Blending drive and bioreactor

Abstract

The utility model discloses a kind of mixing transmission device and bioreactor, mixing transmission device includes magnetic transmission structure, transmission sealing structure and mixing structure;The transmission sealing structure is installed on flexible bag, the magnetic transmission structure is set to the outside of the flexible bag, the mixing structure is arranged in the flexible bag;Among them, the lower end of the mixing structure is suspended and arranged, the upper end of the mixing structure is connected to the magnetic transmission structure by the transmission sealing structure, the magnetic transmission structure is connected with external power source, the power source is rotated by the magnetic transmission structure and drives the mixing structure. The utility model aims at overcoming the defects of the prior art and provides a kind of mixing transmission device, which avoids the pollution of insoluble particles generated by the device while ensuring the mixing effect.

Description

Technical Field

[0001] This utility model relates to a mixing transmission device and a bioreactor. Background Technology

[0002] In recent years, the biopharmaceutical industry and other technologies such as microbial fermentation have used disposable bioreactors for cell or microbial culture. Magnetic coupling is a common driving method for the mixing structure of existing disposable bioreactors during use.

[0003] The existing magnetic coupling method uses a magnetic drive structure located inside a disposable bioreactor bag, which is easy to install. However, to ensure that the fixing parts at the top and bottom ends can be installed in place, the rotating shaft often uses a multi-segment bushing joint. The inner and outer layers of the bushing structure are fitted with a clearance fit. During transportation, the inner shaft of the bushing structure locks into the outer shaft, which facilitates the folding and transport of the bag. However, the inner and outer shaft components of the bushing structure are prone to friction with each other during rotation, generating insoluble particles. These insoluble particles are not easy to remove during the later production process and can easily be introduced into the drug. If the content exceeds the standard, it will cause the batch of drug to be scrapped.

[0004] Therefore, a mixing transmission device is proposed to address the above problems, which ensures the mixing effect while avoiding product contamination by insoluble particles generated by the device. Utility Model Content

[0005] The purpose of this invention is to overcome the existing defects and provide a mixing transmission device that ensures the mixing effect while avoiding the contamination of the product by insoluble particles generated by the device.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a mixing transmission device, comprising a magnetic transmission structure, a transmission sealing structure, and a mixing structure;

[0007] The transmission sealing structure is installed on the flexible bag, the magnetic transmission structure is disposed on the outside of the flexible bag, and the mixing structure is disposed inside the flexible bag;

[0008] The lower end of the mixing structure is suspended, and the upper end of the mixing structure passes through the transmission sealing structure and is connected to the magnetic transmission structure. The magnetic transmission structure is connected to an external power source, and the power source drives the mixing structure to rotate through the magnetic transmission structure.

[0009] Preferably, the magnetic transmission structure includes a fixed base, a locking ring connected to the lower end of the fixed base, a flange shaft disposed inside the fixed base, a ball bearing disposed between the lower end of the flange shaft and the fixed base, a thrust needle roller bearing disposed between the upper end of the flange shaft and the fixed base, a driven magnet disposed outside the thrust needle roller bearing, a magnet limiting ring disposed outside the driven magnet, and a magnet clamping ring disposed at the lower end of the driven magnet and the magnet limiting ring.

[0010] Preferably, the magnetic transmission structure further includes a transmission shaft with a central through hole. The lower end of the flange shaft is inserted into the central through hole. The upper flange of the transmission shaft has a plurality of first threaded holes, which correspond one-to-one with a plurality of second threaded holes on the magnet clamping ring. One end of the fixing bolt in the driven magnet is connected to the magnet clamping ring, and the other end is fixed to the transmission shaft.

[0011] Preferably, the transmission sealing structure includes a fixed sleeve, an inner shaft is connected to the inner side of the fixed sleeve via an inner shaft retaining ring, two second bearings are provided between the upper end of the inner shaft and the fixed sleeve; a first water seal and a second water seal are provided between the lower end of the inner shaft and the fixed sleeve, a water seal clamping ring is connected to the lower end of the fixed sleeve, a sealing ring is provided between the water seal clamping ring and the fixed sleeve, the sealing ring is located outside the first water seal and the second water seal; the lower end face of the fixed sleeve is connected to the port of the flexible bag, and the lower end of the inner shaft extends into the flexible bag.

[0012] Preferably, a dust cover is provided above the fixing sleeve, and the bottom of the fixing sleeve has an annular flange structure for connecting the flexible bag;

[0013] The inner side of the fixed sleeve has an annular limiting structure and a limiting groove. The two second bearings are located on opposite sides of the annular limiting structure and abut against the annular limiting structure. The limiting groove is used to fix the position of the water seal clamping ring.

[0014] The water seal clamping ring has a first mounting groove and a second mounting groove. The first mounting groove surrounds the outside of the second mounting groove. The first mounting groove is used to install the first water seal, and the second mounting groove is used to install the second water seal.

[0015] Preferably, the mixing structure includes: a sleeve assembly, an insert shaft, and a mixing blade;

[0016] The insert shaft is inserted into the sleeve assembly, and the upper end of the insert shaft is fixedly connected to the flange shaft. The lower end of the insert shaft is provided with a plug, which is used to seal the insert shaft and the lower end of the sleeve assembly.

[0017] The sleeve assembly includes a flexible blind shaft and a rigid shaft inserted into the inner side of the flexible blind shaft. The mixing blade is installed on the outer side of the flexible blind shaft, and the position of the mixing blade corresponds to that of the rigid shaft. The rigid shaft is used to provide rigid support for the fixed installation of the mixing blade. The upper end of the flexible blind shaft is sleeved on the lower side wall of the inner shaft.

[0018] Preferably, the upper end of the rigid shaft is located in the lower middle part of the flexible blind shaft and is fixedly connected to the flexible blind shaft; the lower end of the rigid shaft is provided with a stepped structure, and the lower end of the insertion shaft is fitted with a hollow square shaft. The stepped structure cooperates with the hollow square shaft to limit the position of the lower end of the insertion shaft.

[0019] Preferably, both the insert shaft and the flange shaft have pin holes on their end faces, and the end face of the insert shaft is connected to the end face of the flange shaft by a plurality of pins; the upper end face of the flange shaft is provided with an insert shaft limiting plate, which is used to limit the upper position of the insert shaft.

[0020] Preferably, the lower end of the fixed seat is spliced ​​with the locking ring to form an annular structure. An annular groove is provided on the inner wall of the annular structure. The outer flange of the fixed sleeve is located in the annular groove. A second clamp is provided on the outer side of the annular structure. The second clamp is used for the fixed connection of the fixed seat, the locking ring and the transmission sealing structure.

[0021] Accordingly, this utility model also provides a bioreactor, including: a power source and a mixing transmission device as described above;

[0022] The power source is connected to the magnetic transmission structure of the mixing transmission device. The magnetic transmission structure includes a driven magnet. The output end of the power source is provided with a power source magnet. The power source magnet is coupled and transmitted with the driven magnet.

[0023] Compared with existing technologies, the beneficial effects of this invention are as follows: This mixing transmission device places the magnetic transmission structure outside the disposable bioreactor bag. One end of the magnetic transmission structure is connected to the transmission sealing structure, while the other end of the dynamic sealing structure is located inside the disposable bioreactor bag. A flexible blind shaft connects to one end of the dynamic sealing structure. The flexible blind shaft is located inside the disposable bioreactor bag, with a rigid shaft embedded inside near the blind end, and the lower end of the flexible blind end is suspended. In use, a rigid shaft connects the magnetic transmission structure and the rigid shaft inside the flexible shaft, thereby driving the entire flexible blind shaft to rotate, which in turn drives the mixing blades on the flexible blind shaft to rotate for liquid mixing. During operation, the friction between the inner and outer shafts occurs inside the flexible blind shaft, preventing insoluble particles generated by friction from entering the bag, thus avoiding the introduction of insoluble particles into the liquid inside the bag. This solves the problem of insoluble particles contaminating the product caused by friction between components during the rotation of traditional magnetic coupling drives when both ends of the shaft are fixed. Attached Figure Description

[0024] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0025] Figure 1 This is a schematic diagram illustrating the application of the mixing transmission device of this utility model;

[0026] Figure 2 This is a schematic diagram of the magnetic transmission structure of this utility model;

[0027] Figure 3 This is a schematic diagram of the insert shaft connection of this utility model;

[0028] Figure 4 This is a schematic diagram of the transmission sealing structure of this utility model;

[0029] Figure 5 This is a schematic diagram showing the connection position of the power source of this utility model;

[0030] Figure 6 This is a detailed diagram of the power source connection of this utility model;

[0031] Figure 7 This is a detailed view of the connection of the mixing blades of this utility model;

[0032] Figure 8 This is a schematic diagram of the connection between the insert shaft and the flange shaft of this utility model;

[0033] Figure 9 This is a detailed view of the square shaft of this utility model;

[0034] Figure 10 This is a detailed drawing of the flange shaft of this utility model;

[0035] Figure 11 This is a detailed view of the magnet limiting ring of this utility model;

[0036] Figure 12 This is a schematic diagram of the bottom of the magnet clamping ring of this utility model;

[0037] Figure 13 This is a schematic diagram of the upper end face of the magnet clamping ring of this utility model;

[0038] Figure 14 This is a detailed drawing of the fixing base of this utility model;

[0039] Figure 15 Here is a detailed view of the locking ring of this utility model;

[0040] Figure 16 This is a cross-sectional view of the inner shaft of this utility model.

[0041] In the diagram: 1. Flexible bag; 2. Magnetic transmission structure; 2-1. Fixed seat; 2-2. Locking ring; 2-3. Flange shaft; 2-4. Ball bearing; 2-5. Thrust needle roller bearing; 2-6. Driven magnet; 2-7. Outer shaft retaining ring; 2-8. Inner hole retaining ring; 2-9. Magnet clamping ring; 2-10. Magnet limiting ring; 2-11. Pin; 2-12. Transmission shaft; 3. Transmission sealing structure; 3-1. Fixed sleeve; 3-2. Dust cover; 3-3. Inner shaft; 3-4. Second bearing; 3-5. First water seal; 3-6. Sealing ring; 3-7. Water seal clamping ring; 3-8. Inner shaft retaining ring; 3-9. Second water seal; 4. Flexible blind shaft; 5. Insert shaft; 6. Mixing blade; 7. Embedded shaft; 8. Power source; 9. Insert shaft limiting plate; 10. First clamp; 11. Second clamp. Detailed Implementation

[0042] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0043] Please see Figure 1-16 A mixing transmission device includes a magnetic transmission structure 2, a transmission sealing structure 3, and a mixing structure. The transmission sealing structure 3 is installed on a flexible bag 1, the magnetic transmission structure 2 is disposed outside the flexible bag 1, and the mixing structure is disposed inside the flexible bag 1. The lower end of the mixing structure is suspended, and the upper end of the mixing structure passes through the transmission sealing structure 3 and is connected to the magnetic transmission structure 2. The magnetic transmission structure 2 is connected to an external power source 8, and the power source 8 drives the mixing structure to rotate through the magnetic transmission structure 2.

[0044] Specifically, the magnetic transmission structure 2 includes a fixed base 2-1, a locking ring 2-2 connected to the lower end of the fixed base 2-1, a flange shaft 2-3 arranged inside the fixed base 2-1, a ball bearing 2-4 arranged between the lower end of the flange shaft 2-3 and the fixed base 2-1, a thrust needle roller bearing 2-5 arranged between the upper end of the flange shaft 2-3 and the fixed base 2-1, a driven magnet 2-6 arranged outside the thrust needle roller bearing 2-5, a magnet limiting ring 2-10 arranged outside the driven magnet 2-6, and a magnet clamping ring 2-9 arranged at the lower end of the driven magnet 2-6 and the magnet limiting ring 2-10.

[0045] The inner ring of ball bearing 2-4 is fixedly connected to flange shaft 2-3, and the outer ring of ball bearing 2-4 is fixedly connected to fixed seat 2-1. The inner and outer rings of ball bearing 2-4 can rotate relative to each other. The upper end of thrust needle roller bearing 2-5 is fixedly connected to flange shaft 2-3, and the lower end of thrust needle roller bearing 2-5 is fixedly connected to fixed seat 2-1. The upper and lower ends of thrust needle roller bearing 2-5 can rotate relative to each other.

[0046] Specifically, the magnetic transmission structure 2 also includes a transmission shaft 2-12, which has a central through hole. The lower end of the flange shaft 2-3 is inserted into the central through hole of the transmission shaft 2-12. The upper flange of the transmission shaft 2-12 has several first threaded holes, which correspond one-to-one with several second threaded holes on the magnet clamping ring 2-9. The fixing bolt in the driven magnet 2-6 has one end connected to the magnet clamping ring 2-9 and the other end fixed to the transmission shaft 2-12.

[0047] like Figure 3 , 10 As shown, the upper end of the flange shaft 2-3 is provided with an annular flange, and four grooves are provided on the annular flange for engaging with pins 2-11. The lower end of the flange shaft 2-3 is engaged and fixed with the upper end of the insert shaft 5. The pin hole opened on the side wall of the flange shaft 2-3 is used to insert pins to fix the insert shaft 5.

[0048] Specifically, the transmission sealing structure 3 includes a fixed sleeve 3-1. The inner side of the fixed sleeve 3-1 is connected to the inner shaft 3-3 via an inner shaft retainer 3-8. The lower end of the inner shaft 3-3 is provided with a barbed structure, which is used for the fixed connection of the flexible blind shaft 4. The upper end of the inner shaft 3-3 is provided with a plum blossom-shaped port for transmitting torque. The inner shaft 3-3 is fixedly connected to the flange shaft 2-3 through the plum blossom-shaped port. Two second bearings 3-4 are provided between the upper end of the inner shaft 3-3 and the fixed sleeve 3-1. A first water seal 3-5 and a second water seal 3-9 are provided between the lower end of the inner shaft 3-3 and the fixed sleeve 3-1. A water seal clamping ring 3-7 is connected to the lower end of the fixed sleeve 3-1. A sealing ring 3-6 is provided between the water seal clamping ring 3-7 and the fixed sleeve 3-1. The sealing ring 3-6 is located outside the first water seal 3-5 and the second water seal 3-9. The lower end of the inner shaft 3-3 extends into the flexible bag 1. The bottom of the fixing sleeve 3-1 has an annular flange structure for connecting the flexible bag 1. The transmission sealing structure 3 is integrated with the port of the flexible bag 1 through the annular flange structure at the bottom of the fixing sleeve 3-1. The sealing ring 3-6 is located outside the first water seal 3-5 and the second water seal 3-9 to prevent water seal debris from falling into the bag along the edge gaps.

[0049] Specifically, a dust cover 3-2 is provided above the fixing sleeve 3-1. The inner side of the fixing sleeve 3-1 has an annular limiting structure and a limiting groove. Two second bearings 3-4 are located on opposite sides of the annular limiting structure and abut against the annular limiting structure. The limiting groove is used to fix the position of the water seal clamping ring 3-7. The water seal clamping ring 3-7 has a first mounting groove and a second mounting groove. The first mounting groove surrounds the outside of the second mounting groove. The first mounting groove is used to install the first water seal 3-5, and the second mounting groove is used to install the second water seal 3-9.

[0050] Specifically, the mixing structure includes: a sleeve assembly, an insert shaft 5, and a mixing blade 6; the insert shaft 5 is inserted into the sleeve assembly, and the upper end of the insert shaft 5 is fixedly connected to the flange shaft 2-3, and the lower end of the insert shaft 5 is provided with a plug (not shown in the figure), which is used to seal the insert shaft 5 and the lower end of the sleeve assembly; wherein, the sleeve assembly includes a flexible blind shaft 4 and a rigid shaft 7 inserted into the inner side of the flexible blind shaft 4, the mixing blade 6 is installed on the outer side of the flexible blind shaft 4, and the position of the mixing blade 6 corresponds to that of the rigid shaft 7, the rigid shaft 7 is used to provide rigid support for the fixed installation of the mixing blade 6, and the upper end of the flexible blind shaft 4 is sleeved on the lower side wall of the inner shaft 3-3.

[0051] Specifically, the upper end of the rigid shaft 7 is located in the lower middle part of the flexible blind shaft 4 and is fixedly connected to the flexible blind shaft 4 (by means of clamps or cable ties); the lower inner wall of the rigid shaft 7 is provided with a stepped structure, and the lower end of the insert shaft 5 is fitted with a hollow square shaft (see Figure 9The stepped structure of the rigid shaft 7 is matched with the hollow square shaft to limit the lower end position of the insert shaft 5.

[0052] Specifically, pin holes are provided on the end faces of both the insert shaft 5 and the flange shaft 2-3. The end face of the insert shaft 5 is connected to the end face of the flange shaft 2-3 by multiple pins 2-11. The upper end face of the flange shaft 2-3 is provided with an insert shaft limiting plate 9, which is used to limit the upper position of the insert shaft 5.

[0053] like Figure 8 , 9 As shown, the upper end of the insert shaft 5 is connected to the flange shaft 2-3, and the lower end of the insert shaft 5 is connected to a hollow square shaft. The outer wall of the hollow square shaft has ridges, which increases the friction between it and the inner wall of the rigid shaft 7. The inner wall structure of the rigid shaft 7 is adapted to the outer wall structure of the hollow square shaft. Both the hollow square shaft and the rigid shaft 7 are used to transmit torque. The torque of the insert shaft 5 body is transmitted to the mixing blade 6 via the hollow square shaft and the rigid shaft 7.

[0054] like Figure 11 As shown, the inner wall of the magnet limiting ring 2-10 is provided with several limiting structures with trapezoidal cross-sections. A magnet limiting groove is formed between any two adjacent limiting structures, and the driven magnet is installed in the magnet limiting groove. Preferably, the magnet limiting grooves are arranged at equal intervals.

[0055] like Figure 12 , 13 As shown, the end face of the magnet clamping ring 2-9 is provided with alignment grooves. The spacing and shape of the alignment grooves are set according to the spacing and cross-sectional shape of the limiting structure. Each alignment groove is provided with a bolt hole. The bolt hole is used to insert a bolt to fix the driven magnet 2-6 in the magnet limiting ring 2-10.

[0056] like Figure 14 , 15 As shown, the lower end of the fixing seat 2-1 is provided with a semi-circular notch, and the outer dimensions of the locking ring 2-2 are set according to the semi-circular notch.

[0057] Please refer to the reference. Figure 2 , 4 14, 15. The lower end of the fixing seat 2-1 is spliced ​​with the locking ring 2-2 to form a ring structure. The inner wall of the ring structure is provided with an annular groove. The annular groove is adapted to the outer flange of the fixing sleeve 3-1. The outer flange of the fixing sleeve 3-1 is located in the annular groove. A second clamp 11 is provided on the outer side of the ring structure. The second clamp 11 is used for the fixed connection between the fixing seat 2-1, the locking ring 2-2 and the fixing sleeve 3-1.

[0058] Accordingly, this application also provides a disposable bioreactor. Please refer to... Figure 5 and Figure 6The disposable bioreactor includes a power source 8 and a mixing transmission device as described above; the power source 8 is connected to the magnetic transmission structure 2 of the mixing transmission device, the magnetic transmission structure 2 includes a driven magnet 2-6, the output end of the power source 8 is provided with a power source magnet (not shown in the figure), and the power source magnet is coupled and driven by the driven magnet 2-6.

[0059] Specifically, the power source 8 is connected to the fixed base 2-1 through the first clamp 10; the power source 8 can be a motor, and the output end of the motor is equipped with a power source magnet.

[0060] When in use, start the motor, the motor drives the power source magnet to rotate, the power source magnet rotates and drives the driven magnet 2-6 to rotate, the driven magnet 2-6 drives the transmission shaft 2-12 connected to it to rotate, the transmission shaft 2-12 drives the flange shaft 2-3 and the insert shaft 5 connected to it to rotate; the flange shaft 2-3 drives the inner shaft 3-3 connected to it to rotate, and the flexible blind shaft 4 connected to the inner shaft 3-3 and the rigid shaft 7 connected to the insert shaft 5 also rotate accordingly.

[0061] Preferably, the body of the insert shaft 5 is made of carbon fiber. This provides sufficient structural rigidity and reduces weight, thus lessening the load on the motor. Before use, the insert shaft 5 can be packaged and transported separately from the other components of the mixing transmission device. In use, simply insert the insert shaft 5 into the flange shaft 2-3 and the sleeve assembly, and secure it to the flange shaft 2-3 with pins.

[0062] The mixing transmission device provided in this embodiment has a magnetic transmission structure 2 disposed outside a disposable bioreactor bag (i.e., flexible bag 1). The magnetic transmission structure 2 is connected to one end of the transmission sealing structure 3, and the other end of the dynamic sealing structure is located inside the disposable bioreactor bag. A flexible blind shaft 4 is connected to one end of the dynamic sealing structure. The flexible blind shaft 4 is located inside the disposable bioreactor bag, and a rigid shaft (i.e., rigid shaft 7) is embedded inside the flexible blind shaft 4 near the blind end. The lower end of the flexible blind end 4 is suspended. In use, a rigid shaft (i.e., insert shaft 5) is used to connect the magnetic transmission structure 2 and the rigid shaft inside the flexible blind shaft 4, thereby driving the entire sleeve assembly to rotate. The mixing blades 6 on the sleeve assembly rotate accordingly to mix the liquid.

[0063] During operation, the transmission sealing structure 3 and the flexible blind shaft 4 work together to separate the space for power transmission and the space containing the liquid inside the flexible bag 1. All transmission components are located inside the flexible blind shaft 4 and do not come into contact with the liquid-containing space of the flexible bag. Friction between the inner and outer shafts occurs within the flexible blind shaft 4, preventing the insoluble particles generated by this friction from entering the bag. This solves the problem of insoluble particles being generated by friction between components during the rotation of traditional magnetic coupling drives, where the shaft is fixed at both ends, leading to contamination of the product inside the bag.

[0064] Compared to existing technologies, this embodiment provides a mixing transmission device where the magnetic drive structure 2 is located outside the disposable bioreactor bag. During the rotation of the magnetic drive structure, insoluble particles are not introduced into the disposable bioreactor bag. This avoids contamination of the drug solution inside the bag by insoluble particles generated during the stirring process, thus preventing drug spoilage or the need for additional processes to separate insoluble particles. This improves product quality, reduces the probability of defects, and avoids economic losses and cost savings.

[0065] Finally, it should be noted that the above are merely preferred embodiments of this utility model and are not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A mixing transmission device, characterized in that, include: Magnetic drive structure (2), drive sealing structure (3) and mixing structure; The transmission sealing structure (3) is installed on the flexible bag (1), the magnetic transmission structure (2) is disposed on the outside of the flexible bag (1), and the mixing structure is disposed inside the flexible bag (1); The lower end of the mixing structure is suspended, and the upper end of the mixing structure passes through the transmission sealing structure (3) and is connected to the magnetic transmission structure (2). The magnetic transmission structure (2) is connected to an external power source (8), and the power source (8) drives the mixing structure to rotate through the magnetic transmission structure (2).

2. The mixing transmission device according to claim 1, characterized in that, The magnetic transmission structure (2) includes a fixed base (2-1), a locking ring (2-2) connected to the lower end of the fixed base (2-1), a flange shaft (2-3) provided inside the fixed base (2-1), a ball bearing (2-4) provided between the lower end of the flange shaft (2-3) and the fixed base (2-1), a thrust needle roller bearing (2-5) provided between the upper end of the flange shaft (2-3) and the fixed base (2-1), a driven magnet (2-6) provided outside the thrust needle roller bearing (2-5), a magnet limiting ring (2-10) provided outside the driven magnet (2-6), and a magnet clamping ring (2-9) provided at the lower ends of the driven magnet (2-6) and the magnet limiting ring (2-10).

3. The mixing transmission device according to claim 2, characterized in that, The magnetic transmission structure (2) further includes a transmission shaft (2-12), which has a central through hole. The lower end of the flange shaft (2-3) is inserted into the central through hole. The upper flange of the transmission shaft (2-12) has several first threaded holes. The several first threaded holes correspond one-to-one with several second threaded holes on the magnet clamping ring (2-9) for fixing bolts of the driven magnet (2-6). One end of the bolt is connected to the magnet clamping ring (2-9), and the other end is fixed to the transmission shaft (2-12).

4. The mixing transmission device according to claim 2, characterized in that, The transmission sealing structure (3) includes a fixed sleeve (3-1), the inner side of which is connected to an inner shaft (3-3) via an inner shaft retainer (3-8), and two second bearings (3-4) are provided between the upper end of the inner shaft (3-3) and the fixed sleeve (3-1); a first water seal (3-5) and a second water seal (3-9) are provided between the lower end of the inner shaft (3-3) and the fixed sleeve (3-1), the lower end of the fixed sleeve (3-1) is connected to a water seal clamping ring (3-7), and a sealing ring (3-6) is provided between the water seal clamping ring (3-7) and the fixed sleeve (3-1), the sealing ring (3-6) being located outside the first water seal (3-5) and the second water seal (3-9); the lower end face of the fixed sleeve (3-1) is connected to the port of the flexible bag (1), and the lower end of the inner shaft (3-3) extends into the flexible bag (1).

5. The mixing transmission device according to claim 4, characterized in that, A dust cover (3-2) is provided above the fixing sleeve (3-1), and the bottom of the fixing sleeve (3-1) has an annular flange structure, which is used to connect the flexible bag (1); The inner side of the fixed sleeve (3-1) has an annular limiting structure and a limiting groove. The two second bearings (3-4) are located on opposite sides of the annular limiting structure and abut against the annular limiting structure. The limiting groove is used to fix the position of the water seal clamping ring (3-7). The water seal clamping ring (3-7) has a first mounting groove and a second mounting groove. The first mounting groove surrounds the outside of the second mounting groove. The first mounting groove is used to install the first water seal (3-5), and the second mounting groove is used to install the second water seal (3-9).

6. The mixing transmission device according to claim 4, characterized in that, The mixing structure includes: a sleeve assembly, a shaft (5), and a mixing blade (6); The insert shaft (5) is inserted into the sleeve assembly, and the upper end of the insert shaft (5) is fixedly connected to the flange shaft (2-3). The lower end of the insert shaft (5) is provided with a plug, which is used to seal the insert shaft (5) and the lower end of the sleeve assembly. The sleeve assembly includes a flexible blind shaft (4) and a rigid shaft (7) inserted into the inner side of the flexible blind shaft (4). The mixing blade (6) is installed on the outer side of the flexible blind shaft (4), and the position of the mixing blade (6) corresponds to that of the rigid shaft (7). The rigid shaft (7) is used to provide rigid support for the fixed installation of the mixing blade (6). The upper end of the flexible blind shaft (4) is sleeved on the lower side wall of the inner shaft (3-3).

7. The mixing transmission device according to claim 6, characterized in that, The upper end of the rigid shaft (7) is located in the lower middle part of the flexible blind shaft (4) and is fixedly connected to the flexible blind shaft (4); the lower end of the rigid shaft (7) is provided with a stepped structure, and the lower end of the insert shaft (5) is fitted with a hollow square shaft. The stepped structure cooperates with the hollow square shaft to limit the lower end position of the insert shaft (5).

8. The mixing transmission device according to claim 6, characterized in that, Both the insert shaft (5) and the flange shaft (2-3) have pin holes on their end faces. The end face of the insert shaft (5) is connected to the end face of the flange shaft (2-3) by a plurality of pins (2-11). The upper end face of the flange shaft (2-3) is provided with an insert shaft limiting plate (9), which is used to limit the upper position of the insert shaft (5).

9. The mixing transmission device according to claim 4, characterized in that, The lower end of the fixed seat (2-1) is spliced ​​with the locking ring (2-2) to form an annular structure. An annular groove is provided on the inner wall of the annular structure. The outer flange of the fixed sleeve (3-1) is located in the annular groove. A second clamp (11) is provided on the outer side of the annular structure. The second clamp (11) is used for the fixed connection of the fixed seat (2-1), the locking ring (2-2) and the transmission sealing structure (3).

10. A bioreactor, characterized in that, include: The power source (8) and the mixing transmission device as described in any one of claims 1 to 9; The power source (8) is connected to the magnetic transmission structure (2) of the mixing transmission device. The magnetic transmission structure (2) includes a driven magnet (2-6). The output end of the power source (8) is provided with a power source magnet. The power source magnet is coupled and transmitted with the driven magnet (2-6).

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