A rat tail vein injection fixation device

Abstract

This utility model belongs to the technical field of laboratory equipment, specifically relating to a rat tail vein injection fixation device. It includes a sleeve and a limiting sleeve; the first end of the sleeve has a rat placement inlet, and the second end of the sleeve has a sealing plate with a tail operation port; the sleeve has a first sliding groove and a second sliding groove; the first sliding groove is located on the side of the sleeve and communicates with the rat placement inlet; the second sliding groove is located on the sealing plate and communicates with both the first sliding groove and the tail operation port; the limiting sleeve includes a first sliding sleeve and a second sliding sleeve; the second sliding sleeve is disposed within the first sliding sleeve; a fixing member connects the inner wall of the first sliding sleeve and the outer wall of the second sliding sleeve; an inner sleeve for limiting the rat's head is disposed within the second sliding sleeve; the first sliding sleeve also has a locking device. The first sliding sleeve of this rat tail vein injection fixation device is fitted over the outside of the sleeve, forming an additional external support, maintaining the fixation effect even when the rat struggles violently.

Description

Technical Field

[0001] This utility model belongs to the field of laboratory equipment technology, specifically relating to a rat tail vein injection fixation device. Background Technology

[0002] In biomedical research and drug experiments, rats are a commonly used experimental animal model, and the method of immobilization is crucial to the accuracy of experimental results.

[0003] Existing rat tail vein injection fixation devices typically consist of a cylinder with a plug for securing the rat's head. The cylinder has an opening at one end and a tail access port at the other. A through-slot is provided on the cylinder for the rat's tail to pass through, connecting the tail access port and the opening. A locking bolt is located on the plug. In use, the rat is placed inside the cylinder with its tail extending out of the tail access port. The plug secures the rat's head, and the locking bolt is positioned within the through-slot. Tightening the locking bolt causes its head to press against the outer sides of the cylinder on both sides of the through-slot, while the plug is pressed against the inner sides of the cylinder on both sides of the through-slot.

[0004] However, the above solution has a problem: when conducting experiments on rats, due to the material of the device and the results, the rats struggle, which causes the cylinder to deform along the through groove, expands the cylinder, and causes the rats to escape. Utility Model Content

[0005] The purpose of this invention is to provide a rat tail vein injection fixation device to solve the problem in the prior art where, due to the material and design of the device, the cylinder deforms along the through groove when the rat struggles, causing the cylinder to open and allowing the rat to escape.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A rat tail vein injection fixation device, comprising a sleeve and a limiting sleeve; The first end of the sleeve is provided with a mouse placement inlet, and the second end of the sleeve is provided with a sealing plate, on which a tail operation port is provided; the sleeve is provided with a first sliding groove and a second sliding groove; the first sliding groove is located on the side of the sleeve and communicates with the mouse placement inlet; the second sliding groove is provided on the sealing plate and communicates with the first sliding groove and the tail operation port respectively. The limiting sleeve includes a first sliding sleeve and a second sliding sleeve; wherein the second sliding sleeve is disposed inside the first sliding sleeve, and the first sliding sleeve and the second sliding sleeve are coaxially arranged; a fixing member is connected between the inner wall of the first sliding sleeve and the outer wall of the second sliding sleeve; an inner sleeve for limiting the mouse head is disposed inside the second sliding sleeve; a locking device is also disposed on the first sliding sleeve for fixing the relative position of the limiting sleeve and the sleeve.

[0007] Furthermore, the sleeve is cylindrical in shape.

[0008] Furthermore, the sleeve has a first groove on its side that is parallel to the central axis of the sleeve. The first groove is a straight groove that connects to the mouse placement inlet.

[0009] Furthermore, the intersection of the first chute and the mouse placement inlet is provided with rounded corners.

[0010] Furthermore, both the first and second sliding sleeves of the limiting sleeve are annular.

[0011] Furthermore, the inner sleeve is shaped like a cone with openings at both ends and a hollow interior.

[0012] Furthermore, the locking device is a locking bolt.

[0013] Furthermore, it also includes a clamping plate, which comprises an arc-shaped plate and a push bolt; the first end of the push bolt is rotatably connected to the outer arc surface of the arc-shaped plate; the push bolt is threadedly connected to the side wall of the sleeve.

[0014] Compared with the prior art, the beneficial effects of this utility model are as follows: The sleeve of this rat tail vein injection fixation device includes a first groove and a second groove, as well as a nested limiting sleeve (including a first sliding sleeve and a second sliding sleeve). The first sliding sleeve is fitted outside the sleeve, forming an additional external support, which greatly enhances the stability of the entire fixation device and can maintain the fixation effect even when the rat struggles violently.

[0015] The limiting sleeve of this invention can easily slide on the sleeve via the first and second sliding grooves, making the process of fixing the rat simple and quick. At the same time, the locking device (such as a locking bolt) allows the position of the limiting sleeve to be quickly and firmly fixed without complicated operations or multiple people working together.

[0016] The inner sleeve of this invention is designed as a cone shape with openings at both ends and a hollow interior, which can closely fit the shape of the rat's head and improve the restraint effect.

[0017] This invention may also include a clamp to further restrict the position of the rat's tail, providing additional stability without causing additional harm to the rat. Attached Figure Description

[0018] The accompanying drawings, which form part of this application, are used to provide a further understanding of the present invention. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an undue limitation of the present invention. In the drawings: Figure 1This is a schematic diagram of the overall structure of a rat tail vein injection fixation device according to an embodiment of the present invention; Figure 2 The sleeve three-dimensional structure in the embodiment of this utility model Figure 1 ; Figure 3 The sleeve three-dimensional structure in the embodiment of this utility model Figure 2 ; Figure 4 This is a schematic diagram of the limiting sleeve in an embodiment of the present utility model; Figure 5 This is a schematic diagram of the connection structure between the first sliding sleeve and the second sliding sleeve in an embodiment of this utility model; Figure 6 This is a schematic diagram of the inner sleeve structure in an embodiment of this utility model; Figure 7 This is a schematic diagram of the clamping plate structure in an embodiment of the present utility model; Figure 8 This is a schematic diagram of the locking device structure in an embodiment of the present utility model; in: 1. Sleeve; 11. Mouse placement inlet; 12. Sealing plate; 13. Tail operation port; 14. First slide groove; 141. First limit stop; 142. Second limit stop; 15. Second slide groove; 2. Limiting sleeve; 21. First sliding sleeve; 22. Second sliding sleeve; 23. Inner sleeve; 231. First section of the inner sleeve; 232. Second section of the inner sleeve; 24. Fixing component; 3. Locking device; 4. Clamping plate; 41. Curved plate; 42. Push bolt. Detailed Implementation

[0019] The present invention will now be described in detail with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other.

[0020] The following detailed description is exemplary and intended to provide further detailed explanation of the present invention. Unless otherwise specified, all technical terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains. The terminology used in this invention is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to the present invention.

[0021] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined with "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more. In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0022] like Figures 1-8 As shown, this embodiment of the present invention provides a rat tail vein injection fixation device, including a sleeve 1 and a limiting sleeve 2; The sleeve 1 has a mouse placement inlet 11 at its first end and a sealing plate 12 at its second end, with a tail operation port 13 on the sealing plate 12. The sleeve 1 also has a first sliding groove 14 and a second sliding groove 15. The first sliding groove 14 is located on the side of the sleeve 1 and communicates with the mouse placement inlet 11. The second sliding groove 15 is located on the sealing plate 12 and communicates with both the first sliding groove 14 and the tail operation port 13. The limiting sleeve 2 includes a first sliding sleeve 21 and a second sliding sleeve 22; wherein the second sliding sleeve 22 is disposed inside the first sliding sleeve 21, and the first sliding sleeve 21 and the second sliding sleeve 22 are coaxially arranged; a fixing member 24 is connected between the inner wall of the first sliding sleeve 21 and the outer wall of the second sliding sleeve 22; an inner sleeve 23 for limiting the mouse head is disposed inside the second sliding sleeve 22; a locking device 3 is also disposed on the first sliding sleeve 21 for fixing the relative position of the limiting sleeve 2 and the sleeve 1.

[0023] In use, firstly, the rat is placed into the rat placement inlet 11 of the sleeve 1. At this point, the rat's tail is held, allowing it to pass sequentially through the first slide groove 14 and the second slide groove 15. The rat's body moves within the sleeve 1 until its tail blocks the tail operation opening 13 of the sealing plate 12, with the tail extending beyond the tail operation opening 13. Next, the limiting sleeve 2 is installed starting from the first end of the sleeve 1. The first sliding sleeve 21 is fitted outside the sleeve 1, and the second sliding sleeve 22 is positioned inside the sleeve 1. The fixing member 24 is located in the first slide groove 14. The limiting sleeve 2 is moved towards the second end of the sleeve 1, so that the rat's head is positioned within the inner sleeve 23. Finally, the locking device 3 is used to secure the position of the limiting sleeve 2, completing the rat's restraint. This allows the experimenter to perform operations such as injections into the rat's tail through the tail operation opening 13. Fitting the first sliding sleeve 21 outside the sleeve 1 prevents the sleeve from opening when the rat struggles.

[0024] In one optional embodiment, the sleeve 1 is cylindrical in shape, with an opening at the first end and a sealing plate 12 at the second end. A tail operation port 13 is provided on the sealing plate 12 off-center and near the edge. The tail operation port 13 can be an opening smaller than the diameter of the cylinder, for the rat's tail to extend and for personnel to operate on the tail.

[0025] In one optional embodiment, a first groove 14 parallel to the central axis of the sleeve 1 is provided on the side of the sleeve 1. The first groove 14 is a straight groove that connects to the mouse placement inlet 11.

[0026] In a preferred embodiment, the intersection of the first chute 14 and the mouse placement inlet 11 is provided with a rounded corner.

[0027] In one alternative embodiment, the second slide 15 is disposed on the sealing plate 12, and the two ends of the second slide 15 are respectively connected to the tail operation port 13 and the first slide 14, so as to allow the rat's tail to pass smoothly into the tail operation port 13.

[0028] The first slide groove 14 is provided with a first limiting block 141 at one end near the tail operation port 13. The first limiting block 141 protrudes perpendicular to the axis of the sleeve 1 to prevent the fixing member 24 from sliding excessively towards the tail operation port 13. Optionally, the first slide groove 14 may also be provided with a second limiting block 142 at one end near the mouse placement inlet 11 to limit the extreme position of the fixing member 24 sliding towards the mouse placement inlet 11. The second limiting block 142 may be a pluggable pin.

[0029] The height of the first limiting block 141 must ensure that the fixing member 24 can make smooth contact and be effectively blocked, while allowing the limiting sleeve 2 to pass smoothly through other parts of the slide groove during the sliding process.

[0030] The above solution, by setting a first limit stop 141 and a second limit stop 142, increases the number of mechanical limit stops (especially the stop 141 at the tail end), providing the operator with an intuitive physical stop point and ensuring that the limit sleeve can be accurately pushed to the designed position, preventing over-push or under-push. The stop height design ensures functionality and manufacturability.

[0031] The first limiting block 141 set at the end of the first slide 14 provides the operator with a clear physical stop point, ensuring that the limiting sleeve 2 can be quickly and accurately pushed to the optimal fixed position (the rat's head is completely inside the constraint area of ​​the inner sleeve 23), eliminating the uncertainty of position judgment.

[0032] In one optional embodiment, both the first sliding sleeve 21 and the second sliding sleeve 22 of the limiting sleeve 2 are annular, and the diameter of the second sliding sleeve 22 is slightly smaller than that of the first sliding sleeve 21; specifically, the diameter of the first sliding sleeve 21 is larger than the diameter of the sleeve 1, and the diameter of the sleeve 1 is larger than the diameter of the second sliding sleeve 22. A fixing member 24 is connected between the inner wall of the first sliding sleeve 21 and the outer wall of the second sliding sleeve 22.

[0033] In one optional embodiment, the fixing member 24 is configured as at least two (preferably three or four) arc-shaped connecting plates or connecting rods evenly distributed along the axial direction of the first sliding sleeve 21 (in the same direction as the axis of the first sliding sleeve 21), the arc-shaped connecting plates or connecting rods being connected to the inner wall surface of the first sliding sleeve 21 and the outer wall surface of the second sliding sleeve 22. The two ends of the fixing member 24 are respectively fixedly connected to the inner wall of the first sliding sleeve 21 and the outer wall of the second sliding sleeve 22; the use of multiple evenly distributed fixing members 24 significantly enhances the connection stiffness and integrity between the limiting sleeve 2 and the sleeve 1. When the rat struggles, causing the side wall of the sleeve 1 (especially the groove area) to deform outwards, this design can efficiently disperse and transfer local stress to the entire limiting sleeve 2 structure (first sliding sleeve 21 and second sliding sleeve 22). Through the strong constraint of the first sliding sleeve 21 on the outer wall of the sleeve 1, the expansion deformation of the sleeve 1 is effectively suppressed, greatly reducing the risk of rat escape. The rounded corner treatment of the fixing member edges further reduces the risk of stress concentration.

[0034] In one alternative embodiment, the fastener 24 can also be a single rigid connecting plate used to fix the inner wall of the first sliding sleeve 21 and the outer wall of the second sliding sleeve 22. After connection, it resembles an I-shaped structure, which ensures the connection strength and prevents the rat's force from deforming it.

[0035] The fixing member 24 has sufficient rigidity and strength so that when the rat struggles and the side wall of the sleeve 1 (especially the area near the first sliding groove 14) attempts to deform outward, the fixing member 24 can effectively distribute and transfer stress to the overall structure of the limiting sleeve 2 through the constraint of the first sliding sleeve 21, significantly suppressing the deformation of the sleeve 1 and preventing it from opening. The contact edge between the fixing member 24 and the first sliding groove 14 can be rounded to reduce stress concentration.

[0036] In one optional embodiment, the inner sleeve 23 is configured as an integral structure consisting of a first segment 231 near the second sliding sleeve 22 and a second segment 232 toward the first end of the sleeve 1; The first segment 231 is cylindrical, with an inner diameter slightly larger than the maximum diameter of the cheekbone of an adult experimental rat (for example, a range such as 10-15 mm can be defined), and is used to restrain the cheekbone area of ​​the rat's head; The second segment 232 is connected to the end of the first segment 231 and extends toward the first end of the sleeve 1. Its shape is a trumpet shape or a shallow cone with a gradually decreasing inner diameter. The minimum inner diameter of the second segment 232 is greater than the muzzle diameter of an adult experimental rat but smaller than the diameter at the cheekbone (e.g., it can be limited to 5-8 mm). Its axial length is sufficient to accommodate the part of the rat's head from the cheekbone to the muzzle (e.g., 15-25 mm). The outer wall of the first section 231 of the inner sleeve 23 is tightly and fixedly connected to the inner ring of the second sliding sleeve 22; The inner surface of the inner sleeve 23, particularly the inner wall of the first segment 231, is smooth and preferably covered with a soft cushioning layer (such as a silicone pad) to reduce pressure and friction on the rat's head. The stepped structure (cylindrical segment combined with a funnel-shaped opening / shallow conical segment) better conforms to the head morphology of rats (wide at the cheekbones, gradually narrowing towards the snout). The cylindrical segment precisely restrains the most vulnerable area (cheekbones), while the funnel-shaped opening / shallow conical segment provides space to avoid excessive pressure on the back of the head and prevents the head from slipping out from the front of the inner sleeve. The added cushioning layer significantly reduces friction and discomfort, reducing factors that induce struggle.

[0037] The inner sleeve 23 adopts a stepped structure (cylindrical section combined with flared / shallow conical section) and is lined with a buffer layer, which can more accurately and comfortably restrain the key area of ​​the rat's head cheekbone, avoid excessive pressure on the back of the head or loosening of the forehead, effectively conform to the natural shape of the head, significantly reduce the rat's struggle caused by discomfort or friction, and improve fixation reliability and animal welfare.

[0038] In one optional embodiment, a locking device 3 is provided on the first sliding sleeve 21. Specifically, the locking device 3 can be a locking bolt, which, when tightened, presses against the outer wall of the sleeve 1 to fix its position.

[0039] The locking device 3 works in conjunction with the buffer pad to securely lock the limiting sleeve 2 in the preset position of the sleeve 1 after tightening (especially when the fixing member 24 contacts the first limiting block 141), preventing the limiting sleeve 2 from accidentally sliding due to the rat's struggle or external force during operation.

[0040] In a preferred embodiment, the locking bolt is used at the position that contacts the outer wall of the sleeve 1, and a buffer pad is also provided to increase the contact area with the outer wall of the sleeve 1.

[0041] In a preferred embodiment, a clamping plate 4 is further included for further limiting the position of the rat's tail. Specifically, the clamping plate 4 includes an arc-shaped plate 41 and a push bolt 42. The first end of the push bolt 42 is rotatably connected to the outer arc surface of the arc-shaped plate 41. As an example, a thrust bearing can be provided on the outer arc surface of the arc-shaped plate 41 to connect the push bolt 42 and the arc-shaped plate 41. The push bolt 42 is threadedly connected to the side wall of the sleeve 1. When the push bolt is rotated, the arc-shaped plate 41 further limits or loosens the rat.

[0042] In a preferred embodiment, a pair of clamps 4 can be symmetrically arranged to improve the fixing effect.

[0043] In a preferred embodiment, a base tangent to the second sliding sleeve may also be provided on the outside of the first sliding sleeve 21.

[0044] As an example, the sleeve 1 and the limiting sleeve 2 in this device can be made of transparent plastic.

[0045] The method of using the rat tail vein injection fixation device is as follows: Place the sleeve 1 on a stable workbench, gently grasp the rat by its back, and slowly lower it into the sleeve 1 through the rat placement inlet 11. Simultaneously, hold the rat's tail and guide it through the first groove 14, moving it towards the tail operating opening 13 via the second groove 15. As the rat's body enters, continue guiding its tail until it completely passes through the tail operating opening 13 and extends out of the sleeve.

[0046] The limiting sleeve 2 is inserted from the first end of the sleeve 1, the second sliding sleeve 22 is located inside the sleeve 1, the first sliding sleeve 21 is located outside the sleeve 1, and the fixing member 24 slides along the first sliding groove 14. Continue pushing the limiting sleeve 2 towards the second end of the sleeve 1, causing the fixing member 24 to slide along the first groove 14 until it contacts the first limiting block 141, until the rat's head is completely inside the inner sleeve 23. At this point, the inner sleeve 23 fits tightly to the shape of the rat's head; Use the locking device 3 to fix the limiting sleeve 2 onto the sleeve 1.

[0047] Align the arc-shaped plate 41 of the clamp 4 with the tail of the rat, and rotate the push bolt 42 to gradually tighten the arc-shaped plate 41, thereby fixing the position of the rat's tail.

[0048] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0049] As is known from common technical knowledge, this utility model can be implemented through other embodiments that do not depart from its spirit or essential characteristics. Therefore, the disclosed embodiments described above are merely illustrative in all respects and are not the only ones. All modifications within the scope of this utility model or its equivalents are included in this utility model.

Claims

1. A rat tail vein injection fixation device, characterized in that, Includes a sleeve (1) and a limiting sleeve (2); The first end of the sleeve (1) is provided with a mouse placement inlet (11), and the second end of the sleeve (1) is provided with a sealing plate (12), on which a tail operation port (13) is provided; the sleeve (1) is provided with a first sliding groove (14) and a second sliding groove (15); the first sliding groove (14) is located on the side of the sleeve (1) and communicates with the mouse placement inlet (11), and the intersection of the first sliding groove (14) and the mouse placement inlet (11) is provided with a rounded corner; the second sliding groove (15) is provided on the sealing plate (12) and communicates with the first sliding groove (14) and the tail operation port (13) respectively; The limiting sleeve (2) includes a first sliding sleeve (21) and a second sliding sleeve (22); wherein the second sliding sleeve (22) is disposed inside the first sliding sleeve (21), and the first sliding sleeve (21) and the second sliding sleeve (22) are coaxially disposed; a fixing member (24) is connected between the inner wall of the first sliding sleeve (21) and the outer wall of the second sliding sleeve (22); when the limiting sleeve (2) is assembled on the sleeve (1), the first sliding sleeve (21) is sleeved outside the sleeve (1), the second sliding sleeve (22) is located inside the sleeve (1), and the fixing member (24) passes through the first sliding groove (14) and can slide along the first sliding groove (14); the fixing member (24) is configured as at least two arc-shaped connecting plates or connecting rods distributed axially along the first sliding sleeve (21), and the edges of the fixing member (24) are rounded. The second sliding sleeve (22) is provided with an inner sleeve (23) for limiting the rat's head; the inner sleeve (23) is an integral structure consisting of a first section (231) near the second sliding sleeve (22) and a second section (232) facing the first end of the sleeve (1). The first section (231) is cylindrical and is used to restrain the zygomatic region of the rat's head; the second section (232) is connected to the end of the first section (231) and extends towards the first end of the sleeve (1). The second section (232) is a trumpet-shaped or shallow cone-shaped structure with a gradually decreasing inner diameter, and the minimum inner diameter of the second section (232) is greater than the diameter of the rat's snout and smaller than the diameter of the rat's zygomatic bone; the inner surface of the inner sleeve (23) is provided with a soft buffer layer; The first sliding sleeve (21) is also provided with a locking device (3) for fixing the relative position of the limiting sleeve (2) and the sleeve (1).

2. The rat tail vein injection fixator according to claim 1, characterized in that, The sleeve (1) is cylindrical in shape.

3. The rat tail vein injection fixator according to claim 1, characterized in that, The first groove (14) is parallel to the central axis of the sleeve (1), and the first groove (14) is a straight groove that connects to the mouse placement inlet (11).

4. The rat tail vein injection fixator according to claim 1, characterized in that, The first slide (14) has a first limiting block (141) at one end near the tail operation port (13) to prevent the fixing member (24) from sliding excessively towards the tail operation port (13).

5. The rat tail vein injection fixator according to claim 1, characterized in that, The first sliding sleeve (21) and the second sliding sleeve (22) of the limiting sleeve (2) are both annular.

6. The rat tail vein injection fixator according to claim 1, characterized in that, The outer wall of the first section (231) of the inner sleeve (23) is fixedly connected to the inner ring of the second sliding sleeve (22).

7. The rat tail vein injection fixator according to claim 1, characterized in that, The locking device (3) is a locking bolt, and a buffer pad is provided at the position where the locking bolt contacts the outer wall of the sleeve (1).

8. The rat tail vein injection fixator according to claim 1, characterized in that, It also includes a clamping plate (4), which includes an arc plate (41) and a push bolt (42); the first end of the push bolt (42) is rotatably connected to the outer arc surface of the arc plate (41); the push bolt (42) is threadedly connected to the side wall of the sleeve (1).

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