Protein-peptide carrier particle structure in natural whole food form that can be used to improve renal filtration

Abstract

A protein-peptide carrier particle structure in natural whole food form that can be used to improve renal filtration, which is a multi-layer structural body (01), wherein the multi-layer structural body (01) comprises an inner core (10) and a surface layer (20), the inner core (10) is provided inside the multi-layer structural body (01), and the surface layer (20) is provided outside the inner core (10) and forms the outer surface of the multi-layer structural body (01) to prevent the external environment from affecting the activity of the inner core (10), and thus improve the storage stability of the multi-layer structural body (01) and its absorption rate by the human body; wherein the inner core (10) consists of a 3D composite structure in natural whole food form from natural plant sources and contains vitamin B1, selenium, glutathione, pantothenic acid, biotin, magnesium, manganese, β-carotene, molybdenum, choline in combination with protein-peptide carriers; where natural plant sources include carrots, spinach, etc.

Description

Field of the invention

[0001] The present invention relates to a carrier structure and, more particularly, to a protein-peptide carrier particle structure in natural, whole-food form that can be used to improve renal filtration. State of the art

[0002] In addition to urine production, the kidneys also perform essential functions in the filtration of blood toxins, electrolyte balance, hematopoiesis, bone metabolism, endocrine regulation, and the control of blood pressure and fluid balance. Physiologically, kidney function declines by approximately 1% annually from the age of 40. Kidney disease can have serious health consequences. High-risk groups for kidney disease include patients with diabetes mellitus, hypertension, a family history of chronic kidney disease, individuals over 65, and individuals with a history of drug abuse.

[0003] Kidney failure can be divided into acute and chronic kidney failure. Acute kidney failure is usually caused by sudden illnesses or accidents that lead to an abrupt loss of kidney function. With appropriate treatment, kidney function can be restored. Chronic kidney disease, on the other hand, results from glomerular damage, nephritis, the use of various medications, sepsis, or other diseases. If kidney damage persists for more than three months and the structure or function of the kidney cannot be fully restored, it is referred to as chronic kidney disease. Object of the invention

[0004] The main object of the present invention is to provide a protein-peptide carrier particle structure in natural whole food form that can be used to improve renal filtration.

[0005] To achieve the above object, the present invention uses the following technical solutions: A protein-peptide carrier particle structure in natural whole food form that can be used to improve renal filtration is a multi-layer structural body, wherein the multi-layer structural body comprises an inner core and a surface layer, the inner core is provided inside the multi-layer structural body, and the surface layer is provided outside the inner core and forms the outer surface of the multi-layer structural body to prevent the external environment from affecting the activity of the inner core, and thus improve the storage stability of the multi-layer structural body and its absorption rate by the human body.

[0006] The inner core consists of a 3D composite structure in natural whole food form from natural plant sources and contains vitamin B1, selenium, glutathione, pantothenic acid, biotin, magnesium, manganese, β-carotene, molybdenum, choline in combination with protein-peptide carriers.

[0007] Natural plant sources include carrots, spinach, etc.

[0008] Compared with the conventional technology, with the innovative design and technical features of the present invention, the surface layer serving as a coating can significantly extend the shelf life and maintain the activity by avoiding damage caused by the external environment, so as to achieve the industrial applicability of maintaining the activity and functionality of the inner core and increasing its absorption rate and product efficacy. Brief description of the drawings Fig. 1 shows a perspective view according to a first embodiment of the present invention; Fig. 2 shows a schematic perspective view with partial cross section according to the first embodiment of the present invention; Fig. 3 shows a radial sectional view according to the first embodiment of the present invention; Fig. 4 shows a radial sectional view according to a second embodiment of the present invention. Detailed description of the implementation examples

[0009] The figures show exemplary embodiments of the protein-peptide carrier particle structure according to the invention in natural, whole-food form, which can be used to improve renal filtration. The following description only illustrates exemplary embodiments of the invention and is not to be understood as a limitation of the claims.

[0010] It is based on the Fig. 1, Fig. 2 and Fig. 3. The first embodiment of the protein-peptide carrier particle structure in natural whole food form that can be used to improve renal filtration is a multilayer structural body 01, wherein the multilayer structural body 01 includes an inner core 10 and a surface layer 20, the inner core 10 is provided inside the multilayer structural body 01, and the surface layer 20 is provided outside the inner core 10 and forms the outer surface of the multilayer structural body 01 to prevent the external environment from affecting the activity of the inner core 10, and thus improve the storage stability of the multilayer structural body 01 and its absorption rate by the human body.

[0011] The inner core 10 consists of a 3D composite structure in natural whole food form from natural plant sources and contains vitamin B1, selenium, glutathione, pantothenic acid, biotin, magnesium, manganese, β-carotene, molybdenum, choline in conjunction with protein-peptide carriers.

[0012] Natural plant sources include carrots, spinach, etc.

[0013] Vitamin B1 deficiency is common in patients on continuous ambulatory peritoneal dialysis (CAPD) unless supplemented. Vitamin B1 deficiency often leads to beriberi in hemodialysis patients. These patients exhibit central neurological disorders such as chorea, involuntary movements, impaired consciousness, and dementia, as well as symptoms such as heart failure with accompanying pulmonary edema. After intravenous administration of vitamin B1, these symptoms were completely cured in all patients.

[0014] In patients with kidney disease, selenium deficiency can result from insufficient intake of selenium-containing foods or from gastrointestinal malabsorption. This leads to reduced activity of the enzyme glutathione peroxidase (GSH-Px), which contributes to increased oxidative stress and potentially increases the incidence of malignant tumors in patients with chronic kidney failure. The thyroid gland contains the highest selenium density after the liver and kidney. Selenium deficiency in patients with kidney disease also affects the activity of selenium-containing proteins (e.g., GSH-Px, DIO), which in turn inhibits the conversion of the thyroid hormone T4 to T3 in tissues. Previous studies report T3 deficiency in dialysis patients.

[0015] A comparison of 36 dialysis patients and 20 healthy individuals showed that malondialdehyde (MDA) levels in the blood of dialysis patients were significantly higher. This indicates increased lipid peroxidation, which in turn triggers increased oxidative stress in the body. Accordingly, the consumption of the body's own antioxidant glutathione (GSH) is increased. Compared to the control group, the red blood cells of dialysis patients showed significantly lower GSH levels both before and after dialysis.

[0016] Pantothenic acid is a water-soluble vitamin that is lost in large quantities during the dialysis procedure. Adequate supplementation of pantothenic acid can help dialysis patients maintain their normal metabolism and health.

[0017] Muscle cramps are among the most common complications of hemodialysis and usually occur in the leg muscles. Patients report stiffness, tingling, and severe pain during or after dialysis, which in severe cases can lead to discontinuation of treatment. Studies show that biotin supplementation can effectively relieve muscle cramps. In one study, 14 dialysis patients with muscle cramps were rated according to pain intensity, using a score from 0 to 4 (the higher the score, the more severe the pain). More than half of the subjects showed significant improvement within one week of biotin supplementation. With the exception of two patients, all participants reported a significant reduction in cramp intensity during and after dialysis.

[0018] Choline is required for the synthesis of choline phospholipids and sphingomyelin, which ensure the structural integrity of the cell membrane. It is also a precursor of the important neurotransmitter acetylcholine, which is involved in muscle control and memory. Studies show that during continuous ambulatory peritoneal dialysis (CAPD), a significant loss of choline occurs from the blood into the dialysate.

[0019] Hypotension during dialysis is a common complication that not only impairs patients' quality of life but also increases the risk of arrhythmias and cardiovascular or cerebrovascular ischemia. Studies demonstrate a significant association between a decrease in blood magnesium ion concentration during dialysis and the occurrence of dialysis-induced hypotension.

[0020] Hemodialysis patients generally have lower blood manganese concentrations. Studies show a link between low blood manganese levels and an increased risk of carotid artery atherosclerosis in these patients. A systematic literature review of 128 studies found that hemodialysis patients have significantly lower blood manganese levels compared to healthy individuals.

[0021] By binding to free radicals, β-carotene can interrupt the chain reaction of lipid peroxidation, thereby increasing the body's antioxidant capacity. It also prevents the oxidation of cholesterol into harmful forms that accumulate in blood vessels, thus contributing to the prevention of cardiovascular disease. Previous studies have shown that hemodialysis patients have significantly lower blood levels of carotenoids (α-carotene, β-carotene, lycopene, β-cryptoxanthin, lutein).

[0022] Molybdenum is involved in iron utilization and nucleic acid metabolism and serves as a cofactor for numerous enzymes. Due to dietary restrictions in kidney patients, molybdenum intake may be inadequate.

[0023] As mentioned above, Inner Core 10 can improve kidney filtration, alleviate dialysis-related fatigue and lethargy, and positively influence various side effects of dialysis, such as dry, itchy, and dull skin. It also compensates for nutrient loss caused by dialysis, promotes kidney health, and reduces dialysis frequency.

[0024] The composition of the surface layer 20 includes, but is not limited to, proteins such as pea protein, potato protein, corn protein, or yeast protein. The surface layer 20, which serves as a coating, can significantly extend the shelf life of the inner core 10 and maintain its activity by preventing damage caused by the external environment, thus achieving the industrial applicability of maintaining the activity and functionality of the inner core 10 and increasing its absorption rate and product efficacy.

[0025] It will be Fig.4. The difference between the second embodiment and the first embodiment is that an acid-resistant layer 30 is further provided between the inner core 10 and the surface layer 20 to prevent the inner core 10 from being destroyed by gastric acid in the human digestive tract, thereby further improving the absorption rate of the inner core 10 in the human body.

[0026] The composition of the acid-resistant layer 30 includes, but is not limited to, pectin, trehalose, polyunsaturated fatty acids, and acidic amino acids.

[0027] The present invention thus provides a protein-peptide carrier particle structure in natural whole food form that can be used to improve renal filtration, which is a multi-layer structural body, wherein the multi-layer structural body comprises an inner core and a surface layer, and the surface layer forms the outer surface of the multi-layer structural body to prevent the external environment from affecting the activity of the inner core and thus improve the storage stability of the multi-layer structural body and its absorption rate by the human body, wherein the inner core consists of a 3D composite structure in natural whole food form from natural plant sources and contains vitamin B1, selenium, glutathione, pantothenic acid, biotin, magnesium, manganese, β-carotene, molybdenum, choline in combination with protein-peptide carriers, wherein the natural plant sources include carrots, spinach, etc.

Claims

[1] A protein-peptide carrier particle structure in natural whole food form that can be used to improve renal filtration, which is a multi-layer structural body (01), wherein the multi-layer structural body (01) comprises an inner core (10) and a surface layer (20), the inner core (10) is provided inside the multi-layer structural body (01), and the surface layer (20) is provided outside the inner core (10) and forms the outer surface of the multi-layer structural body (01) to prevent the external environment from affecting the activity of the inner core (10), and thus improve the storage stability of the multi-layer structural body (01) and its absorption rate by the human body; wherein the inner core (10) consists of a 3D composite structure in natural whole food form from natural plant sources and contains vitamin B1, selenium, glutathione, pantothenic acid, biotin, magnesium, manganese, β-carotene, molybdenum, choline in combination with protein-peptide carriers; where natural plant sources include carrots, spinach, etc. [2] A protein-peptide carrier particle structure in natural whole food form which can be used to improve renal filtration according to claim 1, wherein the composition of the surface layer (20) comprises proteins such as pea protein, potato protein, corn protein and yeast protein. [3] A protein-peptide carrier particle structure in natural whole food form which can be used for improving renal filtration according to claim 1, further comprising an acid-resistant layer (30) between the inner core (10) and the surface layer (20) to prevent the inner core (10) from being destroyed by gastric acid in the human digestive tract, thereby further improving the absorption rate of the inner core (10) in the human body. [4] A protein-peptide carrier particle structure in natural whole food form which can be used to improve renal filtration according to claim 3, wherein the composition of the acid-resistant layer (30) comprises pectin, trehalose, polyunsaturated fatty acids and acidic amino acids.

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