The invention relates to the field of air conditioning, in particular to a variable refrigerant flow radiation air-conditioning system. The variable refrigerant flow radiation air-conditioning system comprises an indoor machine, an outdoor machine, a sub-water collector, a radiation tail end and a dew-point temperature controller; the indoor machine is connected with the outdoor machine in series; the radiation tail end is connected with the indoor machine through the sub-water collector; the dew-point temperature controller is connected with the sub-water collector and used for perceiving indoor temperature and humidity changes and preventing the phenomenon that condensation may occur on the radiation surface under the circumstance of wind system faults through the mode that a water circulation valve is cut off in advance. According to the variable refrigerant flow radiation air-conditioning system, heating and humidification can be performed in winter, refrigeration and dehumidification are performed in summer, meanwhile, new wind is fed to an indoor area after purification, and it is guaranteed that indoor air temperature and humidity and cleanliness reach a living optimal comfortable state. The variable refrigerant flow radiation air-conditioning system has the advantages that the installation is simple, the reliability is high, the indoor temperature, the humidity and the air cleanliness are adjusted uniformly and softly, and no noise, condensate water, secondary pollution and the strong blowing feeling exist. The equipment whole volume is small, the occupied space is small, the noise is low, and the appearance is beautiful.