The invention provides a fixture for drilling of a PCB, and relates to the technical field of electronic product production. The fixture for drilling of the PCB comprises a mounting base, and two rotating seats are fixedly mounted on the top of the mounting base. According to the fixture for drilling of the PCB, through matching of the mounting base, the rotating seats, transverse rods, rotating handles, clamping rods, adjusting rotary knobs, pressing blocks, rubber blocks and a drilling plate, the relative positions of the transverse rods and the clamping blocks on the top of the drilling plate can be adjusted through the rotating handles and the adjusting rotary knobs, and after adjusting is completed, the top surface of the to-be-drilled PCB can be clamped by utilizing the pressing blocks and the rubber blocks; by arranging the clamping blocks, grooves and clamping springs, the positions of the clamping blocks on the two sides of the top of the drilling plate are adjusted through telescopic springs, and thus the two sides of the to-be-drilled PCB can be clamped; and in conclusion, through matching of two kinds of different clamping modes, the fixture for drilling of the PCB is good in clamping stability, and drilling of the PCB is more accurate, so that the produced PCB is good in quality.