A platelet-rich plasma preparation device hierarchy

Abstract

The application relates to the field of biological sample preparation, in particular to a platelet-rich plasma preparation device hierarchical structure which comprises a first cabin module, a second cabin module, a middle-end cabin module detachably connected between the two, and a center lock rod assembly clamped in a first center through hole of a partition plate in the middle-end cabin module, the middle-end cabin module can rotate relative to the second cabin module, the center lock rod assembly selectively blocks or connects a fluid passage between the second cabin module and the middle-end cabin module, and multiple sealing structures are arranged to ensure the sealing property. The application has the technical effects of flexibly controlling the fluid passage and improving the sealing property, so that the platelet-rich plasma hierarchical preparation is better.

Description

Technical Field

[0001] This application relates to the field of biological sample preparation, and in particular to a graded structure for a platelet-rich plasma preparation device. Background Technology

[0002] Platelet-rich plasma (PRP) therapy has broad application prospects in orthopedics, dentistry, and other fields, as the growth factors released by concentrated platelets can promote tissue repair. With the continuous development of medical technology, the demand for efficient, safe, and economical PRP preparation methods is increasing. The development of PRP preparation technology is of great significance for improving the treatment effect of related diseases and enhancing patient recovery. It provides new methods and ideas for clinical treatment, demonstrating enormous potential and value in the medical field.

[0003] In existing technologies, PRP preparation is mainly achieved through the following methods: First, multi-step centrifugation is used, which separates blood components by centrifuging at different speeds and times to obtain the desired PRP. Second, disposable separation tubes are used, utilizing the principle of density gradient centrifugation to separate blood components. Third, automated PRP preparation systems are employed, which integrate centrifugation and separation functions, enabling relatively efficient PRP preparation. However, these methods all have certain limitations in practical applications.

[0004] The main drawbacks of existing technologies are that manual preparation carries a high risk of sample exposure, easily leading to contamination and affecting the quality and safety of PRP. Multi-step centrifugation is not only cumbersome but also time-consuming, reducing preparation efficiency. Automated equipment is expensive, making it difficult to widely adopt in ordinary medical institutions. Furthermore, the separation effect of these methods is unstable, resulting in large fluctuations in platelet recovery rate and enrichment, making it impossible to guarantee stable PRP quality. Utility Model Content

[0005] To address the aforementioned issues, this application provides a graded structure for a platelet-rich plasma preparation device.

[0006] The graded structure of the platelet-rich plasma (PRP) generator provided in this application adopts the following technical solution: A graded structure for a platelet-rich plasma (PRP) preparation device, comprising: First compartment module; Second compartment module; A mid-level compartment module is detachably connected between the first compartment module and the second compartment module. The mid-level compartment module has a partition with a first central through hole inside, and the partition has a fluid through hole that connects to the inside of the mid-level compartment module. The center locking rod assembly is engaged with the first center through hole. The middle compartment module can rotate relative to the first compartment module and the second compartment module to drive the center locking rod assembly to selectively block or connect the fluid passages between the first compartment module and the middle compartment module, and between the middle compartment module and the second compartment module.

[0007] By adopting the above technical solution, and by setting up three graded and interconnected compartments, and by using the relative movement of the middle compartment module and other compartment modules to drive the central locking rod assembly to control the opening and closing of the fluid passages between the compartments, the graded centrifugation and extraction of blood samples can be completed in a closed device. This simplifies the operation steps, avoids the risk of cross-contamination caused by multiple sample transfers in traditional methods, and improves the efficiency and safety of platelet-rich plasma preparation.

[0008] Optionally, the center locking rod assembly includes a first locking rod and a second locking rod. One end of the first locking rod is inserted into the first center through hole, and the other end of the first locking rod is provided with an enlarged head, which can block the fluid passage between the first compartment module and the middle compartment module. One end of the second locking rod is inserted into the first center through hole, and the other end of the second locking rod can block the fluid passage between the middle compartment module and the second compartment module.

[0009] By adopting the above technical solution, and by specifying the central locking rod assembly as a first locking rod and a second locking rod with an enlarged head, a clearer and more reliable blockage of the upper and lower fluid passages can be achieved, ensuring the airtightness between different compartments when isolation is required, and improving the precision and controllability of the separation process.

[0010] Optionally, the partition has a connecting sleeve protruding from the surface of the partition, the first central through hole is located inside the connecting sleeve, and the outer wall of the first locking rod and / or the second locking rod is connected to a limiting ring, the ring surface of the limiting ring abutting against the tube end face of the connecting sleeve.

[0011] By adopting the above technical solution, the first locking rod and / or the second locking rod can be limited by the contact between the limiting ring and the end face of the connecting sleeve, ensuring the positional stability of the central locking rod assembly during operation, thereby ensuring the accuracy of the sealing or connection of fluid passages between compartments, improving the stability of platelet enrichment and recovery rate, and reducing the risk of contamination caused by changes in the position of the central locking rod assembly.

[0012] Optionally, the peripheral wall of the second compartment module is provided with a blood injection port, which communicates with the inner cavity of the middle compartment module, and a sealing ring is provided on the outer periphery of the blood injection port; wherein, one end of the second locking rod extends close to the blood injection port so that the liquid injected by the syringe can flow down along the outer wall of the second locking rod.

[0013] By adopting the above technical solution, the injected blood is guided to flow down the outer wall of the second locking rod, avoiding direct impact and splashing of the liquid, effectively reducing the rupture of red blood cells (hemolytic effect), thereby ensuring the initial quality of the blood sample and laying the foundation for the preparation of highly active, high-quality platelet-rich plasma.

[0014] Optionally, the outer wall of the second compartment module is threadedly connected to the inner wall of the middle compartment module, and a first sealing ring is provided between the outer wall of the second compartment module and the inner wall of the middle compartment module; the inner wall of the first compartment module is threadedly connected to the outer wall of the middle compartment module, and a second sealing ring is provided between the inner wall of the first compartment module and the outer wall of the middle compartment module.

[0015] By adopting the above technical solution and setting internal and external threads at different positions, the overall dimensions of the grading structure are kept consistent, making it more suitable for subsequent centrifugation operations. The use of threaded connections allows for convenient and secure assembly and disassembly of each compartment module. At the same time, the use of sealing rings ensures the structural stability and overall sealing of the entire device during high-speed centrifugation, preventing any leakage of biological liquids.

[0016] Optionally, the first sealing ring is nested on the outer wall of the second compartment module, and the first sealing ring is closer to the middle of the middle compartment module than the threaded connection between the second compartment module and the middle compartment module.

[0017] By adopting the above technical solution, the threaded structure and the liquid inside the chamber are effectively isolated, preventing blood components from remaining in the thread gaps. This not only facilitates cleaning and disinfection but also prevents the dead space from affecting the purity of the sample.

[0018] Optionally, the second sealing ring is nested on the outer wall of the mid-section module, and the second sealing ring is further away from the center of the mid-section module than the threaded connection between the first section module and the mid-section module.

[0019] By adopting the above technical solution, the contact between the threads and the liquid inside the compartment is also isolated, ensuring the cleanliness of the connection, avoiding potential sources of contamination, and improving the hygiene and safety level of the device.

[0020] Optionally, the first compartment module includes a first red blood cell compartment and a second red blood cell compartment, the inner wall of the first red blood cell compartment is threadedly connected to the outer wall of the second red blood cell compartment, and a third sealing ring is nested on the outer wall of the second red blood cell compartment.

[0021] By adopting the above technical solution, the first compartment module is designed as a detachable two-part structure, which enhances the modularity of the device. This not only facilitates the cleaning and maintenance of the upper compartment, but also provides convenience for subsequent functional expansion or component replacement.

[0022] Optionally, the second compartment module includes a first PRP compartment and a second PRP compartment, the first PRP compartment and the second PRP compartment being threadedly connected, and the second PRP compartment being threadedly connected to the mid-section compartment module; the second PRP compartment is provided with a platelet partition, which separates the second PRP compartment from the inner cavity of the mid-section compartment module; the platelet partition has a second central through hole at its center, and the central locking rod assembly can block the second central through hole.

[0023] By adopting the above technical solution, the second compartment module uses a structure in which the first PRP compartment and the second PRP compartment are threadedly connected, which facilitates assembly and disassembly; the platelet septum separates the second PRP compartment from the inner cavity of the middle compartment module, which can better separate blood components during centrifugation; the central locking rod assembly can block the second central through hole, which can flexibly control the fluid pathway, help improve the stability of platelet enrichment and recovery rate, simplify the PRP preparation process, reduce operation steps and contamination risks, and at the same time, this structure is low in cost, suitable for large-scale clinical application, and can reduce the amount of white blood cells and red blood cells remaining, which meets clinical safety standards.

[0024] Optionally, a silicone sealing cap is provided at the port of the first PRP chamber, the inner wall of the first PRP chamber is threadedly connected to the outer wall of the second PRP chamber, and the outer wall of the silicone sealing cap is threadedly connected to the inner wall of the second PRP chamber.

[0025] By adopting the above technical solution and setting a puncturable silicone sealing cap, the final product (platelet-rich plasma) can be aseptically extracted by puncturing with a syringe without disassembling the device. The system is kept airtight throughout the process, ensuring the sterility of the final product to the greatest extent. The double sealing connection method ensures the airtightness of the device.

[0026] In summary, this application includes at least one of the following beneficial technical effects: 1. It enables multi-stage separation and extraction of blood within a single closed system through simple rotation, greatly simplifying the operation process, reducing the risk of cross-contamination, and ensuring the safety and efficiency of the preparation process; 2. Through optimized sealing structure design (such as the locking rod enlarged head, connecting sleeve, relative position of sealing ring and thread, etc.), the device ensures high sealing performance and structural stability in each stage of assembly, centrifugation and separation, effectively preventing liquid leakage and internal and external contamination; 3. By using a gentle liquid injection method and adding a sterile extraction design, damage to blood cells is effectively reduced, the concentration and purity of platelet-rich plasma are increased, and the sterility of the final product is guaranteed, thus comprehensively improving the quality of the prepared product. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the overall structure of an embodiment of this application.

[0028] Figure 2 This is a cross-sectional view of the overall structure of an embodiment of this application.

[0029] Figure 3 This is an exploded view of the overall structure of an embodiment of this application.

[0030] Explanation of reference numerals in the attached figures: 1. First compartment module; 11. First red blood cell compartment; 12. Second red blood cell compartment; 13. Third sealing ring; 2. Second compartment module; 21. Blood injection port; 22. Sealing ring; 23. First PRP compartment; 231. Silicone sealing cap; 24. Second PRP compartment; 241. Platelet septum; 242. Second central through hole; 243. First sealing ring; 3. Middle compartment module; 31. Septum; 311. First central through hole; 312. Fluid through hole; 32. Connecting sleeve; 33. Second sealing ring; 4. Central locking rod assembly; 41. First locking rod; 411. Enlarged head; 42. Second locking rod; 43. Limiting ring; 5. Fluid passage. Detailed Implementation

[0031] The following will be combined with the appendix Figure 1-3 The technical solutions in the embodiments of the present invention are further described in detail below. The described embodiments are only possible technical implementations of the present invention, but are not limited thereto. Those skilled in the art can certainly combine the embodiments of the present invention to obtain other embodiments without creative effort, which are also within the protection scope of the present invention.

[0032] This application mainly adopts a graded compartment module in conjunction with a central locking rod assembly, which simplifies the PRP preparation process, improves platelet enrichment and recovery stability, and reduces preparation costs. The following is a further detailed description of this application.

[0033] The graded structure of the platelet-rich plasma generator provided in this embodiment is referenced. Figure 1 and Figure 2The system includes a first compartment module 1, a second compartment module 2, a middle compartment module 3, and a central locking rod assembly 4. The middle compartment module 3 is detachably connected between the first compartment module 1 and the second compartment module 2. The middle compartment module 3 has a partition 31 with a first central through hole 311. The central locking rod assembly 4 is engaged in the first central through hole 311. The partition 31 has a fluid through hole 312 that connects to the inside of the middle compartment module 3. The middle compartment module 3 can rotate relative to the first compartment module 1 and the second compartment module 2 to drive the central locking rod assembly 4 to move closer to or away from the first compartment module 1 and the second compartment module 2. This selectively blocks or connects the fluid passages 5 between the first compartment module 1 and the middle compartment module 3, and between the middle compartment module 3 and the second compartment module 2, achieving flexible control of the flow of blood components between the compartments and realizing the efficient preparation of platelet-rich plasma.

[0034] Specifically, the intermediate compartment module 3 is threadedly connected to the first compartment module 1 and the second compartment module 2, respectively. By rotating these three components, the distance between the intermediate compartment module 3 and the first and second compartment modules 1 and 2 can be axially adjusted to enable the central locking rod assembly 4 to open and close the fluid passage 5. The fluid through-hole 312 is used to balance the air pressure at various points within the intermediate compartment module 3 during centrifugation.

[0035] Specifically, the center locking rod assembly 4 includes a first locking rod 41 and a second locking rod 42. One end of the first locking rod 41 is inserted into the first center through hole 311. It has a rod-shaped structure and can be made of stainless steel, which is sturdy and durable and can ensure stable locking force. In some embodiments, the first locking rod 41 can also be made of high-strength engineering plastic, which reduces costs while ensuring a certain strength.

[0036] Preferably, the other end of the first locking rod 41 is provided with an enlarged head 411, which can block the fluid passage 5 between the first compartment module 1 and the middle compartment module 3. The enlarged head 411 can be shaped like a frustum cylinder, with a diameter slightly larger than the diameter of the fluid passage 5, to achieve a good sealing effect. An alternative shape can be a frustum cone, which can also play a sealing role. One end of the second locking rod 42 is inserted into the first central through hole 311, and its structure is similar to that of the first locking rod 41, also a rod-shaped structure. The material can also be stainless steel or engineering plastic. The other end of the second locking rod 42 can block the fluid passage 5 between the middle compartment module 3 and the second compartment module 2. The first locking rod 41 and the second locking rod 42 are connected to the partition 31 by being inserted into the first central through hole 311, and can move together with the middle compartment module 3 when it rotates, thereby achieving the blocking and connection of the fluid passage 5. This combination logic allows the central locking rod assembly 4 to control the flow of blood between different compartments as needed, improving the controllability and stability of the preparation process.

[0037] Specifically, the partition 31 has a connecting sleeve 32 protruding from its surface, and a first central through hole 311 is located within the connecting sleeve 32. The connecting sleeve 32 has a tubular structure, which provides an accurate insertion position for the first locking rod 41 and the second locking rod 42, ensuring the stability of the connection. Polycarbonate can be used as the material, as it is transparent and impact-resistant. Optionally, the first locking rod 41 and the second locking rod 42 can be either interference-fitted with the first central through hole 311 or threadedly connected.

[0038] Preferably, a limiting ring 43 is integrally formed on the outer wall of the first locking rod 41 and / or the second locking rod 42, and the annular surface of the limiting ring 43 abuts against the end face of the connecting sleeve 32. The limiting ring 43 has a ring structure and is made of the same material as the locking rod. The function of the limiting ring 43 is to ensure the positional stability of the central locking rod assembly 4 during operation, thereby ensuring the accuracy of sealing or connecting the fluid passages 5 between the compartments, improving the stability of platelet enrichment and recovery rate, and reducing the risk of contamination caused by changes in the position of the central locking rod assembly 4.

[0039] Reference Figure 2 Specifically, the second compartment module 2 has a blood injection port 21 on its peripheral wall, which communicates with the inner cavity of the middle compartment module 3. A sealing ring 22 is provided around the blood injection port 21. The blood injection port 21 has a tubular structure and can be made of polycarbonate. Its function is to facilitate the injection of blood into the device. The sealing ring 22 has an annular structure and can also be made of medical-grade silicone. Its function is to prevent blood leakage from the connection between the blood injection port 21 and the second compartment module 2 during injection. At least two blood injection ports 21 are provided. When blood needs to be injected through a syringe inserted into a blood injection port 21, the sealing ring 22 of one of the blood injection ports 21 must first be opened to allow air to pass through the preparer. Then, the syringe is inserted through the sealing ring 22, the syringe is tilted relative to the preparer, and finally, blood is injected.

[0040] One end of the second locking rod 42 extends close to the blood injection port 21, and the syringe needle contacts the second locking rod 42, allowing the liquid injected by the syringe to flow down the outer wall of the second locking rod 42. This design avoids direct impact and splashing of liquid, effectively reducing the rupture of red blood cells (hemolytic effect).

[0041] Reference Figure 3Specifically, the first compartment module 1 includes a first red blood cell compartment 11 and a second red blood cell compartment 12. The inner wall of the first red blood cell compartment 11 is threadedly connected to the outer wall of the second red blood cell compartment 12. A third sealing ring 13 is nested on the outer wall of the second red blood cell compartment 12. The third sealing ring 13 has a ring structure and can be made of medical-grade silicone. Its function is to enhance the sealing between the first red blood cell compartment 11 and the second red blood cell compartment 12. Preferably, the first red blood cell compartment 11 has a cap-type structure, which is mainly used to store red blood cells. The second red blood cell compartment 12 has a communicating vessel structure that is narrow in the middle and wide at both ends. Its purpose is to allow the central locking rod assembly 4 to block the communicating hole of the communicating vessel to open and close the first compartment module 1.

[0042] The inner wall of the second red blood cell compartment 12 is threadedly connected to the outer wall of the middle compartment module 3, and a second sealing ring 33 is provided between the inner wall of the second red blood cell compartment 12 and the outer wall of the middle compartment module 3. The second sealing ring 33 is nested in the outer wall of the middle compartment module 3, and is further away from the center of the middle compartment module 3 than the threaded connection between the first compartment module 1 and the middle compartment module 3. The second sealing ring 33 has a ring structure and can be made of medical-grade silicone. Through the threaded connection and the setting of the sealing ring, the connection between each compartment module is tight, ensuring the overall sealing of the device.

[0043] Reference Figure 2 and Figure 3 Specifically, the second compartment module 2 includes a first PRP compartment 23 and a second PRP compartment 24. The first PRP compartment 23 is threadedly connected to the second PRP compartment 24, and the second PRP compartment 24 is threadedly connected to the middle compartment module 3. A platelet partition 241 is provided inside the second PRP compartment 24, separating the second PRP compartment 24 from the inner cavity of the middle compartment module 3. The platelet partition 241 has a plate-like structure and can be made of plastic. Its function is to separate the different compartments, facilitating the separation of blood components. A second central through-hole 242 is provided in the center of the platelet partition 241, and the central locking rod assembly 4 can seal the second central through-hole 242.

[0044] Preferably, a silicone sealing cap 231 is provided at the port of the first PRP chamber 23. The inner wall of the first PRP chamber 23 is threadedly connected to the outer wall of the second PRP chamber 24, and the outer wall of the silicone sealing cap 231 is threadedly connected to the inner wall of the first PRP chamber 23. The silicone sealing cap 231 is made of medical-grade silicone, and its function is to further enhance the sealing performance of the device. Optionally, the port of the first PRP chamber 23 is also provided with an aluminum foil seal.

[0045] Reference Figure 2 and Figure 3Specifically, the outer wall of the second PRP chamber 24 is threadedly connected to the inner wall of the middle chamber module 3, and a first sealing ring 243 is provided between the outer wall of the second PRP chamber 24 and the inner wall of the middle chamber module 3. The first sealing ring 243 is nested in the outer wall of the second PRP chamber 24, and is closer to the middle of the middle chamber module 3 than the threaded connection between the second PRP chamber 24 and the middle chamber module 3. The first sealing ring 243 has a ring structure and can be made of medical-grade silicone. Since different parts need to be rotated during the use of the preparation device to adjust the position of the central locking rod assembly 4 to open or close the fluid passage 5, this application effectively solves the sealing problem and improves the sealing effect by designing threaded structures and sealing rings at different positions, thereby reducing the possibility of contamination.

[0046] The implementation principle of this embodiment is as follows: the graded structure of the platelet-rich plasma (PRP) preparer achieves graded separation of blood components through the detachable connection of each compartment module and the cooperation of the central locking rod assembly 4. In use, the graded structure of the preparer is placed vertically, with the first compartment module 1 at the bottom. Blood is injected into the middle compartment module 3 through the blood injection port 21 and enters the first compartment module 1. Then, a first centrifugation is performed, causing heavier components such as red blood cells to settle into the first compartment module 1, while the luteal layer and other components enter the middle compartment module 3.

[0047] By rotating the middle compartment module 3, the central locking rod assembly 4 blocks the fluid passage 5 between the first compartment module 1 and the middle compartment module 3, isolating the red blood cells. Then, the graded structure of the preparer is inverted, placing the second compartment module 2 at the bottom for a second centrifugation. During this second centrifugation, the denser platelets are enriched at the bottom of the second compartment module 2. Next, the second compartment module 2 is rotated, and the central locking rod assembly 4 blocks the fluid passage 5 between the middle compartment module 3 and the second compartment module 2. Finally, platelet-rich plasma is extracted by puncturing the silicone sealing cap 231 with a syringe. This structural design simplifies the PRP preparation process, reduces operational steps and contamination risks, improves the stability of platelet enrichment and recovery rates, and lowers preparation costs, making it easier to promote and use in medical institutions.

[0048] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A graded structure for a platelet-rich plasma (PRP) preparation device, characterized in that, include: First compartment module (1); Second compartment module (2); The mid-section module (3) is detachably connected between the first compartment module (1) and the second compartment module (2). The mid-section module (3) has a partition (31) with a first central through hole (311) inside. The partition (31) has a fluid through hole (312) that connects to the inside of the mid-section module (3). The center locking rod assembly (4) is engaged with the first center through hole (311). The middle compartment module (3) can rotate relative to the first compartment module (1) and the second compartment module (2) to drive the center locking rod assembly (4) to selectively block or connect the fluid passages (5) between the first compartment module (1) and the middle compartment module (3) and between the middle compartment module (3) and the second compartment module (2).

2. The graded structure of a platelet-rich plasma preparation device according to claim 1, characterized in that: The central locking rod assembly (4) includes a first locking rod (41) and a second locking rod (42). One end of the first locking rod (41) is inserted into the first central through hole (311), and the other end of the first locking rod (41) is provided with an enlarged head (411). The enlarged head (411) can block the fluid passage (5) between the first compartment module (1) and the middle compartment module (3). One end of the second locking rod (42) is inserted into the first central through hole (311), and the other end of the second locking rod (42) can block the fluid passage (5) between the middle compartment module (3) and the second compartment module (2).

3. The graded structure of a platelet-rich plasma preparation device according to claim 2, characterized in that: The partition (31) has a connecting sleeve (32) protruding from the surface of the partition (31) at its center. The first central through hole (311) is located inside the connecting sleeve (32). The outer wall of the first locking rod (41) and / or the second locking rod (42) is connected to a limiting ring (43). The ring surface of the limiting ring (43) abuts against the end face of the connecting sleeve (32).

4. The graded structure of a platelet-rich plasma preparation device according to claim 2, characterized in that: The second compartment module (2) has a blood injection port (21) on its peripheral sidewall. The blood injection port (21) is connected to the inner cavity of the middle compartment module (3). A sealing ring (22) is provided on the outer periphery of the blood injection port (21). One end of the second locking rod (42) extends close to the blood injection port (21) so that the liquid injected by the syringe can flow down along the outer wall of the second locking rod (42).

5. The graded structure of a platelet-rich plasma preparation device according to claim 1, characterized in that: The outer wall of the second compartment module (2) is threadedly connected to the inner wall of the middle compartment module (3), and a first sealing ring (243) is provided between the outer wall of the second compartment module (2) and the inner wall of the middle compartment module (3); the inner wall of the first compartment module (1) is threadedly connected to the outer wall of the middle compartment module (3), and a second sealing ring (33) is provided between the inner wall of the first compartment module (1) and the outer wall of the middle compartment module (3).

6. The graded structure of a platelet-rich plasma preparation device according to claim 5, characterized in that: The first sealing ring (243) is nested on the outer wall of the second compartment module (2), and the first sealing ring (243) is closer to the middle of the middle compartment module (3) than the threaded connection between the second compartment module (2) and the middle compartment module (3).

7. The graded structure of a platelet-rich plasma preparation device according to claim 5, characterized in that: The second sealing ring (33) is nested on the outer wall of the middle compartment module (3). The second sealing ring (33) is further away from the middle of the middle compartment module (3) than the threaded connection between the first compartment module (1) and the middle compartment module (3).

8. The graded structure of a platelet-rich plasma preparation device according to claim 1, characterized in that: The first compartment module (1) includes a first red blood cell compartment (11) and a second red blood cell compartment (12). The inner wall of the first red blood cell compartment (11) is threadedly connected to the outer wall of the second red blood cell compartment (12). The outer wall of the second red blood cell compartment (12) is nested with a third sealing ring (13).

9. The graded structure of a platelet-rich plasma preparation device according to claim 1, characterized in that: The second compartment module (2) includes a first PRP compartment (23) and a second PRP compartment (24). The first PRP compartment (23) is threadedly connected to the second PRP compartment (24), and the second PRP compartment (24) is threadedly connected to the middle compartment module (3). The second PRP compartment (24) is provided with a platelet partition (241), which separates the second PRP compartment (24) from the inner cavity of the middle compartment module (3). The platelet partition (241) has a second central through hole (242) in the center, and the central locking rod assembly (4) can block the second central through hole (242).

10. The graded structure of a platelet-rich plasma preparation device according to claim 9, characterized in that: A silicone sealing cap (231) is provided at the port of the first PRP chamber (23). The inner wall of the first PRP chamber (23) is threadedly connected to the outer wall of the second PRP chamber (24). The outer wall of the silicone sealing cap (231) is threadedly connected to the inner wall of the second PRP chamber (24).

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