Medicine synthesis reaction kettle

Abstract

The application relates to the technical field of reaction kettles, and discloses a medicine synthesis reaction kettle which comprises a reaction kettle body, a temperature control assembly, a stirring assembly and a control assembly. The medicine synthesis reaction kettle is characterized in that the reaction kettle body and the temperature control assembly are cooperatively designed, a cooling jacket and a cooling spiral pipe form a double-channel cooling system, the cooling efficiency is improved, the required low-temperature condition can be quickly reached, the flexible switching of heating and cooling during the reaction is realized by combining the regional layout of the electric heating wire, the temperature regulation and control requirement of complex reactions is met, under the regulation and control of the control assembly, the temperature sensor monitors data in real time and feeds back to the controller, the work of the first circulating pump and the second circulating pump is dynamically adjusted, the temperature change can be more accurately controlled, the selectivity of the reaction and the product quality are improved, and the servo motor in the stirring assembly drives the stirring blade to strengthen the heat transfer uniformity, so that local overheating or uneven cooling is avoided.

Description

Technical Field

[0001] This application relates to the field of reaction vessel technology, specifically a drug synthesis reaction vessel. Background Technology

[0002] In drug synthesis, the raw materials for drug synthesis need to be added to a reaction vessel to react. Most chemical reactions are facilitated by increasing the temperature, but some reactions require cooling to increase the reaction rate, or some reactions are staged reactions that require cooling after the previous step is completed before the next step can proceed.

[0003] An existing patent (publication number: CN220590030U) discloses a drug synthesis reactor, belonging to the field of reactor technology. It addresses the shortcomings of existing drug synthesis reactors, such as the lack of an intermittent feeding structure, which leads to the deposition of solid powdery drug particles and hinders rapid and uniform mixing with liquid drugs. Furthermore, it addresses the slow heating and stirring speed during the heating process. The reactor includes a liquid inlet pipe fixed at the top edge of the reactor. This invention, through an intermittent feeding component driven by a motor and in conjunction with multiple components, causes the rotating tray to rotate. The two feed holes a intermittently overlap with the two feed holes b, allowing the powdery drug to enter the reactor intermittently. This prevents the deposition of solid powdery drug particles at the bottom of the reactor, thus avoiding the problem of insufficient rapid and uniform mixing with liquid drugs and significantly improving reaction efficiency.

[0004] The apparatus described in the aforementioned comparative documents cannot meet the requirements for precise temperature control during drug synthesis, especially in reactions requiring cooling or phased temperature reduction. The existing equipment's temperature control capability is insufficient, resulting in low reaction efficiency and unstable product quality. To address these issues, a drug synthesis reactor is proposed. Utility Model Content

[0005] To address the shortcomings of existing technologies, this application provides a drug synthesis reactor that enables flexible switching between heating and cooling during the reaction process, meeting the temperature control requirements of complex reactions.

[0006] To achieve the above objectives, this application provides the following technical solution: a drug synthesis reactor, comprising a reactor body, a temperature control component, a stirring component, and a control component. The temperature control component includes a cooling jacket fitted on the outer surface of the reactor body and a liquid storage tank fixedly connected to the outer surface of the cooling jacket, as well as an electric heating wire embedded in the inner wall of the reactor body. A first circulation pump is installed on both the upper and bottom surfaces of the cooling jacket. A first suction pipe and a first discharge pipe are respectively installed at one end of the two first circulation pumps. Two second circulation pumps are installed on the upper surface of the reactor body. A second suction pipe and a second discharge pipe are respectively installed on the side of the two second circulation pumps that are far apart from each other. A cooling spiral tube is provided inside the reactor body. The two top ends of the cooling spiral tube are respectively connected to the bottom ends of the two second circulation pumps.

[0007] Through the above-described scheme, the coordinated design of the reactor body and temperature control components, along with the cooling jacket and cooling spiral tube forming a dual-channel cooling system, improves cooling efficiency and enables rapid attainment of the required low-temperature conditions. Combined with the zoned layout of the electric heating wires, flexible switching between heating and cooling during the reaction process is achieved, meeting the temperature control requirements of complex reactions. Furthermore, under the control of the control components, temperature changes can be controlled more precisely, improving reaction selectivity and product quality. The operation of the stirring components can prevent local overheating or uneven cooling. Therefore, this scheme effectively solves the problem of insufficient temperature control capability of traditional reactors, significantly improving drug synthesis efficiency and product quality stability.

[0008] Furthermore, the other ends of both of the first circulation pumps are connected to the interior of the cooling jacket, and one end of the first liquid extraction pipe and the first liquid discharge pipe are both located inside the liquid storage tank.

[0009] The above scheme defines the positional relationship between the components, enabling a more stable delivery of the coolant from the storage tank to the cooling jacket for recycling.

[0010] Furthermore, the bottom ends of the second suction pipe and the second discharge pipe are both located inside the cooling jacket, and the bottom ends of the two second circulation pumps are both located inside the reactor body.

[0011] The above scheme defines the positional relationship between the components, which facilitates the stable circulation and delivery of the coolant inside the cooling jacket in the cooling spiral tube. The cooling spiral tube can directly contact the drug raw materials inside the reactor body to achieve rapid heat exchange.

[0012] Furthermore, a replenishment port is installed at the top of the liquid storage tank, and a drain port is installed at the bottom of the liquid storage tank. Both the replenishment port and the drain port are connected to the interior of the liquid storage tank.

[0013] The above solution allows for the periodic replacement of the coolant stored in the storage tank via the provided replenishment and drainage ports, ensuring the cooling effect of the device.

[0014] Furthermore, the stirring assembly includes a servo motor fixedly connected to the upper surface of the reactor body, and a stirring blade is fixedly connected to the output end of the servo motor. The stirring blade is located inside the reactor body and maintains a certain distance from the cooling spiral tube.

[0015] With the above scheme, when the servo motor starts, it will drive the stirring blade to rotate. The rotation of the stirring blade can achieve the stirring effect, and the heat transfer efficiency can be enhanced during stirring, thereby optimizing the temperature control quality of the device.

[0016] Furthermore, the control assembly includes a temperature sensor fixedly connected to the bottom wall of the reactor body, a controller fixedly connected to the outer surface of the storage tank, the temperature sensor being electrically connected to the controller, and the electrical components inside the temperature control assembly and the stirring assembly being electrically connected to the controller.

[0017] The above scheme allows for real-time detection of the internal temperature of the reactor body using a temperature sensor. The detection data is then fed back to the controller, which in turn controls the corresponding components to adjust the temperature.

[0018] Furthermore, a first feed port and a second feed port are installed at the top of the reactor body, and the output ends of the first feed port and the second feed port are both connected to the interior of the reactor body.

[0019] With the above scheme, liquid or solid drug raw materials can be fed into the reactor body through the first and second feed ports, respectively, which is convenient for use.

[0020] Furthermore, a discharge port is installed on the bottom surface of the reactor body, and the discharge port is fitted onto the bottom of the cooling jacket.

[0021] The above scheme allows the synthesized drugs inside the reactor to be discharged through the designated discharge port, making it convenient to use.

[0022] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0023] This drug synthesis reactor, through the coordinated design of the reactor body and temperature control components, forms a dual-channel cooling system with a cooling jacket and cooling spiral tubes, improving cooling efficiency and enabling rapid attainment of the required low-temperature conditions. Combined with the zoned layout of the electric heating wires, it achieves flexible switching between heating and cooling during the reaction process, meeting the temperature control requirements of complex reactions. Furthermore, under the control of the control components, temperature sensors monitor data in real time and feed it back to the controller, dynamically adjusting the operation of the first and second circulation pumps, enabling more precise control of temperature changes and improving reaction selectivity and product quality. The servo motor-driven stirring blades in the stirring assembly enhance heat transfer uniformity, avoiding localized overheating or uneven cooling. The cooling medium is periodically replaced through the replenishment and drainage pipes to ensure cooling efficiency. Therefore, this solution effectively solves the problem of insufficient temperature control capability in traditional reactors, significantly improving drug synthesis efficiency and product quality stability. Attached Figure Description

[0024] Figure 1 This is a top view of the overall structure of this application.

[0025] Figure 2 This is a schematic diagram of the overall bottom view of the structure of this application;

[0026] Figure 3 This is a schematic cross-sectional plan view of the structure of this application;

[0027] Figure 4 This is a partial sectional top view of the structure of this application;

[0028] Figure 5 This is a partial cross-sectional planar structural diagram of the structure of this application.

[0029] In the picture:

[0030] 1. Reactor body; 2. Temperature control assembly; 201. Cooling jacket; 202. Liquid storage tank; 203. Electric heating wire; 204. First circulation pump; 205. First suction pipe; 206. First drain pipe; 207. Second circulation pump; 208. Second suction pipe; 209. Second drain pipe; 210. Cooling spiral tube; 211. Liquid replenishment port; 212. Liquid drain port; 3. Stirring assembly; 301. Servo motor; 302. Stirring blades; 4. Control assembly; 401. Temperature sensor; 402. Controller; 5. First feed inlet; 6. Second feed inlet; 7. Discharge port. Detailed Implementation

[0031] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0032] Please see Figure 1 , Figure 2 and Figure 3 This embodiment of a drug synthesis reactor includes a reactor body 1, a temperature control component 2, a stirring component 3, and a control component 4. A first inlet 5 and a second inlet 6 are installed at the top of the reactor body 1. The output ends of both the first inlet 5 and the second inlet 6 are connected to the interior of the reactor body 1. Liquid or solid drug raw materials can be fed into the reactor body 1 through the first inlet 5 and the second inlet 6, respectively, for convenient use. A discharge port 7 is installed on the bottom surface of the reactor body 1, which is fitted onto the bottom of a cooling jacket 201. The discharge port 7 allows the synthesized drug inside the reactor body 1 to be discharged, facilitating use. The temperature control component 2 includes a cooling jacket 201 fitted onto the outer surface of the reactor body 1, a storage tank 202 fixedly connected to the outer surface of the cooling jacket 201, and an electric heating wire 203 embedded in the inner wall of the reactor body 1. The upper and lower surfaces of the cooling jacket 201 are equipped with... Equipped with a first circulation pump 204, one end of each first circulation pump 204 is respectively equipped with a first suction pipe 205 and a first discharge pipe 206. The other ends of both first circulation pumps 204 are connected to the interior of the cooling jacket 201. One end of the first suction pipe 205 and the first discharge pipe 206 are located inside the storage tank 202, which defines the positional relationship between the above components. This allows for a more stable delivery of the coolant inside the storage tank 202 to the cooling jacket 201 for circulation. When the upper first circulation pump 204 is started, it can deliver the coolant inside the storage tank 202 to the cooling jacket 201 to cool the reactor body 1. When the lower first circulation pump 204 is started, it can discharge the coolant inside the cooling jacket 201 into the storage tank 202, thus emptying the coolant inside the cooling jacket 201 and preventing it from affecting the coolant during the heating process, making it more practical.

[0033] Please see Figure 2 , Figure 4 and Figure 5Two second circulation pumps 207 are installed on the upper surface of the reactor body 1. A second suction pipe 208 and a second discharge pipe 209 are respectively installed on the sides of the two second circulation pumps 207 that are far apart from each other. A cooling spiral tube 210 is provided inside the reactor body 1. The two top ends of the cooling spiral tube 210 are respectively connected to the bottom ends of the two second circulation pumps 207. The bottom ends of the second suction pipe 208 and the second discharge pipe 209 are both located inside the cooling jacket 201. The bottom ends of the two second circulation pumps 207 are both located inside the reactor body 1, defining the positional relationship between the above components. This facilitates stable circulation of the coolant inside the cooling jacket 201 within the cooling spiral tube 210, which can directly contact the reactor. The drug raw materials inside the main body 1 achieve rapid heat exchange. The top of the liquid storage tank 202 is equipped with a liquid replenishment port 211, and the bottom of the liquid storage tank 202 is equipped with a liquid drain port 212. Both the liquid replenishment port 211 and the liquid drain port 212 are connected to the inside of the liquid storage tank 202. The liquid replenishment port 211 and the liquid drain port 212 can be set to replace the coolant stored inside the liquid storage tank 202 periodically, so as to ensure the cooling effect of the device. When the two second circulation pumps 207 are started at the same time, the coolant inside the cooling jacket 201 can be circulated and transported through the second liquid extraction pipe 208, the second liquid drain pipe 209 and the cooling spiral pipe 210. In this way, in conjunction with the cooling jacket 201, the dual cooling effect of inside and outside can be achieved, improving the cooling efficiency.

[0034] Please see Figure 1 , Figure 2 and Figure 3 The stirring assembly 3 includes a servo motor 301 fixedly connected to the upper surface of the reactor body 1. The output end of the servo motor 301 is fixedly connected to a stirring blade 302. The stirring blade 302 is located inside the reactor body 1 and maintains a certain distance from the cooling spiral tube 210. When the servo motor 301 is started, it will drive the stirring blade 302 to rotate. The rotation of the stirring blade 302 can achieve the stirring effect, and the heat transfer efficiency can be enhanced during stirring, thereby optimizing the temperature control quality of the device. The control assembly 4 includes a temperature sensor 401 fixedly connected to the bottom wall of the reactor body 1. A controller 402 is fixedly connected to the outer surface of the liquid storage tank 202. The temperature sensor 401 is electrically connected to the controller 402. The electrical components inside the temperature control assembly 2 and the stirring assembly 3 are all electrically connected to the controller 402. The temperature sensor 401 can detect the temperature inside the reactor body 1 in real time and feed the detection data back to the controller 402. The controller 402 then controls the corresponding components to adjust the temperature.

[0035] It should be noted that when draining the coolant inside the cooling jacket 201, the corresponding second circulation pump 207 needs to be started. This allows the coolant inside the cooling spiral tube 210 to be drained into the cooling jacket 201 through the second drain pipe 209, thus achieving the effect of draining the coolant inside the cooling spiral tube 210.

[0036] In this embodiment, through the collaborative design of the reactor body 1 and the temperature control component 2, the cooling jacket 201 and the cooling spiral tube 210 form a dual-channel cooling system, which improves the cooling efficiency and can quickly reach the required low temperature conditions. Combined with the regional layout of the electric heating wire 203, flexible switching between heating and cooling during the reaction process is realized, meeting the temperature control requirements of complex reactions. Under the control of the control component 4, the temperature sensor 401 monitors the data in real time and feeds it back to the controller 402, dynamically adjusting the operation of the first circulation pump 204 and the second circulation pump 207, which can more accurately control temperature changes, improve the selectivity of the reaction and the quality of the product. In the stirring component 3, the servo motor 301 drives the stirring blades 302 to enhance the heat transfer uniformity and avoid local overheating or uneven cooling. The cooling medium is replaced regularly through the liquid inlet 211 and the liquid outlet 212 to ensure cooling efficiency. Therefore, this solution effectively solves the problem of insufficient temperature control capability of traditional reactors and significantly improves the efficiency of drug synthesis and the stability of product quality.

[0037] The working principle of the above embodiment is as follows: The drug synthesis achieves precise temperature control through the coordinated operation of the temperature control component 2, the stirring component 3, and the control component 4. During the heating stage, the electric heating wire 203 is activated to heat the material inside the reactor body 1. At the same time, the corresponding first circulation pump 204 and second circulation pump 207 are activated to ensure that the coolant in the cooling jacket 201 is completely drained to the storage tank 202 through the first drain pipe 206 to avoid heat loss. When cooling is required, the controller 402 triggers the corresponding first circulation pump 204 to start based on the real-time data of the temperature sensor 401, and transports the coolant in the storage tank 202 to the storage tank 202 through the first suction pipe 205. Then, the two second circulation pumps 207 are activated so that the coolant inside the cooling jacket 201 can circulate through the second suction pipe 208, the second drain pipe 209, and the cooling spiral pipe 210. The cooling system utilizes a dual cooling mechanism where the coolant inside the cooling jacket 201 interacts with the coolant inside the cooling spiral tube 210. The cooling spiral tube 210 directly contacts the drug material inside the reactor body 1, enabling rapid heat exchange and effectively improving heat dissipation efficiency. Simultaneously, the servo motor 301 of the stirring assembly 3 drives the stirring blades 302 to break the temperature boundary layer and enhance heat transfer uniformity, preventing local overheating or cold zone stagnation and optimizing temperature control. Furthermore, the replenishment port 211 and the drain port 212 support periodic replacement of the cooling medium, ensuring long-term efficient operation of the system. The first feed port 5 and the second feed port 6 allow for separate addition of solid and liquid raw materials, while the discharge port 7 is integrated into the bottom of the reactor body 1. After the reaction is completed with temperature control and stirring, the material is quickly discharged, meeting the temperature control requirements in drug synthesis and significantly improving reaction efficiency and product consistency.

[0038] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0039] Although embodiments of this application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A drug synthesis reactor, comprising a reactor body (1), a temperature control component (2), a stirring component (3), and a control component (4), characterized in that: The temperature control component (2) includes a cooling jacket (201) fitted on the outer surface of the reactor body (1) and a liquid storage tank (202) fixedly connected to the outer surface of the cooling jacket (201), as well as an electric heating wire (203) embedded in the inner wall of the reactor body (1). The upper and lower surfaces of the cooling jacket (201) are equipped with first circulation pumps (204). One end of each of the two first circulation pumps (204) is equipped with a first liquid extraction pipe (205) and a first liquid discharge pipe (206). The upper surface of the reactor body (1) is equipped with two second circulation pumps (207). The two sides of the two second circulation pumps (207) that are far apart from each other are equipped with a second liquid extraction pipe (208) and a second liquid discharge pipe (209). The reactor body (1) is provided with a cooling spiral tube (210). The two top ends of the cooling spiral tube (210) are connected to the bottom ends of the two second circulation pumps (207).

2. The drug synthesis reactor according to claim 1, characterized in that: The other ends of the two first circulation pumps (204) are connected to the interior of the cooling jacket (201), and one end of the first liquid extraction pipe (205) and the first liquid discharge pipe (206) are located inside the liquid storage tank (202).

3. The drug synthesis reactor according to claim 1, characterized in that: The bottom ends of the second liquid extraction pipe (208) and the second liquid discharge pipe (209) are both located inside the cooling jacket (201), and the bottom ends of the two second circulation pumps (207) are both located inside the reactor body (1).

4. The drug synthesis reactor according to claim 1, characterized in that: The top of the liquid storage tank (202) is equipped with a liquid replenishment port (211), and the bottom of the liquid storage tank (202) is equipped with a liquid drain port (212). Both the liquid replenishment port (211) and the liquid drain port (212) are connected to the interior of the liquid storage tank (202).

5. A drug synthesis reactor according to claim 1, characterized in that: The stirring assembly (3) includes a servo motor (301) fixedly connected to the upper surface of the reactor body (1). The output end of the servo motor (301) is fixedly connected to a stirring blade (302). The stirring blade (302) is located inside the reactor body (1) and maintains a certain distance from the cooling spiral tube (210).

6. The drug synthesis reactor according to claim 1, characterized in that: The control component (4) includes a temperature sensor (401) fixedly connected to the bottom wall of the reactor body (1), a controller (402) fixedly connected to the outer surface of the storage tank (202), the temperature sensor (401) being electrically connected to the controller (402), and the electrical components inside the temperature control component (2) and the stirring component (3) being electrically connected to the controller (402).

7. A drug synthesis reactor according to claim 1, characterized in that: The top of the reactor body (1) is equipped with a first feed port (5) and a second feed port (6), and the output ends of the first feed port (5) and the second feed port (6) are connected to the interior of the reactor body (1).

8. A drug synthesis reactor according to claim 1, characterized in that: The bottom surface of the reactor body (1) is equipped with a discharge port (7), which is fitted onto the bottom of the cooling jacket (201).

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