The invention discloses a tool clamp. A guide rail is horizontally and fixedly connected between two side supporting plates, the left side and the right side of the guide rail are each provided with asliding base in a sliding manner, supporting columns are evenly arranged on the upper end faces of the sliding bases, the top end of each supporting column is bonded with a rubber pad, the two ends of a dual-way screw are rotatably connected with the side supporting plates on the left side and the right side through bearings, the dual-way screw horizontally penetrates the two sliding bases, the sliding bases are in threaded connection with the dual-way screw through thread holes, the left end of a connecting rod is fixedly connected with the right end of the dual-way screw, the right end of the connecting rod is fixedly connected with a first handle, upper portions of end faces, away from one side of the center of a base, of the two side supporting plates are each provided with an air cylinder, tail ends of piston rods of the air cylinders are fixedly connected with an L-shaped plate, a U-shaped clamping block is fixedly connected to the end face, facing one side of the center of thebase, of the vertical part of the L-shaped plate, a screw rod is in threaded connection to the horizontal part of the L-shaped plate, a second handle is fixedly connected to the upper end of the screwrod, and a pressing block is fixedly connected to the lower end of the screw rod. The tool clamp has the beneficial effects of being convenient to use and high in clamping stability.