A high-efficiency constant-temperature fat tissue cryopreservation device

Abstract

The utility model relates to the field of biomedical low temperature storage technology especially, and is a kind of efficient constant-temperature adipose tissue low temperature storage equipment, including shell, the inner chamber of shell is provided with partition, the side of shell and partition is provided with copper pipe, the bottom of shell inner chamber is provided with fixed block, the top of fixed block is provided with liquid nitrogen injection device, the top of liquid nitrogen injection device is connected with spray head.The utility model has the advantages of temperature control precision and good heat insulation effect, through the setting of driving mechanism in actual use, liquid nitrogen injection device can be moved, so that liquid nitrogen can be evenly distributed in shell, ensure that sample box on storage rack can be rapidly and evenly cooled, avoid the problem of local temperature too high or too low, partition is biological inert material, shell covers vacuum heat insulation layer, copper pipe and other heat insulation materials are arranged between shell and partition, effectively reduce the influence of external environment on the temperature in storage area.

Description

Technical Field

[0001] This utility model relates to the field of biomedical cryogenic storage technology, specifically to a high-efficiency, constant-temperature cryogenic storage device for adipose tissue. Background Technology

[0002] Adipose tissue is a loose connective tissue composed of a large number of aggregated fat cells. It is the main site for storing triglycerides in the body. When the body needs energy, triglycerides can be broken down into free fatty acids and released into the blood for use by other tissues. Adipose tissue has good thermal insulation properties, which helps to maintain stable body temperature. Especially in cold environments, brown adipose tissue can release energy through non-shivering thermogenesis to generate heat to maintain body temperature.

[0003] When storing adipose tissue, existing cryogenic storage equipment may not be able to distribute liquid nitrogen evenly within the storage chamber. This can lead to uneven cooling of sample cassettes on the storage rack, potentially damaging some samples due to localized overheating or underheating. Furthermore, the fixed location of the temperature sensors prevents real-time monitoring and adjustment of the storage area, further impacting temperature control accuracy. Additionally, the lack of a vacuum insulation layer on the storage device's outer shell allows for significant external environmental influences on the storage temperature. Inaccurate temperature control and poor insulation necessitate increased energy consumption to maintain the required cryogenic environment, increasing operating costs and potentially causing adverse environmental impacts. Utility Model Content

[0004] The purpose of this invention is to provide a high-efficiency, constant-temperature adipose tissue cryogenic storage device, which has the advantages of precise temperature control and good heat insulation, and solves the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a high-efficiency constant-temperature adipose tissue cryogenic storage device, comprising a shell, an inner cavity of the shell having a partition, a copper tube disposed on the opposite side of the shell and the partition, a fixing block disposed at the bottom of the inner cavity of the shell, a liquid nitrogen injection device disposed at the top of the fixing block, a nozzle being connected to the top of the liquid nitrogen injection device, a driving mechanism disposed inside the fixing block, a storage rack disposed in the inner cavity of the shell, support blocks slidably connected to both sides of the storage rack, one side of the support block being fixedly connected to the partition, adjusting blocks rotatably connected to both sides of the top of the storage rack, a square block being fixedly connected to the bottom of the adjusting block, a limit groove being formed at the top of the support block, a locking structure being disposed in the inner cavity of the square block, and temperature sensors being fixedly connected to both sides of the inner cavity of the partition.

[0006] Furthermore, as a preferred embodiment of this utility model, the driving mechanism includes a groove formed on the top of the fixed block, a threaded rod rotatably connected to the inner cavity of the groove, a threaded block threadedly connected to the surface of the threaded rod, the top of the threaded block being fixedly connected to the liquid nitrogen injection device, one end of the threaded rod penetrating to the outside of the fixed block and being fixedly connected to a motor, and one side of the motor being fixedly connected to the partition.

[0007] Furthermore, as a preferred embodiment of this utility model, the locking structure includes two cavities formed inside the square block. A movable plate is slidably connected to the inner cavity of each cavity. A spring is fixedly connected to one side of the movable plate. One end of the spring is fixedly connected to the square block. A wedge block is fixedly connected to one side of the movable plate. Positioning grooves are formed on both sides of the inner cavity of the limiting groove.

[0008] Furthermore, as a preferred embodiment of this utility model, the top of the fixing block is provided with grooves on both sides, and a slider is slidably connected to the inner cavity of the groove, and the top of the slider is fixedly connected to the liquid nitrogen injection device.

[0009] Furthermore, as a preferred embodiment of this utility model, each of the four corners of the bottom of the housing is fixedly connected with a support leg, and the four support legs are arranged symmetrically.

[0010] Beneficial effects: The technical solution of this application has the following technical effects: This utility model has the advantages of precise temperature control and good heat insulation effect. In actual use, through the setting of the drive mechanism, it can drive the liquid nitrogen spraying device to move, so that the liquid nitrogen can be evenly distributed in the shell, ensuring that the sample box on the storage rack can be cooled quickly and evenly, avoiding the problem of local temperature being too high or too low. The partition is made of bio-inert material, the shell is covered with a vacuum heat insulation layer, and heat insulation materials such as copper pipes are set between the shell and the partition, which effectively reduces the influence of the external environment on the temperature in the storage area.

[0011] It should be understood that all combinations of the foregoing concepts and the additional concepts described in more detail below can be considered as part of the utility model subject matter of this disclosure, provided that such concepts do not contradict each other. Attached Figure Description

[0012] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0013] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0014] Figure 2 This is a cross-sectional view of the structure of this utility model;

[0015] Figure 3 This is a partial structural cross-section of the present invention. Figure 1 ;

[0016] Figure 4 This is a partial structural cross-section of the present invention. Figure 2 ;

[0017] Figure 5 This is a cross-sectional view of the square block in this utility model.

[0018] In the figure, the meanings of the various reference numerals are as follows: 1. Shell; 2. Partition; 3. Copper pipe; 4. Fixing block; 5. Liquid nitrogen injection device; 6. Nozzle; 7. Drive mechanism; 71. Groove; 72. Threaded rod; 73. Threaded block; 74. Motor; 8. Storage rack; 9. Support block; 10. Adjusting block; 11. Square block; 12. Limiting groove; 13. Locking structure; 131. Cavity; 132. Movable plate; 133. Spring; 134. Wedge block; 135. Positioning groove; 14. Temperature sensor; 15. Slide groove; 16. Slider; 17. Support leg. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. To better understand the technical content of the present utility model, specific embodiments are provided and described in conjunction with the accompanying drawings. Various aspects of the present utility model are described in this disclosure with reference to the accompanying drawings, which show many illustrative embodiments. It should be understood that the various concepts and embodiments described above, as well as those described in more detail below, can be implemented in any of many ways. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the scope of protection of the present utility model.

[0020] As attached Figure 1 To be continued Figure 5 As shown: This embodiment provides a high-efficiency constant-temperature adipose tissue cryogenic storage device, including a shell 1, an inner cavity of the shell 1 with a partition 2, a copper tube 3 on the opposite side of the shell 1 and the partition 2, a fixing block 4 at the bottom of the inner cavity of the shell 1, a liquid nitrogen injection device 5 at the top of the fixing block 4, a nozzle 6 connected to the top of the liquid nitrogen injection device 5, a drive mechanism 7 inside the fixing block 4, a storage rack 8 in the inner cavity of the shell 1, support blocks 9 slidably connected to both sides of the storage rack 8, one side of the support block 9 fixedly connected to the partition 2, adjusting blocks 10 rotatably connected to both sides of the top of the storage rack 8, a square block 11 fixedly connected to the bottom of the adjusting block 10, a limit groove 12 opened on the top of the support block 9, a locking structure 13 in the inner cavity of the square block 11, and temperature sensors 14 fixedly connected to both sides of the inner cavity of the partition 2.

[0021] Specifically, the drive mechanism 7 includes a groove 71 formed on the top of the fixed block 4. A threaded rod 72 is rotatably connected to the inner cavity of the groove 71. A threaded block 73 is threadedly connected to the surface of the threaded rod 72. The top of the threaded block 73 is fixedly connected to the liquid nitrogen injection device 5. One end of the threaded rod 72 extends through to the outside of the fixed block 4 and is fixedly connected to a motor 74. One side of the motor 74 is fixedly connected to the partition 2.

[0022] In this embodiment, the driving mechanism 7 is used to move the liquid nitrogen injection device 5, increasing the range of movement of the liquid nitrogen injection device 5, so that the liquid nitrogen can be distributed more evenly and quickly in the inner cavity of the shell 1.

[0023] Specifically, the locking structure 13 includes two cavities 131 opened inside the square block 11. A movable plate 132 is slidably connected to the inner cavity of the cavity 131. A spring 133 is fixedly connected to one side of the movable plate 132. One end of the spring 133 is fixedly connected to the square block 11. A wedge block 134 is fixedly connected to one side of the movable plate 132. Positioning grooves 135 are opened on both sides of the inner cavity of the limiting groove 12.

[0024] In this embodiment, the locking structure 13 serves to fix the storage rack 8, while also making it easy for the user to disassemble and replace it.

[0025] Specifically, the top of the fixed block 4 has grooves 15 on both sides, and the inner cavity of the groove 15 is slidably connected to the slider 16. The top of the slider 16 is fixedly connected to the liquid nitrogen injection device 5.

[0026] In this embodiment, the combined use of the slide groove 15 and the slider 16 serves to limit the liquid nitrogen injection device 5, thereby improving the stability of the liquid nitrogen injection device 5 during movement.

[0027] Specifically, each of the four corners of the bottom of the housing 1 is fixedly connected with a support leg 17, and the four support legs 17 are arranged symmetrically.

[0028] In this embodiment, the support legs 17 provide support for the housing 1, thereby improving the stability of the housing 1 during placement.

[0029] The working principle and usage process of this utility model: The user places the sample box in the through groove at the top of the storage rack 8, and sprays liquid nitrogen into the storage area through the liquid nitrogen spraying device 5 to achieve the purpose of low temperature storage. The motor 74 is started, and the output shaft of the motor 74 drives the threaded rod 72 to rotate. The threaded rod 72 drives the threaded block 73 to move, and the threaded block 73 drives the liquid nitrogen spraying device 5 to move, so that the liquid nitrogen can be evenly distributed in the shell 1 through the nozzle 6, ensuring that the sample box on the storage rack 8 can be cooled quickly and evenly.

[0030] Temperature sensors 14 are located on both sides of the inner cavity of the partition 2. They monitor the temperature in the storage area in real time and feed the data back to the control system. The control system adjusts the working state of the liquid nitrogen injection device 5 according to the temperature data to keep the temperature in the storage area constant.

[0031] When the storage rack 8 needs to be disassembled, the user rotates the adjusting block 10, which moves the square block 11. As the square block 11 moves, it moves the wedge block 134 into the inner cavity of the cavity 131. The wedge block 134 moves the movable plate 132, which in turn compresses the spring 133. When the wedge block 134 is fully inside the cavity 131, the square block 11 can be disengaged from the inner cavity of the limiting groove 12, making it easier for the user to remove the storage rack 8.

[0032] It should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

[0033] Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Those skilled in the art to which this invention pertains can make various modifications and refinements without departing from the spirit and scope of the present invention. Therefore, the scope of protection of this invention shall be determined by the claims.

Claims

1. A high-efficiency constant-temperature adipose tissue cryogenic storage device, comprising a shell (1), characterized in that: The inner cavity of the shell (1) is provided with a partition (2), and a copper tube (3) is provided on the opposite side of the shell (1) and the partition (2). A fixing block (4) is provided at the bottom of the inner cavity of the shell (1), and a liquid nitrogen injection device (5) is provided at the top of the fixing block (4). A nozzle (6) is connected to the top of the liquid nitrogen injection device (5). A driving mechanism (7) is provided inside the fixing block (4). A storage rack (8) is provided in the inner cavity of the shell (1). Support blocks (9) are slidably connected to both sides of the storage rack (8). One side of the support block (9) is fixedly connected to the partition (2). Adjustment blocks (10) are rotatably connected to both sides of the top of the storage rack (8). A square block (11) is fixedly connected to the bottom of the adjustment block (10). A limit groove (12) is opened on the top of the support block (9). A locking structure (13) is provided in the inner cavity of the square block (11). Temperature sensors (14) are fixedly connected to both sides of the inner cavity of the partition (2).

2. The high-efficiency constant-temperature adipose tissue cryogenic storage device according to claim 1, characterized in that: The drive mechanism (7) includes a groove (71) opened on the top of the fixed block (4). The inner cavity of the groove (71) is rotatably connected to a threaded rod (72). The surface of the threaded rod (72) is threadedly connected to a threaded block (73). The top of the threaded block (73) is fixedly connected to the liquid nitrogen injection device (5). One end of the threaded rod (72) extends through to the outside of the fixed block (4) and is fixedly connected to a motor (74). One side of the motor (74) is fixedly connected to the partition (2).

3. The high-efficiency constant-temperature adipose tissue cryogenic storage device according to claim 1, characterized in that: The locking structure (13) includes two cavities (131) opened inside the square block (11). A movable plate (132) is slidably connected to the inner cavity of the cavity (131). A spring (133) is fixedly connected to one side of the movable plate (132). One end of the spring (133) is fixedly connected to the square block (11). A wedge block (134) is fixedly connected to one side of the movable plate (132). Positioning grooves (135) are opened on both sides of the inner cavity of the limiting groove (12).

4. The high-efficiency constant-temperature adipose tissue cryogenic storage device according to claim 1, characterized in that: The top of the fixed block (4) is provided with sliding grooves (15) on both sides. The inner cavity of the sliding groove (15) is slidably connected to a slider (16). The top of the slider (16) is fixedly connected to the liquid nitrogen injection device (5).

5. The high-efficiency constant-temperature adipose tissue cryogenic storage device according to claim 1, characterized in that: The four corners of the bottom of the housing (1) are fixedly connected with legs (17), and the four legs (17) are arranged symmetrically.

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