Gas chromatography apparatus for detection of pharmaceutical intermediates

Abstract

The utility model discloses a gas chromatogram device for medical intermediate detects, specifically related to medical intermediate detection technical field, including the gas washing bottle, the inside one side of gas washing bottle is installed with the air inlet pipe, and the inside one side of gas washing bottle is installed with the U -shaped tube away from air inlet pipe, and the one side of U -shaped tube is provided with heating cylinder away from air inlet pipe, and the one end bottom of heating cylinder is installed with chromatograph away from gas washing bottle, the outer wall of gas washing bottle is installed with heating ring, and the inside one side of gas washing bottle is close to air inlet pipe and is installed with liquid inlet pipe, and the bottom of the one side of gas washing bottle is close to U -shaped tube and is installed with the conveying pipe, and the inside of heating cylinder is installed with the central tube, and the one end of air inlet pipe is installed with atomizing nozzle close to the inside of gas washing bottle, and the inside of gas washing bottle is provided with a plurality of current -distributing plates in parallel. The utility model has the advantages of avoiding producing larger bubble, improving the gas washing efficiency, and the advantage that it is convenient to heat gas.

Description

Technical Field

[0001] This utility model relates to the field of gas chromatography technology, and specifically to a gas chromatography apparatus for the detection of pharmaceutical intermediates. Background Technology

[0002] Gas chromatography has a wide range of applications in drug analysis, including drug characterization, content determination, impurity inspection, pesticide residue, residual solvent and trace moisture determination, monitoring of drug intermediates, research on traditional Chinese medicine components, formulation analysis, in vivo drug analysis and clinical diagnosis. The general procedure is to first determine the pretreatment method of pharmaceutical intermediates, then optimize the separation conditions of pharmaceutical intermediates until satisfactory separation results are achieved, and finally detect the corresponding pharmaceutical intermediates by gas chromatography.

[0003] An inlet gas detection device for a gas chromatograph, with publication number CN117571895A, includes a gas washing bottle. A long conduit is installed through the top of the gas washing bottle on one side. A pipe connector is installed at one end of the long conduit, and an anti-backflow component is installed at the other end. A short conduit is installed through the top of the gas washing bottle on the other side. A flow sensor is installed at one end of the short conduit. A stopwatch is fixedly installed at the top of the flow sensor. A soap film flow meter is connected to one side of the flow sensor. A soap film driving assembly is installed at the bottom of the soap film flow meter. The soap film driving assembly includes a base plate. A column is fixedly installed at the top of the base plate on one side. An adapter is provided around the outer ring of the column. A solenoid valve is fixedly installed on one side of the adapter. A locking knob is centrally installed through the other side of the adapter. A cylinder is fixedly installed on one side of the solenoid valve. A ring is provided on one side of the cylinder. This device can prevent liquid backflow in the gas washing bottle and improve detection accuracy.

[0004] The aforementioned existing technology has some defects in actual use. The internal structure of the gas washing bottle of the device is relatively simple and lacks a structure for gas treatment. This can easily lead to the gas being directly discharged to the top through large bubbles during injection, resulting in insufficient contact between the gas and the liquid inside the gas washing bottle, thus affecting the gas washing efficiency. At the same time, the device also lacks a heating structure during use, which can easily lead to changes in gas solubility at different temperatures. Moreover, at lower temperatures, the activity of gas molecules is also lower, affecting the detection efficiency of the device. Utility Model Content

[0005] The purpose of this invention is to provide a gas chromatography apparatus for the detection of pharmaceutical intermediates, which solves the problems of low gas washing efficiency, lack of heating structure, and reduced detection efficiency of existing gas chromatography apparatuses.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a gas chromatography apparatus for detecting pharmaceutical intermediates, comprising a gas washing bottle, an inlet pipe installed on one side of the inside of the gas washing bottle, a U-shaped tube installed on the side of the inside of the gas washing bottle away from the inlet pipe, a heating cylinder provided on the side of the U-shaped tube away from the inlet pipe, and a chromatograph installed at the bottom of the end of the heating cylinder away from the gas washing bottle.

[0007] A heating ring is installed around the outer wall of the gas washing bottle, and a liquid inlet pipe is installed through the inside of the gas washing bottle on the side near the gas inlet pipe.

[0008] A delivery pipe is installed at the bottom of the gas washing bottle near the U-shaped tube, and a central tube is installed through the interior of the heating cylinder.

[0009] An atomizing nozzle is installed at one end of the air inlet pipe near the inside of the gas washing bottle, and multiple flow equalization plates are arranged in parallel inside the gas washing bottle.

[0010] Preferably, one end of the inlet pipe passes through multiple flow equalization plates inside the gas washing bottle, the top end of the inlet pipe is close to the top end of the gas washing bottle, the bottom end of the inlet pipe passes through the inside of the gas washing bottle, and the bottom end of the inlet pipe is connected to the corresponding liquid supply pump through a conduit.

[0011] Preferably, the heating cylinder is hollow inside, with a discharge pipe installed at the top of the end of the heating cylinder away from the gas washing bottle, and the bottom of the end of the heating cylinder near the gas washing bottle connected to a delivery pipe.

[0012] Preferably, the top of the intake pipe is bent away from the side of the U-shaped pipe, and a check valve is installed at one end of the top of the intake pipe. The intake pipe is connected to the gas delivery pipeline through the check valve.

[0013] Preferably, the end of the U-shaped tube away from the air inlet pipe is bent upwards, and the end of the U-shaped tube away from the air inlet pipe is close to the top of the gas washing bottle. The top of the end of the U-shaped tube close to the air inlet pipe penetrates the interior of the gas washing bottle and is connected to the central tube.

[0014] Preferably, a flow meter is connected to one end of the central tube near the chromatograph, and the bottom of the flow meter is connected to the inside of the chromatograph.

[0015] The technical effects and advantages provided by this utility model in the above technical solution are as follows:

[0016] 1. The atomizing nozzle at the bottom of the air inlet pipe effectively disperses and sprays the gas, preventing the gas from forming large bubbles directly in the gas washing bottle. As the bubbles move to the top, the gas can easily pass through multiple flow equalization plates to move upwards. The flow equalization plates can also intercept larger bubbles, preventing them from reaching the top of the gas washing bottle directly. This delays the time it takes for the gas to move upwards, effectively allowing the gas to react with the liquid inside the gas washing bottle, achieving the gas washing effect, avoiding the formation of large bubbles, and improving gas washing efficiency.

[0017] 2. Activating the heating ring heats the gas washing bottle, raising the temperature of the liquid inside. This facilitates heating the gas as it enters the bottle, allowing it to pass through a U-shaped tube towards the bottom before exiting. The liquid heats the U-shaped tube, which in turn heats the gas inside. The heated liquid is then drawn into the heating cylinder through a delivery tube, further heating the central tube. This maintains the temperature of the gas as it passes through the U-shaped tube to the central tube, effectively increasing its activity and thus improving the gas chromatography detection efficiency of the chromatograph. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0019] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0020] Figure 2 This is a front view of the present invention;

[0021] Figure 3 This is a cross-sectional view of the internal structure of the gas washing bottle of this utility model;

[0022] Figure 4 This is a cross-sectional schematic diagram of the internal structure of the gas washing bottle of this utility model;

[0023] Figure 5 This is a schematic diagram of the internal piping structure of the gas washing bottle of this utility model.

[0024] Explanation of reference numerals in the attached figures:

[0025] 1. Gas washing bottle; 101. Heating ring; 102. Liquid inlet pipe; 2. Gas inlet pipe; 201. Check valve; 202. Atomizing nozzle; 3. Heating cylinder; 301. Central tube; 302. Delivery pipe; 303. Discharge pipe; 4. U-shaped tube; 401. Flow equalization plate; 5. Chromatograph; 501. Flow meter. Detailed Implementation

[0026] To enable those skilled in the art to better understand the technical solution of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings.

[0027] This utility model provides, for example Figures 1-5The gas chromatography apparatus shown for the detection of pharmaceutical intermediates includes a gas washing bottle 1, an inlet pipe 2 installed on one side of the inside of the gas washing bottle 1, a U-shaped tube 4 installed on the side of the inside of the gas washing bottle 1 away from the inlet pipe 2, a heating cylinder 3 installed on the side of the U-shaped tube 4 away from the inlet pipe 2, and a chromatograph 5 installed at the bottom of the end of the heating cylinder 3 away from the gas washing bottle 1; a heating ring 101 is installed around the outer wall of the gas washing bottle 1, and a liquid inlet pipe 102 is installed through the inside of the gas washing bottle 1 near the inlet pipe 2; a delivery pipe 302 is installed at the bottom of the side of the gas washing bottle 1 near the U-shaped tube 4, and a central tube 301 is installed through the inside of the heating cylinder 3; an atomizing nozzle 202 is installed at the end of the inlet pipe 2 near the inside of the gas washing bottle 1, and multiple flow equalization plates 401 are arranged in parallel inside the gas washing bottle 1.

[0028] The atomizing nozzle 202 at the bottom of the air inlet pipe 2 effectively disperses and sprays the gas, preventing the formation of large bubbles directly in the gas washing bottle 1. As the bubbles move upwards, they are facilitated by passing through multiple flow equalization plates 401, which also intercept larger bubbles, preventing them from reaching the top of the gas washing bottle 1. This effectively slows down the gas's upward movement, allowing it to react with the liquid inside the gas washing bottle 1, thus achieving the gas washing effect. The heating ring 101 is then activated to heat the gas washing bottle 1. This process raises the temperature of the liquid inside the gas washing bottle 1, and facilitates the heating of the gas as it enters the gas washing bottle 1. Furthermore, the presence of the U-shaped tube 4 allows the liquid to heat the U-shaped tube 4, which in turn heats the gas inside the U-shaped tube 4, effectively increasing the gas temperature. The heated liquid is then drawn into the heating cylinder 3 through the delivery pipe 302, further heating the central tube 301. This ensures that the gas maintains its temperature as it is delivered to the central tube 301 through the U-shaped tube 4, effectively increasing the gas activity and thus improving the gas chromatography detection efficiency of the chromatograph 5.

[0029] like Figure 3 , Figure 4 As shown, one end of the liquid inlet pipe 102 penetrates multiple flow equalization plates inside the gas washing bottle 1. The top end of the liquid inlet pipe 102 is close to the top of the inside of the gas washing bottle 1, and the bottom end of the liquid inlet pipe 102 penetrates the inside of the gas washing bottle 1. The bottom end of the liquid inlet pipe 102 is connected to the corresponding liquid supply pump through a conduit. When the bubbles move to the top, the gas can easily move to the top through multiple flow equalization plates 401. In this way, the flow equalization plates 401 can also intercept larger bubbles, preventing them from directly reaching the top of the gas washing bottle 1. It can also effectively delay the time for the gas to move to the top, effectively allowing the gas to react with the liquid inside the gas washing bottle 1, thus achieving the function of gas washing.

[0030] like Figure 4 , Figure 5As shown, the heating cylinder 3 is hollow inside. A discharge pipe 303 is installed at the top of the end of the heating cylinder 3 furthest from the gas washing bottle 1. The bottom of the end of the heating cylinder 3 closest to the gas washing bottle 1 is connected to the delivery pipe 302. The end of the U-shaped tube 4 furthest from the inlet pipe 2 bends upwards, while the end of the U-shaped tube 4 furthest from the inlet pipe 2 is close to the top of the gas washing bottle 1. The top of the end of the U-shaped tube 4 closest to the inlet pipe 2 penetrates the interior of the gas washing bottle 1 and is connected to the central pipe 301. Due to the presence of the U-shaped tube 4, the gas must pass through the U-shaped tube before being discharged. The tube 4 moves towards the bottom of the gas washing bottle 1, and the liquid heats the U-shaped tube 4, which in turn heats the gas inside the U-shaped tube 4, thus significantly increasing the gas temperature. In use, the discharge pipe 303 can be connected to a suction pump, which draws out the liquid inside the heating cylinder 3 and then draws the heated liquid into the heating cylinder 3 through the delivery pipe 302, thereby heating the central tube 301. As a result, the gas temperature is maintained when it is delivered to the central tube 301 through the U-shaped tube 4.

[0031] like Figure 3 , Figure 5 As shown, the top of the intake pipe 2 bends away from the side of the U-shaped pipe 4. A check valve 201 is installed at one end of the top of the intake pipe 2. The intake pipe 2 is connected to the gas delivery pipeline through the check valve 201, which can effectively prevent the gas from moving in the opposite direction.

[0032] like Figure 1 , Figure 2 As shown, a flow meter 501 is connected to one end of the central tube 301 near the chromatograph 5. The bottom of the flow meter 501 is connected to the inside of the chromatograph 5. The flow meter is used to observe the gas flow rate, and the chromatograph 5 is used for detection.

[0033] In use, the gas from the pharmaceutical intermediate can be conveniently delivered to the gas washing bottle 1 through one end of the inlet pipe 2. The gas is then delivered to the central tube 301 through the U-shaped tube 4, and finally to the chromatograph 5 at the bottom for detection through the flow meter 501. When the gas passes through the inlet pipe 2, it can be effectively dispersed and sprayed out by the atomizing nozzle 202 at the bottom of the inlet pipe 2, avoiding the formation of large bubbles directly in the gas washing bottle 1. As the bubbles move to the top, the gas can easily move to the top through multiple flow equalization plates 401. The flow equalization plates 401 can also intercept larger bubbles, preventing them from reaching the top of the gas washing bottle 1 directly, and can also effectively delay the time it takes for the gas to move to the top, effectively allowing the gas to react with the liquid inside the gas washing bottle 1, thus achieving the gas washing effect. Finally, the gas reaches the top of the gas washing bottle 1, and is then delivered to the central tube 301 through the U-shaped tube 4, avoiding the formation of large bubbles and improving the gas washing efficiency.

[0034] During use, the heating ring 101 can be easily activated to heat the gas washing bottle 1, raising the temperature of the liquid inside the gas washing bottle 1. This also facilitates the heating of the gas as it enters the gas washing bottle 1. Furthermore, due to the presence of the U-shaped tube 4, the gas must first pass through the U-shaped tube 4 towards the bottom of the gas washing bottle 1 before being discharged. The liquid heats the U-shaped tube 4, which in turn heats the gas inside, effectively increasing the gas temperature. Additionally, by connecting the discharge pipe 303 to a suction pump, the liquid inside the heating cylinder 3 can be drawn out and then drawn back into the heating cylinder 3 through the delivery pipe 302. This allows the liquid to heat the central tube 301, maintaining the temperature even as the gas is transported to the central tube 301 through the U-shaped tube 4. This effectively increases the gas activity and improves the gas chromatography detection efficiency of the chromatograph 5.

[0035] The foregoing description only illustrates certain exemplary embodiments of the present invention. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A gas chromatography apparatus for detecting pharmaceutical intermediates, comprising a gas washing bottle (1), characterized in that: An inlet pipe (2) is installed on one side of the inside of the gas washing bottle (1). A U-shaped tube (4) is installed on the side of the inside of the gas washing bottle (1) away from the inlet pipe (2). A heating cylinder (3) is provided on the side of the U-shaped tube (4) away from the inlet pipe (2). A chromatograph (5) is installed at the bottom of the end of the heating cylinder (3) away from the gas washing bottle (1). A heating ring (101) is installed around the outer wall of the gas washing bottle (1), and a liquid inlet pipe (102) is installed through the gas washing bottle (1) on the side near the gas inlet pipe (2). The gas washing bottle (1) has a conveying pipe (302) installed at the bottom of the side near the U-shaped tube (4), and a central tube (301) is installed through the inside of the heating cylinder (3). The air inlet pipe (2) is equipped with an atomizing nozzle (202) at one end near the inside of the gas washing bottle (1), and multiple flow equalization plates (401) are arranged in parallel inside the gas washing bottle (1).

2. The gas chromatography apparatus for detecting pharmaceutical intermediates according to claim 1, characterized in that: One end of the inlet pipe (102) penetrates multiple flow equalization plates (401) inside the gas washing bottle (1). The top end of the inlet pipe (102) is close to the top of the inside of the gas washing bottle (1). The bottom end of the inlet pipe (102) penetrates the inside of the gas washing bottle (1). The bottom end of the inlet pipe (102) is connected to the corresponding liquid supply pump through a conduit.

3. The gas chromatography apparatus for detecting pharmaceutical intermediates according to claim 1, characterized in that: The heating cylinder (3) is hollow inside. A discharge pipe (303) is installed on the top of the end of the heating cylinder (3) away from the gas washing bottle (1). The bottom of the end of the heating cylinder (3) near the gas washing bottle (1) is connected to the delivery pipe (302).

4. The gas chromatography apparatus for detecting pharmaceutical intermediates according to claim 1, characterized in that: The top of the air inlet pipe (2) bends away from the U-shaped pipe (4), and a check valve (201) is installed at one end of the top of the air inlet pipe (2). The air inlet pipe (2) is connected to the gas delivery pipeline through the check valve (201).

5. The gas chromatography apparatus for detecting pharmaceutical intermediates according to claim 1, characterized in that: The end of the U-shaped tube (4) away from the air inlet pipe (2) bends upwards, and the end of the U-shaped tube (4) away from the air inlet pipe (2) is close to the top of the gas washing bottle (1). The top of the end of the U-shaped tube (4) close to the air inlet pipe (2) penetrates the interior of the gas washing bottle (1) and is connected to the central tube (301).

6. The gas chromatography apparatus for detecting pharmaceutical intermediates according to claim 1, characterized in that: A flow meter (501) is connected to one end of the central tube (301) near the chromatograph (5), and the bottom of the flow meter (501) is connected to the inside of the chromatograph (5).

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