A nucleic acid quantitative detection device experimental module

Abstract

The utility model relates to nucleic acid detection field discloses a nucleic acid quantitative detection device experiment module, including shell, the placing rack that sets up in shell, the placing hole that sets up in the placing rack, the amplification structure that sets up in shell, the detection component that sets up in the shell below the placing rack and be used for the drive component that drives detection component to move, drive component includes the drive motor that sets up in the shell below the placing rack, the screw rod that can rotate with the output shaft of drive motor together and set up the slider on the screw rod and move along the axial movement of screw rod with the rotation of screw rod, the slider top surface sets up one with slider fixed mounting block, and detection component is detachably set up on mounting block through detachable component, and the movement of detection component can be realized through the movement of slider, thereby realizes the detection of detection component to test tube, reduces the probability that drive component is damaged due to the reaction force that detection component produces to drive component, improves the service life of drive component.

Description

Technical Field

[0001] This utility model relates to the field of nucleic acid detection, and in particular to an experimental module for a nucleic acid quantitative detection device. Background Technology

[0002] Chinese Patent No. CN109929751B discloses a fluorescence quantitative amplification detector, including a housing, a nucleic acid amplification module disposed within the housing, an XY-axis linear module disposed at the bottom of the housing, two fluorescence detection modules with different wavelengths disposed side by side at the output end of the XY-axis linear module, a control panel disposed on the front of the housing for controlling the working status of the nucleic acid amplification module, the fluorescence detection module, and the XY-axis linear module, and displaying detection data. The XY-axis linear module includes a drive motor, a drive pulley disposed on the output shaft of the drive motor, a driven pulley driven by the drive pulley, and a transmission belt disposed between the drive pulley and the driven pulley for realizing the transmission between the two. One end of the fluorescence detection module is perpendicularly connected to the transmission belt.

[0003] In the above structure, one end of the fluorescence detection module is perpendicularly connected to the transmission belt, allowing the fluorescence detection module to move under the drive of the transmission belt. However, when the transmission belt moves the fluorescence detection module, the fluorescence detection module will apply a force to the transmission belt in the opposite direction of the transmission belt's movement, thereby pulling the transmission belt and causing it to shift towards the fluorescence detection module. At this time, the side wall of the transmission belt will rub against the side wall of the pulley, resulting in a reduction in the service life of the transmission belt. Utility Model Content

[0004] This invention addresses the drawback of existing technologies where, when a transmission belt drives a fluorescence detection module, the fluorescence detection module pulls the transmission belt towards the fluorescence conveyor belt, causing the sidewall of the transmission belt to rub against the sidewall of the pulley during rotation, thus affecting the service life of the transmission belt. This invention provides an experimental module for a nucleic acid quantitative detection device.

[0005] To solve the above-mentioned technical problems, the present invention provides a solution through the following technical method:

[0006] An experimental module for a nucleic acid quantitative detection device includes a shell, a placement rack inside the shell, a plurality of placement holes for placing test tubes arranged in parallel at intervals inside the placement rack, an amplification structure inside the shell for amplifying the analyte in the test tube, a detection component inside the shell below the placement rack for detecting the substance in the test tube, and a driving component for driving the detection component to move along the arrangement direction of the plurality of test tubes. The driving component includes a drive motor inside the shell below the placement rack, a lead screw that can rotate with the output shaft of the drive motor, and a slider on the lead screw that moves along the axial direction of the lead screw as the lead screw rotates. A mounting block fixed to the slider is provided on the top surface of the slider, and the detection component is detachably mounted on the mounting block by a detachable component.

[0007] The above scheme uses a drive motor to move the slider along the axial direction of the lead screw. When the slider moves along the axial direction of the lead screw, the mounting block on top of the slider moves with it. Since the detection component is mounted on the mounting block, it moves along the bottom of the placement rack with the slider, thus detecting the test tubes placed inside the rack. The movement of the slider enables the horizontal movement of the detection component within the housing to detect the test tubes, thereby reducing the probability of damage to the drive component due to the reaction force generated by the detection component when driving the detection component. This improves the service life of the drive component. Furthermore, the detection component is detachably mounted on the mounting block, making it easy for the operator to remove the detection component from the mounting block for inspection or replacement if it malfunctions.

[0008] Preferably, the detection component includes a detector, and the detachable component includes a mounting slot on the mounting block for inserting the detector, a vertical anti-detachment component between the mounting slot and the detector for preventing the detector from vertically detaching from the mounting slot, and a horizontal anti-detachment component for preventing the detector from horizontally detaching from the mounting slot.

[0009] Preferably, the vertical anti-detachment component has horizontally extending grooves on both sides of the mounting groove and sliding blocks protruding on both sides of the detector that can slide horizontally into the grooves and limit the detector from vertically detaching from the mounting groove.

[0010] With the above scheme, the sliding blocks set on both sides of the detector can slide horizontally into the sliding grooves on both sides of the mounting slot when the detector needs to be installed on the mounting block. After the sliding blocks are horizontally inserted into the sliding grooves, the vertical movement of the sliding blocks will be restricted by the inner wall of the sliding grooves, thereby reducing the probability of the detector being vertically removed from the mounting slot.

[0011] Preferably, the horizontal anti-detachment component includes a receiving groove respectively provided on the inner wall of the two sliding grooves. A limiting block is telescopically provided in the receiving groove. The sliding blocks on both sides of the detector are provided with limiting grooves for the limiting block to be inserted and restrict the movement of the sliding block in the sliding groove when the detector moves to a designated position in the mounting groove. An elastic component for driving the limiting block to extend out of the receiving groove is provided in the receiving groove. An unlocking component for driving the limiting block to disengage from the limiting groove is provided on the mounting block.

[0012] Using the above scheme, the telescopically adjustable limiting block installed in the storage slot can insert into the limiting groove on the sliding block when the detector moves to a designated position in the mounting slot, restricting the sliding block from moving in the groove, thereby reducing the probability of the detector horizontally detaching from the mounting slot. The elastic component installed in the storage slot can drive the limiting block to extend out of the storage slot. At the same time, the elastic component can also drive the limiting block to remain partially extended out of the storage slot under normal conditions, so that the limiting block remains inserted in the limiting groove after being inserted. The unlocking component can release the limiting block's restriction on the sliding block's movement when the detector needs to be removed from the mounting block, allowing the detector to slide horizontally out of the mounting slot.

[0013] Preferably, the elastic component includes a spring disposed between the receiving groove and the limiting block, with both ends abutting against both.

[0014] Using the above solution, the spring installed between the storage slot and the limiting block can drive the limiting block to extend into the storage slot, and at the same time, it can also keep the limiting block partially extending out of the storage slot under normal conditions.

[0015] Preferably, the unlocking component includes a through groove on the mounting block that is connected to the storage groove and is smaller in size than the storage groove, and a pull rod that is slidably disposed in the through groove, with one end passing through the through groove and connected to the limiting block.

[0016] Using the above scheme, the pull rod that slides in the groove can drive the limiting block to come out of the limiting groove on the sliding block when the detector needs to be removed from the mounting block. At this time, the sliding block can slide horizontally in the groove, thereby realizing the disassembly and assembly of the detector and the mounting block.

[0017] Preferably, the amplification structure includes a heating plate disposed on the top of the placement rack to heat the test sample located at the top of the test tube, a heating ring disposed in each placement hole near the bottom of the test tube to heat the test sample located at the bottom of the test tube at a temperature higher than that of the test sample located at the top of the test tube, and heat dissipation components disposed on both sides of the placement rack to dissipate heat from the test sample between the heating plate and the heating ring.

[0018] Using the above scheme, the heating ring set near the bottom of the test tube at the placement hole can heat the test substance inside the test tube. The heated test substance will move to the top of the test tube due to the heat. As the heated test substance rises, the heat dissipation component will dissipate heat from the test tube, thereby realizing the internal circulation of the test substance inside the test tube, and finally realizing the amplification of the test substance inside the test tube, which facilitates the subsequent detection component to detect the substances inside the test tube.

[0019] Preferably, the heat dissipation component includes heat sinks respectively provided on both sides of the placement frame and a heat dissipation fan provided on the side of the heat sink away from the placement frame to improve the heat dissipation efficiency of the heat sink, and the outer casing is provided with ventilation openings to enable air circulation between the inside and outside of the outer casing.

[0020] Using the above scheme, the heat sinks on both sides of the placement rack can dissipate heat from the test tubes placed in the placement holes, thereby allowing the test material inside the test tubes to circulate internally and ultimately achieve amplification. The cooling fan can improve the heat dissipation efficiency of the heat sinks.

[0021] This utility model, by adopting the above technical solution, has significant technical effects: the drive motor can drive the slider to move along the axial direction of the lead screw, and when the slider moves along the axial direction of the lead screw, the mounting block set on the top of the slider will move with the slider. Since the detection component is set on the mounting block, the detection component will move at the bottom of the placement rack with the movement of the slider, thereby detecting the test tubes placed in the placement rack. The movement of the slider can realize the horizontal movement of the detection component in the shell to detect the test tubes placed in the placement rack, thereby reducing the probability of damage to the drive component due to the reaction force generated by the detection component on the drive component when driving the detection component to move, thereby improving the service life of the drive component. At the same time, the detection component is installed on the mounting block by a detachable component, so that when the detection component fails, the operator can easily remove the detection component from the mounting block for inspection or replacement. Attached Figure Description

[0022] Figure 1 This is an isometric view of an experimental module of a nucleic acid quantitative detection device in this embodiment;

[0023] Figure 2 This is an isometric view of the placement rack, amplification structure, driving component, and detection component in this embodiment;

[0024] Figure 3 This is an isometric view of the heating plate and the placement frame in this embodiment;

[0025] Figure 4 This is an isometric view of the frame placed in this embodiment;

[0026] Figure 5This is an isometric view of the driving component and the detector in this embodiment;

[0027] Figure 6 yes Figure 5 Enlarged view of point A in the middle;

[0028] Figure 7 This is an isometric view of the red drive component in this embodiment;

[0029] Figure 8 yes Figure 7 Enlarged view of point B in the middle;

[0030] Figure 9 This is a cross-sectional view of the driving component and the detector in this embodiment;

[0031] Figure 10 yes Figure 9 Enlarged view of point C in the middle.

[0032] The parts referred to by the numbers in the above attached diagrams are as follows: 1. Outer shell; 2. Placement rack; 3. Placement hole; 4. Drive motor; 5. Lead screw; 6. Slider; 7. Mounting block; 8. Detector; 9. Mounting groove; 10. Slide groove; 11. Sliding block; 12. Storage groove; 13. Limiting block; 14. Limiting groove; 15. Spring; 16. Through groove; 17. Pull rod; 18. Heating plate; 19. Heating ring; 20. Heat sink; 21. Cooling fan; 22. Vent; 23. Guide slope. Detailed Implementation

[0033] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments.

[0034] Example

[0035] An experimental module for a nucleic acid quantitative detection device includes a housing 1, a placement rack 2 inside the housing 1, a plurality of placement holes 3 arranged parallel to each other inside the placement rack 2 for placing test tubes, an amplification structure inside the housing 1 for amplifying the analyte in the test tubes, a detection component inside the housing 1 below the placement rack 2 for detecting the substance in the test tubes, and a driving component for moving the detection component along the arrangement direction of the plurality of test tubes. The driving component includes a drive motor 4 inside the housing 1 below the placement rack 2, a lead screw 5 that can rotate with the output shaft of the drive motor 4, and a slider 6 on the lead screw 5 that moves along the axial direction of the lead screw 5 as the lead screw 5 rotates. A mounting block 7 fixed to the slider 6 is provided on the top surface of the slider 6, and the detection component is detachably mounted on the mounting block 7 by a detachable component.

[0036] The detection component includes a detector 8, and the detachable component includes a mounting groove 9 provided on the mounting block 7 for the detector 8 to be inserted, a vertical anti-detachment component provided between the mounting groove 9 and the detector 8 to prevent the detector 8 from vertically detaching from the mounting groove 9, and a horizontal anti-detachment component to prevent the detector 8 from horizontally detaching from the mounting groove 9.

[0037] The vertical anti-detachment component includes horizontally extending grooves 10 on both sides of the mounting groove 9 and sliding blocks 11 protruding on both sides of the detector 8 that can slide horizontally into the grooves 10 and limit the detector 8 from vertically detaching from the mounting groove 9.

[0038] The horizontal anti-detachment component includes a receiving groove 12 respectively provided on the inner wall of the two sliding grooves 10. A limiting block 13 is telescopically provided in the receiving groove 12. The sliding blocks 11 on both sides of the detector 8 are provided with limiting grooves 14 for the limiting block 13 to be inserted and restrict the movement of the sliding block 11 in the sliding groove 10 when the detector 8 moves to a designated position in the mounting groove 9 (i.e., the position when one end of the detector 8 abuts against the bottom of the mounting groove 9). An elastic component is provided in the receiving groove 12 for driving the limiting block 13 to extend out of the receiving groove 12. In this embodiment, the limiting block 13 is located at the end away from the receiving groove 12. An inlet ramp 23 is provided to allow the limiting block 13 to automatically retract into the storage groove 12 during the installation of the detector 8 to the mounting block 7. The mounting block 7 is provided with an unlocking component for driving the limiting block 13 out of the limiting groove 14. The elastic component includes a spring 15 provided between the storage groove 12 and the limiting block 13, with both ends abutting against the two respectively. The unlocking component includes a through groove 16 provided on the mounting block 7 that is connected to the storage groove 12 and is smaller in size than the storage groove 12. A pull rod 17 is slidably provided in the through groove 16, with one end passing through the through groove 16 and connected to the limiting block 13.

[0039] The amplification structure includes a heating plate 18 installed at the top of the placement rack 2 to heat the test sample located at the top of the test tube; a heating ring 19 installed in each placement hole 3 near the bottom of the test tube to heat the test sample located at the bottom of the test tube at a temperature higher than that of the test sample located at the top of the test tube; and heat dissipation components installed on both sides of the placement rack 2 to dissipate heat from the test sample between the heating plate 18 and the heating ring 19. The heat dissipation components include heat sinks 20 installed on both sides of the placement rack 2 and a cooling fan 21 installed on the side of the heat sinks 20 away from the placement rack 2 to improve the heat dissipation efficiency of the heat sinks 20. The outer shell 1 is provided with a vent 22 to allow air circulation between the inside and outside of the outer shell 1.

[0040] Specific disassembly and assembly process: When the detector 8 needs to be installed on the mounting block 7, firstly, insert the sliding blocks 11 on both sides of the detector 8 into the sliding grooves 10 on the mounting block 7. During the installation of the sliding blocks 11 into the sliding grooves 10, the sliding blocks 11 will abut against the guide slope 23 on the limiting block 13. As the sliding blocks 11 continue to go deeper, the sliding blocks 11 will squeeze the guide slope 23, causing the limiting block 13 to automatically retract into the receiving groove 12 and squeeze the spring 15, causing the spring 15 to be compressed. Then, when one end of the detector 8 abuts against the bottom of the mounting groove 9... At this time, the limiting groove 14 set on the sliding block 11 will be directly opposite the limiting block 13. At this time, the spring 15 compressed by the force will return to its original state, thereby pushing the limiting block 13 to insert into the limiting groove 14, restricting the sliding block 11 from moving in the slide groove 10, thereby reducing the probability of the detector 8 falling off the mounting block 7. When the detector 8 needs to be removed from the mounting block 7, first pull the pull rod 17, so that the pull rod 17 drives the limiting block 13 to fall off from the limiting groove 14. At this time, the sliding block 11 will slide horizontally out of the slide groove 10, and the detector 8 can be removed from the mounting block 7.

[0041] The specific detection process is as follows: The heating ring 19 heats the bottom of the test tube, causing the heated test sample to rise. During the rise of the test sample, the heat sink 20 and the cooling fan 21 dissipate heat from the test tube, thereby reducing the temperature of the test sample in the middle of the test tube. This achieves internal circulation of the test sample within the test tube, thus amplifying the test sample. Afterward, the drive motor 4 is started, causing the drive motor 4 to drive the lead screw 5 to rotate. At this time, the lead screw 5 will drive the slider 6 to move along the axis of the lead screw 5, thereby causing the slider 6 to drive the detector 8 to move along the axis of the lead screw 5, so that the detector 8 can detect the test tube placed in the placement rack 2.

[0042] The above description is merely a preferred embodiment of this utility model. The protection scope of this utility model is not limited to the above embodiments. All technical solutions falling within the scope of this utility model's concept are protected. It should be noted that for those skilled in the art, any improvements and modifications made without departing from the principle of this utility model should also be considered within the protection scope of this utility model.

Claims

1. An experimental module for a nucleic acid quantitative detection device, comprising a shell (1), a placement rack (2) disposed inside the shell (1), a plurality of placement holes (3) for placing test tubes arranged in parallel at intervals inside the placement rack (2), an amplification structure disposed inside the shell (1) for amplifying the analyte in the test tube, a detection component disposed below the placement rack (2) inside the shell (1) for detecting the substance in the test tube, and a driving component for driving the detection component to move along the arrangement direction of the plurality of test tubes, characterized in that: The driving component includes a drive motor (4) disposed inside the housing (1) below the placement frame (2), a lead screw (5) that can rotate with the output shaft of the drive motor (4), and a slider (6) disposed on the lead screw (5) that moves along the axial direction of the lead screw (5) as the lead screw (5) rotates. A mounting block (7) is disposed on the top surface of the slider (6) and is fixed to the slider (6). The detection component is detachably disposed on the mounting block (7) by means of a detachable component.

2. The experimental module of a nucleic acid quantitative detection device according to claim 1, characterized in that: The detection component includes a detector (8), and the detachable component includes a mounting groove (9) provided on the mounting block (7) for the detector (8) to be inserted, a vertical anti-detachment component provided between the mounting groove (9) and the detector (8) to prevent the detector (8) from vertically detaching from the mounting groove (9), and a horizontal anti-detachment component to prevent the detector (8) from horizontally detaching from the mounting groove (9).

3. The experimental module of a nucleic acid quantitative detection device according to claim 2, characterized in that: The vertical anti-detachment component has a horizontally extending groove (10) on both sides of the mounting groove (9) and a sliding block (11) protruding on both sides of the detector (8) that can slide horizontally into the groove (10) and limit the detector (8) from vertically detaching from the mounting groove (9).

4. The experimental module of a nucleic acid quantitative detection device according to claim 3, characterized in that: The horizontal anti-detachment component includes a storage groove (12) respectively provided on the inner wall of the two sliding grooves (10). A limiting block (13) is telescopically provided in the storage groove (12). The sliding blocks (11) on both sides of the detector (8) are provided with a limiting groove (14) for the limiting block (13) to be inserted and the sliding block (11) to be restricted from moving in the sliding groove (10) when the detector (8) moves to the designated position in the mounting groove (9). The storage groove (12) is provided with an elastic component for driving the limiting block (13) to extend out of the storage groove (12). The mounting block (7) is provided with an unlocking component for driving the limiting block (13) to disengage from the limiting groove (14).

5. The experimental module of a nucleic acid quantitative detection device according to claim 4, characterized in that: The elastic component includes a spring (15) disposed between the receiving groove (12) and the limiting block (13), with its two ends respectively abutting against both.

6. The experimental module of a nucleic acid quantitative detection device according to claim 4, characterized in that: The unlocking component includes a through groove (16) provided on the mounting block (7) that is connected to the storage groove (12) and is smaller in size than the storage groove (12). A pull rod (17) is slidably provided in the through groove (16) with one end passing through the through groove (16) and connected to the limiting block (13).

7. The experimental module of a nucleic acid quantitative detection device according to claim 1, characterized in that: The amplification structure includes a heating plate (18) installed on the top of the placement rack (2) to heat the test sample located at the top of the test tube, a heating ring (19) installed in each placement hole (3) near the bottom of the test tube to heat the test sample located at the bottom of the test tube and the heating temperature is higher than that of the test sample located at the top of the test tube, and heat dissipation components installed on both sides of the placement rack (2) to dissipate heat from the test sample between the heating plate (18) and the heating ring (19).

8. The experimental module of a nucleic acid quantitative detection device according to claim 7, characterized in that: The heat dissipation component includes heat sinks (20) respectively provided on both sides of the placement frame (2) and a heat dissipation fan (21) provided on the side of the heat sink (20) away from the placement frame (2) to improve the heat dissipation efficiency of the heat sink (20). The outer shell (1) is provided with a vent (22) for realizing the air circulation between the inside and outside of the outer shell (1).

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