An immunoassay substrate supply device

Abstract

This utility model relates to the field of medical testing equipment technology and provides an immunoassay substrate supply device, comprising: an immunoassay substrate solution storage container; a micropump, the input end of which is connected to the storage container; a supply tube assembly, connected to the output end of the micropump via a first tube body; the supply tube assembly includes a three-way valve, an electrochromic glass temporary storage tube, and a detection substrate solution output nozzle; the first end of the three-way valve is connected to the first tube body, the second end is connected to the electrochromic glass temporary storage tube, and the third end is connected to the second tube body; the detection substrate solution output nozzle is located at the end of the electrochromic glass temporary storage tube; the second tube body is connected to an external inert gas supply device for injecting inert gas into the temporary storage tube to drive the substrate solution output. This utility model can avoid substrate solution inactivation upon contact with oxygen, while simultaneously filling the detection container with inert gas to create an anaerobic environment, thus solving the problems of photodegradation, oxidative inactivation, and microbial contamination of immunoassay substrate solution during the supply process.

Description

Technical Field

[0001] This utility model relates to the field of medical testing equipment technology, and more specifically, to an immune testing substrate supply device. Background Technology

[0002] Immunoassay substrate solutions (such as TMB in ELISA, chemiluminescent substrates, etc.) are the core reagents in immunoassays, and their stability directly affects the accuracy of the test results. In existing technologies, substrate solutions are typically supplied using the following methods:

[0003] Manual sampling by opening the container: The operator needs to repeatedly open the storage container, which exposes the substrate liquid to light and air, causing photo-oxidative deterioration (such as TMB decomposition in light) and microbial contamination.

[0004] Traditional pipeline transportation: Some equipment uses pipelines to transport the substrate solution from the storage tank to the sampling port, but it has the following drawbacks:

[0005] Substrate solution remains in the pipeline for a long time, which breeds bacteria and contaminates subsequent samples;

[0006] The lack of light-blocking design means that the transparent pipes cause the substrate liquid to degrade under light during transportation;

[0007] Without inert gas protection, the substrate liquid is oxidized and deactivated upon contact with air.

[0008] Therefore, there is an urgent need for a substrate liquid supply device that can simultaneously avoid the risks of light, oxidation and contamination, ensuring the stability of the entire process from storage to output. Utility Model Content

[0009] The problem this invention addresses is: how to prevent the immunoassay solution from deteriorating during the supply of immunoassay substrates.

[0010] To address the above problems, this utility model provides an immunoassay substrate supply device, comprising:

[0011] Storage container for immunoassay substrate solutions;

[0012] A micro-pump, the input of which is connected to the storage container;

[0013] The supply tube assembly is connected to the output end of the micro-pump via the first tube body;

[0014] The supply tube assembly includes a three-way tube, an electrochromic glass storage tube, and a detection base liquid output nozzle.

[0015] The first end of the three-way tube is connected to the first tube body, the second end is connected to the electrochromic glass storage tube, and the third end is connected to the second tube body.

[0016] The detection base liquid output nozzle is located at the end of the electrochromic glass temporary storage tube and is equipped with a first solenoid valve;

[0017] The second tube is connected to an external inert gas supply device, which is used to inject inert gas into the temporary storage tube to drive the output of the substrate liquid.

[0018] Optionally, the outer wall of the electrochromic glass storage tube is provided with scale lines.

[0019] Optionally, the first tube is equipped with a metering solenoid valve to control the volume of the substrate liquid entering the temporary storage tube.

[0020] Optionally, the first tube body is provided with a reflux pipe, and a third solenoid valve is installed on the reflux pipe for guiding the substrate liquid back to the storage container.

[0021] Optionally, a one-way valve is provided at the connection between the reflux pipe and the storage container.

[0022] Optionally, the transmittance of the electrochromic glass temporary storage tube is dynamically controlled by an electrical signal.

[0023] Optionally, the gas output by the inert gas supply device is nitrogen or argon.

[0024] Optionally, it also includes a control module, which is electrically connected to the micro-pump, the first solenoid valve, the metering solenoid valve and the third solenoid valve.

[0025] Compared with the prior art, the immunoassay substrate supply device of this invention has the following advantages:

[0026] This invention uses a micro-pump to draw substrate solution from a light-proof immunoassay substrate storage container, delivers it through a first tube to a three-way valve, and then through the second end of the three-way valve into an electrochromic glass temporary storage tube. At this point, the temporary storage tube is in a low-transmittance, dark state, blocking light. Then, an inert gas-driven output occurs. Specifically, the metering solenoid valve is closed to stop the liquid inflow, the first solenoid valve is opened, and external inert gas, such as nitrogen or argon, is injected into the temporary storage tube through the second tube and the third end of the three-way valve. The gas pressure pushes the substrate solution out through the nozzle. The electrochromic glass dynamically blocks light to prevent photosensitive deterioration of the substrate solution, such as TMB. The entire process is driven by inert gas to prevent the substrate solution from being deactivated by contact with oxygen. Simultaneously, the inert gas fills the detection container, creating an oxygen-free environment. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the structure of the immunoassay substrate supply device in an embodiment of this utility model;

[0028] Figure 2 This is a schematic diagram of the supply tube head assembly in an embodiment of the present invention.

[0029] Explanation of reference numerals in the attached figures:

[0030] 100. Immunoassay substrate solution storage container; 110. Micropump; 120. First tube; 130. Reflux tube; 140. Third solenoid valve; 150. Quantitative solenoid valve; 160. Second tube; 170. Three-way valve; 180. Electrochromic glass temporary storage tube; 190. Detection substrate solution output nozzle; 200. First solenoid valve. Detailed Implementation

[0031] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings.

[0032] In the attached diagram, the Z-axis represents the vertical direction, i.e., up and down, with the positive direction of the Z-axis representing up and the negative direction representing down. The X-axis represents the horizontal direction, specifically the left and right positions, with the positive direction of the X-axis representing the right side and the negative direction representing the left side. The Y-axis represents the front and back positions, with the positive direction of the Y-axis representing the rear and the negative direction representing the front. It should be noted that the aforementioned representations of the Z, Y, and X axes are merely for ease of description and simplification of the present invention, and do not indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the present invention.

[0033] It should be noted that the terms "first," "second," etc., used in the specification, claims, and accompanying drawings of this utility model are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of this utility model described herein can be implemented in sequences other than those illustrated or described herein.

[0034] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0035] In the description of this specification, references to terms such as "embodiment," "one embodiment," and "one implementation" indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or implementation is included in at least one embodiment or implementation of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or implementation. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or implementations.

[0036] like Figures 1 to 2 As shown, this embodiment of the present invention provides an immunoassay substrate supply device, comprising:

[0037] 100g storage container for immunoassay substrate solutions;

[0038] A micro-pump 110, the input of which is connected to a storage container 100;

[0039] The supply tube assembly is connected to the output end of the micro pump 110 via the first tube body 120;

[0040] The supply tube assembly includes a three-way tube 170, an electrochromic glass storage tube 180, and a detection base liquid output nozzle 190; the transmittance of the electrochromic glass storage tube 180 is dynamically controlled by an electrical signal.

[0041] The first end of the three-way tube 170 is connected to the first tube body 120, the second end is connected to the electrochromic glass storage tube 180, and the third end is connected to the second tube body 160.

[0042] The detection base liquid output nozzle 190 is located at the end of the electrochromic glass temporary storage tube 180 and is equipped with a first solenoid valve 200;

[0043] The second tube 160 is connected to an external inert gas supply device, which is used to inject inert gas into the temporary storage tube 180 to drive the output of the substrate liquid.

[0044] In this embodiment, the substrate solution is first delivered. A micro-pump 110 draws the substrate solution from a light-proof immunoassay substrate storage container 100, delivers it through the first tube 120 to the three-way tube 170, and then through the second end of the three-way tube 170 into an electrochromic glass temporary storage tube 180. At this time, the temporary storage tube is in a low-transmittance, dark state, blocking light. Then, an inert gas-driven output occurs. Specifically, the quantitative solenoid valve 150 is closed to stop the liquid inflow, and the first solenoid valve 200 is opened. External inert gas, such as nitrogen or argon, is injected into the temporary storage tube 180 through the second tube 160 and the third end of the three-way tube 170. The gas pressure pushes the substrate solution out of the nozzle 190. The electrochromic glass dynamically blocks light to prevent photosensitive deterioration of the substrate solution, such as TMB. The entire process is driven by inert gas to prevent the substrate solution from being deactivated by contact with oxygen. Simultaneously, the inert gas fills the detection container, creating an oxygen-free environment.

[0045] The electrochromic glass storage tube 180 has graduation lines on its outer wall.

[0046] Specifically, before output, the transmittance of the electrochromic glass temporary storage tube 180 is increased by an electrical signal to make the scale line visible and directly read the volume of the substrate liquid.

[0047] The first tube 120 is equipped with a metering solenoid valve 150, which is used to control the volume of the substrate liquid entering the temporary storage tube 180.

[0048] When the micro-pump 110 delivers the substrate liquid, the metering solenoid valve 150 opens and closes according to a preset volume, precisely controlling the amount of liquid entering the temporary storage tube 180, eliminating excessive delivery errors, and thus adapting to micro-detection needs.

[0049] The first tube 120 is provided with a return pipe 130, and a third solenoid valve 140 is installed on the return pipe 130 for guiding the substrate liquid back to the storage container 100.

[0050] A one-way valve is provided at the connection between the reflux pipe 130 and the storage container 100.

[0051] Specifically, the third solenoid valve 140 is opened, and the micro-pump 110 runs in reverse, pushing the residual substrate solution in the first tube 120 back to the storage container 100 through the return tube 130. The one-way valve at the connection between the return tube 130 and the container prevents backflow of the liquid. This avoids bacterial growth in the tubing and contamination of subsequent samples, while also recovering the expensive substrate solution and reducing costs.

[0052] In this embodiment, the inert gas supply device outputs nitrogen or argon. The external gas supply device provides high-purity nitrogen or argon, which is injected into the system through the second tube 160. Nitrogen / argon has strong chemical inertness, completely blocking the oxidation reaction of the substrate liquid.

[0053] It also includes a control module, which is electrically connected to the micro-pump 110, the first solenoid valve 200, the metering solenoid valve 150 and the third solenoid valve 140.

[0054] In this embodiment, the control module coordinates the various components, opening the quantitative solenoid valve 150 and the micro-pump 110 to quantitatively infuse the substrate solution. It then closes the quantitative valve, activates the inert gas and the first solenoid valve 200 to drive the output. The third solenoid valve 140 and the reflux pipe 130 are periodically opened to clean the tubing. This reduces manual intervention, improves operational efficiency and consistency, and automatically triggers light shielding, gas protection, and cleaning to ensure reagent stability.

[0055] Although the present invention has been disclosed above, its protection scope is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present invention, and all such changes and modifications will fall within the protection scope of the present invention.

Claims

1. An immunoassay substrate supply device, characterized in that, include: Immunoassay substrate storage container (100); A micro-pump (110) is connected to the storage container (100) at its input end; The supply tube assembly is connected to the output end of the micro-pump (110) via the first tube body (120); The supply tube assembly includes a three-way tube (170), an electrochromic glass storage tube (180), and a detection base liquid output nozzle (190); The first end of the three-way tube (170) is connected to the first tube body (120), the second end is connected to the electrochromic glass storage tube (180), and the third end is connected to the second tube body (160). The detection base liquid output nozzle (190) is located at the end of the electrochromic glass temporary storage tube (180) and is equipped with a first solenoid valve (200); The second tube (160) is connected to an external inert gas supply device for injecting inert gas into the temporary storage tube (180) to drive the substrate liquid output.

2. The immunoassay substrate supply device according to claim 1, characterized in that, The electrochromic glass storage tube (180) has scale lines on its outer wall.

3. The immunoassay substrate supply device according to claim 1, characterized in that, The first tube (120) is equipped with a quantitative solenoid valve (150) for controlling the volume of substrate liquid entering the temporary storage tube (180).

4. The immunoassay substrate supply device according to claim 1, characterized in that, The first tube (120) is provided with a return pipe (130), and a third solenoid valve (140) is installed on the return pipe (130) for guiding the substrate liquid back to the storage container (100).

5. The immunoassay substrate supply device according to claim 4, characterized in that, A one-way valve is provided at the connection between the reflux pipe (130) and the storage container (100).

6. The immunoassay substrate supply device according to claim 1, characterized in that, The transmittance of the electrochromic glass storage tube (180) is dynamically controlled by an electrical signal.

7. The immunoassay substrate supply device according to claim 1, characterized in that, The inert gas supply device outputs either nitrogen or argon.

8. The immunoassay substrate supply device according to claim 4, characterized in that, It also includes a control module, which is electrically connected to the micro-pump (110), the first solenoid valve (200), the metering solenoid valve (150) and the third solenoid valve (140).

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