A laboratory pre-treatment solid phase extractor

Abstract

The utility model belongs to the field of laboratory pretreatment solid phase extraction, especially a kind of for laboratory pretreatment solid phase extractor, to the extraction of sample in the prior art, first, the test tube is placed in the test tube holder in glass jar, panel is placed in the top of glass jar, vacuum is extracted by vacuum pump, then extraction is carried out by multiple steps, however, panel is placed in the top of glass jar, and air leakage occurs easily in the vacuum process, reduces the vacuum effect problem, and the following scheme is presented, it includes vacuum pump and glass jar, the bottom of glass jar is fixedly provided with base, the top of glass jar is placed with panel, the sealing property between panel and glass jar can be improved by reinforcing mechanism and sealing ring, the vacuum effect is significantly improved, reinforcing mechanism can be easily rotated to suitable position by movable mechanism, cover in the upper side of panel edge, this rotating operation is simple and fast, need not complex tool or step, greatly save the preparation time before experiment.

Description

Technical Field

[0001] This utility model relates to the field of laboratory pretreatment solid-phase extraction technology, and in particular to a solid-phase extractor for laboratory pretreatment. Background Technology

[0002] Over the past two decades, solid-phase extraction (SPE) has emerged as a powerful tool for chemical separation and purification. From trace sample pretreatment to industrial-scale chemical separation, adsorbent extraction plays an increasingly important role in pharmaceuticals, fine chemicals, biomedicine, food analysis, organic synthesis, environmental applications, and other fields. SPE is a physical extraction process involving both liquid and solid phases. In SPE, the adsorption force of the solid phase on the separated analyte is greater than that of the solvent dissolving the analyte. When the sample solution passes through an adsorbent bed, the separated analyte concentrates on its surface, while other sample components pass through the adsorbent bed. By using adsorbents that adsorb only the separated analyte without adsorbing other sample components, high-purity and concentrated separated analytes can be obtained.

[0003] When extracting samples, the test tubes are first placed in a test tube rack in a glass jar, and the panel is placed on top of the glass jar. A vacuum pump is used to evacuate the sample, and then extraction is carried out through multiple steps. However, since the panel is placed on top of the glass jar, air leakage is likely to occur during the vacuuming process, which reduces the vacuum effect. Utility Model Content

[0004] The purpose of this invention is to address the shortcomings of existing technologies where, during sample extraction, test tubes are placed in a test tube rack within a glass jar, a panel is placed on top of the jar, a vacuum pump is used to create a vacuum, and extraction is performed through multiple steps. However, since the panel is placed on top of the jar, air leakage is likely to occur during the vacuuming process, reducing the vacuum effect. Therefore, this invention proposes a solid-phase extractor for laboratory sample preparation.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A solid-phase extractor for laboratory pretreatment includes a vacuum pump and a glass cylinder. A base is fixedly mounted on the bottom of the glass cylinder, and a panel is placed on the top of the glass cylinder. The panel is concave and has multiple circular holes. A guide tube is fixedly mounted on the inner wall of the circular holes, and a valve is fixedly mounted on the top of the guide tube. A solid-phase extraction column is inserted into the valve. A test tube rack is placed inside the glass cylinder. A reinforcing mechanism is provided on the base. When the panel is placed on the glass cylinder, the reinforcing mechanism can enhance the sealing between the panel and the glass cylinder.

[0007] To improve the ease of use of the reinforcement mechanism, a movable mechanism is also included, which allows the reinforcement mechanism to be rotated.

[0008] In one possible design, the reinforcement mechanism includes two L-plates, two threaded rods, and two pressure plates. Nuts are embedded in one side of each of the two L-plates. The two threaded rods are threadedly connected to the two nuts respectively. One side of each of the two pressure plates is slidably connected to the inner side of the two L-plates. A first bearing is fixedly installed on the top of each pressure plate. The bottom end of each threaded rod is fixedly connected to the inner wall of the inner ring of the first bearing. A knob is fixedly installed on the top of each threaded rod to facilitate its rotation.

[0009] In one possible design, the movable mechanism includes two hinge seats, the bottom of which is fixedly connected to the top two sides of the base respectively. A rotating shaft is fixedly provided on both sides of the bottom end of the L-plate. A second bearing is fixedly provided on the inner walls of both sides of the hinge seat. One end of the rotating shaft is fixedly connected to the inner wall of the inner ring of the second bearing.

[0010] In one possible design, a tube is fixedly installed on the bottom side of the glass cylinder and connected to it. A vacuum gauge and a pressure relief valve are installed on the tube. A connecting pipe is fixedly installed at one end of the tube, and one end of the connecting pipe is fixedly connected to the output port of the vacuum pump.

[0011] In one possible design, the inner side of the L-plate is provided with a T-shaped groove, and the inner wall of the groove is slidably connected to a matching T-shaped slider, one end of which is fixedly connected to one side of the lower pressure plate.

[0012] In one possible design, a sealing ring is fixedly provided on the top inner wall of the glass cylinder to improve the sealing between the glass cylinder and the panel.

[0013] In one possible design, the placement holes of the test tube rack correspond to the positions of the guide tubes.

[0014] In this application, during use, the test tube rack is placed in the glass jar, and the test tubes are placed in the test tube rack. The inverted concave panel is placed on top of the glass jar, with the edge of the panel roughly aligned with the top edge of the glass jar. The L-plates are rotated by hand to a suitable position so that the L-plates cover the edge of the panel. At this point, one side of the L-plate is aligned with the panel, and the lower pressure plate is above the panel. Rotating the knob causes the threaded rod to move downwards, driving the lower pressure plate to slide down along the groove on the inner side of the L-plate. When the lower pressure plate contacts the panel, continue rotating the knob to apply pressure to the panel, thereby enhancing the seal between the panel and the glass jar. The same method is used for the other L-plate and its matching reinforcing components. The solid-phase extraction column is inserted sequentially into the valve at the top of the guide tube on the panel, ensuring that the solid-phase extraction column is securely installed without any looseness. The number of solid-phase extraction (SPE) columns is the same as the number of test tubes in the test tube rack. The SPE columns are located on the valves of the flow guide tubes. According to the experimental requirements, the sample to be processed is added to the SPE columns. Unused valves are closed, and used valves are opened, allowing the sample to slowly pass through the SPE columns under gravity for solid-phase extraction. The extract will flow through the flow guide tube into the corresponding test tubes in the test tube rack inside the glass cylinder. The vacuum pump is started. After the vacuum pump is started, a negative pressure environment is formed inside the glass cylinder, thereby accelerating the flow of the sample in the SPE columns. During vacuum-assisted extraction, the vacuum level inside the glass cylinder can be monitored by observing the vacuum gauge. If the vacuum is too high or too low, the operating status of the vacuum pump can be adjusted appropriately according to the experimental requirements, or the pressure can be released through the pressure relief valve. It should be noted that the vacuum pump needs to be controlled by an external controller and powered by an external power source.

[0015] The beneficial effects of this utility model are as follows:

[0016] In this invention, a solid-phase extractor for laboratory pretreatment is described. Through a reinforcement mechanism, when the panel is placed on the glass cylinder, rotating the knob causes the threaded rod to slide the lower pressure plate down along the groove on the inner side of the L-plate until sufficient pressure is applied to the panel. This design tightly compacts the contact surface between the panel and the glass cylinder, effectively filling any possible micro-gaps, greatly reducing the risk of leakage, and significantly improving the vacuum effect. The sealing ring on the inner wall of the top of the glass cylinder complements the reinforcement mechanism, further enhancing the reliability of the seal. This double sealing ensures that a stable negative pressure environment can be formed inside the glass cylinder during vacuuming, providing ideal conditions for solid-phase extraction, ensuring efficient extraction, and improving the purity and quality of the extracted product. The type of valve can be selected according to actual needs.

[0017] In this utility model, the solid phase extractor for laboratory pretreatment can easily rotate the L-plate to a suitable position by means of a movable mechanism, a hinged seat and a rotating shaft, so as to cover the edge of the panel. This rotation operation is simple and quick, without the need for complicated tools or steps, which greatly saves the preparation time before the experiment.

[0018] In this invention, the sealing between the panel and the glass cylinder can be improved by the reinforcement mechanism and the sealing ring, which significantly enhances the vacuum effect. The reinforcement mechanism can be easily rotated to a suitable position by the movable mechanism to cover the edge of the panel. This rotation operation is simple and quick, without the need for complicated tools or steps, which greatly saves the preparation time before the experiment. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the main structure of a solid-phase extractor for laboratory pretreatment proposed in this utility model.

[0020] Figure 2 This is a bottom view of the panel structure of a laboratory pretreatment solid phase extractor proposed in this utility model.

[0021] Figure 3 This is a schematic diagram of the internal structure of a glass cylinder for a laboratory pretreatment solid-phase extractor proposed in this utility model.

[0022] Figure 4 This is a side view of the L-plate structure of a laboratory pretreatment solid-phase extractor proposed in this utility model.

[0023] Figure 5 This is a partial structural schematic diagram of a solid-phase extractor for laboratory pretreatment proposed in this utility model.

[0024] In the diagram: 1. Base; 2. Glass cylinder; 3. Panel; 4. Solid phase extraction column; 5. Valve; 6. L-plate; 7. Hinge seat; 8. Vacuum pump; 9. Threaded rod; 10. Connecting pipe; 11. Rotating shaft; 12. Guide tube; 13. Test tube rack; 14. Lower pressure plate; 15. First bearing; 16. Slide groove. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0026] In one embodiment: Refer to Figure 1-5A solid-phase extractor includes components such as a vacuum pump 8, a glass cylinder 2, a base 1, and a panel 3. The base 1 is securely mounted at the bottom of the glass cylinder 2 via adhesive or bolts, providing stable support for the entire device. The top of the glass cylinder 2 is designed as an open structure to house the panel 3. The panel 3 is concave, a shape that facilitates placement on top of the glass cylinder 2 and also helps prevent liquid spillage. Multiple evenly spaced circular holes are provided on the panel 3, each with a tightly fixed guide tube 12 on its inner wall. The guide tube 12 is made of corrosion-resistant and high-pressure-resistant material to ensure stable operation during experiments. A valve 5 is fixedly mounted at the top of the guide tube 12. The valve 5 has good sealing performance and can be manually opened and closed. A solid-phase extraction column 4 can be easily inserted into the valve 5. The selection of the solid-phase extraction column 4 depends on the experimental sample and extraction requirements; its connection with the valve 5 is tight to prevent liquid leakage.

[0027] Inside the glass jar 2, a test tube rack 13 is placed. The design of the test tube rack 13 takes into full consideration the positional correspondence with the guide tube 12. Its placement hole is precisely aligned with the position of the guide tube 12, ensuring that the extract can flow into the test tube accurately.

[0028] To address the issue of air leakage during vacuuming when the panel 3 is placed on top of the glass tank 2, this invention incorporates a reinforcing mechanism on the base 1. This mechanism includes two L-plates 6, two threaded rods 9, and two lower pressure plates 14. Nuts are embedded in one side of each L-plate 6, and the nuts are securely connected to the L-plates 6 via interference fits or other methods. The two threaded rods 9 are threadedly connected to the two nuts, allowing them to move up and down within the nuts by rotating them. One side of each lower pressure plate 14 is slidably connected to the inner side of the two L-plates 6. A first bearing 15 is fixedly mounted on the top of each lower pressure plate 14, and the bottom end of each threaded rod 9 is fixedly connected to the inner wall of the inner ring of the first bearing 15. This ensures that when the threaded rods 9 are rotated, the lower pressure plates 14 do not rotate with them but instead slide up and down along the inner side of the L-plates 6. A knob is fixedly mounted on the top of each threaded rod 9 to facilitate rotation. The knob's surface is designed with anti-slip textures for easy gripping and rotation by the operator.

[0029] To improve the convenience of the reinforcement mechanism, a movable mechanism is also provided. This movable mechanism includes two hinge seats 7, the bottoms of which are firmly connected to the top sides of the base 1 by welding or bolts. Rotating shafts 11 are fixedly installed on both sides of the bottom end of the L-plate 6, and are fixedly connected to the L-plate 6 by welding or other methods. Second bearings are fixedly installed on the inner walls of both sides of the hinge seats 7, and one end of the rotating shaft 11 is fixedly connected to the inner ring of the second bearing. This allows the L-plate 6 to rotate on the hinge seats 7 via the rotating shafts 11, facilitating the operator to rotate the L-plate 6 to a suitable position for reinforcement of the panel 3.

[0030] This application is used in the field of laboratory pretreatment solid-phase extraction, but it can also be used in other fields applicable to this application.

[0031] In another embodiment: Reference Figure 1-5 A solid-phase extraction apparatus for laboratory pretreatment, which is used in the field of laboratory pretreatment solid-phase extraction.

[0032] A tube is fixedly installed and connected to the bottom side of the glass cylinder 2, and the tube is sealed to the glass cylinder 2 by means of adhesive bonding or other methods. A vacuum gauge and a pressure relief valve are installed on the tube. The vacuum gauge is used to display the vacuum level inside the glass cylinder 2 in real time, allowing operators to adjust the operating status of the vacuum pump 8 according to experimental requirements. The pressure relief valve is used to release pressure when the vacuum is too high, preventing damage to the equipment due to excessive pressure. A connecting pipe 10 is fixedly installed at one end of the tube, and one end of the connecting pipe 10 is fixedly connected to the output port of the vacuum pump 8 by means of a sealing joint or other methods to ensure that the vacuum system does not leak during operation.

[0033] To further enhance the sealing between the glass cylinder 2 and the panel 3, a sealing ring is fixedly installed on the inner wall of the top of the glass cylinder 2. The sealing ring is made of corrosion-resistant and high-pressure resistant rubber material, which has good elasticity and sealing performance and can effectively fill the tiny gaps between the panel 3 and the glass cylinder 2.

[0034] However, as is well known to those skilled in the art, the working principle and wiring method of vacuum pump 8 are commonplace and are all conventional methods or common knowledge, so they will not be described in detail here. Those skilled in the art can make any selections according to their needs or convenience.

[0035] The accompanying drawings in this application are for illustrative purposes only. The dimensions and shapes of the components shown are not actual limitations but are merely schematic representations. In actual implementation, the components can be reasonably configured and adjusted according to specific needs and actual conditions.

[0036] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A solid-phase extractor for laboratory pretreatment, comprising a vacuum pump (8) and a glass cylinder (2), characterized in that, The bottom of the glass cylinder (2) is fixedly provided with a base (1), and the top of the glass cylinder (2) is provided with a panel (3). The panel (3) is concave and has multiple round holes. The inner wall of the round holes is fixedly provided with a guide tube (12). The top of the guide tube (12) is fixedly provided with a valve (5). A solid phase extraction column (4) is inserted into the valve (5). A test tube rack (13) is placed inside the glass cylinder (2). The base (1) is provided with a reinforcement mechanism. When the panel (3) is placed on the glass cylinder (2), the reinforcement mechanism can enhance the sealing between the panel (3) and the glass cylinder (2). To improve the ease of use of the reinforcement mechanism, a movable mechanism is also included, which allows the reinforcement mechanism to be rotated.

2. A solid-phase extractor for laboratory pretreatment according to claim 1, characterized in that, The reinforcement mechanism includes two L-plates (6), two threaded rods (9), and two lower pressure plates (14). Nuts are embedded in one side of each of the two L-plates (6). The two threaded rods (9) are threadedly connected to the two nuts respectively. One side of each of the two lower pressure plates (14) is slidably connected to the inner side of the two L-plates (6). A first bearing (15) is fixedly installed on the top of the lower pressure plate (14). The bottom end of the threaded rod (9) is fixedly connected to the inner wall of the inner ring of the first bearing (15). A knob is fixedly installed on the top of the threaded rod (9) to facilitate the rotation of the threaded rod (9).

3. A solid-phase extractor for laboratory pretreatment according to claim 2, characterized in that, The movable mechanism includes two hinge seats (7), the bottom of the two hinge seats (7) are fixedly connected to the top two sides of the base (1), and a rotating shaft (11) is fixedly provided on both sides of the bottom end of the L plate (6). A second bearing is fixedly provided on the inner wall of both sides of the hinge seat (7), and one end of the rotating shaft (11) is fixedly connected to the inner wall of the inner ring of the second bearing.

4. A solid-phase extractor for laboratory pretreatment according to claim 1, characterized in that, A tube is fixedly installed on one side of the bottom of the glass cylinder (2) and connected to it. A vacuum gauge and a pressure relief valve are installed on the tube. A connecting pipe (10) is fixedly installed at one end of the tube. One end of the connecting pipe (10) is fixedly connected to the output port of the vacuum pump (8).

5. A solid-phase extractor for laboratory pretreatment according to claim 2, characterized in that, The inner side of the L plate (6) is provided with a T-shaped groove (16), and the inner wall of the groove (16) is slidably connected with a T-shaped slider for use. One end of the slider is fixedly connected to one side of the lower pressure plate (14).

6. A solid-phase extractor for laboratory pretreatment according to claim 1, characterized in that, A sealing ring is fixedly provided on the top inner wall of the glass cylinder (2) to improve the sealing between the glass cylinder (2) and the panel (3).

7. A solid-phase extractor for laboratory pretreatment according to claim 1, characterized in that, The placement hole of the test tube rack (13) corresponds to the position of the guide tube (12).

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