A pharmaceutical granulation device

Abstract

The utility model discloses a medicine granulating device relates to wet granulation technical field, contains stirring device. The stirring device is used for the feeding, slurry adding and stirring of material, and its outer wall is linked with the discharge pipe. The inside of one end of discharge pipe near the outer wall of mixer is equipped with the plug cap. The utility model discloses through setting up granulating component, and the filter screen and the radial rotation rotary scraper of the component are equipped with the length far more than the pipe diameter of discharge pipe. With the extension of electric push rod, drive the pressing plate to extrude and lock the part of filter screen in the notch groove, and cooperate with the shape of guide groove, make the filter screen form the inner circular arc surface that is favorable to granulating. With the rotation of scraper, material is extruded from filter screen, thereby realizing granulating. Through the contraction of electric push rod, the locking of pressing plate to filter screen in discharge pipe is released, and the filter screen of blocked part can be pulled out from discharge pipe through electric roller at this time, and further realizes the replacement of filter screen.

Description

Technical Field

[0001] This utility model relates to the field of wet granulation technology, and in particular to a pharmaceutical granulation apparatus. Background Technology

[0002] In modern industrial production, wet granulation machines play a crucial role and are widely used in numerous industries such as pharmaceuticals, food, and chemicals. In the pharmaceutical field, they are used to prepare granules for various products, such as granules, tablets, and capsules. By thoroughly mixing drugs and excipients to form uniform granules, they can effectively improve the bioavailability and stability of drugs, ensuring drug quality and efficacy.

[0003] In existing wet granulation technology, the equipment mainly uses a stirring paddle to mix powder and prepare soft materials, and a bottom cutter and filter screen to complete the granulation. Although the granulation process has been mechanized, there are still technical pain points that need to be addressed in practical applications. For example, after prolonged use, the pores of the filter screen are easily clogged by the adhesion of soft materials, resulting in excessive particle size deviation, rough surface, or uneven internal density of the produced particles. This makes it difficult to meet the strict requirements for particle quality in high-precision solid dosage forms, and production efficiency and ease of operation are limited. The granulation pots of existing equipment are mostly fixed structures, requiring manual operation after machine shutdown during material input, soft material observation, and equipment cleaning. This not only prolongs the production cycle but also increases the labor intensity. Furthermore, material residues are easily left inside the equipment, posing a risk of cross-contamination, which does not meet the stringent cleanliness standards of the pharmaceutical industry. Clogged filters prevent some material from being effectively granulated, forming waste and increasing material loss rate, thus increasing production costs. Timely replacement of the filter screen can avoid the above problems, but the replacement process is also extremely inconvenient. Since the filter screen is usually installed in a relatively hidden and confined space inside the pelleting pot, each replacement requires a lot of time to disassemble and reinstall. This not only requires operators to have a high level of technical skills and patience, but may also lead to a long-term shutdown of the production line. Utility Model Content

[0004] To address the above shortcomings, this utility model provides a pharmaceutical granulation device that solves the problem of inconvenient disassembly and replacement of the filter screen in the granulation device.

[0005] A pharmaceutical granulation apparatus includes a stirring device for feeding, slurrying, and stirring materials. The outer wall of the stirring device is connected to a discharge pipe, and a plug is provided at one end of the discharge pipe near the outer wall of the mixer. Specifically, it also includes a granulation component, which is disposed in the discharge pipe at the end away from the mixer. The granulation component includes a support, a rotating scraper rotatably disposed on the top of the support, and a filter screen inserted into the cross-section of the support. A slit groove corresponding to the width of the filter screen is opened through the inner wall of the discharge pipe located on the upper end face of the seat. Guide grooves are provided on both sides of the inner wall of the seat. An installation plate is fitted on the outer wall of the discharge pipe. One end of the filter screen is connected to the installation plate, and the other end of the filter screen is inserted into the guide groove through the slit groove, and extends out of the slit groove at the other end of the guide groove and is connected to the other side of the installation plate. An electric push rod is provided on the mounting plate. A pressure plate matching the shape of the slit groove is provided on the telescopic rod of the electric push rod. The inner wall of the pressure plate is in contact with the outer wall of the discharge pipe. The upper end face of the pressure plate abuts against the filter screen. When the telescopic rod of the electric push rod retracts, the pressure plate moves away from the slit groove.

[0006] Furthermore, in the above scheme, the seat support has a circular outer circumferential surface, and a square through groove is provided at the center of the seat support. The guide groove is provided on both sides of the inner wall of the through groove, and the opening end of the through groove is provided with rounded corners.

[0007] Furthermore, in the above scheme, the guide groove is in the shape of a concave arc.

[0008] Furthermore, the outer wall of the discharge pipe is radially provided with a through circular hole, and the two ends of the rotating scraper are rotatably connected to the circular hole.

[0009] A motor is mounted on the mounting plate, and the output shaft of the motor is connected to one end of the rotating scraper.

[0010] Furthermore, in the above scheme, electric rollers are installed on both sides of the mounting plate, and both ends of the filter screen extend to the electric rollers on both sides of the mounting plate and are connected to the electric rollers.

[0011] Furthermore, in the above scheme, the length of the filter screen is at least three times the diameter of the discharge pipe, and the filter screen is wound around the outer circumferential surface of the electric roller along the circumference of the electric roller.

[0012] Furthermore, in the above scheme, the discharge pipe can be divided into an upper pipe section and a lower pipe section. The lower end of the upper pipe section and the upper end of the lower pipe section can be separated from or joined together. The support is located inside the lower pipe section, and a grooved clamp flange is fitted at the joint.

[0013] Furthermore, the upper surface of the pressure plate is provided with a gasket, and the gasket has an anti-slip part that abuts against the filter screen. Compared with the prior art, the beneficial effects of this utility model are: when the filter screen in the discharge pipe is blocked, a granulation component is set in the discharge pipe. The granulation component has a filter screen that is much longer than the diameter of the discharge pipe and a radially rotating scraper. The extension and retraction of the electric push rod drives the pressure plate to squeeze and lock a part of the filter screen in the cutting groove. The shape of the guide groove makes the filter screen form an inner arc surface that is conducive to granulation. As the scraper rotates, the material is squeezed out of the filter screen to achieve granulation. The retraction of the electric push rod releases the pressure plate from locking the filter screen in the discharge pipe. At this time, the filter screen can be replaced by pulling it, thereby reducing the maintenance difficulty of the equipment and improving the working efficiency of the equipment. Attached Figure Description

[0014] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below.

[0015] Figure 1 This is a three-dimensional schematic diagram of a pharmaceutical granulation device proposed in this utility model; Figure 2 This is a structural diagram showing the connection method between the mixing device and the discharge pipe; Figure 3 This is a schematic diagram of the overall structure of the pelleting component; Figure 4 This is a partial structural diagram of the granulation assembly located within the lower pipe section; Figure 5 This is a partial structural diagram of the filter screen after it has been removed. Figure 6 This is a schematic diagram of the pressure plate component structure.

[0016] In the diagram: 1. Mixing device; 11. Discharge hole; 12. Discharge pipe; 121. Upper pipe section; 122. Lower pipe section; 13. Plug; 14. Grooved clamp flange; 2. Granulation assembly; 21. Support; 211. Through groove; 212. Guide groove; 213. Rounded corner; 22. Rotary scraper; 221. Support; 222. Rotating shaft; 223. Scraper; 23. Filter screen; 24. Cutting groove; 25. Mounting plate; 26. Electric push rod; 261. Pressure plate; 27. Motor; 28. Gasket; 281. Anti-slip part; 29. ​​Electric roller. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the scope of protection of the present utility model.

[0018] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0019] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances. Furthermore, the technical features involved in the different embodiments of this utility model described below can be combined with each other as long as they do not conflict with each other.

[0020] Please see Figures 1 to 6 A preferred embodiment of this utility model provides a pharmaceutical granulation device, including a stirring device 1, a granulation component 2, and a mounting plate 25.

[0021] In this embodiment, the stirring device 1 is a mixer with a cylindrical shape. The mixer is equipped with an axial stirring paddle and a radial stirring rod that can rotate after being powered on. When the mixer is powered on, the axial stirring paddle and the radial stirring rod can stir the material. By putting the material into the mixer and adding the adhesive, as the axial stirring paddle and the radial stirring rod are activated, the dry material particles are fully mixed with the adhesive to form agglomerates with suitable moisture. The outer wall of the cylindrical container is provided with a discharge hole 11 that communicates with the outside. A discharge pipe 12 perpendicular to the stirring device 1 is connected to the discharge hole 11. A plug 13 for blocking the discharge hole 11 is provided at one end of the discharge pipe 12 near the outer wall of the stirring device 1. A hydraulic cylinder is fixedly installed on the outer wall of the discharge pipe 12. The plug rod of the hydraulic cylinder extends into the discharge pipe and is connected to the end face of the plug. After the plug rod of the hydraulic cylinder retracts, the plug 13 opens, so that the material can be squeezed into the discharge pipe 12 through the discharge hole 11 while the axial stirring paddle and the radial stirring rod are rotating.

[0022] The pelletizing assembly 2 includes a support 21, a rotating scraper 22 rotatably disposed on the top of the support 21, and a filter screen 23 penetrating the cross-section of the support 21.

[0023] In this preferred embodiment, the discharge pipe 12 is a hollow metal pipe with a 90° bend at the upper end. The discharge pipe 12 can be divided into an upper pipe section 121 and a lower pipe section 122. The support 21 is installed in the port of the lower pipe section 122. The upper pipe section 121 is fixedly connected to the lower pipe section 122 through a grooved clamp flange 14. The upper pipe section 121 and the lower pipe section 122 can be joined and separated by tightening or loosening the clamp, thereby realizing the rapid maintenance and installation of the pelletizing component 2.

[0024] The support 21 is used to support the filter screen 23 and fix the filter screen 23 in a specific shape to ensure the granulation effect of the material. In this embodiment, the support 21 has a circular outer circumference and is fixedly connected to the inner wall of the discharge pipe 12, thereby preventing uncrushed material from leaking from the gap between the support 21 and the inner wall of the discharge pipe 12. A square through groove 211 is provided at the center of the support 21. The opening end of the through groove 211 is provided with rounded corners 213. Due to the setting of the support 21, the inner wall of the discharge pipe 12 has a stepped structure. With the setting of the rounded corners 213, the stepped structure will not block the falling of the material. The material that does not directly pass through the through groove 211 will roll back into the through groove 211 through the rounded corners 213, thereby avoiding the retention of the material. The inner walls of the channel 211 are provided with guide grooves 212 corresponding to the thickness of the filter screen 23 on both sides, and the inner wall of the discharge pipe 12 on the upper end face of the seat 21 is provided with a cut groove 24 corresponding to the width of the filter screen 23.

[0025] In this embodiment, the length of the filter screen 23 is 7 times the diameter of the discharge pipe 12, and the initial state of the filter screen 23 is in a roll shape. The roll-shaped filter screen 23 occupies less space and is easy to install. One end of the filter screen 23 is located on the outer circumference of the roll, and the other end is located on the inner circumference of the roll. The filter screen 23 has fine filter holes for material extrusion granulation. During installation, the filter screen 23 located at one end of the outer wall of the roll-shaped circumference is torn open, and the filter screen 23 is passed through the adjacent slit groove 24. The filter screen 23 passing through the slit groove 24 is manually squeezed at its upper end, causing the flat filter screen 23 to bend and be inserted into the guide groove 212 along the rounded corner 213. The concave arc-shaped guide groove 212 fixes the filter screen 23 located in the discharge pipe 12 into a semi-circle. As the filter screen 23 is further inserted, the filter screen 23 passes through the slit groove 24 at the other end of the guide groove 212, thus completely covering the diameter of the through groove 211. When the filter screen 23 located in the slit groove 24 is fixed, the shape of the filter screen 23 located in the discharge pipe 12 remains unchanged, thereby ensuring the stability of the material during extrusion.

[0026] The rotary scraper 22 is radially arranged on the inner wall of the discharge pipe 12, and when the rotary scraper 22 rotates, it can squeeze the material located in the filter screen 23 out of the filter screen 23, thereby completing the granulation of the material. Due to the arrangement of the filter screen 23, the arrangement of the rotary scraper 22 needs to be able to squeeze the material out of the filter screen 23 without affecting the material falling. Therefore, the rotary scraper 22 includes a support 221, a rotating shaft 222, and a scraper 223. The inner wall of the discharge pipe 12 has a through hole in the radial direction. A support bearing is installed in the through hole. The length of the rotating shaft 222 is greater than the diameter of the discharge pipe 12 and is rotatably connected to the through hole. Part of the rotating shaft 222 extends out of the through hole. An L-shaped bracket 221 is welded on the rotating shaft 222 located on the inner wall of the discharge pipe 12. The two sides of the bracket 221 are close to the inner wall of the through groove 211 and the inner side wall of the guide groove 212, respectively. The scraper 223 is installed on the bracket 221 on one side of the inner side wall of the guide groove 212. The side of the scraper 223 close to the inner side wall of the guide groove 212 is arc-shaped. The arc-shaped transition surface ensures that the scraper 223 squeezes the filter screen 23 without damaging the filter screen 23.

[0027] The mounting plate 25 is a rectangular plate with a slot at its center that has the same diameter as the outer wall of the discharge pipe 12. The mounting plate 25 is fitted onto the lower section 122 of the discharge pipe 12 through the slot and welded to the outer wall of the discharge pipe 12 to meet the requirement of being able to bear a certain weight.

[0028] A vertically mounted electric push rod 26 is provided on the mounting plate 25. A pressure plate 261, matching the shape of the notch groove 24, is provided at the end of the telescopic rod of the electric push rod 26. The inner wall of the pressure plate 261 fits against the outer wall of the discharge pipe 12. The pressure plate 261 is used to fix the position of the filter screen 23 within the notch groove 24. When the telescopic rod of the electric push rod 26 extends, the upper end face of the pressure plate 261 abuts against the filter screen 23 to lock the position of the filter screen 23. A gasket 28 made of PP is provided on the upper end face of the pressure plate 261. The soft gasket 28 reduces the pressure applied to the filter screen 23 by the rotating scraper 22, preventing excessive pulling force on the filter screen 23. The gasket 28 has a sliding part 281 that abuts against the filter screen 23. The sliding part 281 consists of multiple small flanges arranged in a rectangular array, allowing the sliding part 281 to insert into the filter holes of the filter screen 23, thereby improving the locking effect of the filter screen 23. The mounting plate 25 is also equipped with a vertically mounted motor 27. The output shaft of the motor 27 is equipped with a bevel gear, and the shaft 222 at one end located on the outer wall of the discharge pipe 12 is equipped with a gear that meshes with the bevel gear.

[0029] In a preferred embodiment, for example, electric rollers 29 are installed on both sides of the mounting plate 25. The cylinder of the electric roller 29 is equipped with a drive motor, so that the electric roller 29 can rotate after being energized. The inner side of the cylindrical filter screen 23 is installed on the outer circumference of the left electric roller 29, and its outer side passes through the notch 24 and is installed on the outer circumference of the right electric roller 29. As the two electric rollers 29 rotate in the same direction, different parts of the filter screen 23 can move in the discharge pipe 12, thereby realizing the rapid replacement of the filter screen 23, thereby improving the production efficiency of granulation and reducing the difficulty of replacing the filter screen 23.

[0030] In practice, the wet granulation machine first starts the material mixing stage, and the material to be granulated is put into the cylindrical container inside the mixing device 1. The high-speed force generated by the rotation of the stirring paddle inside the cylindrical container pushes the material to be cut and rotated inside the cylindrical container. At the same time, the binder is added, and the binder is evenly dispersed and coats the material particles, causing the dry material particles to clump together. As the stirring continues, the material particles are fully wetted by the binder, and "liquid bridges" are formed between the particles through the binder. The loose dry powder gradually gathers into a moist soft material. The mixing device 1 is equipped with a hydraulic rod connected to the plug 13. After the plug rod of the hydraulic rod retracts, the plug 13 opens, and the discharge pipe 12 is connected to the cylindrical container. As the stirring paddle rotates, the soft material that has reached the ideal state is squeezed into the discharge pipe 12 by the stirring paddle. In this embodiment, the lower section 122 of the discharge pipe 12 is located at the lowest point of the device, and the discharged soft material naturally falls onto the filter screen 23 in the support 21. As the motor 27 starts, the rotating scraper 22 rotates synchronously, causing the soft material inside the filter screen 23 to be squeezed. The squeezed soft material is then pressed into particles that meet production requirements through the filter holes on the filter screen 23. During the above process, the falling soft material can roll onto the filter screen 23 through the rounded corners 213 around the opening of the through groove 211, thereby avoiding the retention of some soft material.

[0031] As the device granulates for an extended period, the filter screen 23 will inevitably become clogged. At this time, the telescopic rod of the electric push rod 26 retracts, and the pressure plate 261 on it slides downward along the outer wall of the discharge pipe 12, thereby releasing the locking of the anti-slip part 281 on the filter screen 23 at the cutting groove 24. Furthermore, the electric rollers 29 located on the left and right sides of the mounting plate 25 are activated to rotate counterclockwise, thereby pulling the clogged part of the filter screen 23 located in the discharge pipe 12 out of the cutting groove 24 along the path of the inner arc-shaped guide groove 212. Meanwhile, the filter screen 23 located on the left side of the outer wall of the discharge pipe 12 is pulled into the cutting groove 24 on the left side of the discharge pipe 12 and moves along the path of the guide groove 212 to the cutting groove 24 on the right side until the clogged part of the filter screen 23 is completely pulled out of the discharge pipe 12 by the electric roller 29 on the right side, thus completing the switching of the part of the filter screen 23 located inside the discharge pipe 12. The clogged part of the filter screen 23 is then rolled up and straightened by the electric roller 29 on the right side. Subsequently, the telescopic rod of the electric push rod 26 extends, causing the pressure plate 261 to slide upward along the outer wall of the discharge pipe 12 until the gasket 28 on the pressure plate 261 is inserted into the filter hole of the filter screen 23 by means of the flange on the anti-slip part 281 and the mutual squeezing of the pressure plate 261 and the cutting groove 24 to achieve locking, and in conjunction with the shape of the guide rail, the granulation effect of the filter screen 23 after switching is guaranteed.

[0032] Preferably, when the length of the left-side filter screen 23 is insufficient, the electric roller 29 on the right side of the mounting plate 25 can no longer switch the filter screen 23 by rotation. In this case, the filter screen 23 needs to be cleaned and replaced. At this time, the operator goes to the lower pipe section 122 and opens the grooved clamp flange 14, thereby exposing the seat 21. At this time, the telescopic rod of the drive electric push rod 26 retracts, causing the cutting groove 24 to open, thereby removing the two ends of the filter screen 23 roll to be replaced from the electric rollers 29 on both sides, and pulling out the filter screen 23 partially stuck in the discharge pipe 12 through the cutting groove 24. The operator then takes the new filter screen 23 roll. The filter screen 23 is re-attached to the electric roller 29 on the left side. One end of the filter screen 23 is inserted into the adjacent notch 24 and then into the guide groove 212. As the filter screen 23 is further inserted, it moves along the path of the guide groove 212 until the other end of the filter screen 23 extends out of the guide groove 212 and is pulled out through the opposite notch 24 until the filter screen 23 is pulled to the electric roller 29 on the right side and is fixedly connected to the outer circumference of the electric roller 29 there. This completes the replacement of the filter screen 23. At this time, the telescopic rod of the electric push rod 26 extends to fix the filter screen 23.

[0033] In another embodiment, the operator can directly clean the exposed surface of the clogged filter screen 23 that is pulled out onto the right-side electric roller 29 at any time without having to disassemble and replace the grooved clamp flange 14 after the filter screen 23 is completely clogged. When the filter screen 23 on the left side of the mounting plate 25 is too short due to the replacement of the screen surface by the seat 21, the electric roller 29 on the left side of the mounting plate 25 rotates clockwise, which is the same as the above working procedure. The difference is that when the length of the filter screen 23 at either end is insufficient, the electric roller 29 on the end with insufficient length of filter screen 23 rotates actively, thereby pulling the filter screen 23 on the other side of the discharge pipe 12 that is of sufficient length and has been cleaned into the seat 21 of the discharge pipe 12, thereby completing the switching of the clogged filter screen 23. The above description is merely a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the protection scope of the claims.

Claims

1. A pharmaceutical granulation apparatus, comprising a stirring device (1) for feeding, slurrying, and stirring materials, wherein a discharge pipe (12) is connected to the outer wall of the stirring device (1), and a plug (13) is provided inside the end of the discharge pipe (12) near the outer wall of the stirring device (1), characterized in that, It also includes a granulation component (2), which is disposed in a discharge pipe (12) at one end away from the stirring device (1). The granulation component (2) includes a support (21), a rotating scraper (22) rotatably disposed on the top of the support (21), and a filter screen (23) passing through the cross section of the support (21). A cut groove (24) corresponding to the width of the filter screen (23) is provided through the inner wall of the discharge pipe (12) located on the upper end face of the seat (21). Guide grooves (212) are provided on both sides of the inner wall of the seat (21). An installation plate (25) is fitted on the outer wall of the discharge pipe (12). One end of the filter screen (23) is connected to the installation plate (25). The other end of the filter screen (23) is inserted into the guide groove (212) through the cut groove (24) and extends out of the cut groove (24) at the other end of the guide groove (212) and is connected to the other side of the installation plate (25). An electric push rod (26) is provided on the mounting plate (25). A pressure plate (261) matching the shape of the notch (24) is provided on the telescopic rod of the electric push rod (26). The inner wall of the pressure plate (261) is in contact with the outer wall of the discharge pipe (12). The upper end face of the pressure plate (261) abuts against the filter screen (23). When the telescopic rod of the electric push rod (26) retracts, the pressure plate (261) moves away from the notch (24).

2. The pharmaceutical granulation apparatus according to claim 1, characterized in that, The seat (21) has a circular outer circumferential surface, which is fixedly connected to the inner wall of the discharge pipe (12). The center of the seat (21) is provided with a square through groove (211), and the guide groove (212) is provided on both sides of the inner wall of the through groove (211). The opening end of the through groove (211) is provided with rounded corners (213).

3. The pharmaceutical granulation apparatus according to claim 2, characterized in that, The guide groove (212) is a concave arc shape.

4. The pharmaceutical granulation apparatus according to claim 1, characterized in that, The outer wall of the discharge pipe (12) is radially provided with a through circular hole. The two ends of the rotating scraper (22) are rotatably connected to the circular hole. A motor (27) is provided on the mounting plate (25). The output shaft of the motor (27) is connected to one end of the rotating scraper (22).

5. A pharmaceutical granulation apparatus according to claim 1, characterized in that, Electric rollers (29) are installed on both sides of the mounting plate (25), and the two ends of the filter screen (23) extend to the electric rollers (29) on both sides of the mounting plate (25) and are connected to the electric rollers (29).

6. A pharmaceutical granulation apparatus according to claim 5, characterized in that, The length of the filter screen (23) is at least three times the diameter of the discharge pipe (12), and the filter screen (23) is wound around the outer circumferential surface of the electric roller (29) along the circumference of the electric roller (29).

7. A pharmaceutical granulation apparatus according to claim 3, characterized in that, The discharge pipe (12) can be divided into an upper pipe section (121) and a lower pipe section (122). The lower end of the upper pipe section (121) and the upper end of the lower pipe section (122) can be separated or joined together. The seat (21) is located inside the lower pipe section (122), and a grooved clamp flange (14) is fitted at the joint.

8. A pharmaceutical granulation apparatus according to claim 3, characterized in that, The upper end face of the pressure plate (261) is provided with a gasket (28), and the gasket (28) is provided with a non-slip part (281) that abuts against the filter screen (23).

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