A rectification device for producing a pharmaceutical intermediate

Abstract

This utility model belongs to the technical field of chemical production equipment, specifically disclosing a distillation apparatus for the production of pharmaceutical intermediates. It includes an insulated tank, with three fixed frames fixedly connected inside. A separator tank is fixedly connected within each frame, and several fixed plates are fixedly connected inside the separator tank. A distillation tank is fixedly connected to the other end of each plate. A heating coil and a feed coil are spirally sleeved outside the distillation tank. The top end of the feed coil is fixedly connected to the upper part of the distillation tank and extends through it. The bottom end of the feed coil extends from the inside out through the separator tank and the insulated tank, reaching the outside of the insulated tank. An electronic thermometer is fixedly connected to the outside of the insulated tank. By creating a gap between the separator tank and the distillation tank, heat storage salt can be filled between them. When high-temperature steam is introduced into the distillation tank for distillation, some heat is transferred through the distillation tank to heat the heat storage salt between the separator tank and the distillation tank, causing it to melt from a solid state into a liquid state.

Description

Technical Field

[0001] This utility model belongs to the field of chemical production equipment technology, specifically a distillation device for the production of pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are essentially chemical raw materials or products used in drug synthesis processes. To increase the purity of pharmaceutical intermediates, distillation units are used during production to further purify them and remove impurities remaining from the processing. Distillation units primarily condense and purify the pharmaceutical intermediate mixture through heating. However, existing distillation units for pharmaceutical intermediate production lack effective heat preservation, allowing heat to easily dissipate from the distillation tank, affecting temperature stability and making the internal temperature susceptible to external temperature fluctuations. This results in long preheating periods and hinders rapid resumption of pharmaceutical intermediate production after maintenance shutdowns. Therefore, we propose a new distillation unit for pharmaceutical intermediate production to address these issues. Utility Model Content

[0003] To address the above technical problems, this utility model provides a distillation apparatus for the production of pharmaceutical intermediates.

[0004] To solve the above technical problems, the technical solution adopted by this utility model is as follows: a distillation apparatus for the production of pharmaceutical intermediates, comprising an insulated tank, three fixed frames fixedly connected inside the insulated tank, a partition tank fixedly connected inside the fixed frames, several fixed plates fixedly connected inside the partition tank, a distillation tank fixedly connected to the other end of each fixed plate, a heating coil and a feed coil spirally sleeved outside the distillation tank, the top end of the feed coil fixedly connected to the upper part of the distillation tank and penetrating therethrough, and the bottom end of the feed coil extending from the inside... The device extends outward from the partition tank and the insulation tank, and is fixedly connected to the outside of the insulation tank. The probe of the electronic thermometer extends through the insulation tank and the partition tank and to the outer surface of the distillation tank. The top of the distillation tank is fixedly connected to an exhaust pipe, and the bottom is fixedly connected to a drain pipe. The upper part of the distillation tank is fixedly connected to a reflux pipe, and the lower part is fixedly connected to an air inlet pipe. The exhaust pipe, drain pipe, air inlet pipe, and reflux pipe all extend through the partition tank and the insulation tank and to the outside of the insulation tank.

[0005] Furthermore, it also includes a PLC controller, the heating coil is an electric heating tube, the electronic thermometer is electrically connected to the PLC controller, and the PLC controller is electrically connected to the heating coil.

[0006] Furthermore, a set of connecting plates is fixedly connected to the outside of the heat insulation tank, and a support frame is fixedly connected to the bottom of the connecting plates.

[0007] Furthermore, the support frame has two reinforcing plates fixedly connected to opposite sides and a mounting plate fixedly connected to the bottom, and the upper surface of the mounting plate is provided with mounting slots.

[0008] Furthermore, the ends of the air inlet pipe, return pipe, exhaust pipe and drain pipe are all fixedly connected to a first connecting flange, and each first connecting flange has several first connecting through holes on its side.

[0009] Furthermore, a second connecting flange is fixedly connected to the end of the feed coil, and a second connecting through hole arranged at equal intervals is provided on one side of the second connecting flange.

[0010] Furthermore, two sealing and reinforcing rings are fixedly connected to the outer surface of the electronic thermometer, and one side of each of the two sealing and reinforcing rings is fixedly connected to the outer surface of the separator and the outer surface of the insulation tank, respectively.

[0011] This utility model has the following advantages compared with the prior art:

[0012] 1. By setting up a gap between the partition tank and the distillation tank, heat storage salt can be filled between the partition tank and the distillation tank. When high-temperature steam is introduced into the distillation tank for distillation, some of the heat will be transferred through the distillation tank to heat the heat storage salt between the partition tank and the distillation tank, causing it to melt from solid to liquid. This solid-liquid conversion stores a large amount of heat. At the same time, it works with the insulation tank to form a heat insulation zone, preventing excessive heat loss from the inside of the distillation tank. This keeps the internal temperature of the distillation tank stable and effectively reduces the impact of the low external temperature environment on the internal temperature of the distillation tank. This gives the distillation unit for pharmaceutical intermediate production good heat storage and insulation function. By utilizing the heat slowly released during the conversion of the heat storage salt from liquid to solid, the distillation tank can be preheated in advance, reducing the preheating period of the distillation tank and allowing the distillation unit to quickly resume pharmaceutical intermediate production after shutdown and maintenance.

[0013] 2. By installing a heating coil, the heat storage salt between the distillation tank and the separator can be heated externally using electric heating. This improves the preheating efficiency of the distillation unit used for pharmaceutical intermediate production. Furthermore, the feed coil allows the pharmaceutical intermediate mixture to flow through the outside of the distillation tank before entering for distillation. The residual heat of the distillation tank and the heat stored in the heat storage salt, combined with the timely heating from the heating coil, preheat the pharmaceutical intermediate mixture. This ensures that the mixture has a certain temperature before entering the distillation tank, eliminating the need for additional equipment to preheat the mixture, reducing heat loss from high-temperature steam inside the distillation tank, and improving the distillation efficiency of pharmaceutical intermediates. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model.

[0015] Figure 2 This is a schematic diagram of the feed coil structure of this utility model.

[0016] Figure 3 This is a schematic diagram of the structure of the heat insulation tank of this utility model.

[0017] Figure 4 This is a schematic diagram of the separator tank structure of this utility model.

[0018] Figure 5 This is a schematic diagram of the distillation tank structure of this utility model.

[0019] The components include: 1. Insulated tank; 2. Fixing frame; 3. Dividing tank; 4. Distillation tank; 5. Heating coil; 6. Feed coil; 7. Fixing plate; 8. Electronic thermometer; 9. Connecting plate; 10. Support frame; 11. Reinforcing plate; 12. Mounting plate; 13. Mounting through slot; 14. Exhaust pipe; 15. Drain pipe; 16. Air inlet pipe; 17. Return pipe; 18. First connecting flange; 19. First connecting through hole; 20. Second connecting flange; 21. Second connecting through hole; 22. Sealing reinforcement ring. Detailed Implementation

[0020] The present invention will be further described below with reference to the accompanying drawings.

[0021] like Figures 1-5The illustrated distillation apparatus for producing pharmaceutical intermediates includes an insulated tank 1. Three fixed supports 2 are fixedly connected inside the insulated tank 1. A separator tank 3 is fixedly connected to each of the fixed supports 2. Several fixed plates 7 are fixedly connected inside the separator tank 3. A distillation tank 4 is fixedly connected to the other end of each fixed plate 7. A heating coil 5 and a feed coil 6 are spirally sleeved on the outside of the distillation tank 4. The top end of the feed coil 6 is fixedly connected to the upper part of the distillation tank 4 and passes through it. The bottom end of the feed coil 6 passes through the separator tank 3 and the insulated tank 1 sequentially from the inside out and extends... An electronic thermometer 8 is fixedly connected to the outside of the heat insulation tank 1. The probe of the electronic thermometer 8 passes through the heat insulation tank 1 and the partition tank 3 and extends to the outer surface of the distillation tank 4. The top of the distillation tank 4 is fixedly connected to an exhaust pipe 14 and the bottom is fixedly connected to a drain pipe 15. The upper part of the distillation tank 4 is fixedly connected to a reflux pipe 17 and the lower part is fixedly connected to an air inlet pipe 16. The exhaust pipe 14, the drain pipe 15, the air inlet pipe 16, and the reflux pipe 17 all pass through the partition tank 3 and the heat insulation tank 1 and extend to the outside of the heat insulation tank 1.

[0022] It should be noted that the inner wall of the heat insulation tank 1 is fixedly connected to three fixing brackets 2, and the inner wall of the three fixing brackets 2 is fixedly connected to the partition tank 3. The outer surface of the heat insulation tank 1 is fixedly connected to two connecting plates 9, and the bottom surface of the two connecting plates 9 is fixedly connected to the support frame 10. The connecting plates 9 and the support frame 10 can support the device and increase the stability and reliability of the device during use.

[0023] To facilitate heating, a PLC controller is also included. The heating coil 5 is an electric heating element. The electronic thermometer 8 is electrically connected to the PLC controller, and the PLC controller is electrically connected to the heating coil 5.

[0024] For ease of support, a set of connecting plates 9 are fixedly connected to the outside of the heat insulation tank 1, and a support frame 10 is fixedly connected to the bottom of the connecting plates 9.

[0025] To facilitate a stable connection, two reinforcing plates 11 are fixedly connected to the opposite sides of the support frame 10, and a mounting plate 12 is fixedly connected to the bottom. The upper surface of the mounting plate 12 is provided with mounting slots 13. The reinforcing plates 11 can improve the support stability of the support frame 10 for the device. By using the mounting plate 12 in conjunction with the mounting slots 13 and bolts and other fasteners, the device can be very stably fixed in the working position.

[0026] For ease of connection, the ends of the air inlet pipe 16, return pipe 17, exhaust pipe 14 and drain pipe 15 are all fixedly connected with first connecting flanges 18, and each first connecting flange 18 has several first connecting through holes 19 on its side.

[0027] To facilitate feeding, a second connecting flange 20 is fixedly connected to the end of the feeding coil 6, and a second connecting through hole 21 arranged at equal intervals is provided on one side of the second connecting flange 20.

[0028] To facilitate sealing, two sealing rings 22 are fixedly connected to the outer surface of the electronic thermometer 8. One side of each sealing ring 22 is fixedly connected to the outer surface of the separator 3 and the outer surface of the insulation tank 1, respectively.

[0029] The specific working process of this utility model is as follows:

[0030] In use, first connect the heating coil 5 and electronic thermometer 8 to the external power supply and controller. Then, through the gap formed by the separator 3 and the distillation tank 4, heat storage salt can be filled between the separator 3 and the distillation tank 4. When high-temperature steam is introduced into the distillation tank 4 for distillation processing, through the principle of heat conduction, some heat will be transferred to the distillation tank 4 to heat the heat storage salt filled between the separator 3 and the distillation tank 4, causing it to melt from solid to liquid. This solid-liquid conversion stores a large amount of heat. Simultaneously, the insulation tank 1 forms a heat insulation zone, preventing excessive heat loss from the inside of the distillation tank 4, thus maintaining a stable internal temperature. This effectively reduces the impact of low external temperatures on the internal temperature of the distillation tank 4, giving the distillation unit for pharmaceutical intermediate production excellent heat storage and insulation capabilities. Utilizing the slowly released heat during the liquid-to-solid conversion of the heat storage salt allows for advance prediction of the distillation tank 4's temperature, reducing the preheating period and enabling rapid resumption of pharmaceutical intermediate production after maintenance shutdowns. The electronic thermometer 8 can monitor the temperature between the separator 3 and the distillation tank 4 in real time. When the temperature is too low and may adversely affect the internal temperature of the distillation tank 4, the electronic thermometer 8 can send an electrical signal to the heating coil 5 through a wire to start it working. At this time, the heating coil 5 can use electric heating to heat the distillation tank 4 and the heat storage salt between the separator 3 and the distillation tank 4 from the outside, thereby improving the preheating efficiency and temperature stability of the distillation unit for pharmaceutical intermediate production. Furthermore, through the fixing of the feed coil 6 and the fixing plate 7, the pharmaceutical intermediate mixture can flow through the outside of the distillation tank 4 before entering the distillation tank 4 for distillation. The residual heat of the distillation tank 4 and the heat stored in the heat storage salt, combined with the timely heating of the heating coil 5, can preheat the pharmaceutical intermediate mixture in advance, so that it has a certain temperature when it enters the distillation tank 4. Therefore, it is not necessary to use additional equipment to preheat the pharmaceutical intermediate mixture, reducing the heat loss of high-temperature steam inside the distillation tank 4 and further improving the distillation efficiency of pharmaceutical intermediates.

Claims

1. A distillation apparatus for producing pharmaceutical intermediates, comprising an insulated tank (1), wherein three fixed supports (2) are fixedly connected inside the insulated tank (1), and a separator tank (3) is fixedly connected inside the fixed supports (2), characterized in that: Several fixing plates (7) are fixedly connected inside the partition tank (3). A distillation tank (4) is fixedly connected to the other end of the fixing plate (7). A heating coil (5) and a feed coil (6) are spirally sleeved on the outside of the distillation tank (4). The top end of the feed coil (6) is fixedly connected to the upper part of the distillation tank (4) and passes through it. The bottom end of the feed coil (6) passes through the partition tank (3) and the insulation tank (1) from the inside to the outside and extends to the outside of the insulation tank (1). An electronic thermometer (8) is fixedly connected to the outside of the insulation tank (1). The probe of the sub-thermometer (8) penetrates the heat insulation tank (1) and the partition tank (3) and extends to the outer surface of the distillation tank (4). The top of the distillation tank (4) is fixedly connected to an exhaust pipe (14) and the bottom is fixedly connected to a drain pipe (15). The upper part of the distillation tank (4) is fixedly connected to a reflux pipe (17) and the lower part is fixedly connected to an air inlet pipe (16). The exhaust pipe (14), drain pipe (15), air inlet pipe (16), and reflux pipe (17) all penetrate the partition tank (3) and the heat insulation tank (1) and extend to the outside of the heat insulation tank (1).

2. The distillation apparatus for producing pharmaceutical intermediates according to claim 1, characterized in that: It also includes a PLC controller, the heating coil (5) is an electric heating tube, the electronic thermometer (8) is electrically connected to the PLC controller, and the PLC controller is electrically connected to the heating coil (5).

3. The distillation apparatus for producing pharmaceutical intermediates according to claim 1, characterized in that: A set of connecting plates (9) are fixedly connected to the outside of the heat insulation tank (1), and a support frame (10) is fixedly connected to the bottom of the connecting plates (9).

4. The distillation apparatus for producing pharmaceutical intermediates according to claim 3, characterized in that: The support frame (10) has two reinforcing plates (11) fixedly connected to each other on opposite sides and a mounting plate (12) fixedly connected to the bottom. The upper surface of the mounting plate (12) is provided with mounting slots (13).

5. The distillation apparatus for producing pharmaceutical intermediates according to claim 1, characterized in that: The ends of the air inlet pipe (16), return pipe (17), exhaust pipe (14) and drain pipe (15) are all fixedly connected with a first connecting flange (18), and each first connecting flange (18) has several first connecting through holes (19) on its side.

6. The distillation apparatus for producing pharmaceutical intermediates according to claim 1, characterized in that: The end of the feed coil (6) is fixedly connected to a second connecting flange (20), and one side of the second connecting flange (20) is provided with second connecting through holes (21) arranged at equal intervals.

7. The distillation apparatus for producing pharmaceutical intermediates according to claim 1, characterized in that: Two sealing and reinforcing rings (22) are fixedly connected to the outer surface of the electronic thermometer (8), and one side of each sealing and reinforcing ring (22) is fixedly connected to the outer surface of the separator (3) and the outer surface of the heat insulation tank (1), respectively.

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