Dietary supplement containing guaiaverine and phloretin for reducing and / or inhibiting intestinal glucose absorption

Description

[0001] The invention relates to a dietary supplement according to the preamble of patent claim 1.

[0002] Dietary supplements and their use, for example, in sports or to promote health, are well known. Dietary supplements are intended to supplement the general diet, consisting of, for example, carbohydrate- or protein-containing foods such as pasta, meat, or the like, or even sweets such as cakes or cookies, or to make them more digestible, for example by reducing the calorie content of the food or by reducing calorie intake.

[0003] In contrast to conventional foods and beverages, food supplements are usually a concentrate of food supplements or other substances with nutritional physiological effects. They are usually sold in dosed form, in particular in the form of capsules, lozenges, tablets, pills, effervescent tablets and similar dosage forms, powder sachets, liquid ampoules, bottles with dropper inserts and similar dosage forms of liquids and powders for ingestion in measured small quantities.

[0004] Dietary supplements typically contain a variety of nutrients, such as vitamins and / or minerals, in a predetermined ratio. Other typical ingredients include antioxidants, which are also dosed in a predetermined ratio.

[0005] In contrast to most known food supplements, which provide a consumer with substances that the consumer needs in a specific situation, such as during sports, another aim of food supplements in recent times has been to specifically influence or adjust the bioavailability of a specific substance, such as sugar, i.e. sucrose, glucose and / or fructose, so that, for example, only a portion of the respective sugar is absorbed or sugar absorption is avoided altogether.

[0006] In the context of this invention, bioavailability is understood in particular as a pharmacological measurement curve for the proportion of an active ingredient that is available unchanged in the systemic circulation, namely in particular the bloodstream. The term "bioavailability" indicates whether and how quickly, and to what extent, for example, sugar is absorbed, i.e., reabsorbed, or not reabsorbed.

[0007] In order to reduce such intestinal sugar absorption, various but unsatisfactory attempts have been made in the past using anthocyanins and / or delphinidins, as can be seen, for example, from US 2014 / 0128333 A1.

[0008] Wang H. et al. describe the activity of guava extracts on digestive enzymes ("α-Glucosidase and α-amylase inhibitory activities of guava leaves", Food Chemistry, Volume 123, Issue 1, 1 November 2010, Pages 6-13, https: / / doi.org / 10.1016 / j.foodchem.2010.03.088).

[0009] The object of the invention is to provide a composition suitable for producing a dietary supplement and effectively allowing the bioavailability of sugar to be adjusted. Furthermore, the object of the invention is to provide a dietary supplement containing such a composition, a use of such a composition for producing a dietary supplement, and a method for producing a dietary supplement.

[0010] This object is achieved by a dietary supplement according to patent claim 1.

[0011] In particular, the object of the invention is achieved by a dietary supplement comprising a composition for reducing and / or inhibiting intestinal glucose absorption, wherein the composition contains a guava extract containing guaijaverine and an apple extract containing at least phloretin, wherein the extract containing guaijaverine is obtained from the leaves and / or from the fruit of the guava (Psidium guajava), wherein the dietary supplement has a guava extract concentration in the range of 0.1 mg / kg to 1000 mg / kg, wherein the extract has a guaijaverine concentration in the range of 100 ng / kg to 1000 µg / kg, and wherein the apple extract has a phloretin concentration in the range of 1 mg / kg to 1000 mg / kg. The guaijaverine concentration is present in the composition at at least a physiologically effective concentration or at a higher concentration if the composition is diluted to a use concentration for preparing a dietary supplement or for use as a dietary supplement.

[0012] The composition contains at least one flavonoid from apple, phloretin. The guaijaverine concentration and the flavonoid concentration are present in the composition at at least a physiologically effective concentration, or at a higher concentration if the composition is diluted to a use concentration for the preparation of a dietary supplement or for use as a dietary supplement.

[0013] The composition contains a guaijaverin-containing extract obtained from the leaves and / or fruit of the guava (Psidium guajava). The basis for producing the guava fruit extract can be guava puree or guava fruit pulp. The use of fruit pulp or puree from the fruit of the guava is particularly preferred according to the invention, as such a fruit pulp or puree can be produced easily and inexpensively. For example, the procedure described in US 2009 / 0186110 A1, Example 2, can be used.

[0014] The composition further contains at least one phloretin-containing apple extract, which can be obtained from the fruit of a cultivated apple (Malus domestica) in principle the same way as guava extract. For this purpose, a puree or mush can be prepared from a cultivated apple, for example, which is then extracted with a solvent, for example an alcohol such as methanol or ethanol. This solvent is removed from the cultivated apple after extraction. The use of ethanol instead of methanol for extraction is preferred. The final apple extract is an aqueous base.

[0015] An alcoholic solvent, especially ethanol, is used to produce the guava extract. According to the invention, methanol or another short-chain alcohol can be used as an alternative to ethanol, although this is not preferred. However, the solvents are subsequently removed during the extract production process, and the final extract has an aqueous base.

[0016] It should be noted here that the guava extract and the optional apple extract can either be produced separately and then blended. Alternatively, it is also possible to make a puree or pulp from the guava fruit and the apple fruit, which is then extracted to create a mixture of guava extract and apple extract.

[0017] Surprisingly, the inventors were able to find out that a composition containing guava extract according to the invention is suitable for bringing about a targeted inhibition of glucose transport in the intestinal cells of mammals, i.e. in human and animal intestinal cells.In this regard, the inventors were able to demonstrate, within the scope of their inventive activity, that guava extract is particularly well-suited for inhibiting sugar absorption, especially glucose absorption, since guava extract does not experience a significant loss of effectiveness due to gastric juice or the intestinal environment, but rather retains its physiologically effective activity and is suitable for inhibiting the glucose transporter GLUT2, through which glucose is normally transported from the small intestine into the bloodstream. Consequently, glucose absorption is inhibited and, consequently, the concentration of glucose in the bloodstream does not increase as much as in the absence of guava extract. Due to the reduced absorption of glucose into the bloodstream, glucose transport to target cells, such as muscle and fat cells, is also influenced, making the composition according to the invention suitable for a weight-loss regimen.

[0018] Surprisingly, it was also found that a composition containing guava extract in combination with apple extract according to the invention is also suitable for specifically inhibiting glucose transport in the intestinal cells of mammals, i.e., in human and animal intestinal cells. In this regard, the inventors were able to demonstrate, within the scope of their inventive activity, that the combination of guava extract with apple extract is particularly suitable for inhibiting sugar absorption, in particular glucose absorption, and has a mutual synergistic effect.Furthermore, guava extract is neither attacked by gastric juice nor by the intestinal environment and does not experience any significant loss of effectiveness, but rather retains its physiologically effective activity. In combination with apple extract, it is particularly well suited to inhibiting the glucose transporter GLUT2, through which glucose is normally transported from the small intestine into the bloodstream. As a result, the absorption of glucose into the bloodstream is inhibited and, as a result, the concentration of glucose in the bloodstream does not increase as much as in the absence of the inventive composition of guaijaverine in combination with phloretin or guava extract in combination with apple extract. Due to the reduced absorption of glucose into the bloodstream, glucose transport to target cells, such as muscle and fat cells, is also influenced, so that the inventive composition is also suitable for a weight-loss regimen.

[0019] The composition and / or extract can be in liquid form, provided it contains a solvent. Alternatively, the composition and / or extract can have a solid, particularly powdered, consistency. Since the composition has a defined concentration of guaijaverine and other secondary plant constituents, this allows for easy dosing of the composition to produce a dietary supplement or to use the composition in a ready-to-use dosage or mixture. The composition has a defined concentration of guaijaverine, other secondary guava plant constituents, as well as phloretin and other secondary apple plant constituents.

[0020] In addition, the composition may further comprise one or more zinc and / or chromium compounds, particularly in the form of their salts. Such a combination of zinc and / or chromium compounds with guava extract, or guaijaverine, or optionally with guava and apple extract, or guaijaverine and phloretin, can be considered advantageous with regard to weight management, since zinc, on the one hand, promotes improved insulin storage in the beta cells of the islets of Langerhans in the pancreas and, on the other hand, like chromium, improves insulin sensitivity in muscle and fat cells. In this way, glucose metabolism can be positively influenced by the addition of zinc and / or chromium.

[0021] The guava extract has a guaijaverine concentration in the range of 100 ng / kg to 1000 µg / kg, preferably in the range of 1 µg / kg to 350 µg / kg, and particularly preferably in the range of 5 µg / kg to 80 µg / kg. This guava extract can be used to easily produce a dietary supplement with a defined guaijaverine concentration.

[0022] The apple extract has a phloretin concentration in the range of 1 mg / kg to 1000 mg / kg, preferably in the range of 1 mg / kg to 500 mg / kg, and particularly preferably in the range of 10 mg / kg to 350 mg / kg. Using this guava extract in combination with the apple extract, a dietary supplement with a defined guaijaverine and phloretin concentration can be easily produced.

[0023] According to one embodiment of the invention, the composition or extract, which itself has an oily consistency after extraction due to the presence of essential oils, can be freeze-dried. Such a treatment can convert the composition or extract, depending on the freeze-dried product, into a powdery state, resulting in a free-flowing product that is easy to dose.

[0024] Accordingly, the composition or extract according to the invention can have a liquid, pasty, or solid, in particular powdery, consistency. In this context, it should be emphasized that the composition and / or extract, as mentioned above, can be present as a solid or pasty substance. However, the composition or extract is also effective according to the invention when dissolved in a solvent, which can be aqueous and / or alcoholic, in particular ethanolic. Such a liquid preparation of the composition or the guava extract used according to the invention can be adjusted to a defined active ingredient concentration and is advantageously easy to dose.

[0025] The dietary supplement can be in powder or liquid form, whereby "fluid" according to the invention also includes a dispersion, an emulsion, or a solution, so that the dietary supplement can be easily dosed. The dietary supplement can be provided as a concentrate or as a ready-to-use diluted product.

[0026] According to the invention, the food supplement has, based on a ready-to-use diluted product, a guava extract concentration in the range of 0.1 mg / kg to 1000 mg / kg, preferably in the range of 1 mg / kg to 500 mg / kg and particularly preferably in the range of 10 mg / kg to 350 mg / kg

[0027] Furthermore, the dietary supplement may alternatively and / or additionally contain one or more zinc and / or chromium compounds, particularly in the form of their salts, to the composition according to the invention. This is particularly advantageous if the composition according to the invention itself contains no zinc and / or chromium or only a small amount of zinc and / or chromium compounds.

[0028] According to the invention, a total concentration of zinc in the zinc compound(s) per 100 grams of food supplement is in the range of 1 mg to 250 mg, preferably in the range of 33 mg to 200 mg and particularly preferably in the range of 100 mg to 149 mg.

[0029] According to the invention, a corresponding total concentration of chromium in the chromium compound(s) per 100 grams of food supplement is in the range from 10 µg to 1000 µg, preferably in the range from 450 µg to 900 mg and particularly preferably in the range from 650 µg to 896 µg.

[0030] In particular, the food supplement according to the invention can comprise one or more of the following ingredients, these ingredients comprising the following: acerola extract powder, in particular maltodextrin, vitamin C, acerola extract; algae powder; apple fiber; flavoring; beta-carotene; biotin; chromium picolinate; dextrose; iron citrate; pea fiber; coloring, in particular beta-carotene; folic acid; fructose; vegetable powder, in particular powder from broccoli, white cabbage, carrots, in particular in combination with maltodextrin, carrots, peppers, spinach, tomatoes; green tea extract; guarana extract powder, in particular in combination with maltodextrin, guarana extract, caffeine; gum arabic; oat bran; inulin; potassium citrate; calcium carbonate; calcium lactate; copper gluconate; turmeric extract with gamma-cyclodextrin; inulin; magnesium citrate; magnesium carbonate; manganese gluconate; Lactic acid cultures, in particular Lactobacillus acidophilus, Lactobacillus reuteri;Multienzyme complex, in particular amylase, lactase, protease, cellulase, lipase; sodium selenite; niacin; pantothenic acid; rice bran; beetroot powder, in particular beetroot juice concentrate, maltodextrin, acidity regulator, in particular citric acid; acidifier, in particular citric acid; selenium yeast; sweeteners, in particular steviol glycosides, flavoring; grape seed extract; thickeners, in particular guar gum, pectin; vitamin B1; vitamin B12; vitamin B2; vitamin B6; vitamin C; vitamin D3; vitamin E; zinc gluconate.

[0031] Furthermore, a method for producing a dietary supplement is also disclosed, the method comprising the following steps: Producing and / or providing a composition according to the above; and mixing the composition with one or more of the following ingredients, which comprise the following: acerola extract powder, in particular maltodextrin, vitamin C, acerola extract; algae powder; apple fiber; flavoring; beta-carotene; biotin; chromium picolinate; dextrose; iron citrate; pea fiber; coloring, in particular beta-carotene; folic acid; fructose; vegetable powder, in particular powder from broccoli, white cabbage, carrots, in particular in combination with maltodextrin, carrots, peppers, spinach, tomatoes; green tea extract; guarana extract powder, in particular in combination with maltodextrin, guarana extract, caffeine; gum arabic; oat bran; inulin; potassium citrate; calcium carbonate; calcium lactate; copper gluconate; turmeric extract with gamma-cyclodextrin; inulin; magnesium citrate; magnesium carbonate; manganese gluconate; Lactic acid cultures, in particular Lactobacillus acidophilus, Lactobacillus reuteri;Multienzyme complex, in particular amylase, lactase, protease, cellulase, lipase; sodium selenite; niacin; pantothenic acid; rice bran; beetroot powder, in particular beetroot juice concentrate, maltodextrin, acidity regulator, in particular citric acid; acidifier, in particular citric acid; selenium yeast; sweetener, in particular steviol glycosides, flavoring; grape seed extract; thickeners, in particular guar gum, pectin; vitamin B1; vitamin B12; vitamin B2; vitamin B6; vitamin C; vitamin D3; vitamin E; zinc gluconate; to prepare the food supplement.

[0032] The dietary supplement according to the invention can be processed into a powdered dietary supplement. Alternatively, it is also possible to prepare the ingredients of the dietary supplement, depending on the ingredients, in the form of an aqueous and / or alcoholic dispersion, emulsion, or solution. It is also possible to produce the dietary supplement as a concentrate or, alternatively, in a ready-to-use concentration.

[0033] Further embodiments of the invention emerge from the subclaims.

[0034] The invention is described in more detail below using exemplary embodiments. Example 1

[0035] The following are ingredients of a first embodiment, which is a dietary supplement in powder form.The ingredients are, in addition to vitamins, minerals, carbohydrates and fiber, in particular fructose, gum arabic, oat bran, pea fiber, thickener (guar gum, pectin), acidifier (citric acid), guarana extract powder (maltodextrin, guarana extract, caffeine), flavoring, acerola extract powder (maltodextrin, vitamin C, acerola extract), vitamin C, beetroot powder (beetroot juice concentrate, maltodextrin, acidity regulator (citric acid)), apple fiber, vegetable powder (broccoli, white cabbage, carrots (maltodextrin, carrots), peppers, spinach, tomatoes), multienzyme complex (amylase, lactase, protease, cellulase, lipase), inulin, rice bran, lactic acid cultures (Lactobacillus acidophilus, Laciobacillus reuteri), turmeric extract with gamma-cyclodextrin, sweetener (steviol glycosides (Steviol glycosides, flavoring)), selenium yeast, niacin, green tea extract, algae powder, vitamin E, beta-carotene, pantothenic acid, grape seed extract, vitamin B6, vitamin B2, vitamin B1, folic acid, biotin and vitamin B12.Furthermore, the dietary supplement according to this embodiment contains guava extract with a guaijaverine concentration of 100 mg / kg based on the volume of the guava extract. Optionally, the dietary supplement can contain apple extract with a phloretin concentration of 100 mg / kg based on the volume of the apple extract.

[0036] Further nutritional information of the food supplement is shown in Table 1 below, whereby the respective information refers to 100 g of the food supplement: Table 1 Fat < 0,4 g Carbohydrates 53 g Fiber 33 g protein 1,0 g Salt (sodium chloride) < 0,3 g selenium 200 µg Vitamin C 1000 mg niacin 340 mg NE Vitamin E 67 mg alpha-TE Pantothenic acid 60 mg Vitamin B1 14 mg Vitamin B2 16 mg Vitamin B6 20 mg Vitamin B12 10 µg Vitamin A (from provitamin A) 2220 µg RE Folic acid 2000 µg Biotin 1500 µg Caffeine, especially from guarana extract powder 200 mg Example 2

[0037] The following are ingredients of a second embodiment, which is a dietary supplement in powder form. In addition to vitamins, minerals, carbohydrates, and fiber, the ingredients include, in particular, fructose, acidifier (citric acid), calcium carbonate, magnesium carbonate, calcium lactate, potassium citrate, flavoring, magnesium citrate, zinc gluconate, sweetener (steviol glycosides (steviol glycosides, flavoring)), iron citrate, manganese gluconate, copper gluconate, chromium picolinate, coloring (beta-carotene), sodium selenite, and vitamin D3. Furthermore, the dietary supplement according to this second embodiment contains guava extract with a guaijaverine concentration of 25 mg / kg based on the volume of the guava extract. Optionally, the dietary supplement can contain apple extract with a phloretin concentration of 100 mg / kg based on the volume of the apple extract.

[0038] Further nutritional information of the food supplement is shown in Table 2 below, whereby the respective information refers to 100 g of the food supplement: Table 2 Fat < 0,5 g Carbohydrates 49 g protein < 0,1 g Salt (sodium chloride) < 0,01 g calcium 4000 mg magnesium 2000 mg iron 31 mg zinc 149 mg copper 10000 µg manganese 15 mg chrome 896 µg selenium 251 µg Vitamin D 112 µg Example 3

[0039] Below are listed ingredients of a third embodiment, which is a dietary supplement in powder form. In addition to vitamins, minerals, carbohydrates and dietary fiber, the ingredients are fructose, gum arabic, oat bran, pea fiber, thickener (guar gum, pectin), acidifier (citric acid), acerola extract powder (maltodextrin, vitamin C, acerola extract), flavoring, apple fiber, vegetable powder (broccoli, white cabbage, carrots (maltodextrin, carrots), peppers, spinach, tomatoes), multi-enzyme complex (amylase, lactase, protease, cellulase, lipase), vitamin C, inulin, rice bran, sweetener (steviol glycosides (steviol glycosides, flavoring)), lactic acid cultures (Lactobacillus acidophilus, Lactobacillus reuteri), turmeric extract with gamma-cyclodextrin, selenium yeast, green tea extract, vitamin E, beta-carotene, grape seed extract.Furthermore, the dietary supplement according to this third embodiment contains guava extract with a guaijaverine concentration of 250 mg / kg based on the volume of the guava extract. Optionally, the dietary supplement can contain apple extract with a phloretin concentration of 100 mg / kg based on the volume of the apple extract.

[0040] Further nutritional information of the food supplement is shown in Table 3 below, whereby the respective information refers to 100 g of the food supplement: Table 3 Fat < 0,5 g Carbohydrates 45 g Fiber 42 g protein 1,2 g Salt (sodium chloride) < 0,3 g selenium 250 µg Vitamin C 500 mg Vitamin E 83 mg alpha-TE Vitamin A (from provitamin A) 2775 µg RE Example 4

[0041] The following are ingredients of a fourth embodiment, which is a dietary supplement in powder form. In addition to vitamins, minerals, carbohydrates, and fiber, the ingredients include, in particular, dextrose, guarana extract powder (maltodextrin, guarana extract, caffeine), acidifier (citric acid), beetroot powder (beetroot juice concentrate, maltodextrin, acidity regulator (citric acid), vitamin C, flavoring, niacin, sweetener (acesulfame K), pantothenic acid, algae powder, vitamin B6, vitamin B2, vitamin B1, folic acid, biotin, and vitamin B12. Furthermore, the dietary supplement according to this fourth embodiment contains guava extract with a guaijaverine concentration of 500 mg / kg based on the volume of the guava extract. Optionally, the dietary supplement can contain apple extract with a phloretin concentration of 100 mg / kg based on the volume of the apple extract.

[0042] Further nutritional information of the food supplement is shown in Table 4 below, whereby the respective information refers to 100 g of the food supplement: Table 4 Vitamin C 750 mg niacin 340 mg NE Pantothenic acid 60 mg Vitamin B1 14 mg Vitamin B2 16 mg Vitamin B6 20 mg Vitamin B12 10 µg Folic acid 2000 µg Biotin 1500 µg Caffeine, especially from guarana extract powder 200 mg

[0043] Based on these exemplary embodiments, it was demonstrated that the intestinal uptake of glucose into the bloodstream is reduced by 50% through the action of guaijaverine and / or guava extract in the intestine of mammals, even at a concentration of 25 mg / kg guaijaverine, based on the guava extract immediately after extraction and removal of the solvent or extractant. At a guaijaverine concentration of 250 mg / kg to 500 mg / kg, based on the guava extract after extraction and removal of the solvent or extractant, the intestinal uptake of glucose could be reduced by up to over 80% compared to glucose uptake from the intestine into the bloodstream without the effect of the composition according to the invention.

[0044] With the optional additional use of phloretin and / or apple extract, it was shown that the intestinal uptake of glucose into the bloodstream in the intestine of mammals is reduced by more than 50% due to the effect of guaijaverine and / or guava extract in combination with phloretin and / or apple extract, even at a concentration of 25 mg / kg guaijaverine, based on the guava extract immediately after extraction and removal of the solvent or extractant, in combination with a concentration of 100 mg / kg phloretin, based on the apple extract immediately after extraction and removal of the solvent or extractant. At a guaijaverine concentration of 250 mg / kg to 500 mg / kg, based on the guava extract after extraction and removal of the solvent or extractant.Extractant in combination with a concentration of 100 mg / kg phloretin based on the apple extract immediately after extraction and removal of the solvent or extractant, the intestinal absorption of glucose could be reduced by almost 90% compared to glucose absorption from the intestine into the bloodstream without the effect of the composition according to the invention.

Claims

1. Nutritional supplement, comprising a composition for reducing and / or inhibiting intestinal glucose resorption, wherein the composition contains a guava extract comprising guaijaverin and at least one apple extract comprising phloretin, wherein the extract comprising guaijaverin is obtained from the leaves and / or from the fruit of the true guava (Psidium guajava), wherein the nutritional supplement has a guava extract concentration in the range of 0.1 mg / kg to 1000 mg / kg, wherein the extract has a guaijaverin concentration in the range of 100 ng / kg to 1000 µg / kg, and wherein the apple extract has a phloretin concentration in the range of 1 mg / kg to 1000 mg / kg.

2. Nutritional supplement as claimed in the preceding claim, characterized in that the composition contains further secondary plant ingredients from guava.

3. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the apple extract is obtained in particular from the species of the cultivated apple (Malus domestica), wherein the composition possibly contains further secondary plant ingredients from apple.

4. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the extract is produced from the leaves and / or the fruit of the true guava, by extraction of a purée and / or mash produced from the leaves and / or the fruit using an alcoholic solvent, in particular methanol and / or ethanol.

5. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the composition comprises one or more zinc and / or chromium compound(s), in particular in the form of their salts.

6. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the extract has a guaijaverin concentration in the range of 1 µg / kg to 350 µg / kg and particularly preferably in the range of 5 µg / kg to 80 µg / kg.

7. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the apple extract has a phloretin concentration in the range of 1 mg / kg to 500 mg / kg and particularly preferably in the range of 10 mg / kg to 350 mg / kg.

8. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the composition or the extract is freeze-dried.

9. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the composition of the extract has a liquid, pasty, or solid, in particular powdered, consistency.

10. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the nutritional supplement is powdered or fluid, in particular a dispersion, emulsion, or solution.

11. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the nutritional supplement is a concentrate or a ready-to-use product.

12. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the nutritional supplement has a guava extract concentration in the range of 1 mg / kg to 500 mg / kg and particularly preferably in the range of 10 mg / kg to 350 mg / kg.

13. Nutritional supplement as claimed in any one of the preceding claims, characterized in that the nutritional supplement comprises, alternatively and / or additionally to the composition, one or more zinc and / or chromium compound(s), in particular in the form of their salts.

14. The nutritional supplement as claimed in claim 13, characterized in that a total concentration of zinc in the zinc compound(s) per 100 g of nutritional supplement is in the range of 1 mg to 250 mg, preferably in the range of 33 mg to 200 mg, and particularly preferably in the range of 100 mg to 149 mg.

15. The nutritional supplement as claimed in claim 13, characterized in that a total concentration of chromium in the chromium compound(s) per 100 g of nutritional supplement is in the range of 10 µg to 1000 µg, preferably in the range of 450 µg to 900 mg, and particularly preferably in the range of 650 µg to 896 µg.