A connected fed-batch fermenter

Abstract

The utility model relates to biological pharmacy instrument technical field, proposes a kind of fermentation tank of connecting feeding, it includes: fermentation tank main part;Feeding unit is fixedly installed at the top of fermentation tank main part, for connecting the material inside the inside of fermentation tank main part is input;Purification device is fixedly installed at the side of fermentation tank main part, for purifying the gas in the inside of fermentation tank main part;Stirring and turning material unit is fixedly installed in the inside of fermentation tank main part, for stirring the material in the inside of fermentation tank main part;Control panel is fixedly installed on the outer surface of fermentation tank main part;The feeding unit includes fixed mounting frame that is fixedly installed at the top of fermentation tank main part. By conveying pump, the material inside feeding tank can be continuously sent into the inside of fermentation tank main part, and then control the growth of cell or engineering bacteria in the inside of fermentation tank main part, the gas in the inside of fermentation tank main part can be filtered by purification filter element, prevent the gas with harmful substance in the inside of fermentation tank main part from being directly discharged into air, pollute air.

Description

Technical Field

[0001] This utility model belongs to the field of biopharmaceutical equipment technology, specifically relating to a fermentation tank for connecting feeding. Background Technology

[0002] Fermenters for biopharmaceutical applications are essential equipment in the biopharmaceutical field for culturing microorganisms, cells, or other biological systems. These fermenters provide a controlled and optimized environment for biological reactions to facilitate the production of biopharmaceuticals.

[0003] A known authorized patent with application number CN202422740168.8 discloses a fermenter for biopharmaceuticals: It includes a tank body, a top cover, a rotating column that is rotatably connected to the bottom of the top cover near its center, a rotating rod that is rotatably connected to the bottom of the rotating column, a square ring plate fixedly connected to the bottom of the rotating column, and inclined arc plates fixedly connected to both ends of the square ring plate. A conveying auger is fitted onto and fixedly connected to the surface of the rotating rod. In this invention, a drive motor drives a third bevel gear to rotate, which in turn drives two other bevel gears to rotate in opposite directions. The rotating column and rotating rod then drive the square ring plate and the conveying auger to rotate respectively. The rotation of the square ring plate pushes the edge liquid towards the center, while the rotation of the conveying auger conveys the liquid from the center and bottom upwards, thus improving the mixing degree of the liquid and increasing the fermentation efficiency.

[0004] However, the implementation of the relevant technology revealed the following problems with the above-mentioned technical solution: the device cannot continuously deliver drugs during use, while mammalian cells or engineered bacteria are commonly used in biopharmaceuticals. The growth and expression of these cells and engineered bacteria require continuous nutrition. A single-use delivery will lead to excessive cell proliferation in the early stages and subsequent nutrient depletion and death in the later stages.

[0005] Therefore, a fermenter with connected feeding system is proposed to solve the above problems. Utility Model Content

[0006] This invention proposes a fermenter with a feeding connection, which solves the problem in related technologies where the fermenter cannot be continuously fed with chemicals, thus affecting the cultivation of microorganisms inside the fermenter.

[0007] The technical solution of this utility model is as follows: A fermentation tank connected to the feeding system, comprising: Fermentation tank body; A feeding unit fixedly installed on the top of the fermenter body is used to connect and feed materials into the interior of the fermenter body; A purification device is fixedly installed on one side of the fermenter body to purify the gas inside the fermenter body; A stirring and turning unit is fixedly installed inside the fermenter body to stir the materials inside the fermenter body. A control panel that is fixedly installed on the outer surface of the fermenter body; The feeding unit includes a fixed frame fixedly installed on the top of the fermenter body, a feeding box fixedly installed inside the fixed frame, a partition fixedly installed inside the feeding box, a first feeding port fixedly installed on the top of the feeding box, a second feeding port fixedly installed on the top of the feeding box, a conveying pump fixedly installed on the top of the fermenter body, a conveying pipe fixedly installed at the input end of the conveying pump, a discharge pipe fixedly installed at the output end of the conveying pump, a tee joint fixedly installed at the bottom of the feeding box, a first normally closed valve fixedly installed inside the tee joint, and a second normally closed valve fixedly installed inside the tee joint.

[0008] Preferably, the purification unit includes a limiting member fixedly installed on one side of the fermenter body, a purification box fixedly installed inside the limiting member, an air supply pipe fixedly installed on the top of the purification box, an air outlet pipe fixedly installed on the bottom of the purification box, and a purification filter element fixedly installed inside the purification box.

[0009] Preferably, the stirring and turning unit includes a chassis fixedly installed on the top of the fermentation tank body, a motor fixedly installed inside the chassis, a fixed bearing fixedly installed inside the fermentation tank body, a drive shaft fixedly installed inside the fixed bearing, an external gear fixedly installed at the top of the drive shaft, a drive gear fixedly installed at the output end of the motor, a scraper fixedly installed outside the drive shaft, and a feeding screw fixedly installed outside the drive shaft.

[0010] Preferably, a discharge port is fixedly installed at the bottom of the fermentation tank body, and a solenoid valve is fixedly installed inside the discharge port.

[0011] Preferably, a support frame is fixedly installed on the outside of the fermentation tank body, and anti-slip feet are fixedly installed on the bottom of the support frame.

[0012] Preferably, one end of the conveying pipe is fixedly connected to one end of the tee connector, and the partition divides the interior of the feeding box into two spaces, which are respectively connected to the first feeding port and the second feeding port.

[0013] Preferably, a feed inlet is fixedly installed on the top of the fermentation tank body, and a sealing cover is movably installed on the top of the feed inlet.

[0014] Preferably, the control panel is internally fixedly connected with wires, and the control panel is electrically connected to the delivery pump, motor, normally closed valve No. 1, normally closed valve No. 2 and solenoid valve through the wires.

[0015] The working principle and beneficial effects of this utility model are as follows: the material inside the feeding box can be continuously fed into the fermentation tank body through the delivery pump, thereby controlling the growth of cells or engineered bacteria inside the fermentation tank body. The purification filter can filter the gas inside the fermentation tank body, preventing the gas containing harmful substances inside the fermentation tank body from being directly discharged into the air and causing air pollution. Attached Figure Description

[0016] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0017] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a cross-sectional view of the overall structure of the fermenter body of this utility model; Figure 3 This utility model Figure 2 A magnified view of part A in the image; Figure 4 This is a cross-sectional view of the overall structure of the chassis of this utility model; Figure 5 This utility model Figure 4 A magnified view of part B in the image.

[0018] In the diagram: 1. Fermentation tank body; 2. Control panel; 3. Fixing frame; 4. Feeding box; 5. Baffle; 6. Feeding port 1; 7. Feeding port 2; 8. Conveying pump; 9. Feeding pipe; 10. Discharge pipe; 11. T-connector; 12. Normally closed valve 1; 13. Normally closed valve 2; 14. Limiting device; 15. Purification box; 16. Gas supply pipe; 17. Gas outlet pipe; 18. Chassis; 19. Motor; 20. Fixed bearing; 21. Drive shaft; 22. External gear; 23. Drive gear; 24. Scraper; 25. Feeding screw; 26. Discharge port; 27. Solenoid valve; 28. Support frame; 29. ​​Feed inlet; 30. Sealing cover; 31. Purification filter element. Detailed Implementation

[0019] The technical solutions of this utility model will be clearly and completely described below with reference to the embodiments of this utility model. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this utility model.

[0020] Please see Figure 1 -5, a fermentation tank connected to a feeding system, comprising: Fermentation tank body 1; A feeding unit is fixedly installed on the top of the fermenter body 1, which is used to connect and feed materials into the interior of the fermenter body 1; A purification device is fixedly installed on one side of the fermenter body 1 to purify the gas inside the fermenter body 1; A stirring and turning unit is fixedly installed inside the fermentation tank body 1 to stir the materials inside the fermentation tank body 1; Control panel 2 is fixedly installed on the outer surface of the fermenter body 1; The feeding unit includes a fixed frame 3 fixedly installed on the top of the fermenter body 1, a feeding box 4 fixedly installed inside the fixed frame 3, a partition 5 fixedly installed inside the feeding box 4, a first feeding port 6 fixedly installed on the top of the feeding box 4, a second feeding port 7 fixedly installed on the top of the feeding box 4, a conveying pump 8 fixedly installed on the top of the fermenter body 1, a conveying pipe 9 fixedly installed at the input end of the conveying pump 8, a discharge pipe 10 fixedly installed at the output end of the conveying pump 8, a tee joint 11 fixedly installed at the bottom of the feeding box 4, a first normally closed valve 12 fixedly installed inside the tee joint 11, and a second normally closed valve 13 fixedly installed inside the tee joint 11.

[0021] The technical solution provided in this embodiment is as follows: When in use, different materials are first added into different compartments inside the feeding box 4 through the first feeding port 6 and the second feeding port 7. Then, when in use, the conveying pump 8 can be started to open the first normally closed valve 12 or the second normally closed valve 13, and the materials inside the different compartments can be extracted through the conveying pipe 9 and then sent into the interior of the fermentation tank body 1 through the discharge pipe 10. Then, the motor 19 is started to rotate the drive gear 23, which drives the external gear 22 to rotate the drive shaft 21, so that the scraper 24 scrapes off the material on the inner wall of the fermentation tank body 1. The feeding screw 25 is rotated to turn the material at the bottom of the fermentation tank body 1 to the top, so that the materials inside the fermentation tank body 1 are fully mixed, thereby making the fermentation faster. The gas produced by fermentation will enter the interior of the purification box 15 through the gas conveying pipe 16, and then the harmful impurities in the gas will be adsorbed by the purification filter element 31, and then discharged through the gas outlet pipe 17.

[0022] Furthermore, the purification unit includes a limiting member 14 fixedly installed on one side of the fermenter body 1, a purification box 15 fixedly installed inside the limiting member 14, an air supply pipe 16 fixedly installed on the top of the purification box 15, an air outlet pipe 17 fixedly installed on the bottom of the purification box 15, and a purification filter element 31 fixedly installed inside the purification box 15.

[0023] Specifically, by fixing the purification filter element 31 inside the purification box 15, the gas produced by the fermentation of the material inside the fermentation tank body 1 can be purified, preventing the gas after fermentation from being directly emitted into the air and polluting the environment.

[0024] Furthermore, the mixing and turning unit includes a housing 18 fixedly installed on the top of the fermentation tank body 1, a motor 19 fixedly installed inside the housing 18, a fixed bearing 20 fixedly installed inside the fermentation tank body 1, a drive shaft 21 fixedly installed inside the fixed bearing 20, an external gear 22 fixedly installed at the top of the drive shaft 21, a drive gear 23 fixedly installed at the output end of the motor 19, a scraper 24 fixedly installed outside the drive shaft 21, and a feeding screw 25 fixedly installed outside the drive shaft 21.

[0025] Specifically, by fixing the scraper 24 to the outside of the drive shaft 21, the material on the inner wall of the fermentation tank body 1 can be scraped off by the scraper 24, preventing the material from sticking to the inner wall and affecting the fermentation of the material.

[0026] Furthermore, a discharge port 26 is fixedly installed at the bottom of the fermentation tank body 1, and a solenoid valve 27 is fixedly installed inside the discharge port 26.

[0027] Specifically, by fixing a solenoid valve 27 inside the discharge port 26, the solenoid valve 27 can be opened after the material fermentation is completed, allowing the material to be discharged through the discharge port 26.

[0028] Furthermore, a support frame 28 is fixedly installed on the outside of the fermentation tank body 1, and anti-slip feet are fixedly installed on the bottom of the support frame 28.

[0029] Specifically, by fixing anti-slip feet to the bottom of the support frame 28, friction can be increased when using the fermenter, preventing the fermenter body 1 from shifting due to vibration.

[0030] Furthermore, one end of the conveying pipe 9 is fixedly connected to one end of the tee connector 11, and the partition 5 divides the interior of the feeding box 4 into two spaces, which are respectively connected to the first feeding port 6 and the second feeding port 7.

[0031] Specifically, the interior of the feeding box 4 is divided into two spaces by the partition 5, which allows two materials to be placed inside the feeding box 4 and prevents the two materials from mixing in advance. Different materials can be conveniently fed through the three-way connector 11, the first normally closed valve 12 and the second normally closed valve 13.

[0032] Furthermore, a feed inlet 29 is fixedly installed on the top of the fermenter body 1, and a sealing cover 30 is movably installed on the top of the feed inlet 29.

[0033] Specifically, by movably setting the sealing cap 30 on top of the feed inlet 29, external impurities can be prevented from entering the interior of the fermenter body 1 through the feed inlet 29, and gas inside the fermenter body 1 can also be prevented from leaking through the feed inlet 29.

[0034] Furthermore, the control panel 2 is internally fixedly connected with wires, and the control panel 2 is electrically connected to the delivery pump 8, motor 19, normally closed valve 12, normally closed valve 13 and solenoid valve 27 via the wires.

[0035] Specifically, by electrically connecting the control panel 2, the delivery pump 8, the motor 19, the first normally closed valve 12, the second normally closed valve 13, and the solenoid valve 27 together with wires, the control panel 2 can control the delivery pump 8 through the wires, thereby continuously adding the material inside the feeding box 4 into the fermentation tank body 1.

Claims

1. A connected fed-batch fermenter, characterized in that, include: Fermentation tank body (1); A feeding unit is fixedly installed on the top of the fermenter body (1) for connecting to the inside of the fermenter body (1) to feed materials; A purification device is fixedly installed on one side of the fermenter body (1) for purifying the gas inside the fermenter body (1); A stirring and turning unit is fixedly installed inside the fermentation tank body (1) for stirring the materials inside the fermentation tank body (1); A control panel (2) is fixedly installed on the outer surface of the fermenter body (1); The feeding unit includes a fixed frame (3) fixedly installed on the top of the fermentation tank body (1), a feeding box (4) fixedly installed inside the fixed frame (3), a partition (5) fixedly installed inside the feeding box (4), a first feeding port (6) fixedly installed on the top of the feeding box (4), a second feeding port (7) fixedly installed on the top of the feeding box (4), a conveying pump (8) fixedly installed on the top of the fermentation tank body (1), a conveying pipe (9) fixedly installed at the input end of the conveying pump (8), a discharge pipe (10) fixedly installed at the output end of the conveying pump (8), a three-way connector (11) fixedly installed at the bottom of the feeding box (4), a first normally closed valve (12) fixedly installed inside the three-way connector (11), and a second normally closed valve (13) fixedly installed inside the three-way connector (11).

2. A fermentation tank with a connection for feeding according to claim 1, characterized in that: The purification device includes a limiting member (14) fixedly installed on one side of the fermenter body (1), a purification box (15) fixedly installed inside the limiting member (14), an air supply pipe (16) fixedly installed on the top of the purification box (15), an air outlet pipe (17) fixedly installed on the bottom of the purification box (15), and a purification filter element (31) fixedly installed inside the purification box (15).

3. A fermentation tank with a connection for feeding according to claim 1, characterized in that: The mixing and turning unit includes a housing (18) fixedly installed on the top of the fermentation tank body (1), a motor (19) fixedly installed inside the housing (18), a fixed bearing (20) fixedly installed inside the fermentation tank body (1), a drive shaft (21) fixedly installed inside the fixed bearing (20), an external gear (22) fixedly installed at the top of the drive shaft (21), a drive gear (23) fixedly installed at the output end of the motor (19), a scraper (24) fixedly installed outside the drive shaft (21), and a feeding screw (25) fixedly installed outside the drive shaft (21).

4. A connected fed-batch fermenter according to claim 1, wherein: The bottom of the fermenter body (1) is fixedly installed with a discharge port (26), and a solenoid valve (27) is fixedly installed inside the discharge port (26).

5. A fermentation tank with a connecting feed according to claim 1, characterized in that: The fermenter body (1) is fixedly mounted with a support frame (28), and the bottom of the support frame (28) is fixedly mounted with anti-slip feet.

6. A fermentation tank for connecting and feeding according to claim 1, characterized in that: One end of the conveying pipe (9) is fixedly connected to one end of the three-way connector (11), and the partition (5) divides the interior of the feeding box (4) into two spaces, which are connected to the first feeding port (6) and the second feeding port (7) respectively.

7. A fermentation tank for connecting and feeding according to claim 1, characterized in that: The fermenter body (1) is fixedly equipped with a feed inlet (29) on the top, and a sealing cover (30) is movably provided on the top of the feed inlet (29).

8. A fermentation tank for connecting and feeding according to claim 4, characterized in that: The control panel (2) is internally fixed with wires, and the control panel (2) is electrically connected to the delivery pump (8), motor (19), first normally closed valve (12), second normally closed valve (13) and solenoid valve (27) through the wires.

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