Cosmetic care composition with Manuka honey for use on sensitive and irritation-prone children's and adult skin

Abstract

Cosmetic care composition for topical application to sensitive and inflamed skin, in particular for the relief of psoriasis symptoms or atopic dermatitis symptoms, comprising in weight percent: Manuka honey with a defined UMF ≥15+ or MGO ≥540 mg / kg in a concentration of at least 4% in combination with Aloe Vera juice concentrate in a concentration of at least 0.1%, Panthenol in a concentration of at least 3.0%, squalane in a concentration of at least 6.0%, Shea butter in a concentration of at least 4.0%, and hyaluronic acid in a concentration of at least 0.02%, at least one natural emulsifier and humectant, and a preservation system, and where the rest is water ad 100%.

Description

Technical area

[0001] The present utility model relates to the field of cosmetic dermatology, in particular dermatologically tested care creams, washing lotions and gels for children and adults with sensitive skin or skin prone to neurodermatitis, eczema or psoriasis.

[0002] In particular, a novel cosmetic care formulation for children with sensitive skin is being developed. The formulation features a synergistic combination of UMF-certified Manuka honey and herbal active ingredients. State of the art

[0003] In the field of cosmetic skin care, there are numerous products containing herbal ingredients such as aloe vera, chamomile, bisabolol, or panthenol. Manuka honey is also known as an ingredient in certain cosmetic products and is valued for its antimicrobial and anti-inflammatory properties.

[0004] Manuka honey is a single-variety honey obtained from the nectar of the flowers of the manuka tree. This variety is produced by honeybees of the species Apis mellifera from New Zealand manuka plants that produce a specific flower variety called Leptospermum scoparium (Alvarez-Suarez J, Gasparrini M, Forbes-Hernandez T, et al. The composition and biological activity of honey: a focus on Manuka honey. Foods. 2014;3:420-432. doi: 10.3390 / foods3030420.), also known as manuka honey. Typically, Manuka honey is evaluated using a classification system known as the Unique Manuka Factor (UMF), which indicates the equivalent phenol concentration (%, w / v) required to achieve the same antibacterial effect as honey (Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Nigam PS. Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiol. 2018 Nov 27;4(4):655-664. doi: 10.3934 / microbiol.2018.4.655.PMID: 31294240; PMCID: PMC6613335.).

[0005] Genuine New Zealand Manuka honey is characterized by a complex composition comprising over 2,300 different components, which determine both its unique flavor and its special health-promoting properties (https: / / www.umf.org.nz / de / unique-manuka-factor / , accessed on July 4, 2025). To ensure and certify the quality of Manuka honey, the internationally recognized UMF™ (Unique Manuka Factor) quality assurance system is used, as described above (https: / / www.umf.org.nz / de / unique-manuka-factor / , accessed on July 4, 2025). This system is based on an independent four-factor test that examines the potency, authenticity, freshness, and purity of each batch and summarizes them in a uniform key figure (https: / / www.umf.org.nz / de / unique-manuka-factor / , accessed on July 4, 2025). Only honey that meets these strict criteria receives the UMF™ seal.

[0006] A key quality characteristic of Manuka honey is its methylglyoxal (MGO) content, which is produced by the conversion of dihydroxyacetone (DHA) (https: / / www.umf.org.nz / de / unique-manuka-factor / , accessed on July 4, 2025). MGO is responsible for the characteristic antibacterial properties. The MGO content is expressed in mg / kg of honey and is a measure of the product's effectiveness; the higher the value, the more pronounced the antibacterial activity (https: / / www.umf.org.nz / de / unique-manuka-factor / , accessed on July 4, 2025). Commercially available honey contains only small amounts of MGO, whereas Manuka honey is characterized by significantly higher concentrations.

[0007] The UMF™ system supplements the MGO determination with additional quality parameters and ensures, through regular inspections, that only Manuka honey harvested, tested, and bottled in New Zealand is permitted to bear the UMF™ seal (https: / / www.umf.org.nz / de / unique-manuka-factor / , accessed on July 4, 2025). This ensures consistent quality standards worldwide. While the UMF™ value is used as the primary indicator in New Zealand and internationally, the MGO value is more commonly used in other markets, such as Germany (https: / / www.umf.org.nz / de / unique-manuka-factor / , accessed on July 4, 2025). The simultaneous indication of both values, along with appropriate certificates, confirms the authenticity and quality of Manuka honey from New Zealand (https: / / www.umf.org.nz / de / unique-manuka-factor / , accessed on July 4, 2025).

[0008] Since both UMF and MGO values ​​have similar evaluation criteria, they can be easily compared. The so-called UMF value ("Unique Manuka Factor") represents a measure of antibacterial activity and shows a close correlation with the MGO content (Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Nigam PS. Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiol. 2018 Nov 27;4(4):655-664. doi: 10.3934 / microbiol.2018.4.655. PMID: 31294240; PMCID: PMC6613335.). The following table illustrates the correlation between UMF and MGO values: Table 1: UMF in correlation with MGO content4 UMF (Unique Manuca Factor) MGO salary N / A Under MGO 83 + 5+ UMF MGO 83+ 10+ UMF MGO 263+ 12+ UMF MGO 400+ 15+ UMF MGO 514+ 18+ UMF MGO 692 + 20+ UMF MGO 829+ 26+ UMF MGO 1282+

[0009] In addition to its antibacterial effect, Manuka honey also has immunomodulatory properties (Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Nigam PS. Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiol. 2018 Nov 27;4(4):655-664. doi: 10.3934 / microbiol.2018.4.655. PMID: 31294240; PMCID: PMC6613335.). It can activate macrophages through the protein apalbumin 1, leading to the release of pro-inflammatory mediators such as TNF-α, IL-1β, and IL-6 (Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Nigam PS. Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiol. 2018 Nov 27;4(4):655-664. doi: 10.3934 / microbiol.2018.4.655. PMID: 31294240; PMCID: PMC6613335.). These cytokines play a central role in fighting infections and promoting tissue repair (Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Nigam PS).Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiol. 2018 Nov 27;4(4):655-664. doi: 10.3934 / microbiol.2018.4.655. PMID: 31294240; PMCID: PMC6613335.).

[0010] Manuka honey also has antioxidant properties, which are mainly attributed to its phytochemicals and other bioactive components (Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Nigam PS. Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiol. 2018 Nov 27;4(4):655-664. doi: 10.3934 / microbiol.2018.4.655. PMID: 31294240; PMCID: PMC6613335.).

[0011] For the reasons mentioned above, Manuka honey is particularly suitable as a wound and burn dressing and is also used in the treatment of skin conditions such as pityriasis, ringworm, seborrhea, dandruff, diaper rash, and psoriasis. In cosmetic formulations, Manuka honey has moisturizing, soothing, and skin-conditioning effects, helping to maintain the youthful appearance of the skin and prevent the formation of wrinkles, regulates pH, and protects against infections caused by pathogens (Burlando B, Cornara L. Honey in dermatology and skin care: a review. J Cosmet Dermatol. 2013 Dec;12(4):306-13. doi: 10.1111 / jocd.12058. PMID: 24305429).

[0012] Another common ingredient in skincare products is aloe vera. Aloe vera is a medicinal plant that has been used for centuries, especially in the cosmetics industry, and is valued for its diverse effects (Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020 Mar 13;25(6):1324. doi: 10.3390 / molecules25061324. PMID: 32183224; PMCID: PMC7144722.). Botanically, it belongs to the Xanthorrhoeaceae family and is believed to have originated in Arabian regions. As a succulent plant, it stores water in its thick leaves, the gel of which has numerous nourishing and healing properties (Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020 Mar 13;25(6):1324. doi: 10.3390 / molecules25061324.PMID: 32183224; PMCID: PMC7144722.). The gel contains over 75 different active ingredients, including vitamins, enzymes, minerals, and polysaccharides (Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020 Mar 13;25(6):1324. doi: 10.3390 / molecules25061324. PMID: 32183224; PMCID: PMC7144722.). Aloe vera has moisturizing, anti-inflammatory, and wound-healing properties and can support skin regeneration (Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020 Mar 13;25(6):1324. doi: 10.3390 / molecules25061324. PMID: 32183224; PMCID: PMC7144722.). To obtain the aloe vera juice concentrate, only mature, outer leaves are cut from the plant (https: / / www.aloe-vera-akademie.de).The leaves are carefully harvested to avoid damaging the gel inside. After cutting, the leaf is held vertically. This releases a yellow, bitter sap called aloin juice (https: / / www.aloe-vera-akademie.de). This sap contains anthraquinones, which are irritating and are not used in cosmetics. The leaf is then cut open, usually at the side. The clear, transparent gel inside is carefully scraped out. This gel contains the nourishing substances: e.g., polysaccharides (acemannan), vitamins, minerals, and enzymes (https: / / www.naturkosmetikschachner.at). The gel is then filtered to remove any fibers or remnants of the green peel. Finally, it is preserved (e.g., by pasteurization or with natural preservatives) to ensure its shelf life.

[0013] Furthermore, panthenol, also known as dexpanthenol or provitamin B5, is considered a proven active ingredient that is widely used, especially in dermatological and cosmetic applications. Panthenol is very well absorbed by the skin and converted into pantothenic acid (vitamin B5). It is clinically proven that panthenol stimulates cell regeneration and thus accelerates skin regeneration. Furthermore, panthenol promotes lipid synthesis, which helps strengthen the skin barrier and increase skin moisture. These properties make panthenol an effective agent for supporting wound healing, preventing skin dryness, and improving skin protection and elasticity.Due to its good tolerability and long-standing safe use, panthenol is particularly suitable for cosmetic and pharmaceutical formulations, for example, for the treatment of abrasions, for the relief of symptoms of skin diseases such as atopic dermatitis, rosacea, and psoriasis, and as a moisturizing and protective component in skin care products (https: / / www.aerzteblatt.de / archiv / dexpanthenol-wirkmechanismus-aufgeklaert-aa9f2131-b9f6-49c5-a2c3-2ceedddaecca, Proksch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773. doi: 10.1080 / 09546634.2017.1325310. Epub 2017 May 14. PMID: 28503966. ).

[0014] Squalane (INCI: Squalane) is a clear, odorless, and oily liquid, today primarily obtained from olives. It makes up approximately 5-12% of the skin's natural hydrolipid film (Squalane | Non-irritating lipid for natural cosmetics | Olionatura, accessed on July 3, 2025). Unlike olive oil, however, squalane is not a traditional oil, but rather a saturated hydrocarbon (alkane). Although its physical properties are similar to those of an oil, it is chemically different. Squalane feels creamy and nourishing on the skin, yet leaves no greasy film and is quickly absorbed. It is particularly well tolerated, does not clog pores and is therefore also suitable for sensitive or oily skin (Proksch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773. doi: 10.1080 / 09546634.2017.1325310. Epub 2017 May 14.PMID: 28503966.). The substance retains moisture, supports the skin's protective barrier, and provides a silky-soft skin feel without a heavy or greasy finish. (https: / / www.eucerin.de / hautzustand / trockene-haut / squalan, accessed on July 3, 2025) As the main component of the polyunsaturated lipids on the skin's surface, squalene plays an important role in skin physiology. It has a moisturizing, antioxidant effect and serves as an emollient (Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology Molecules. 2009 Jan 23:14(1):540-54. doi· 10.3390 / molecules14010540. PMID: 19169201; PMCID: PMC6253993.).

[0015] International patent application WO 2016 024875 discloses a cosmetic and / or pharmaceutical formulation for the relief of psoriasis symptoms, in which the base of the cream consists of 30 emulsifiers, thickeners, preservatives and the formulation consists of 100% by weight of 0.3-20% by weight of one or a mixture of linseed oil, shea oil, or cottonseed oil, 0.3-25% by weight of one of Manuka honey or Manuka leaf extract or Manuka milk or Manuka leaf essential oil, 0.3-20% by weight of one of the following oils: sweet almond oil or macadamia nut oil, 0.01-10% by weight of panthenol, 0.01-10% by weight of vitamin E, 0.01-10% by weight of glycerin, 0.01-5% by weight of essential jasmine oil or eucalyptus oil, and 0.01-5 wt% cedar essential oil.

[0016] Although there are numerous cosmetic products on the market that contain some of the active ingredients mentioned above, to date no dermatologically tested care composition, especially for children, with a defined content of UMF-certified Manuka honey in combination with the herbal ingredients according to the utility model, which has been specifically developed for sensitive children's and adult skin and has a synergistic effect, is known. Abandonment of the utility model

[0017] The goal is to provide a safe, highly tolerated, and at the same time highly effective cosmetic care composition that protects the skin's microbiome, alleviates inflammatory processes, and strengthens the skin barrier in children and sensitive adults. Only cosmetically certified ingredients are used. This cosmetic care composition can help restore balance, especially in skin conditions such as atopic dermatitis, where the natural lipid balance is disrupted and the skin's protective film becomes permeable (Atopic Dermatitis - DocCheck Flexikon, accessed on July 3, 2025).

[0018] In patients with atopic dermatitis, a compromised skin barrier often leads to altered skin flora. Particularly noticeable is an increased colonization with the lipophilic yeast Malassezia furfur and the bacterium Staphylococcus aureus (https: / / www.eucerin.de / hautzustand / trockene-haut / squalan, accessed on July 3, 2025). The barrier defect, particularly on scratched skin areas, increases the risk of superinfections, as the weakened skin protection function promotes the penetration and proliferation of various pathogens, which can further exacerbate inflammatory reactions and symptoms (https: / / www.eucerin.de / hautzustand / trockene-haut / squalan, accessed on July 3, 2025). Cracks in the epithelial layer make it easier for fungi, bacteria, and viruses to penetrate the skin (https: / / www.eucerin.de / hautzustand / trockene-haut / squalan, accessed on July 3, 2025).25), For example, herpes viruses can trigger the clinical picture of eczema herpeticatum, which manifests itself as weeping blisters and can spread rapidly in atopic dermatitis patients (https: / / www.eucerin.de / hautzustand / trockene-haut / squalan, accessed on 3 July 2025).

[0019] Proper skin care is also essential for other skin diseases, as it can help alleviate symptoms and contribute to a better quality of life. Psoriasis, also known as psoriasis, is a chronic autoimmune disease that occurs in relapses (Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology Molecules. 2009 Jan 23:14(1):540-54. doi· 10.3390 / molecules14010540. PMID: 19169201; PMCID: PMC6253993.). It is primarily characterized by scaly skin changes. Similar to atopic dermatitis, psoriasis is characterized by a deficiency of important epidermal lipids, particularly ceramides (http: / / ceramol.de / blogs / skinmag / psoriasis-ein-problem-der-hautbarriere, accessed July 2, 2025). This lipid deficiency weakens the skin barrier, making it harder for the skin to retain moisture and allowing harmful substances to penetrate more easily.

[0020] A weakened skin barrier can trigger or worsen psoriasis symptoms. It promotes the excessive proliferation of skin cells and activates inflammatory messengers, which intensifies inflammatory reactions. The impaired skin barrier can no longer adequately fulfill its protective function. Moisture loss and the penetration of irritants lead to further inflammation (Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology Molecules. 2009 Jan 23:14(1):540-54. doi· 10.3390 / molecules14010540. PMID: 19169201; PMCID: PMC6253993.). Inflammatory processes accelerate cell regeneration, which leads to the typical scaly skin patches (Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology Molecules. 2009 Jan 23:14(1):540-54. doi· 10.3390 / molecules14010540. PMID: 19169201; PMCID: PMC6253993.). Persistent inflammation and lipid deficiency reinforce each other, causing symptoms to recur or worsen. This complex cycle makes the treatment of psoriasis particularly challenging and requires targeted care to strengthen and support the skin barrier.

[0021] The aim of this care composition is therefore to provide the skin with long-lasting moisture, to strengthen the skin barrier and thus promote regeneration and ensure protection against further irritations. Solution to the problem

[0022] The present utility model provides a cosmetic care composition comprising manuka honey with a defined UMF ≥ 15+ or MGO ≥ 540 mg / kg in a proportion of at least 4.00% by weight, panthenol in a proportion of at least 3% by weight, aloe vera juice concentrate in a proportion of at least 0.1% by weight, squalane (vegetable) in a proportion of at least 6% by weight, shea butter in a proportion of at least 4% by weight, low molecular weight hyaluronic acid (1200-2000 kDa) in a proportion of at least 0.02% by weight, natural emulsifiers and humectants such as glycerin, cetearyl olivate, sorbitan olivate, a gentle preservative system in potassium sorbate, sodium benzoate in a dermocosmetically approved range, and a pH of 4.5-5.5, the remainder of the cosmetic care composition being composed of water.The dermocosmetically approved range is typically 0.5-1.5% for most preservative systems in the final product.

[0023] The combination of these ingredients in the stated proportions has demonstrated exceptionally good skin tolerance and clinically relevant improvement in typical skin irritations such as redness, dryness, and itching in observational and laboratory tests. The galenic formulation is stable for a period of at least 18 months, and the present care composition demonstrates high dermatological compatibility and is suitable for use on skin types prone to neurodermatitis, eczema, and psoriasis.

[0024] Normally, the production of lipid-water systems, hereinafter referred to as creams, is carried out in such a way that the molten lipid component is processed with water at temperatures of about seventy degrees Celsius to form an emulsion, which solidifies into a homogeneous cream upon slow cooling to room temperature with continuous stirring (R. Voigt, Textbook of Pharmaceutical Technology, Verlag Chemie, Weinheim 1975).

[0025] The cosmetic care composition is manufactured under GMP (Good Manufacturing Practice) conditions and includes the following steps: Creams are mixtures of oil / fat and water that combine to form an oil-in-water emulsion. For successful production, both phases must be at the same temperature (70 °C) at the beginning of processing; otherwise, they will not combine and will precipitate (https: / / www.unibremen.de / fileadmin / user_upload / sites / freiex / LCA_2_Lebensmittel_Material / LCA_Lebensmittel_Palmoel / ZUS ATZMATERIAL_PRAXIS_Herstellung_einer_Creme.pdf).

[0026] In a first step, phase A (fat phase) is heated to 70 °C while stirring. Phase B (water phase) is also heated to 70 °C.

[0027] In a second step, phases A and B are combined under homogeneous stirring.

[0028] The combined phases are then cooled to 40 °C while stirring slowly.

[0029] Sensitive active ingredients (e.g. Manuka honey, aloe vera and panthenol) are then added to the composition and worked in at 40 °C.

[0030] This is followed by a pH adjustment of the composition to a target range of 5.0-5.5.

[0031] Finally, the cosmetic care composition is filled into appropriate containers under aseptic conditions.

[0032] To produce care compositions, special mixing equipment is required to ensure proper homogenization and mixing of the selected components. Detailed description of the embodiment

[0033] A first embodiment of the cosmetic care composition for topical application to sensitive and inflamed skin, in particular for the relief of psoriasis symptoms or atopic dermatitis symptoms, contains in weight percent Manuka honey with a defined UMF ≥15+ or MGO ≥540 mg / kg in a concentration of at least 4% in combination with Aloe Vera juice concentrate in a concentration of at least 0.1%, panthenol in a concentration of at least 3.0%, squalane in a concentration of at least 6.0%, shea butter in a concentration of at least 4.0%, and hyaluronic acid in a concentration of at least 0.02%, at least one natural emulsifier and humectant, and one preservative, and the remainder of the cosmetic care composition is water. All components of the cosmetic care composition add up to 100%.

[0034] According to a second embodiment, the cosmetic care composition may comprise Manuka honey in a concentration of 4%-25% in combination with Aloe Vera juice concentrate in a concentration of 0.1%-10%, Panthenol in a concentration of 3.0%-10%, Squalane in a concentration of 6.0% to 10%, Shea butter in a concentration of 4.0% to 20%, Hyaluronic acid in a concentration of 0.02%-5.0%, and the remainder is water ad.

[0035] According to a third embodiment, the cosmetic care composition may comprise, based on its weight, 4.0% Manuka honey (UMF10+), 3.0% panthenol, 0.1% aloe vera juice concentrate, 6.0% squalane, 4.0% shea butter, 0.02% low molecular weight hyaluronic acid, and the remainder of the cosmetic care composition may be composed of water ad 100%.

[0036] According to a further embodiment, the preservative system of the cosmetic care composition may comprise potassium sorbate and sodium benzoate.

[0037] Furthermore, according to a further embodiment, the natural emulsifier may be glycerin.

[0038] According to a further embodiment, the glycerin is present in a concentration of 1 to 5 percent by weight.

[0039] Additionally, the humectant may be selected from Cetearyl Oilvate and / or Sorbitan Olivate.

[0040] According to a further embodiment, cetearyl oilvate and / or sorbitan olivate may be present in a concentration of 1 to 3% by weight.

[0041] According to a further embodiment, the cosmetic composition can be a water-in-oil emulsion. According to a further embodiment, the cosmetic care composition can be in the form of a cream, washing lotion, or gel.

[0042] In a further embodiment, the pH of the cosmetic care composition can be in a range of 4.5-5.5. In addition, according to a further embodiment, the cosmetic composition can be free of synthetic additives, in particular synthetic fragrances.

[0043] The cosmetic composition according to a further embodiment may be ideally suited for use in children from 2 years of age with sensitive, atopic or flaky skin. Example

[0044] An example of the cosmetic care composition contains in grams based on the total mass of 100g: - Manuka honey (UMF10+): 4.0 g - Aloe Vera juice concentrate: 1.0 g - Panthenol: 3.0 g - Squalane: 6.0 g - Shea butter: 4.0 g - Hyaluronic acid: 0.2 g - Glycerin: 5.0 g - Cetearyl Olivate / Sorbitan Olivate: 3.0 g - Water to 100g Areas of application of the cosmetic care composition

[0045] This cosmetic care composition is suitable for a wide range of applications in the field of cosmetic skin care, in particular for the daily basic care of sensitive children's skin, especially in skin areas prone to dryness or irritation.

[0046] In addition, this cosmetic care composition is suitable for supportive care in chronic inflammatory skin diseases such as neurodermatitis (atopic eczema), psoriasis (psoriasis) and other eczemas, without the use of pharmacologically active substances.

[0047] Furthermore, this cosmetic care composition can be used for soothing aftercare in cases of mild mechanical or thermal skin irritations, such as after scratching, diaper rash or contact with irritating textiles, as well as for preventative care in the sense of prophylaxis against skin barrier disorders, especially during seasonally stressed phases (e.g. winter, pollen count, air conditioning). Advantages of the cosmetic care composition

[0048] This care composition offers a variety of synergistic benefits tailored to the specific needs of sensitive skin, especially that of children: The targeted combination of antimicrobial UMF-certified Manuka honey with anti-inflammatory and skin-soothing substances such as aloe vera, panthenol, and plant lipids has been proven to have a more powerful effect than the individual ingredients alone.

[0049] The targeted use of skin-related lipids such as squalane and shea butter supports and strengthens the integrity of the skin barrier. At the same time, moisturizing factors such as panthenol and aloe vera ensure lasting hydration of the epidermis.

[0050] The formula is completely free of synthetic preservatives, parabens, PEGs, mineral oils, and synthetic fragrances. This reduces the risk of microbial imbalances and contributes to stabilizing the natural skin microbiome.

[0051] Furthermore, this cosmetic care composition has a soft, easy-to-spread consistency that leaves a pleasant feeling on the skin and is specifically tailored to the sensory needs of children. The subtle, allergen-free fragrance is based on natural ingredients and avoids any potentially irritating additives.

[0052] The galenic formulation has been proven to remain physicochemically stable for a period of at least 18 months, without any loss of consistency, pH or efficacy of the active ingredients QUOTES CONTAINED IN THE DESCRIPTION

[0000] This list of documents submitted by the applicant was generated automatically and is included solely for the convenience of the reader. This list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions. Zitierte Patentliteratur

[0000] WO 2016 024875

[0015] Zitierte Nicht-Patentliteratur

[0000] Alvarez-Suarez J, Gasparrini M, Forbes-Hernändez T, et al The composition and biological activity of honey: a focus on Manuka honey. Foods. 2014;3:420-432. doi: 10.3390 / foods3030420

[0004] Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Nigam PS. Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiol. 2018 Nov 27;4(4):655-664. doi: 10.3934 / microbiol.2018.4.655. PMID: 31294240; PMCID: PMC6613335.

[0004] https: / / www.umf.org.nz / de / unique-manuka-factor / [0005, 0006, 0007] Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Nigam PS. Antibacterial activity of Manuka honey and its components: An overview. AIMS Microbiol. 2018 Nov 27;4(4):655-664. doi: 10.3934 / microbiol.2018.4.655. PMID: 31294240; PMCID: PMC6613335 [0008, 0009, 0010] Burlando B, Cornara L. Honey in dermatology and skin care: a review. J Cosmet Dermatol. 2013 Dec;12(4):306-13. doi: 10.1111 / jocd.12058. PMID: 24305429

[0011] Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020 Mar 13;25(6):1324. doi: 10.3390 / molecules25061324. PMID: 32183224; PMCID: PMC7144722

[0012] https: / / www.aloe-vera-akademie.de

[0012] https: / / www.naturkosmetikschachner.at

[0012] https: / / www.aerzteblatt.de / archiv / dexpanthenol-wirkmechanismus-aufgeklaert-aa9f2131-b9f6-49c5-a2c3-2ceedddaecca, Proksch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773. doi: 10.1080 / 09546634.2017.1325310. Epub 2017 May 14. PMID: 28503966

[0013] Proksch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70th anniversary article. J Dermatologist Treat. 2017 Dec;28(8):766-773. doi: 10.1080 / 09546634.2017.1325310. Epub 2017 May 14. PMID: 28503966

[0014] Huang ZR, Lin YK, Fang JY. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology Molecules. 2009 Jan 23:14(1):540-54. doi 10.3390 / molecules14010540. PMID: 19169201; PMCID: PMC6253993 [0014, 0019, 0020] https: / / www.eucerin.de / hautzustand / trockene-haut / squalan

[0018] httρs: / / ceramol.de / blogs / skinmag / psoriasis-ein-problem-der-hautbarriere

[0019] R. Voigt, Textbook of Pharmaceutical Technology, Verlag Chemie, Weinheim 1975

[0024] https: / / www.unibremen.de / fileadmin / user_upload / sites / freiex / LCA_2_Lebensmittel_Material / LCA_Lebensmittel_Palmoel / ZUS ATZMATERIAL_PRAXIS_Herstellung_einer_Creme.pdf

[0025]

Claims

[1] Cosmetic care composition for topical application to sensitive and inflamed skin, in particular for the relief of psoriasis symptoms or atopic dermatitis symptoms, comprising in weight percent: Manuka honey with a defined UMF ≥15+ or MGO ≥540 mg / kg in a concentration of at least 4% in combination with Aloe Vera juice concentrate in a concentration of at least 0.1%, Panthenol in a concentration of at least 3.0%, squalane in a concentration of at least 6.0%, Shea butter in a concentration of at least 4.0%, and hyaluronic acid in a concentration of at least 0.02%, at least one natural emulsifier and humectant, and a preservation system, and where the rest is water ad 100%. [2] The composition of claim 1, wherein the care composition comprises, by weight, Manuka honey in a concentration of 4% - 25% in combination with aloe vera juice concentrate in a concentration of 0.1%-10%, Panthenol in a concentration of 3.0%-10%, Squalane in a concentration of 6.0% to 10%, Shea butter in a concentration of 4.0% to 20%, Hyaluronic acid in a concentration of 0.02%-5.0%, where the rest is water ad 100%. [3] Composition according to any one of claims 1 to 2, wherein the care composition comprises, based on its weight in weight percent: 4.0% Manuka honey, UMF10+, 3.0% panthenol, 0.1% Aloe Vera juice concentrate, 6.0% squalane, 4.0% shea butter, 0.02% low molecular weight hyaluronic acid, and water ad 100%. [4] A composition according to any one of claims 1 to 3, wherein the preservative system comprises potassium sorbate and sodium benzoate. [5] The composition of claim 1, wherein the natural emulsifier is glycerin. [6] Composition according to claim 5, wherein glycerin is present in a concentration of 1 to 5% by weight. [7] The composition of claim 1, wherein the humectant is selected from cetearyl oilvate and / or sorbitan olivate. [8] Composition according to claim 7, wherein Cetearyl Oilvate and / or Sorbitan Olivate is present in a concentration of 1 to 3% by weight. [9] Composition according to any one of the preceding claims, wherein the care composition is a water-in-oil emulsion. [10] Composition according to any one of the preceding claims, wherein the care composition is in the form of a cream, washing lotion or gel. [11] Composition according to claim 10, wherein the care composition is in the form of a cream. [12] Composition according to any one of the preceding claims, wherein the pH of the cosmetic care composition is in a range of 4.5-5.

5. [13] Composition according to one of the preceding claims, wherein the care composition is free from synthetic additives, in particular free from synthetic fragrances. [14] Composition according to any one of the preceding claims for use in children aged 2 years and over with sensitive, atopic or flaky skin.