The invention discloses a shaft work piece clamping device. The shaft work piece clamping device comprises a rectangular bottom plate, wherein a plurality of installation grooves are formed in the side wall of the rectangular bottom plate, a baffle is fixedly arranged on the upper side of the rectangular bottom plate, a V-shaped cushion block used to support a shaft work piece is fixedly arranged on the right side of the baffle, a support plate parallel to the baffle is fixedly arranged on the upper side of the rectangular bottom plate, a threaded hole is formed in the support plate, a threaded rod matched with the support plate so as to form a thread pair is arranged in the threaded hole, a V-shaped press block used to tightly press the shaft work piece is hinged with the left end of the threaded rod, and a rotatable handle is fixedly installed at the right end of the threaded rod. The shaft work piece clamping device has the advantages of being reasonable in design, reliable in work piece clamping, large in increase force, unrestricted in stroke, simple in structure, convenient and quick to disassemble and assemble, convenient to carry, long in use life, wide in application range, low in production cost, and convenient to popularize and use.