A cell cryopreservation tube

Abstract

This utility model discloses a cell cryopreservation tube, including a tube body, a sealing element, and a cap body. The cap body seals onto the tube body. The sealing element is positioned between the tube body and the cap body. The cap body has a break portion, with the lower end face or part of the lower end face of the break portion corresponding to the upper end face or part of the upper end face of the sealing element. The advantages of this utility model are that the cap body can be separated vertically, allowing for normal tightening and loosening under normal torque. With appropriately increased torque, the upper and lower cap components can be separated via the break portion. When using the solution later, the operator does not need to loosen the entire cap body; only the upper cap component needs to be separated. The solution can be directly drawn by penetrating the sealing assembly with a syringe, ensuring no contamination. This process avoids cross-contamination and improves extraction safety. The cap body is adaptable to automated filling, storage, and operation systems, and can also be easily tightened by hand.

Description

Technical Field

[0001] This utility model relates to the field of sample storage technology, and in particular to a cell cryopreservation tube. Background Technology

[0002] In the field of biological samples, cryovials store biological sample solutions. When extracting biological samples, the top cap of the cryovial needs to be opened first by an opening mechanism or manually, and then the biological sample solution inside the cryovial needs to be extracted by an extraction mechanism. Not only will the extraction process expose the sample to a low-temperature environment, which can easily lead to sample loss, but it can also easily cause cross-contamination of the sample inside the cryovial.

[0003] To address this, the inventors designed a cell cryopreservation tube that improves the insulation effect of the cryopreservation tube while also enabling sample extraction, and without causing cross-contamination of the samples. Utility Model Content

[0004] The purpose of this section is to outline some aspects of embodiments of the present invention and to briefly describe some preferred embodiments. Simplifications or omissions may be made in this section, as well as in the abstract and title of this application, to avoid obscuring the purpose of these documents; however, such simplifications or omissions should not be construed as limiting the scope of the present invention.

[0005] In view of the problems existing in the above or prior art, this utility model is proposed.

[0006] Therefore, the purpose of this utility model is to provide a cell cryopreservation tube, which uses a robotic arm to unscrew the tube cap as a whole, stores the solution into the tube in a low-temperature environment, and automatically tightens and refrigerates it. When taking it out, the upper cap component and the broken part are twisted or broken off by hand, so that the upper cap component and the broken part are separated from the lower cap component, and the sealing component of the broken part is exposed. This makes it easy for staff to insert a penetrator into the tube to draw out the solution, ensuring no contamination. This not only avoids cross-infection but also improves the safety of extraction.

[0007] To solve the above-mentioned technical problems, the present invention provides the following technical solution: a cell cryopreservation tube, comprising a tube body, a sealing element, and a cap body; the cap body sealably covers the tube body; the sealing element is sealed between the tube body and the cap body; the cap body is provided with a broken portion, the lower end face or part of the lower end face of the broken portion corresponding to the upper end face of the sealing element or part of the upper end face of the sealing assembly.

[0008] As a preferred embodiment of the cell cryopreservation tube of this utility model, the tube cap body includes an upper cap component, a lower cap component, and a break portion, wherein the upper cap component and the lower cap component are connected through the break portion; the lower cap component can be sealed and closed on the tube body.

[0009] As a preferred embodiment of the cell cryopreservation tube of this utility model, the lower cover component has a threaded cap groove area formed downwards, and can be sealed on the tube body by threaded connection.

[0010] As a preferred embodiment of the cell cryopreservation tube of this utility model, the sealing element is in the shape of a gasket and is sealed and pressed against the upper end of the tube body by the tube cap body; the sealing element is made of flexible material.

[0011] As a preferred embodiment of the cell cryopreservation tube of this utility model, the tube cap body includes an upper cap component and a lower cap component, and the broken part is a hollow internal broken groove with a relatively small diameter that extends from the lower cap component toward the upper cap component.

[0012] As a preferred embodiment of the cell cryopreservation tube of this utility model, the sealing body is provided with a protrusion, the protrusion is located inside the broken part, and the protrusion extends upward and is located on the lower end face of the upper cover component.

[0013] As a preferred embodiment of the cell cryopreservation tube of this utility model, the protrusion is hollow inside, and the inner side of the protrusion is connected to the inside of the tube cap body.

[0014] As a preferred embodiment of the cell cryopreservation tube of this utility model, a sealing gasket is provided at the lower end of the protrusion facing the circumferential direction, and the sealing gasket can seal the tube body.

[0015] As a preferred embodiment of the cell cryopreservation tube of this utility model, the lower cover component includes a lower cover with multiple sets of lower friction strips on its peripheral side; the upper cover component includes an upper cover with multiple sets of upper friction strips on its peripheral side; the multiple sets of lower friction strips and upper friction strips are arranged with concave and convex surfaces.

[0016] As a preferred embodiment of the cell cryopreservation tube of this utility model, a limiting hole is provided at the upper end of the top cover, and the inner wall of the limiting hole is provided with concave and convex features.

[0017] As a preferred embodiment of the cell cryopreservation tube of this utility model, a support frame is provided on the tube body, which can support the tube body and limit the position of the lower cover component.

[0018] As a preferred embodiment of the cell cryopreservation tube of this utility model, the tube cap body is made of PPO special plastic material.

[0019] The beneficial effects of this utility model are:

[0020] 1. The cap body can be separated into upper and lower parts. Under normal torque conditions, the cap can be tightened and loosened normally. With appropriate increase of torque, the upper and lower cap parts can be separated through the break.

[0021] 2. When using the solution later, the operator does not need to loosen the entire tube cap body. They only need to separate the top cap part and directly use a syringe to penetrate the sealing component to draw the solution, ensuring no contamination. This operation process avoids cross-contamination and improves the safety of extraction.

[0022] 3. A sealing assembly is provided inside the lower cover component to seal the tube body;

[0023] 4. The cap body can be adapted to automated filling, storage, and operation, and can also be easily tightened by hand;

[0024] 5. The pipe cap body is made of PPO high-strength special plastic material that is resistant to extremely low temperatures. Attached Figure Description

[0025] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Among them:

[0026] Figure 1 This is a three-dimensional schematic diagram of a cell cryopreservation tube.

[0027] Figure 2 This is an internal cross-sectional view of a cell cryopreservation tube.

[0028] Figure 3 for Figure 2 A magnified view of a portion of the cap of a cell cryopreservation tube.

[0029] Figure 4 This is a top view of a cell cryopreservation tube.

[0030] Reference numerals: tube body, 1; seal, 2; tube cap body, 3; upper cover component, 31; lower cover component, 32; broken part, 33; protrusion, 21; sealing gasket, 22; lower cover, 321; lower friction strip, 322; upper cover, 311; upper friction strip, 312; limiting hole, 313; support frame, 4; Detailed Implementation

[0031] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings.

[0032] Many specific details are set forth in the following description in order to provide a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art can make similar extensions without departing from the spirit of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0033] Secondly, the term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that excludes other embodiments. Example 1

[0034] Reference Figures 1-3 This is the first embodiment of the present invention. This embodiment provides a cell cryopreservation tube, which includes a tube body 1, a sealing element 2, and a tube cap body 3. The tube cap body 3 can seal onto the tube body 1. The sealing element 2 is sealed between the tube body 1 and the tube cap body 3. The tube cap body 3 is provided with a broken portion 33, and the lower end face or part of the lower end face of the broken portion 33 corresponds to the upper end face of the sealing element 2 or part of the upper end face of the sealing assembly.

[0035] Preferably, the break portion 33 will not break under normal torque. Based on the normal torque, if the torque is increased, the tube cap body 3 can be separated through the break portion 33, and the partial sealing component will be exposed. The sealing component is inserted into the tube body 1 using an inserter, thereby drawing the solution from the tube body 1.

[0036] Preferably, the lower end face or part of the lower end face of the broken part 33 corresponds to the upper end face of the seal 2 or part of the upper end face of the sealing assembly. This correspondence is to partially expose the sealing assembly, thereby facilitating the extraction needle and inserter to extract the solution inside the tube 1.

[0037] Preferably, the sealing element 2 can play a role in heat preservation and sealing isolation, preventing the solution inside the tube 1 from being damaged due to temperature changes.

[0038] In summary, by setting the break portion 33, this utility model allows the tube cap body 3 to be separated, thereby exposing a portion of the seal 2. This facilitates the extraction needle to pass through the seal 2 to extract the solution from the tube body 1. This device enables the tube cap body 3 to be rotated and opened under normal torque. By increasing the torque based on the normal torque and using the break portion 33, the tube cap body 3 can be separated, thus enabling the extraction of the solution in the tube body 1 without opening the entire tube cap body 3. Example 2

[0039] Reference Figures 1-4 This is the second embodiment of the present invention. In the previous embodiment, the cell cryopreservation tube includes a tube body 1, a sealing element 2, and a tube cap body 3. The tube cap body 3 can seal onto the tube body 1. The sealing element 2 is sealed between the tube body 1 and the tube cap body 3. The tube cap body 3 is provided with a broken portion 33, and the lower end face or part of the lower end face of the broken portion 33 corresponds to the upper end face of the sealing element 2 or part of the upper end face of the sealing assembly.

[0040] Preferably, the break portion 33 will not break under normal torque. Based on the normal torque, if the torque is increased, the tube cap body 3 can be separated through the break portion 33, and the partial sealing component will be exposed. The sealing component is inserted into the tube body 1 using an inserter, thereby drawing the solution from the tube body 1.

[0041] Preferably, the lower end face or part of the lower end face of the broken part 33 corresponds to the upper end face of the seal 2 or part of the upper end face of the sealing assembly. This correspondence is to partially expose the sealing assembly, thereby facilitating the extraction needle and inserter to extract the solution inside the tube 1.

[0042] Preferably, the sealing element 2 can play a role in heat preservation and sealing isolation, preventing the solution inside the tube 1 from being damaged due to temperature changes.

[0043] Furthermore, the pipe cover body 3 includes an upper cover component 31, a lower cover component 32, and a break portion 33. The upper cover component 31 and the lower cover component 32 are connected through the break portion 33; the lower cover component can be sealed and covered onto the pipe body 1.

[0044] Furthermore, the lower cover component 32 has a threaded cap groove area formed downwards, and can be sealed on the tube body 1 by threaded connection.

[0045] Preferably, the pipe body 1 can be connected and sealed by the lower cover component 32, and the pipe body 1 can be further insulated and sealed by the sealing element 2.

[0046] Ideally, the seal 2 can not only keep the solution in the tube 1 warm, but also prevent external contamination of the solution inside the tube.

[0047] Furthermore, the sealing element is in the shape of a gasket and is sealed and pressed onto the upper end of the pipe body 1 by the pipe cap body 3; the sealing element is made of flexible material.

[0048] Preferably, flexible materials refer to soft, flexible, or variable materials that can be penetrated by a needle, such as silicone and rubber.

[0049] Furthermore, the pipe cover body 3 includes an upper cover component 31 and a lower cover component 32. The broken portion 33 is a hollow internal broken groove with a relatively small diameter that extends from the lower cover component 32 toward the upper cover component 31.

[0050] Preferably, the fracture portion 33 adopts a thin-walled design, which makes it convenient for workers to break or rotate the fracture portion 33.

[0051] Preferably, the fracture portion 33 is a hollow fracture groove with a relatively small diameter. A protrusion 21 is provided on the inner side of the fracture portion 33, so that when the fracture portion 33 breaks, the inserter can be inserted into the tube body 1 through the protrusion 21 to draw the solution without having to open the entire tube cap body 3, thus avoiding cross-contamination.

[0052] It should be noted that the broken part 33 can also be other regular geometric shapes, such as square, or other irregular shapes; the lower cover 321 and the tube body 1 can be threaded or other existing connection methods, such as snap-fit, plug-in, etc.

[0053] Preferably, the broken portion 33 can also be made in a manner similar to a cone or an inverted cone. By appropriately increasing the rotational torque, the broken portion 33 will break, thereby exposing the protrusion 21 inside the broken portion 33, which facilitates the insertion of the inserter.

[0054] It should be noted that the fractured part 33 can be designed with thin walls, and can also be designed with weak stress rings or stress points, such as a concave circle, or other shapes that facilitate fracture.

[0055] Furthermore, the sealing element 2 body is provided with a protrusion 21, which is located inside the broken part 33 and extends upward to the lower end face of the upper cover component 31.

[0056] Preferably, by providing the protrusion 21 inside the break portion 33 and providing the upper end face of the protrusion 21 on the lower end face of the upper cover component 31, the protrusion 21 can be exposed when the break portion 33 is broken, thus facilitating the insertion of the protrusion 21 with an inserter to extract the solution inside the inner tube 1.

[0057] Furthermore, the protrusion 21 is hollow inside, and the inner side of the protrusion 21 is connected to the inside of the tube cover body 3.

[0058] Preferably, by making the protrusion 21 hollow and communicating with the inside of the cap body 3, the extraction needle can easily pass through the protrusion 21 to extract the solution inside the cap body 3.

[0059] Furthermore, a sealing gasket 22 is provided on the lower end of the protrusion 21 extending in the circumferential direction, and the sealing gasket 22 can seal the tube body 1.

[0060] It should be noted that cell cryopreservation tubes differ from biological sample cryopreservation tubes. Cell cryopreservation tubes require the cell fluid to be extracted and diluted using an extraction needle before being directly introduced into the human body. Therefore, the filling process can be automated. After the cell fluid is filled, the upper cap component 31 is rotated using automated equipment. At this time, the torque is at normal levels, and the break portion 33 rotates together with the upper cap component 31 and the lower cap component 32, thereby automatically tightening the tube body 1 for cryopreservation. When cell fluid extraction is required, it can be unscrewed by machine or manually. At this time, the break portion 33 will break, separating the upper cap component 31 and the lower cap component 32, exposing the protrusion 21 inside the break portion 33, revealing a small silicone opening, which facilitates the insertion of the extraction needle into the tube body 1 for solution extraction. This ensures no contamination and avoids cross-contamination in the operation process, improving the safety of extraction.

[0061] Furthermore, the lower cover component 32 includes a lower cover 321, and a plurality of lower friction strips 322 are provided on the peripheral side of the lower cover 321; the upper cover component 31 includes an upper cover 311, and a plurality of upper friction strips 312 are provided on the peripheral side of the upper cover 311; the plurality of lower friction strips 322 and upper friction strips 312 are arranged in a concave-convex manner.

[0062] Preferably, multiple sets of lower friction strips 322 and upper friction strips 312 are respectively provided on the sides of the lower cover 321 and the upper cover 311, and the lower friction strips 322 and upper friction strips 312 are concave and convex, which facilitates the operation without slippage when manually rotated, and can increase friction.

[0063] Furthermore, a limiting hole 313 is provided at the upper end of the upper cover 311, and the inner wall of the limiting hole 313 is provided with concave and convex features.

[0064] Preferably, by setting the limiting hole 313, the automated equipment can be easily driven, thereby allowing the upper cover component 31 to rotate, and preventing the automated equipment from sliding within the limiting hole 313.

[0065] Furthermore, a support frame 4 is provided on the tube body 1, which can support the tube body 1 and limit the position of the lower cover component 32.

[0066] Furthermore, the cap body 3 is made of PPO special plastic material.

[0067] Preferably, the pipe cap body 3 is made of PPO high-strength special plastic material that is resistant to extremely low temperatures.

[0068] In summary, this device allows for the separation of the cap body into upper and lower sections. Under normal torque conditions, the cap can be tightened and loosened normally. With an appropriate increase in torque, the upper and lower cap components can be separated via the break section 33. When using the solution later, the operator does not need to loosen the entire cap body; only the upper cap component needs to be separated. The solution can then be directly drawn through the sealing assembly using a syringe, ensuring no contamination. This process avoids cross-contamination and improves extraction safety. The lower cap component contains a sealing assembly to seal the tube. The cap body is compatible with automated filling, storage, and operation systems, and can also be easily tightened by hand. The cap body is made of PPO high-strength special plastic material that is resistant to extremely low temperatures.

[0069] It is important to note that the constructions and arrangements of this application shown in several different exemplary embodiments are merely illustrative. Although only a few embodiments are described in detail in this disclosure, those who consult this disclosure will readily understand that many modifications are possible (e.g., changes in the size, dimensions, structure, shape and proportion of various elements, as well as parameter values ​​(e.g., temperature, pressure, etc.), mounting arrangements, use of materials, color, orientation, etc.) without substantially departing from the novel teachings and advantages of the subject matter described in this application). For example, an element shown as integrally formed may be composed of multiple parts or elements, the position of elements may be inverted or otherwise altered, and the nature or number or position of discrete elements may be changed or altered. Therefore, all such modifications are intended to be included within the scope of this utility model. The order or sequence of any process or method steps may be changed or reordered according to alternative embodiments. In the claims, any "device plus function" clause is intended to cover the structure described herein that performs the function, and not only structural equivalents but also equivalent structures. Without departing from the scope of this invention, other substitutions, modifications, alterations, and omissions may be made in the design, operation, and arrangement of the exemplary embodiments. Therefore, this invention is not limited to the specific embodiments, but extends to various modifications that still fall within the scope of the appended claims.

[0070] Furthermore, in order to provide a concise description of exemplary embodiments, not all features of actual embodiments (i.e., those features that are not relevant to the best mode of carrying out the present invention as currently considered, or those features that are not relevant to implementing the present invention) may be omitted.

[0071] It should be understood that numerous specific implementation decisions can be made during the development of any practical implementation, such as in any engineering or design project. Such development efforts may be complex and time-consuming, but for those skilled in the art who benefit from this disclosure, the development effort will be a routine work of design, manufacturing, and production without requiring much experimentation.

[0072] It should be noted that the above embodiments are only used to illustrate the technical solution of this utility model and are not intended to limit it. Although this utility model has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications or substitutions should be covered within the scope of the claims of this utility model.

Claims

1. A cell cryopreservation tube, characterized in that: It includes a pipe body (1), a sealing element (2), and a pipe cap body (3); the pipe cap body (3) can seal and cover the pipe body (1); the sealing element (2) is sealed between the pipe body (1) and the pipe cap body (3); the pipe cap body (3) is provided with a broken part (33), and the lower end face or part of the lower end face of the broken part (33) corresponds to the upper end face or part of the upper end face of the sealing element (2).

2. The cell cryotube of claim 1, wherein: The tube cap body (3) includes an upper cover component (31), a lower cover component (32), and a break portion (33). The upper cover component (31) and the lower cover component (32) are connected through the break portion (33). The lower cover component (32) can seal and cover the tube body (1).

3. The cell cryotube of claim 2, wherein: The lower cover component (32) has a threaded cap groove area formed downwards, and can be sealed on the tube body (1) by threaded connection.

4. The cell cryotube of any one of claims 1 to 3, wherein: The sealing element (2) is in the shape of a gasket and is sealed and pressed against the upper end of the pipe body (1) by the pipe cap body (3); the sealing element (2) is made of flexible material.

5. The cell cryotube of claim 4, wherein: The tube cap body (3) includes an upper cover component (31) and a lower cover component (32). The broken part (33) is a hollow, relatively small-diameter broken groove that extends from the lower cover component (32) toward the upper cover component (31).

6. The cell cryotube of claim 5, wherein: The sealing element (2) has a protrusion (21) on its body. The protrusion (21) is located inside the broken part (33) and extends upward to the lower end face of the upper cover part (31).

7. The cell cryotube of claim 6, wherein: The protrusion (21) is hollow inside, and the inside of the protrusion (21) is connected to the inside of the tube cover body (3).

8. The cell cryotube of claim 6, wherein: The lower end of the protrusion (21) extends in the circumferential direction and is provided with a sealing gasket (22), which can seal the tube body (1).

9. The cell cryotube of claim 2 or 3, wherein: The lower cover component (32) includes a lower cover (321), and a plurality of lower friction strips (322) are provided on the peripheral side of the lower cover (321); the upper cover component (31) includes an upper cover (311), and a plurality of upper friction strips (312) are provided on the peripheral side of the upper cover (311); the plurality of lower friction strips (322) and upper friction strips (312) are arranged in a concave-convex manner.

10. The cell cryotube of claim 9, wherein: The upper end of the cover (311) has a limiting hole (313), and the inner wall of the limiting hole (313) is circumferentially concave and convex.

11. The cell cryotube of claim 2, wherein: The tube body (1) is provided with a support frame (4), which can support the tube body (1) and limit the lower cover component (32).

12. The cell cryotube of claim 5, wherein: The cap body (3) is made of PPO special plastic material.

Images