Cell filtration collection bag

Abstract

This utility model relates to the field of biological cell collection technology and discloses a cell filter collection bag, including a collection bag body. The upper end of the collection bag body is provided with an inlet pipe and an air pipe, and the lower end of the collection bag body is connected to an outlet. The lower end of the outlet is connected to an outlet pipe through a connecting mechanism, and a filter screen is provided inside the outlet. The connecting mechanism includes a fixing seat, which is fixedly sleeved on the lower outer wall of the outlet. An installation plate is sleeved on the upper outer wall of the outlet pipe, and a plurality of connecting posts are symmetrically arranged on the top circumference of the installation plate. This utility model uses the movement of the driving block in the connecting mechanism within the adjustment groove to drive the fixing plate and the driving ring to rotate, causing the part of the fixing plate that is stuck in the slot to move out, releasing the restriction on the connecting posts, thereby quickly separating the outlet and the outlet pipe to replace the filter screen. At the same time, the control valve two closes the lower opening of the collection bag to avoid internal exposure during disassembly and damage to the sterile environment, reducing the risk of cell suspension contamination.

Description

Technical Field

[0001] This utility model relates to the field of biological cell collection technology, and in particular to a cell filtration and collection bag. Background Technology

[0002] Bioreactors are a very important piece of equipment in the field of bioengineering. They can use biochemical reactions within organisms to produce chemicals, drugs, enzymes, and other biological products. When collecting cell suspensions from bioreactors, if they are not filtered, large cell clumps will enter downstream processes, such as continuous flow centrifuges. Filtration is generally required by filtering the cell suspension through a cell filter screen installed at the mouth of the centrifuge bottle under open conditions in a biosafety cabinet.

[0003] Referring to the patent with announcement number CN222348996U, a cell filtration collection bag is disclosed. The cell filtration collection bag provided by this utility model, by setting up a collection bag body, a feed pipe, a filter screen, a discharge pipe, a first control valve, a second control valve, an air pipe and a microfiltration cartridge, can realize continuous and closed operation of cell suspension, reducing the risk of microbial contamination of cell suspension.

[0004] However, during the use of the above-mentioned collection bag, when using the flat filter screen for filtration, the filter screen will gradually become clogged and blocked by the filter material with continuous use, thus affecting the filtration effect. Therefore, it is necessary to disassemble and replace it. However, the filter screen in the above-mentioned device is installed and fixed in a fixed manner, which makes it inconvenient to quickly disassemble and replace the filter screen. Utility Model Content

[0005] In view of the problem that the existing cell filtration collection bag uses a flat-type fixed filter screen, which is inconvenient to disassemble and replace when it needs to be removed and replaced after being clogged by the filtered material, this utility model is proposed.

[0006] To solve the above technical problems, the present invention provides the following technical solution: a cell filtration collection bag, comprising a collection bag body, an inlet pipe and an air pipe at the upper end of the collection bag body, an outlet connected to the lower end of the collection bag body, an outlet pipe connected to the lower end of the outlet through a connecting mechanism, and a filter screen provided inside the outlet;

[0007] The connecting mechanism includes a fixed base, which is fixedly sleeved on the lower outer wall of the discharge port. An installation plate is sleeved on the upper outer wall of the discharge pipe, and several connecting posts are symmetrically arranged on the top circumference of the installation plate.

[0008] As a preferred embodiment, the connecting mechanism further includes a fixing plate. The fixing base has a cavity inside, and the fixing plate is rotatably installed in the cavity. A drive ring is fixedly installed on the top of the fixing plate. A torsion spring is provided inside the cavity on the inner side of the drive ring, and both ends of the torsion spring are fixedly connected to the inner wall of the cavity and the drive ring, respectively. A plurality of limiting grooves are symmetrically provided on the top of the fixing plate. The upper end of the connecting column passes through the limiting groove. A slot is provided on the outer wall of the connecting column at one end of the inner wall corresponding to the limiting groove. An adjustment groove communicating with the cavity is provided on the outer wall of the fixing base. A drive block is provided in the adjustment groove, and one end of the drive block is fixedly connected to the fixing plate.

[0009] As a preferred embodiment, the fixing base, mounting plate, and fixing plate are all annular, the cross-section of the combined structure of the fixing plate and the drive ring is inverted T-shaped, and the upper end of the drive ring is in contact with the top wall of the cavity.

[0010] As a preferred embodiment, the limiting groove is concentric with the fixing plate, the bottom of the fixing seat has a through hole adapted to the connecting column at the corresponding position, and a sealing ring is embedded between the discharge port and the discharge pipe.

[0011] As a preferred embodiment, the inner walls of the discharge port and the discharge pipe at opposite ends are respectively provided with mounting grooves, and the two ends of the filter screen are respectively located in the mounting grooves provided on the discharge port and the discharge pipe.

[0012] As a preferred embodiment, the feed pipe and the discharge port are respectively equipped with control valve one and control valve two, the air pipe is equipped with a microfiltration element, and the discharge pipe is equipped with control valve three.

[0013] Compared with the prior art, the present invention has at least the following beneficial effects:

[0014] 1. This utility model, through a connecting mechanism, allows the driving block to move within the adjusting groove, causing the driving block to drive the fixed plate and driving ring to rotate synchronously. This causes the limiting groove on the fixed plate to move synchronously, resulting in the portion of the fixed plate that was inserted into the groove being removed from the groove. This releases the fixed plate's restriction on the connecting column, allowing the discharge port to be pulled down and the connecting column to be separated from the fixed base. This enables the filter screen to be disassembled, facilitating quick and easy separation of the discharge port from the discharge pipe for rapid filter screen removal and replacement. It is convenient to use and has enhanced practicality.

[0015] 2. By using the second control valve, this utility model can close the lower opening of the collection bag body when disassembling and replacing the filter screen, thereby preventing the inside of the collection bag body from being exposed, which would damage the sterile environment and increase the risk of cell suspension contamination. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0017] Figure 2 This is a partial cross-sectional structural diagram of the material outlet and the material outlet pipe of this utility model;

[0018] Figure 3 This is a schematic diagram of the structure between the fixing plate and the mounting plate of this utility model;

[0019] Figure 4 This is a schematic diagram of the structure between the fixed base, the drive block, and the adjustment groove of this utility model.

[0020] Explanation of reference numerals in the attached figures:

[0021] 1. Collection bag body; 2. Feed pipe; 3. Control valve one; 4. Discharge port; 5. Control valve two; 6. Discharge pipe; 7. Control valve three; 8. Filter screen; 9. Air pipe; 10. Microfiltration cartridge; 11. Fixing base; 12. Mounting plate; 13. Connecting column; 14. Fixing plate; 15. Drive ring; 16. Limiting groove; 17. Slot; 18. Torsion spring; 19. Sealing ring; 20. Drive block; 21. Adjustment groove. Detailed Implementation

[0022] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings.

[0023] Reference Figures 1-4 As shown, a cell filtration collection bag is provided, including a collection bag body 1. The upper end of the collection bag body 1 is provided with an inlet pipe 2 and an air pipe 9. The lower end of the collection bag body 1 is connected to an outlet 4. The lower end of the outlet 4 is connected to an outlet pipe 6 through a connecting mechanism. A filter screen 8 is provided inside the outlet 4; it can realize the filtration and collection functions of cell suspension.

[0024] The connecting mechanism includes a fixed base 11, which is fixedly sleeved on the lower outer wall of the discharge port 4. An installation plate 12 is sleeved on the upper outer wall of the discharge pipe 6, and a number of connecting posts 13 are symmetrically arranged on the top circumference of the installation plate 12; providing a structural basis for the quick connection between the discharge pipe 6 and the discharge port 4.

[0025] In this example, the connecting mechanism also includes a fixing plate 14. The fixing seat 11 has a cavity inside, and the fixing plate 14 is rotatably installed in the cavity. A drive ring 15 is fixedly installed on the top of the fixing plate 14. A torsion spring 18 is provided inside the cavity on the inner side of the drive ring 15, and the two ends of the torsion spring 18 are fixedly connected to the inner wall of the cavity and the drive ring 15, respectively. Several limiting grooves 16 are symmetrically provided on the top of the fixing plate 14. The upper end of the connecting column 13 passes through the limiting groove 16. A slot 17 is provided on the inner wall of the outer wall of the connecting column 13 corresponding to one end of the limiting groove 16. An adjustment groove 21 communicating with the cavity is provided on the outer wall of the fixing seat 11. A drive block 20 is provided in the adjustment groove 21, and one end of the drive block 20 is fixedly connected to the fixing plate 14. The mechanical linkage structure enables quick disassembly and assembly of the discharge pipe 6 and the discharge port 4, thereby facilitating the quick disassembly and replacement of the filter screen 8 and improving work efficiency.

[0026] In this example, the fixed base 11, the mounting plate 12, and the fixed plate 14 are all annular. The cross-section of the combined structure of the fixed plate 14 and the drive ring 15 is inverted T-shaped, and the upper end of the drive ring 15 is in contact with the top wall of the cavity. This ensures the structural stability and sealing during connection. The fixed plate 14 and the drive ring 15 work together to limit the movement in the lateral and vertical directions.

[0027] In this example, the limiting groove 16 is concentric with the fixing plate 14, and the bottom of the fixing base 11 is provided with a through hole that matches the connecting column 13. A sealing ring 19 is embedded between the discharge port 4 and the discharge pipe 6; liquid leakage is prevented through precise positioning and sealing design.

[0028] In this example, the inner walls of the outlet 4 and the outlet pipe 6 are respectively provided with mounting grooves at opposite ends, and the two ends of the filter screen 8 are respectively located in the mounting grooves provided on the outlet 4 and the outlet pipe 6; so that the filter screen 8 can be disassembled and quickly replaced, and the filter screen 8 is limited and fixed by the mounting grooves on the outlet 4 and the outlet pipe 6.

[0029] In this example, control valve 3 and control valve 5 are respectively installed on the feed pipe 2 and the discharge port 4, microfiltration element 10 is installed on the air pipe 9, and control valve 7 is installed on the discharge pipe 6; closed aseptic operation is achieved through multiple valve control and sterilization design.

[0030] During use, when it is necessary to connect the discharge port 4 and the discharge pipe 6, push the drive block 20 to drive the connecting fixed plate 14 and drive ring 15 to rotate, so that the drive ring 15 torsion spring 18. Then, align the connecting post 13 on the mounting plate 12 with the through hole at the bottom of the fixed base 11 and insert it until the connecting post 13 passes through the limiting groove 16. At this time, under the action of the torsion spring 18, part of the structure on the fixed plate 14 is inserted into the slot 17 of the connecting post 13, so as to achieve a stable connection between the discharge pipe 6 and the discharge port 4. The sealing ring 19 ensures that the connection is sealed and prevents cell suspension leakage.

[0031] The cell suspension enters the collection bag body 1 through the feed pipe 2. Control valve 1 3 and control valve 2 5 are opened, and control valve 3 7 is closed. The cell suspension is temporarily stored in the collection bag body 1. Excess air is discharged through the micro-filter cartridge 10 on the air pipe 9 to achieve sterilization. Subsequently, control valve 3 7 is opened, and the cell suspension is filtered through the filter screen 8 in the discharge port 4. After intercepting larger cell clumps, it is discharged from the discharge pipe 6 to enter the downstream process.

[0032] When the filter screen 8 is clogged and needs to be replaced, push the drive block 20 to move in the adjustment groove 21. The drive block 20 drives the fixing plate 14 and the drive ring 15 to rotate synchronously, so that the part of the fixing plate 14 that is stuck in the slot 17 is removed, releasing the restriction on the connecting column 13. Pull down the discharge pipe 6, separate the connecting column 13 from the fixing seat 11, take out the old filter screen 8, and embed both ends of the new filter screen 8 into the installation grooves of the discharge port 4 and the discharge pipe 6. Reverse the operation to complete the reconnection.

[0033] Before disassembling and replacing filter screen 8, close control valve 2 5 and cut off the lower passage of collection bag body 1 to avoid internal exposure, maintain a sterile environment, and reduce the risk of cell suspension contamination.

[0034] It should be noted that the above embodiments are only used to illustrate the technical solution of this utility model and are not intended to limit it. Although this utility model has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications or substitutions should be covered within the scope of the claims of this utility model.

Claims

1. A cell filtration collection bag comprising a collection bag body (1), characterized in that: The upper end of the collection bag body (1) is provided with a feed pipe (2) and an air pipe (9), the lower end of the collection bag body (1) is connected to a discharge port (4), the lower end of the discharge port (4) is connected to a discharge pipe (6) through a connecting mechanism, and a filter screen (8) is provided inside the discharge port (4). The connecting mechanism includes a fixed seat (11), which is fixedly sleeved on the lower outer wall of the discharge port (4). The upper outer wall of the discharge pipe (6) is sleeved with an installation plate (12), and the top of the installation plate (12) is symmetrically provided with several connecting columns (13).

2. A cell filtration collection bag according to claim 1, wherein: The connecting mechanism also includes a fixing plate (14), the fixing seat (11) has a cavity inside, the fixing plate (14) is rotatably installed in the cavity, the top of the fixing plate (14) is fixedly installed with a drive ring (15), the inner side of the drive ring (15) is provided with a torsion spring (18) in the cavity, and the two ends of the torsion spring (18) are fixedly connected to the inner wall of the cavity and the drive ring (15) respectively. The top of the fixing plate (14) is symmetrically provided with several limiting grooves (16), the upper end of the connecting column (13) passes through the limiting groove (16), the outer wall of the connecting column (13) is provided with a slot (17) at one end of the inner wall of the limiting groove (16), the outer wall of the fixing seat (11) is provided with an adjustment groove (21) communicating with the cavity, the adjustment groove (21) is provided with a drive block (20), and one end of the drive block (20) is fixedly connected to the fixing plate (14).

3. A cell filtration collection bag according to claim 2, wherein: The fixed base (11), mounting plate (12) and fixed plate (14) are all annular. The cross-section of the combined structure of fixed plate (14) and drive ring (15) is inverted T-shaped, and the upper end of drive ring (15) is in contact with the top wall of the cavity.

4. A cell filtration collection bag according to claim 3, wherein: The limiting groove (16) is concentric with the fixing plate (14). The bottom of the fixing seat (11) is provided with a through hole that is compatible with the connecting column (13). A sealing ring (19) is embedded between the discharge port (4) and the discharge pipe (6).

5. A cell filtration collection bag according to claim 4, wherein: The discharge port (4) and the discharge pipe (6) are respectively provided with installation grooves on the inner walls of opposite ends, and the two ends of the filter screen (8) are respectively located in the installation grooves opened on the discharge port (4) and the discharge pipe (6).

6. A cell filtration collection bag according to claim 2, wherein: The feed pipe (2) and the outlet (4) are respectively equipped with control valve one (3) and control valve two (5), the air pipe (9) is equipped with microfiltration filter element (10), and the outlet pipe (6) is equipped with control valve three (7).

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