of the condenser, and an installation hole is provided at the end of the condenser away from the connecting pipe. A removable pressure relief valve is provided in the installation hole, and a vacuum pump connection port is also provided on the condenser.

[0004] In practical operation, existing rotary evaporators often require batches of solvent to be added to the flask for evaporation when the product volume is large. The conventional method is to remove the flask when the previous batch of solvent has largely evaporated, and then pour the product into the flask. However, larger containers are typically used for larger products. Overly large containers are too heavy to pour directly, while using smaller containers to transfer the product from larger ones easily leads to spillage, wasting product and contaminating the work surface. Some containers, such as conical flasks, have very small openings, making filling difficult. If the product could be drawn into the flask through a vacuum, the workload would be greatly reduced. However, current rotary evaporators do not have this function. Utility Model Content

[0005] 1. The technical problem to be solved:

[0006] To address the aforementioned technical problems, this utility model provides a rotary evaporator for pharmaceutical synthesis experiments.

[0007] 2. Technical Solution:

[0008] A rotary evaporator for pharmaceutical synthesis experiments includes a main body and a sleeve. The sleeve has a flow guide tube inside, and the outer wall of the flow guide tube is fixedly connected to the inner wall of the sleeve through multiple connecting ribs. Through holes are provided between the multiple connecting ribs. One end of the sleeve has a frosted outer interface that connects to the opening of a flask on the main body, and the other end of the sleeve has a frosted inner interface that connects to a connecting tube on the main body. One end of the flow guide tube is inserted into the flask, and the other end of the flow guide tube extends to the vicinity of the pressure relief valve mounting hole of the condenser tube on the main body. A flow guide valve can be inserted into the pressure relief valve mounting hole, and the flow guide valve extends into one side of the condenser tube and is connected to the flow guide tube.

[0009] Furthermore, the flow guide valve includes a reducing pipe and an outer pipe. The outer wall of the reducing pipe is provided with a frosted surface that fits the inner frosted surface of the pressure relief valve mounting hole. The end of the reducing pipe is provided with a plug interface. The end of the flow guide pipe near the pressure relief valve mounting hole is provided with a plug connector. After the reducing pipe is inserted into the pressure relief valve mounting hole, the plug connector is fully inserted into the plug interface. A valve seat is provided between the reducing pipe and the outer pipe, and a perforated valve core is rotatably connected inside the valve seat.

[0010] Furthermore, the mating surfaces of the connector and the interface are frosted and coated with sealing silicone grease.

[0011] Furthermore, the side of the guide tube closest to the flask is curved.

[0012] Furthermore, the sleeve, guide tube, connecting rib, and plug are all made of glass and are manufactured as a single piece.

[0013] Furthermore, the entire flow guide valve is made of glass.

[0014] Furthermore, a movable rod is hinged to the shell of the main body, and a clamp is provided at the end of the movable rod, which is clamped at the rear end of the protruding edge of the flask neck.

[0015] 3. Beneficial effects:

[0016] This invention provides a rotary evaporator for pharmaceutical synthesis experiments. It allows for the addition of product to the flask under negative pressure via a guide tube without removing the flask. During normal flask rotation, the guide tube does not contact the pressure relief valve and does not affect the flask's rotation. When product needs to be added, the pressure relief valve is simply replaced with a guide valve. The guide valve and guide tube are connected and sealed, allowing the product to be drawn into the flask through the guide valve and guide tube. To prevent the flask from slipping due to weakened negative pressure, a hinged movable rod is provided. The movable rod is secured to the flask opening by a clamp at its end, preventing the flask from slipping. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of the rotary evaporator of this utility model;

[0018] Figure 2 This is a side view of the sleeve and guide tube of this utility model.

[0019] Figure 3 This is a top view of the sleeve and guide tube of this utility model;

[0020] Figure 4 This is a schematic diagram of the cooperation structure between the flow guide valve and the flow guide pipe of this utility model;

[0021] Figure 5 This is a schematic diagram showing the positional relationship between the pressure relief valve and the guide pipe after insertion. Detailed Implementation

[0022] The present invention will now be described in detail with reference to the accompanying drawings.

[0023] As attached Figure 1 To be continued Figure 5 , Specific implementation examples:

[0025] To facilitate a better understanding of the technical solution of this utility model, the mechanism of an existing rotary evaporator will be briefly described below:

[0026] The existing rotary evaporator includes a main body, on which a base 1, a water bath 2, a condenser tube 3, and a flask 4 are mounted. The water bath 2 is mounted on the base 1. A lifting and adjusting mechanism 5 is located on one side of the water bath 2. A ring-shaped shell 6 is located on the top of the lifting and adjusting mechanism 5. One side of the shell 6 is fixedly connected to the condenser tube 3. A rotating mechanism is located inside the shell 6. An inclined connecting pipe 7 is located on the side of the shell 6 closest to the water bath 2. The rotating mechanism controls the rotation of the connecting pipe 7, maintaining communication between the connecting pipe 7 and the condenser tube 3. A collection bottle 8 is connected to the bottom of the condenser tube 3. A mounting hole is located at the end of the condenser tube 3 away from the connecting pipe 7, and a removable pressure relief valve 9 is located inside the mounting hole. A vacuum pump connection port 10 is also provided on the condenser tube 3. More detailed structural details are not described here, as they are all existing technology.

[0027] In operation, first turn on the vacuum pump and close the pressure relief valve 9. Attach flask 4 to the end of the connecting pipe 7. Flask 4 will be firmly attached to the connecting pipe 7 due to the vacuum effect, generally requiring no further clamping. Turn on the condenser 3 to release the condenser water. Adjust the position of flask 4 using the lifting and adjusting mechanism 5 so that it is immersed to a certain depth below the water surface in the water bath 2. Turn on the rotating mechanism to rotate flask 4. The product in flask 4 will be heated, the solvent will evaporate, and then condense and be collected through the collecting bottle 8. If the solvent has almost evaporated, product needs to be added to flask 4. At this time, open the pressure relief valve 9, then remove flask 4 and add product. When dealing with large quantities of products requiring rotary evaporation, this operation is very cumbersome. In practice, due to experimental conditions, larger rotary evaporators are generally not available. Larger equipment is more dangerous and requires stricter control, necessitating separate application.

[0028] To solve the above problems, this utility model provides a rotary evaporator with the following structure.

[0029] A rotary evaporator for pharmaceutical synthesis experiments includes a sleeve 11, with a guide tube 12 inside the sleeve 11. The outer wall of the guide tube 12 is fixedly connected to the inner wall of the sleeve 11 through multiple connecting ribs 13. Through holes are provided between the multiple connecting ribs 13. One end of the sleeve 11 has a frosted outer interface that connects to the opening of a flask 4, and the other end of the sleeve 11 has a frosted inner interface that connects to a connecting tube 7. One end of the guide tube 12 is inserted into the flask 4, and the other end of the guide tube 12 extends to the vicinity of the pressure relief valve 9 mounting hole of the condenser tube 3. A guide valve 14 can be inserted into the pressure relief valve 9 mounting hole, and the guide valve 14 extends into one side of the condenser tube 3 and is inserted and connected to the guide tube 12.

[0030] It should be noted that the flow guide valve 14 of this invention is only used when product needs to be added to the flask 4. During rotary evaporation, the pressure relief valve 9 is installed in a conventional pressure relief valve 9 mounting hole. When product needs to be added to the flask 4, the pressure relief valve 9 is opened and replaced with the flow guide valve 14. At this time, the flow guide valve 14 is connected to the flow guide tube 12. The flow guide valve 14 blocks the mounting hole of the pressure relief valve 9. The vacuum pump will draw away the gas in the flask 4 to create a vacuum. A flexible tube is connected to the external interface of the flow guide valve 14 and inserted into the container holding the product. The vacuum will draw in the product, which is then introduced into the flask 4 through the flow guide tube 12. The through holes between the multiple connecting ribs 13 are to allow the gas in the flask 4 to be emptied under vacuum without affecting the flow of solvent vapor.

[0031] Specifically, the flow guide valve 14 includes a reducing pipe 141 and an outer connecting pipe 142. The outer wall of the reducing pipe 141 is frosted, which fits the frosted interior of the mounting hole of the pressure relief valve 9. The end of the reducing pipe 141 has a connector 143. The end of the flow guide pipe 142 near the mounting hole of the pressure relief valve 9 has a connector 121. After the reducing pipe 141 is inserted into the mounting hole of the pressure relief valve 9, the connector 121 is fully inserted into the connector 143. A valve seat 144 is provided between the reducing pipe 141 and the outer connecting pipe 142, and a perforated valve core 145 is rotatably connected inside the valve seat 144. The flow guide valve 14 of this invention is structurally similar to a conventional pressure relief valve 9, the difference being the connector 143 at the end of the reducing pipe 141. In conventional pressure relief valves, this side is either open or a thin glass tube.

[0032] In practice, to maintain the seal between the connector 121 and the interface 143, the mating surfaces of the connector 121 and the interface 143 are frosted and coated with sealing silicone grease.

[0033] Preferably, the side of the guide tube 12 closest to the flask 4 is curved.

[0034] The sleeve 11, guide tube 12, connecting rib 13, and plug 121 are all made of glass and machined as a single piece. The guide valve 14 is also made entirely of glass. It should be noted that the frosted glass connection ensures a tight seal; for even higher sealing requirements, silicone sealant can be applied.

[0035] Because the negative pressure of the adsorption flask 4 is low when extracting the product, the flask 4 is more likely to fall off. Therefore, the following structure is designed: a movable rod 15 is hinged to the shell 6, and a clamp 16 is provided at the end of the movable rod 15. The clamp 16 is clamped at the rear end of the protruding edge of the mouth of the flask 4.

[0036] Although the present invention has been disclosed above with reference to preferred embodiments, these are not intended to limit the present invention. Anyone skilled in the art can make various changes or modifications without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention shall be determined by the scope of protection of the claims of this application.

Claims

1. A rotary evaporator for pharmaceutical synthesis experiments, characterized in that, The device includes a main body and a sleeve. The sleeve has a flow guide tube inside, and the outer wall of the flow guide tube is fixedly connected to the inner wall of the sleeve through multiple connecting ribs. Through holes are provided between the multiple connecting ribs. One end of the sleeve has a frosted outer interface that connects to the opening of a flask on the main body, and the other end of the sleeve has a frosted inner interface that connects to a connecting tube on the main body. One end of the flow guide tube is inserted into the flask, and the other end of the flow guide tube extends to the vicinity of the pressure relief valve mounting hole of the condenser tube on the main body. A flow guide valve can be inserted into the pressure relief valve mounting hole, and the flow guide valve extends into one side of the condenser tube and is connected to the flow guide tube.

2. The rotary evaporator for pharmaceutical synthesis experiments according to claim 1, characterized in that, The flow guide valve includes a reducing pipe and an outer connecting pipe. The outer wall of the reducing pipe is frosted and fits the inner frosted part of the pressure relief valve mounting hole. The end of the reducing pipe is provided with a plug interface. The end of the flow guide pipe near the pressure relief valve mounting hole is provided with a plug connector. After the reducing pipe is inserted into the pressure relief valve mounting hole, the plug connector is fully inserted into the plug interface. A valve seat is provided between the reducing pipe and the outer connecting pipe, and a perforated valve core is rotatably connected inside the valve seat.

3. The rotary evaporator for pharmaceutical synthesis experiments according to claim 2, characterized in that, The mating surfaces of the connector and the interface are frosted and coated with sealing silicone grease.

4. The rotary evaporator for pharmaceutical synthesis experiments according to claim 2, characterized in that, The side of the guide tube closest to the flask is curved.

5. A rotary evaporator for pharmaceutical synthesis experiments according to claim 1 or 2, characterized in that, The sleeve, guide tube, connecting rib, and plug are all made of glass and are manufactured as a single piece.

6. A rotary evaporator for pharmaceutical synthesis experiments according to claim 5, characterized in that, The entire flow guide valve is made of glass.

7. A rotary evaporator for pharmaceutical synthesis experiments according to claim 6, characterized in that, A movable rod is hinged to the shell of the main body, and a clamp is provided at the end of the movable rod. The clamp is engaged with the rear end of the protruding edge of the flask neck.

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