Multi-target test strip and multi-target detection reagent card

Abstract

The utility model relates to test strip technical field especially multi -target test strip and multi -target detection reagent card, its technical scheme discloses multi -target test strip, including combination layer, still including filter mechanism, the filter device sets up in the one side of combination layer for to the impurity of sample collection carries out the filtration, the one side fixed mounting of combination layer has detection layer, the one side fixed mounting of detection layer has water absorption pad, the filter mechanism includes the pretreatment layer fixed mounting in the one side of combination layer, a plurality of equidistance arrangement's filter screen is fixedly installed on the pretreatment layer, a plurality of equidistance arrangement's filter hole is opened to the filter screen, the radius of filter hole gradually reduces from top to bottom. The utility model has realized the filtration to the impurity before the detection of sample, has improved detection accuracy.

Description

Technical Field

[0001] This utility model relates to the field of test strip technology, and in particular to multi-target test strips and multi-target detection reagent cards. Background Technology

[0002] Multi-target test strips are used to simultaneously detect multiple disease biomarkers, helping doctors diagnose diseases quickly and accurately. Traditional single-target detection methods require individual testing of each target substance, a cumbersome and time-consuming process. Multi-target test strips and test kits, on the other hand, can analyze multiple targets simultaneously in a single test, significantly reducing testing time.

[0003] In the use of multi-target test strips, a blood sample from the patient is required for testing. Since blood samples contain a large number of blood cells, and these cells carry various charges and protein components on their surface, they may non-specifically adsorb test reagents. For example, red blood cells have a large number of glycoproteins and glycolipids on their surface, which may adsorb antibodies or antigens labeled with fluorescent substances or enzymes. In multi-target detection, if the test reagent is non-specifically adsorbed by blood cells, it will lead to an increase in the background value of the detection signal, affecting the accuracy of the detection. Therefore, this application proposes a multi-target test strip and a multi-target detection reagent card.

[0004] content

[0005] The purpose of this invention is to address the problem in the prior art where a large number of blood cells in the sample affects the accuracy of detection, and to propose a multi-target test strip and a multi-target detection reagent card.

[0006] Firstly, the technical solution of this utility model: a multi-target test strip, including a binding layer, and further comprising:

[0007] The filtration mechanism includes a filtration device disposed on one side of the bonding layer for filtering impurities in the collected sample. A detection layer is fixedly installed on one side of the bonding layer, and an absorbent pad is fixedly installed on one side of the detection layer.

[0008] Optionally, the filtration mechanism includes a pretreatment layer fixedly installed on one side of the bonding layer. Multiple filter screens arranged at equal intervals are fixedly installed on the pretreatment layer. Each filter screen has multiple filter holes arranged at equal intervals, with the radius of the filter holes decreasing from top to bottom. An isolation layer is fixedly installed inside the pretreatment layer. Multiple filter tubes arranged horizontally at equal intervals are fixedly installed inside the pretreatment layer. One end of each filter tube communicates with the isolation layer, and a glass fiber layer is disposed inside the filter tube. The other end of the glass fiber layer communicates with the side of the bonding layer.

[0009] Optionally, the isolation layer has a connection port, and the filter tube is connected to the connection port.

[0010] Optionally, the detection layer has multiple equally spaced detection lines, and antigens are disposed on the detection lines.

[0011] Optionally, the thickness of the pretreatment layer is 0.5-1cm, and the length of the pretreatment layer is less than the length of the bonding layer.

[0012] Optionally, the thickness of the detection layer is 0.5-1cm, and the length of the detection layer is greater than the length of the bonding layer.

[0013] Optionally, the absorbent pad has a length of 1-2 cm and is located at one end of the test strip.

[0014] Secondly, this utility model proposes a multi-target detection reagent card, including the multi-target test strip described in the first aspect.

[0015] Optionally, the housing is provided with a through hole and an observation groove, the through hole being located above the pretreatment layer and the observation groove being located above the detection layer.

[0016] Compared with the prior art, the present invention has the following beneficial technical effects:

[0017] This invention uses a filter in the pretreatment layer to initially filter blood cells in the sample. The filtered sample then enters a spirally arranged filter tube where it is adsorbed by a glass fiber layer, greatly reducing the blood cell content in the sample, increasing the contact area between the plasma and the detection line, and improving the accuracy of the detection. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of a multi-target test strip;

[0019] Figure 2 This is a schematic diagram of the shell structure;

[0020] Figure 3 This is a schematic diagram of the cross-sectional structure of the pretreatment layer.

[0021] Reference numerals: 1. Shell; 2. Observation slot; 3. Through hole; 4. Pretreatment layer; 5. Bonding layer; 6. Glass fiber layer; 7. Detection layer; 8. Detection line; 9. Water-absorbing pad; 10. Filter screen; 11. Filter hole; 12. Connection port; 13. Isolation layer; 14. Filter tube. Detailed Implementation

[0022] The technical solution of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some embodiments of this utility model, but not all embodiments.

[0023] The components of the present invention embodiments described and shown in the accompanying drawings can typically be arranged and designed in a variety of different configurations. Therefore, the following detailed description of the embodiments of the present invention provided in the drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention.

[0024] Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0025] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0026] It should be noted that the terms "comprising," "including," or any other variations thereof are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0027] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances. Example 1

[0028] like Figure 1 , Figure 2As shown, the multi-target test strip proposed in this utility model includes a binding layer 5 and a filtering mechanism. The filtering device is disposed on one side of the binding layer 5 to filter impurities in the collected sample. A detection layer 7 is fixedly installed on one side of the binding layer 5, and an absorbent pad 9 is fixedly installed on one side of the detection layer 7 to drive the liquid on the test strip to flow.

[0029] like Figure 3 As shown, in this embodiment, the multi-target test strip also includes a filtering mechanism. The filtering mechanism includes a pretreatment layer 4 fixedly installed on one side of the binding layer 5. Multiple equally spaced filter screens 10 are fixedly installed on the pretreatment layer 4. Multiple equally spaced filter holes 11 are opened on the filter screens 10. The radius of the filter holes 11 decreases from top to bottom, which is used to perform multi-stage filtration of impurities in the sample and improve the filtration effect. An isolation layer 13 is fixedly installed inside the pretreatment layer 4. Multiple equally spaced horizontally arranged filter tubes 14 are fixedly installed inside the pretreatment layer 4. The filter tubes 14 are spirally arranged to increase the contact time between the sample and the filter tubes 14 and improve the filtration effect. One end of the filter tube 14 is connected to the isolation layer 13. A glass fiber layer 6 is provided inside the filter tube 14, which can adsorb blood cells by physical adsorption, allowing plasma to better penetrate into the subsequent detection area and improve detection accuracy. The other end of the glass fiber layer 6 is connected to the side of the binding layer 5.

[0030] like Figure 2 , Figure 3 As shown, the isolation layer 13 has a connection port 12, the filter tube 14 is connected to the connection port 12, and the detection layer 7 has multiple detection lines 8 arranged at equal intervals, with antigens on the detection lines 8.

[0031] The thickness of the pretreatment layer 4 is 0.5-1cm, and the length of the pretreatment layer 4 is less than the length of the bonding layer 5. The thickness of the detection layer 7 is 0.5-1cm, and the length of the detection layer 7 is greater than the length of the bonding layer 5. The length of the absorbent pad 9 is 1-2cm, and the absorbent pad 9 is located at one end of the test paper. Example 2

[0032] This utility model proposes a multi-target detection reagent card, including the multi-target test strip in Example 1. For example... Figure 1-2 As shown, the housing 1 has a through hole 3 and an observation groove 2. The through hole 3 is located above the pretreatment layer 4 and is used to drop the sample to be tested. The observation groove 2 is located above the detection layer 7 and is used to observe the color development of the detection line.

[0033] The working principle of this embodiment is as follows: the blood sample to be tested is dripped into the through hole 3. The blood enters the pretreatment layer 4 and first comes into contact with the filter screen 10 and flows downward. The filter screen 10 performs multi-layer filtration of blood cells in the blood. The filtered sample enters the filter tube 14 through the connection port 12 for filtration again. Since the filter tube 14 is spirally designed, the residence time in the filter tube 14 is increased. The filtered sample enters the detection layer 7 and comes into contact with the detection line 8, and a color reaction occurs. This achieves the filtration of impurities in the sample before detection and improves the detection accuracy.

[0034] The above specific embodiments are merely several optional embodiments of this utility model. Based on the technical solution of this utility model and the relevant teachings of the above embodiments, those skilled in the art can make various alternative improvements and combinations to the above specific embodiments.

Claims

1. A multi-target test strip, including a binding layer (5), characterized in that, Also includes: The filtering mechanism is disposed on one side of the binding layer (5) for filtering impurities in the collected sample. A detection layer (7) is fixedly installed on one side of the binding layer (5), and an absorbent pad (9) is fixedly installed on one side of the detection layer (7). The filtration mechanism includes a pretreatment layer (4) fixedly installed on one side of the bonding layer (5). Multiple filter screens (10) arranged at equal intervals are fixedly installed on the pretreatment layer (4). Multiple filter holes (11) arranged at equal intervals are opened on the filter screens (10). The radius of the filter holes (11) decreases from top to bottom. An isolation layer (13) is fixedly installed inside the pretreatment layer (4). Multiple filter tubes (14) arranged horizontally at equal intervals are fixedly installed inside the pretreatment layer (4). One end of the filter tube (14) is connected to the isolation layer (13). A glass fiber layer (6) is provided inside the filter tube (14). The other end of the glass fiber layer (6) is connected to the side of the bonding layer (5).

2. The multi-target test strip according to claim 1, characterized in that, The isolation layer (13) has a connection port (12), and the filter tube (14) is connected to the connection port (12).

3. The multi-target test strip according to claim 1, characterized in that, The detection layer (7) has multiple equally spaced detection lines (8), and antigens are provided on the detection lines (8).

4. The multi-target test strip according to claim 1, characterized in that, The thickness of the pretreatment layer (4) is 0.5-1cm, and the length of the pretreatment layer (4) is less than the length of the bonding layer (5).

5. The multi-target test strip according to claim 1, characterized in that, The thickness of the detection layer (7) is 0.5-1cm, and the length of the detection layer (7) is greater than the length of the bonding layer (5).

6. The multi-target test strip according to claim 1, characterized in that, The absorbent pad (9) is 1-2 cm long and is located at one end of the test paper.

7. A multi-target detection reagent card, characterized in that, The multi-target detection reagent card includes a housing (1) and a multi-target test strip of any one of claims 1-6 within the housing (1).

8. The multi-target detection reagent card according to claim 7, characterized in that, The housing (1) has a through hole (3) and an observation groove (2). The through hole (3) is located above the pretreatment layer (4), and the observation groove (2) is located above the detection layer (7).

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