Barrier system, cleanroom, process for the catalytic reduction of hydrogen peroxide in a barrier system

Abstract

The invention relates to a barrier system (10) for the aseptic handling of products, in particular pharmaceutical active ingredients and / or medicinal products, comprising a fluidically connected flow chamber (14), wherein the flow chamber (14) includes a working area (16) that is physically separated from an operator environment (20) and is designed for the aseptic handling of the products, at least one heat exchanger (52) arranged in the flow chamber (14), and wherein the heat exchanger (52) has a flow path through which a gas mixture located in the flow chamber (14) can flow. It is provided that the heat exchanger (52) has, at least in a region, a catalytically active material (70) on a surface (68) defining the flow path (14), which is designed to catalyze the reduction of hydrogen peroxide.

Description

[0001] The present invention relates to a barrier system. Furthermore, the present invention relates to a cleanroom comprising such a barrier system. Furthermore, the present invention relates to a method for the catalytic reduction of hydrogen peroxide in such a barrier system.

[0002] In pharmaceutical production, products such as active pharmaceutical ingredients or medicinal products are often handled under aseptic conditions. For example, liquid preparations such as injections, infusions, or ophthalmics are typically filled into their respective primary packaging under aseptic conditions.

[0003] So-called barrier systems are conventionally used for aseptic handling. A barrier system comprises a fluidically connected flow space that has a work area. The work area is physically separated from an operator environment and designed for the aseptic handling of products. Due to the physical separation of the work area from the operator environment, the aseptic nature of products handled in the work area is not compromised by one or more operators. Typically, such a barrier system comprises at least one heat exchanger arranged in the flow space. The heat exchanger can influence the temperature in the flow space.

[0004] Before commissioning, barrier systems are often decontaminated with hydrogen peroxide. This ensures aseptic conditions, particularly in the work area. However, hydrogen peroxide may remain in the flow chamber after decontamination. Sensitive pharmaceutical active ingredients in particular can be chemically altered by the remaining hydrogen peroxide. Therefore, a catalyst unit designed to catalyze the reduction of hydrogen peroxide is typically arranged in the flow chamber. The hydrogen peroxide is converted into water and oxygen during the reduction process.

[0005] While the catalyst unit can effectively reduce hydrogen peroxide, it impairs the available space in the flow chamber, limiting the design flexibility for the remaining components. Furthermore, the catalyst unit has the disadvantage of increasing flow resistance in the flow chamber. This makes the circulation of a gas mixture within the flow chamber more difficult.

[0006] Patent EP 0 774 263 B1 discloses a barrier system in which a heat exchanger and a catalyst unit are arranged structurally separate from each other in the flow path of the sterilization system. JP 5 462 025 B2, JP 5 294 323 B2, and DE 10 2013 102 516 A1 also each disclose a barrier system in which a heat exchanger and a catalyst unit are structurally separate from each other.

[0007] The patent specification DE 10 2004 029 803 B4 discloses a vessel treatment machine comprising a heat exchanger with a catalytically active material.

[0008] The invention is concerned with the task of improving the utilization of the available installation space in a barrier system.

[0009] This object is achieved according to the invention by a barrier system having the features of claim 1, by a clean room having the features of claim 9 and by a method having the features of claim 10.

[0010] The respective subclaims and the description indicate advantageous variants and embodiments.

[0011] According to the invention, a barrier system is provided for the aseptic handling of products. The products can be pharmaceutical active ingredients and / or drugs. However, the barrier system can also be used for handling other products whose aseptic properties must be maintained during a handling process.

[0012] The barrier system according to the invention comprises a fluidically connected flow space. Individual regions of the flow space are thus fluidically connected to one another. The flow space comprises a working area. In addition to the working area, the flow space can comprise further areas, as will be explained in more detail later.

[0013] The work area is physically separated from the operator environment and designed for the aseptic handling of products. The work area can be physically separated from the operator environment, for example, by a particularly transparent barrier wall of the barrier system. The barrier wall can be equipped with one or more glove openings, allowing an operator to perform manual work within the work area. Alternatively or additionally, one or more handling devices, such as four-axis or six-axis robots, are arranged in the work area, allowing the products in the work area to be handled automatically.

[0014] The barrier system according to the invention also comprises at least one heat exchanger arranged in the flow space. The heat exchanger has a flow path through which a gas mixture located in the flow space can flow. Preferably, only one heat exchanger is arranged in the flow space. However, multiple heat exchangers can also be present in the flow space.

[0015] It is now proposed that the heat exchanger be provided with a catalytically active material, designed to catalyze the reduction of hydrogen peroxide, at least in some areas on a surface defining the flow path. The catalytically active material is thus integrated into the heat exchanger. In particular, only the catalytically active material integrated into the heat exchanger is present, thus eliminating the need for a separate catalyst unit with a catalytically active material.

[0016] By integrating the catalytically active material into the heat exchanger, the utilization of the available installation space can be optimized. Specifically, the space typically occupied by the catalyst unit is freed up. If, in addition to the catalytically active material integrated into the heat exchanger, a separate catalyst unit is also present, this catalyst unit can be made smaller. This also optimizes the utilization of the installation space. Eliminating the catalyst unit or using a smaller catalyst unit also reduces the flow resistance in the flow chamber.

[0017] The heat exchanger is also particularly suitable for accommodating the catalytically active material because both the function of the heat exchanger and the function of the catalytically active material, i.e. the heat exchange with the gas mixture in the flow space and the catalysis of the reduction of hydrogen peroxide contained in the gas mixture, require a large contact area with the gas mixture.

[0018] In the context of the disclosure, the “surface” means the entire surface of the heat exchanger which defines or limits the flow path and thus comes into direct contact with the gas mixture as it flows through the flow path.

[0019] The barrier system is preferably designed to generate an air flow, in particular a recirculating air flow, in the flow space. For this purpose, the barrier system comprises an air conveying device with at least one air conveying unit arranged in the flow space. However, the barrier system can also be free of an air conveying device. In this case, an air flow, in particular a recirculating air flow, can be generated in the flow space, for example, by an air conveying device of a clean room in which the barrier system is arranged.

[0020] Preferably, the heat exchanger has the catalytically active material only in certain areas of the surface. The surface thus comprises at least a first area where the catalytically active material is present and at least a second area that is free of the catalytically active material.

[0021] In some preferred embodiments, the barrier system is designed as a RAB system (RAB = Restricted Access Barrier). In an RAB system, the work area is physically separated from the operator environment by special machine protection consisting of a machine housing and securely locked doors. The RAB system can be designed as either an active RAB system or a passive RAB system. In an active RAB system, the RAB system itself is equipped with a ventilation system. In a passive RAB system, the RAB system does not have its own ventilation system and is connected to the ventilation system of a clean room in which the RAB system is located. Furthermore, the RAB system can be designed as either an open RAB system or a closed RAB system. In an open RAB system, a gas mixture can flow from the work area into the clean room in which the RAB system is located.In a closed RAB system, such a fluidic connection between the work area and the cleanroom is not present. The closed and open designs can be combined with both active and passive designs. Alternatively, in some preferred embodiments, the barrier system is designed as an isolator. An isolator is a completely closed system, which is associated with the best possible separation of the work area and the operator environment. The fundamental difference between an isolator and a RAB system is that the isolator itself has a decontamination device. An isolator can therefore also be used in a Class C (ISO 8) cleanroom, for example. A RAB system, on the other hand, typically does not have a decontamination device. For decontamination, the decontamination device of the cleanroom in which the RAB system is installed is therefore generally used.Given this, RAB systems are typically used in a Class B (ISO 5) cleanroom.

[0022] According to the invention, the heat exchanger has a further flow path for a cooling medium that is fluidically separated from the flow space, the heat exchanger comprises at least one heat-conducting element that forms the surface at least in part and is in heat-conducting contact with the further flow path, and the heat-conducting element comprises the catalytically active material. The catalytically active material is therefore present on a part of the heat exchanger that is jointly responsible for the function of the heat exchanger, i.e., influencing the temperature of the gas mixture in the flow space. By arranging the catalytically active material on the heat-conducting element, the temperature of the catalytically active material can be actively influenced by the heat exchanger. The heat exchanger preferably comprises a plurality of heat-conducting elements, in particular a multiplicity of heat-conducting elements.It is provided that at least one of the heat-conducting elements comprises the catalytically active material, at least in some areas. Preferably, several of the heat-conducting elements each comprise the catalytically active material, at least in some areas. In particular, all heat-conducting elements each comprise the catalytically active material, at least in some areas. Depending on the design of the heat exchanger, the heat-conducting element(s) can each be designed differently.

[0023] Various media can be used as the cooling medium. The cooling medium is preferably a water-based coolant, especially water. However, the cooling medium can also be a refrigerant such as R413A.

[0024] According to the invention, the heat exchanger is designed as a finned heat exchanger or a plate heat exchanger. In a finned heat exchanger, one or more fluid lines are present, the interior of which forms the further flow path. Additionally, several heat-conducting elements designed as heat-conducting fins are provided, which are arranged on the fluid line(s) and are in thermal contact with the fluid line(s). A finned heat exchanger is particularly advantageous for use in a barrier system. However, other types of heat exchangers are also possible.

[0025] In some preferred embodiments, it is provided that the heat-conducting element or at least one of the heat-conducting elements is made of the catalytically active material. The catalytically active material thus forms the respective heat-conducting element(s) in a self-supporting manner. Such a design of the heat exchanger is simple to realize in terms of manufacturing technology. In particular, a manufacturing step in which the catalytically active material is applied as a coating to a heat-conducting element is not necessary. The heat-conducting element can be designed as a solid heat-conducting element. Alternatively, the heat-conducting element can also be formed from a self-supporting catalyst foam. This has the advantage of achieving a particularly large surface area.

[0026] In some preferred embodiments, the heat exchanger is coated at least partially with the catalytically active material. In these embodiments, the catalytically active material is therefore not self-supporting, but is carried as a coating by the heat exchanger. The heat exchanger itself is preferably formed from a copper sheet, in particular galvanized. Compared to the aforementioned production of one or more heat-conducting elements from the catalytically active material, a coating has the advantage that less of the comparatively expensive catalytically active material is required. Furthermore, the provision of the coating can be controlled as needed. In particular, the coating is left out at least partially. Particularly preferably, the heat-conducting element or at least one of the heat-conducting elements is at least partially coated with the catalytically active material.

[0027] In some preferred embodiments, the catalytically active material is a platinum material, a palladium material, or a manganese oxide material. These materials are particularly suitable for catalyzing the reduction of hydrogen peroxide.

[0028] In some preferred embodiments, it is provided that the heat exchanger or at least one of the heat exchangers is arranged in a recirculation line of the flow space. The flow space therefore also comprises at least one recirculation line in addition to the working area. If the heat exchanger is arranged in the recirculation line, at least a large part of the gas mixture flows through the first flow path of the heat exchanger during operation of the barrier system, which is accompanied by an effective reduction of hydrogen peroxide. Preferably, the working area has at least one inlet with a HEPA filter, wherein the working area is fluidly connected to a pre-chamber of the flow space via the inlet. The arrangement of the heat exchanger in the recirculation line has the advantage over the arrangement in the pre-chamber, for example, that liquids condensed on the heat exchanger do not reach the HEPA filter.Wetting the HEPA filter with condensed liquids could promote the growth of germs in the HEPA filter. The arrangement of the heat exchanger in the recirculation duct thus allows for active condensation of condensable components of the gas mixture on the heat exchanger or the catalytically active material. The hydrogen peroxide contained in the gas mixture can thus be specifically enriched on the catalytically active material because hydrogen peroxide condenses together with the water contained in the gas mixture. The heat exchanger is preferably arranged in a horizontally extending section of the recirculation duct. If arranged in a vertically extending section, the attachment of the heat exchanger would be more difficult than in the horizontally extending section.

[0029] In some preferred embodiments, the heat exchanger, or at least one of the heat exchangers, is arranged in an outlet of a recirculating air line of the flow chamber. The arrangement of the heat exchanger in the outlet also makes it possible for at least a large portion of the gas mixture to flow through the first flow path of the heat exchanger. Preferably, the recirculating air line is fluidly connected to the aforementioned prechamber of the flow chamber via the outlet.

[0030] In some preferred embodiments, the heat exchanger is arranged in an add-on part that is detachably connected to the barrier system by at least one valve. The arrangement of the heat exchanger in the add-on part has the advantage that a barrier system can also be retrofitted with the heat exchanger. If the add-on part is connected to the barrier system by the valve, the interior of the add-on part also forms the flow space. Preferably, the add-on part is detachably connected to the barrier system by two valves. This allows effective flow through the add-on part during operation of the barrier system. Particularly preferably, an air conveying unit is present in the add-on part in addition to the heat exchanger.

[0031] The cleanroom according to the invention comprises a barrier system designed as described above. The barrier system is arranged in the cleanroom. If the barrier system is designed as a RAB system, the barrier system is preferably connected to a ventilation system of the cleanroom.

[0032] Regarding the advantages that can be achieved with a cleanroom, please refer to the relevant information on the barrier system. The features described in connection with the barrier system can be used to further configure the cleanroom.

[0033] The process according to the invention for the catalytic reduction of hydrogen peroxide in a barrier system designed as described above comprises at least the following: Generating an air flow, in particular a recirculating air flow, in the flow space, so that a gas mixture located in the flow space flows through the flow path of the heat exchanger and the reduction of hydrogen peroxide contained in the gas mixture is catalyzed by the catalytically active material.

[0034] Regarding the advantages achievable with the process, reference is made to the relevant comments on the barrier system. The features described in connection with the barrier system can be used to further refine the process.

[0035] Preferably, the air flow is generated by an air conveying device of the barrier system. However, the air flow can also be generated by an air generating device external to the barrier system, for example, by an air generating device of a clean room in which the barrier system is located.

[0036] In some preferred embodiments of the method, the heat exchanger is cooled to a temperature that falls below the dew point temperature of the gas mixture in the flow space, so that hydrogen peroxide contained in the gas mixture at least partially condenses on the catalytically active material. The condensation of hydrogen peroxide on the catalytically active material can increase the effectiveness with regard to hydrogen peroxide reduction because the hydrogen peroxide is specifically supplied to the catalytically active material. Particularly preferably, the heat exchanger is arranged in a recirculation line of the barrier system. Such an arrangement can prevent HEPA filters upstream of the work area from becoming wetted by condensed liquid.The cooling of the heat exchanger can be achieved, for example, by reducing the temperature of a cooling medium or by increasing the flow of the cooling medium.

[0037] In some preferred embodiments of the method, the air humidity of the gas mixture is measured, and the dew point temperature is determined based on the measured air humidity. This procedure enables particularly precise adjustment of a suitable temperature for the heat exchanger.

[0038] The invention is described in more detail below with reference to the figures, wherein identical or functionally identical elements may be provided with reference numerals only once. The description serves as an example and is not to be understood as limiting. Fig. 1 a barrier system in a schematic representation; and Fig. 2 a heat exchanger of the Fig. 1 shown barrier system in a partial sectional view.

[0039] In the Fig. 1 and Fig. 2 shows a barrier system 10 and a heat exchanger 52 of the barrier system 10. The barrier system 10 is designed for the aseptic handling of products such as pharmaceutical active ingredients or medicaments. For example, pharmaceutical active ingredients or medicaments can be filled into primary packaging in the barrier system 10. In the illustrated embodiment, the barrier system 10 is designed as an isolator 10. Alternatively, the barrier system 10 can also be a RAB system. The barrier system 10 is installed in a clean room 22.

[0040] The barrier system 10 comprises a flow space 14. The flow space 14 comprises various fluidically interconnected regions, which are explained in more detail below.

[0041] The flow space 14 comprises a work area 16 intended for the aseptic handling of the products. The work area 16 is physically separated from an operator environment 20 by a barrier wall 18 of the barrier system 10. Due to the physical separation of the work area 16 from the operator environment 20, the asepticity of products handled in the work area 16 cannot be compromised by operators located in the operator environment 20. In particular, several glove openings (not shown) are provided in the barrier wall 18, enabling operators to manually handle products in the work area 16.

[0042] The work area 16 also includes a first inlet 24 and a second inlet 26 formed in a ceiling of the work area 16. The first inlet 24 and the second inlet 26 each include a HEPA filter 28 and 29, respectively. The work area 16 is fluidically connected to a prechamber 30 of the flow space 14 through the first inlet 24 and the second inlet 26.

[0043] The flow chamber 14 also includes a recirculation line 32. The recirculation line 32 is fluidically connected to the working area 16 on the inlet side in the region of a floor of the working area 16. On the outlet side, the recirculation line 32 is fluidically connected to the prechamber 30.

[0044] In this case, the flow chamber 14 also comprises a further recirculation line 34. The further recirculation line 34 is also fluidically connected to the working area 16 on the inlet side in the region of the floor of the working area 16 and to the prechamber 30 on the outlet side.

[0045] The barrier system 10 also includes an air conveying device 36. The air conveying device 36 is designed to generate a recirculating air flow in the flow space 14. For this purpose, the air conveying device 36 comprises a first air conveying unit 38 and a second air conveying unit 40.

[0046] The first air delivery unit 38 is assigned to the first inlet 24. The second air delivery unit 40 is assigned to the second inlet 26. The air delivery units 38 and 40 are aligned such that their pressure sides face the inlet 24 and the inlet 26, respectively.

[0047] If a gas mixture located in the flow chamber 14 is conveyed by the air conveying units 38 and 40, the gas mixture passes through the HEPA filters 28 and 29 from the pre-chamber 30 into the working area 16. In the working area 16, the gas mixture flows from the ceiling of the working area 16 towards the floor of the working area 16. There, the gas mixture enters the recirculation lines 32 and 34, where it flows vertically upwards and returns to the pre-chamber 30. The flow direction in the recirculation mode of the barrier system 10 is in Fig. 1 marked by arrows.

[0048] In the illustrated embodiment, the barrier system 10 also comprises an attachment 42. An interior space 44 of the attachment 42 is fluidically connected to the prechamber 30 via valves 46 and 48. The interior space 44 of the attachment 42 thus forms the flow chamber 14.

[0049] In Fig. 1 also shows several heat exchangers 52, namely a first heat exchanger 52-1, a second heat exchanger 52-2, and a third heat exchanger 52-3. It should be noted that, unlike this illustration, the barrier system 10 typically only includes one of the heat exchangers 52, so that the joint illustration essentially serves to illustrate various possible installation positions. However, two or three of the illustrated heat exchangers 52 may also be present together as part of the barrier system 10.

[0050] The first heat exchanger 52-1 is arranged in the recirculation duct 32, in this case in a horizontally extending section of the recirculation duct 32. A lower boundary of the horizontally extending section is formed by a ceiling of the prechamber 30. The first heat exchanger 52-1 is therefore arranged vertically above the prechamber 30. In this case, a further HEPA filter 56 is arranged upstream of the first heat exchanger 52-1.

[0051] The second heat exchanger 52-2 is arranged in an outlet of the further recirculation duct 34. In the present case, the further recirculation duct is formed by a wall 53 that is aligned parallel to the barrier wall 18. The second heat exchanger 52-2 is arranged between the ceiling of the prechamber 30 and a vertically upper end of this wall 53.

[0052] The third heat exchanger 52-3 is arranged in the interior space 44 of the attachment 42. In addition, a further air conveying unit 50 is arranged in the interior space 44.

[0053] In view of the arrangement of the heat exchangers 52, the gas mixture located in the flow space 14 flows through the heat exchangers 52 during operation of the barrier system 10.

[0054] In the following, with reference to Fig. 2, the design of the first heat exchanger 52-1 is explained in more detail. It should be noted that the heat exchangers 52-1, 52-2 and 52-3 are of the same design. The Fig. 2 and the heat exchanger 52-1 are therefore also implemented in the heat exchangers 52-2 and 52-3.

[0055] The heat exchanger 52-1 comprises a supply line 58 for a liquid cooling medium and a discharge line 60 for the cooling medium. Furthermore, the heat exchanger 52-1 comprises a plurality of fluid lines 62 that extend through a frame-shaped housing 64 of the heat exchanger 52-1. The supply line 58 is fluidically connected to the discharge line 60 via the fluid lines 62.

[0056] The heat exchanger 52 also comprises a plurality of heat-conducting elements 66, which in this case are lamella-shaped. The heat-conducting elements 66 or heat-conducting lamellae 66 are attached to the fluid lines 62. Accordingly, the heat-conducting elements 66 are in thermal contact with the fluid lines 62 and a cooling medium located therein.

[0057] The heat exchanger 52-1 comprises a flow path through which the gas mixture located in the flow chamber 14 can flow. The flow path is formed by the surfaces 68 of the heat exchanger facing the flow chamber 14, in particular by the surfaces 69 of the heat-conducting elements 66. In this case, the flow path runs perpendicular to a frame opening of the housing 64 through the heat exchanger 52-1.

[0058] The heat exchanger 52-1 also includes an additional flow path formed by the interior of the fluid lines 62. The additional flow path is fluidically separated from the flow path defined by the surfaces 68.

[0059] During commissioning, barrier systems are typically decontaminated with hydrogen peroxide. For this purpose, the barrier system 10, which is designed as an isolator in this case, comprises a decontamination device (not shown) designed to supply hydrogen peroxide to the flow chamber 14. Although most of the hydrogen peroxide is removed from the flow chamber 14 following decontamination, hydrogen peroxide residues may remain in the flow chamber 14. These residues could chemically alter, particularly oxidize, sensitive substances during subsequent operation of the barrier system 10.

[0060] To prevent this, the heat exchanger 52-1 comprises a catalytically active material 70 on the surface 68 defining the flow path, which is designed to catalyze the reduction of hydrogen peroxide. The catalytically active material 70 can be, for example, a platinum material, a palladium material, or a manganese oxide material.

[0061] In the Fig. 1 and Fig. In the embodiment shown in Figure 2, the base bodies of the heat-conducting elements 66 are coated with the catalytically active material 70. The catalytically active material 70 thus forms a coating 72 on the base bodies of the heat-conducting elements 66. The base bodies of the heat-conducting elements 66 themselves are made of a copper sheet, in particular a galvanized copper sheet.

[0062] According to an alternative embodiment, the heat-conducting elements 66 are made of the catalytically active material 70. The heat-conducting elements 66 can be solid or foam-like.

[0063] When the recirculating air flow is generated in the flow chamber 14, the gas mixture flows through the flow path defined by the surface 68. Hydrogen peroxide contained in the gas mixture thus comes into contact with the catalytically active material 70, catalyzing the reduction of the hydrogen peroxide into water and oxygen.

[0064] Preferably, while generating the recirculating air flow, the existing heat exchanger 52 is cooled to a temperature below the dew point temperature of the gas mixture present in the flow chamber 14. For example, this can be achieved by cooling the cooling medium and / or increasing the flow velocity of the cooling medium. This measure specifically condenses water vapor contained in the gas mixture on the existing heat exchanger 52, in particular on the heat-conducting elements 66. Hydrogen peroxide contained in the gas mixture condenses together with the water vapor. Cooling the heat exchanger 52 therefore results in the hydrogen peroxide being specifically supplied to the catalytically active material 70.

Claims

[1] Barrier system (10) for the aseptic handling of products, comprising a fluidically connected flow space (14), wherein the flow space (14) comprises a working area (16) which is physically separated from an operator environment (20) and is provided for aseptic handling of the products, and at least one heat exchanger (52) arranged in the flow space (14), which is designed as a finned heat exchanger or as a plate heat exchanger, wherein the heat exchanger (52) has a flow path through which a gas mixture located in the flow space (14) can flow, wherein the heat exchanger (52) has, at least in regions, on a surface (68) defining the flow path (14), a catalytically active material (70) which is designed to catalyze the reduction of hydrogen peroxide, wherein the heat exchanger (52) has a further flow path for a cooling medium which is fluidically separated from the flow space (14), wherein the heat exchanger (52) comprises at least one heat-conducting element (66) which forms the surface (68) at least in regions and is in heat-conducting contact with the further flow path, and wherein the heat-conducting element (66) comprises the catalytically active material (70). [2] Barrier system (10) according to claim 1, characterized by that the barrier system (10) is designed as a RAB system or as an isolator. [3] Barrier system (10) according to one of the preceding claims, characterized by that the heat-conducting element (66) or at least one of the heat-conducting elements (66) is made of the catalytically active material (70). [4] Barrier system (10) according to one of the preceding claims, characterized bythat the heat exchanger (52) is coated at least in regions with the catalytically active material (70). [5] Barrier system (10) according to one of the preceding claims, characterized by that the catalytically active material (70) is a platinum material, a palladium material or a manganese oxide material. [6] Barrier system (10) according to one of the preceding claims, characterized by that the heat exchanger (52) or at least one of the heat exchangers (52) is arranged in a recirculating air line (32) of the flow space (14). [7] Barrier system (10) according to one of the preceding claims, characterized by that the heat exchanger (52) or at least one of the heat exchangers (52) is arranged in an outlet of a recirculating air line (34) of the flow space (14). [8] Barrier system (10) according to one of the preceding claims, characterized bythat the heat exchanger (52) or at least one of the heat exchangers (52) is arranged in an attachment (44) which is detachably connected to the barrier system (10) by at least one valve (46, 48). [9] Clean room (22) in which a barrier system (10) according to one of the preceding claims is arranged. [10] A method for the catalytic reduction of hydrogen peroxide in a barrier system (10) for the aseptic handling of products, wherein the barrier system (10) comprises a fluidically connected flow space (14), wherein the flow space (14) comprises a working area (16) which is physically separated from an operator environment (20) and is provided for the aseptic handling of the products, wherein at least one heat exchanger (52) designed as a finned heat exchanger or as a plate heat exchanger is arranged in the flow space (14), which heat exchanger has a flow path through which a gas mixture located in the flow space (14) can flow, wherein the heat exchanger (52) has, at least in regions, on a surface (68) defining the flow path (14), a catalytically active material (70) which is designed to catalyze the reduction of hydrogen peroxide,wherein the heat exchanger (52) has a further flow path for a cooling medium which is fluidically separated from the flow space (14), wherein the heat exchanger (52) comprises at least one heat-conducting element (66) which forms the surface (68) at least in regions and is in heat-conducting contact with the further flow path, and wherein the heat-conducting element (66) comprises the catalytically active material (70), the method comprising: , - generating an air flow in the flow space (14) such that a gas mixture located in the flow space (14) flows through the flow path and the reduction of hydrogen peroxide contained in the gas mixture is catalyzed by the catalytically active material (70). [11] Method according to claim 10, characterized bythat the heat exchanger (52) is cooled to a temperature which is below a dew point temperature of the gas mixture in the flow space (14), so that hydrogen peroxide contained in the gas mixture condenses at least partially on the catalytically active material (70).

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