A sealed integrated sample collection and processing device

Abstract

The utility model provides a sealed integrated sample collection, processing device, including cotton swab, diluent pipe, collection pipe and seal cap, diluent pipe includes diluent storage section, transition section and connecting seat section which are sequentially arranged from top to bottom, is provided with collection inner tube in transition section and connecting seat section, the one end of collection inner tube is closed to diluent storage section, and the one end of collection inner tube and diluent storage section form closed space, and the one end of collection inner tube and collection inner tube are connected, and the one end of collection inner tube and collection inner tube are connected, and the one of collection inner tube and collection inner tube are connected, and the one end of collection inner tube is connected, and the one end of collection inner tube is connected, and the one end of collection pipe is connected, and the one end of collection pipe is connected, and the one end of collection tube is connected, and the one end of collection tube is connected, and the one end of collection pipe is connected, and the one end of the filter core is set between the two inner walls of the lower end of collection pipe. The utility model is used in combination with the matched diluent and filter core, effectively removes the impurities in the sample, improves the purity of the sample, reduces the interference to the detection process, the whole collection and processing process is simple and easy to operate, can be completed without professional personnel, saves time and manpower cost.

Description

Technical Field

[0001] This utility model relates to the field of medical testing technology, and in particular to a sealed integrated sample collection and processing device. Background Technology

[0002] In biological fluids, the detection and quantitative analysis of biomarkers play an extremely important role in determining the pathological state of an organism, its genetic susceptibility, and its response to drugs and environmental factors. Any change in the structure or function of a biomarker may reflect changes in the overall biological system. Therefore, biomarkers play a key role in the prevention, diagnosis, prognosis, and monitoring of disease progression.

[0003] Saliva, as a human biological fluid, has significant advantages such as being non-invasive, low-cost, safe, and easy to obtain. It also contains specific biomarkers, making it an ideal choice for early disease detection. The future development of saliva diagnostic technology is expected to revolutionize disease screening methods, risk assessment, and health management models, potentially providing more personalized treatment plans at various stages of disease. In medical testing, saliva sample collection is crucial for the diagnosis of many diseases. However, existing saliva collection methods have several problems. Firstly, traditional methods struggle to precisely control the volume of collected saliva, leading to unstable sample sizes and affecting the accuracy of test results. Secondly, saliva often contains food residue and large pieces of mucoprotein, which can interfere with subsequent testing processes, reducing efficiency and quality. Furthermore, existing collection devices are complex to operate, requiring professional personnel and increasing labor costs and operation time. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a sealed, integrated sample collection and processing device that can semi-quantitatively collect fixed-volume saliva samples, effectively process saliva samples and remove impurities, and is simple and easy to operate.

[0005] The technical solution adopted in this utility model is: A sealed, integrated sample collection and processing device includes a cotton swab, a diluent tube, a collection tube, and a sealing cap. The diluent tube comprises a diluent storage section, a transition section, and a connecting seat section arranged sequentially from top to bottom. A collection inner cylinder is disposed within the transition section and the connecting seat section. One end of the collection inner cylinder facing the diluent storage section is closed, forming a closed space between one end of the collection inner cylinder and the diluent storage section. A flexible rod and diluent are disposed within the closed space. One end of the flexible rod is connected to the collection inner cylinder. The connecting seat section is threadedly connected to one end of the collection tube. The other end of the collection tube is connected to the sealing cap. A filter element is disposed between the two inner walls at the lower end of the collection tube.

[0006] Preferably, in the sealed integrated sample collection and processing device, the cotton swab includes a swab rod and a swab head, and a break line is provided on the swab rod.

[0007] Preferably, in the sealed integrated sample collection and processing device, the diameter of the diluent storage section is smaller than the diameter of the connecting seat section, and an arc-shaped transition section is formed between the diluent storage section and the connecting seat section.

[0008] Preferably, in the sealed integrated sample collection and processing device, the collection tube includes a collection section, a filtration section, and a liquid outlet section arranged sequentially from top to bottom. The diameter of the filtration section is smaller than the diameter of the collection section, and a filter element is provided inside the filtration section.

[0009] Preferably, in the sealed integrated sample collection and processing device, a liquid outlet is provided on the liquid outlet section, an external thread is provided on the outer periphery of the liquid outlet section, and an internal thread is provided on the inner periphery of the sealing cap to cooperate with the external thread.

[0010] Preferably, in the sealed integrated sample collection and processing device, the filter element includes a first filter element and a second filter element arranged sequentially from top to bottom between the two inner walls at the lower end of the collection tube.

[0011] Preferably, in the sealed integrated sample collection and processing device, the first filter element has a pore size of 10-15 micrometers and a thickness of 1-1.5 mm; the second filter element has a pore size of 0.8-1 micrometer and a thickness of 1-1.5 mm.

[0012] Preferably, the sealed integrated sample collection and processing device is used for the collection and processing of saliva, bronchoalveolar lavage fluid, urine, feces, and blood samples.

[0013] Advantages of this utility model: (1) The sealed integrated sample collection and processing device of this utility model can absorb a fixed volume of saliva with the cotton swab, ensuring that the sample volume collected each time is consistent and improving the accuracy and reliability of the test results; the combination of the matching diluent and filter cartridge effectively removes impurities in the saliva, improves the purity of the sample, and reduces interference with the test process; the whole collection and processing process is simple and easy to operate, and can be completed without professional personnel, saving time and labor costs.

[0014] (2) The sealed integrated sample collection and processing device of this utility model is easy to operate, reduces unnecessary repetitive operations and material waste, and reduces energy consumption and raw material usage; the use of filter core reduces waste emissions during sample processing, making it more environmentally friendly. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the sealed integrated sample collection and processing device of this utility model.

[0016] Figure 2 This is a schematic diagram of the structure of the cotton swab of this utility model.

[0017] Figure 3 This is a schematic diagram of the filter element of this utility model. Detailed Implementation

[0018] The present invention will be further described below with reference to the specific accompanying drawings and embodiments.

[0019] like Figures 1-3 A sealed integrated sample collection and processing device includes a cotton swab 1, a diluent tube 2, a collection tube 3, and a sealing cap 4. The diluent tube 2 includes a diluent storage section 21, a transition section 22, and a connecting seat section 23 arranged sequentially from top to bottom. A collection inner cylinder 5 is arranged inside the transition section 22 and the connecting seat section 23. One end of the collection inner cylinder 5 facing the diluent storage section 21 is closed, and one end of the collection inner cylinder 5 and the diluent storage section 21 form a closed space. An easy-break rod 51 and diluent are arranged in the closed space. One end of the easy-break rod 51 is connected to the collection inner cylinder 5. The connecting seat section 23 is threadedly connected to one end of the collection tube 3. The other end of the collection tube 3 is connected to the sealing cap 4. A filter element 6 is arranged between the two inner walls at the lower end of the collection tube 3.

[0020] The cotton swab 1 includes a swab rod 11 and a swab head 12, and a break line 13 is provided on the swab rod 11; the diameter of the diluent storage section 21 is smaller than the diameter of the connecting seat section 23, and an arc-shaped transition section 22 is formed between the diluent storage section 21 and the connecting seat section 23; the collection tube 3 includes a collection section 31, a filtration section 32 and an outlet section 33 arranged sequentially from top to bottom, the diameter of the filtration section 32 is smaller than the diameter of the collection section 31, and a filter element 6 is provided inside the filtration section 32; an outlet 34 is provided on the outlet section 33, and an external thread is provided on the outer periphery of the outlet section 33, and an internal thread that cooperates with the external thread is provided on the inner periphery of the sealing cap 4.

[0021] The filter element 6 includes a first filter element 61 and a second filter element 62 arranged sequentially from top to bottom between the two inner walls at the lower end of the collection tube 3; the pore size of the first filter element 61 is 10-15 micrometers and the thickness is 1-1.5 mm; the pore size of the second filter element 62 is 0.8-1 micrometer and the thickness is 1-1.5 mm; the integrated sample collection and processing device is used for the collection and processing of saliva, bronchoalveolar lavage fluid, urine, feces and blood samples.

[0022] The swab 1 has good adsorption properties and can adsorb a fixed volume of saliva. The diluent can be either TBS buffer or PBS buffer. The diluent can effectively dilute the saliva sample while maintaining the sample's biological activity. The diluent is located in the diluent storage section 21. By breaking the easy-break rod 51, a diluent outlet is formed in the collection inner tube 5, which can easily release the diluent into the saliva sample in the collection tube 3. The filter core adopts a composite structure, consisting of multiple layers of filter screens with different pore sizes, which can effectively block food residues and disperse large pieces of mucin, ensuring the purity of the sample.

[0023] The operation process of this utility model: Step S1. Gently wipe the inside of the mouth with cotton swab 1 to collect saliva sample, break the cotton swab 11 at the break line 13, and put the cotton swab head 12 that collected the saliva sample into the collection tube 3; Step S2. Break the easy-break rod 51 to form a diluent outlet in the inner collection cylinder 5, release the matching diluent, mix it with the saliva sample, and perform dilution treatment; Step S3. Pass the diluted saliva sample through the filter cartridge, and finally add the saliva sample to the test container for testing.

[0024] Saliva samples were collected from 20 normal individuals using conventional spitting methods and the cotton swabs of this invention. The theoretical collection volume was 0.5 mL for each sample. A fixed amount of pepsin (100 ng) was added to each sample to prepare a theoretical concentration of 200 ng / mL. The samples were then tested using a salivary pepsin detection kit. The test results are shown in Table 1.

[0025] As shown in Table 1, conventional sampling methods involve subjective errors due to the need to visually estimate the amount of saliva collected, resulting in a larger CV in the test results. Therefore, the amount of saliva sample collected using cotton swabs is more accurate. In addition, the filter cartridge can effectively filter out food residues in some saliva samples, avoiding interference from impurities with the test results.

[0026] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solution of this utility model and not to limit it. Although this utility model has been described in detail with reference to examples, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications and substitutions should be covered within the scope of the claims of this utility model. Table 1

[0027] As shown in Table 1, conventional sampling methods involve subjective errors due to the need to visually estimate the amount of saliva collected, resulting in a larger CV in the test results. Therefore, the amount of saliva sample collected using cotton swabs is more accurate. In addition, the filter cartridge can effectively filter out food residues in some saliva samples, avoiding interference from impurities with the test results.

[0028] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solution of this utility model and not to limit it. Although this utility model has been described in detail with reference to examples, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications and substitutions should be covered within the scope of the claims of this utility model.

Claims

1. A sealed, integrated sample collection and processing device, characterized in that: The device includes a cotton swab (1), a diluent tube (2), a collection tube (3), and a sealing cap (4). The diluent tube (2) includes a diluent storage section (21), a transition section (22), and a connecting seat section (23) arranged sequentially from top to bottom. A collection inner cylinder (5) is provided in the transition section (22) and the connecting seat section (23). The collection inner cylinder (5) is closed at one end facing the diluent storage section (21). One end of the collection inner cylinder (5) and the diluent storage section (21) form a closed space. A flexible rod (51) and diluent are provided in the closed space. One end of the flexible rod (51) is connected to the collection inner cylinder (5). The connecting seat section (23) is threaded to one end of the collection tube (3). The other end of the collection tube (3) is connected to the sealing cap (4). A filter element (6) is provided between the two inner walls at the lower end of the collection tube (3).

2. The sealed integrated sample collection and processing device according to claim 1, characterized in that: The cotton swab (1) includes a swab rod (11) and a swab head (12), and a break line (13) is provided on the swab rod (11).

3. The sealed integrated sample collection and processing device according to claim 1, characterized in that: The diameter of the diluent storage section (21) is smaller than the diameter of the connecting seat section (23), and an arc-shaped transition section (22) is formed between the diluent storage section (21) and the connecting seat section (23).

4. The sealed integrated sample collection and processing device according to claim 1, characterized in that: The collection tube (3) includes a collection section (31), a filtration section (32) and an outlet section (33) arranged from top to bottom. The diameter of the filtration section (32) is smaller than the diameter of the collection section (31), and a filter element (6) is provided inside the filtration section (32).

5. The sealed integrated sample collection and processing device according to claim 4, characterized in that: The liquid outlet section (33) is provided with a liquid outlet (34), the outer circumference of the liquid outlet section (33) is provided with an external thread, and the inner circumference of the sealing cap (4) is provided with an internal thread that cooperates with the external thread.

6. The sealed integrated sample collection and processing device according to claim 1, characterized in that: The filter element (6) includes a first filter element (61) and a second filter element (62) arranged sequentially from top to bottom between the two inner walls at the lower end of the collection tube (3).

7. The sealed integrated sample collection and processing device according to claim 6, characterized in that: The first filter element (61) has a pore size of 10-15 micrometers and a thickness of 1-1.5 mm; the second filter element (62) has a pore size of 0.8-1 micrometers and a thickness of 1-1.5 mm.

8. The sealed integrated sample collection and processing device according to claim 1, characterized in that: The integrated sample collection and processing device is used for the collection and processing of saliva, bronchoalveolar lavage fluid, urine, feces, and blood samples.

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