Device for assisting the use of a device for dispensing a liquid product

Abstract

The invention relates to a device (10) for assisting with the use of a device for dispensing a liquid product in the form of drops comprising a tank, the assistance device (10) comprising: • - means (17) for rigid connection to the dispensing device; • - optical means (26, 28) intended to be arranged near a dispensing opening, configured to provide a piece of information on the dispensing of a drop of the liquid product by the dispensing device; • - means for measuring inclination, configured to provide a piece of information on the inclination of the dispensing device rigidly connected to the assistance device (10); and • - a system (23) for processing information on the dispensing of a drop and on the inclination of the dispensing device rigidly connected to the assistance device (10) in order to provide a piece of information on the amount of liquid product dispensed. •. The invention also relates to a dispensing kit and a method for determining the amount of liquid product dispensed in the form of drops by a liquid-dispensing device, by means of the assistance device (10).

Description

Device to assist in the use of a liquid product dispensing device

[0001] The invention relates to a device for assisting in the use of a device for dispensing a liquid product in the form of drops.

[0002] When administering a liquid, it is often useful to know the quantity dispensed. This is especially true for the administration of medications, where the amount given must be precisely controlled according to the prescription. Insufficient or excessive medication intake must be avoided to protect the patient's health.

[0003] US patent application 2014 / 0257206 describes a control device for the instillation of ophthalmic fluid drops that incorporates a drop counter based on optical principles. The device detects the presence of a drop as it is dispensed from a medication bottle and counts the number of drops delivered. This allows the device and / or the user to control the number of drops administered. However, this device does not provide information on the quantity of liquid dispensed. Indeed, the volume of a drop is not always constant. It depends on numerous parameters that vary according to the dispensing conditions of each drop.

[0004] The invention aims in particular to provide a device for determining the quantity of liquid product dispensed.

[0005] To this end, the invention relates to a device for assisting the use of a device for dispensing a liquid product in the form of drops, comprising a reservoir, the assistance device comprising: - means of solidarity within the distribution system, - optical means intended to be placed in the vicinity of a liquid product dispensing orifice, configured to provide information on the dispensing of a drop of the liquid product by the dispensing device, - means for measuring inclination configured to provide information on the inclination of the distribution device attached to the assistance device, and - a system for processing information on the distribution of a drop and on the inclination of the distribution device attached to the assistance device to provide information on the quantity of liquid product distributed.

[0006] Following numerous experiments and studies, it has been observed that the inclination of the dispensing device at the moment a drop is dispensed influences its volume. Therefore, measuring this inclination allows for the estimation of the drop's volume after processing this information. Thus, the proposed assistance device includes a means for measuring the inclination of the dispensing device to which it is attached, as well as an information processing system. It is therefore capable of providing relevant information that subsequently allows for the estimation of the dispensed drop's volume and, consequently, the quantity of liquid product dispensed.Furthermore, it incorporates optical means for detecting the presence of a droplet near the dispensing orifice, thereby obtaining information on the distribution of a droplet of the liquid product by the dispensing device. This information then allows the data processing system to analyze the distribution pattern in relation to the dispensing device's angle at the moment of droplet dispensing. The resulting assistance device is capable of determining a numerical value for the quantity of liquid product dispensed.

[0007] Furthermore, based on the quantity of liquid dispensed, the information processing system can advantageously deduce the quantity of liquid remaining in the dispensing device's reservoir. This quantity can then be converted into a theoretical number of drops remaining, assuming theoretical operating conditions for the dispensing device. This information is likely to be of interest to the user, allowing them to anticipate when the reservoir will be empty and thus assess its operating autonomy. It can also be used for other types of analysis or processing aimed at obtaining additional information.

[0008] It should be noted that information processing can take into account other information made available to the information processing system to estimate the quantity of liquid distributed, for example information on the physical or chemical properties of the liquid product, on the geometry of the valve, tables of predefined values.

[0009] The term "optical" refers to any electromagnetic wave, whether or not it belongs to the visible spectrum. Optical devices are generally those capable of emitting, receiving, and / or reflecting such a wave.

[0010] The assistance system may also include one or more of the following: the following characteristics, taken alone or in combination. [0001 1 ] - The assistance device includes a contact area intended to be in contact with the reservoir of the dispensing device when the user activates the reservoir to activate the dispensing of drops, the contact area including means for measuring the activation pressure exerted on the contact area to trigger the optical means and / or providing additional information on the quantity of liquid product dispensed, preferably information on the intensity of the activation pressure applied and the duration of application of this activation pressure.The activation pressure exerted on the contact area measured by these devices is a translation of the activation pressure exerted by the user on the reservoir, for example, by direct or indirect pressure on the assistance device, which is then transmitted to the dispensing device, or by direct or indirect pressure on the dispensing device by any suitable means. Information regarding the activation pressure exerted on the contact area can be particularly valuable. In particular, activating the optical devices only once the user exerts a certain activation pressure reduces their energy consumption, extends their lifespan, and avoids generating unnecessary data outside of periods of device use.Furthermore, in addition to the tilt of the dispensing device, the activation pressure exerted by the user also influences the volume of a dispensed drop. Therefore, by measuring this activation pressure, the information processing system can make a further and / or more precise estimate of the quantity of liquid dispensed and, ideally, also of the quantity of liquid remaining in the dispensing device's reservoir.

[0012] The term "means for measuring activation pressure" generally refers to any means that allows for the direct measurement of pressure or force.

[0013] The assistance device includes means for measuring the weight of the dispensing device attached to the assistance device, configured to provide information on the quantity of liquid in the reservoir. From the information on the quantity of liquid in the reservoir before and after use, the quantity of product dispensed can be deduced. This information can be combined with information obtained from other detection means, for example, information on the tilt of the dispensing device, to obtain a more precise estimate of the volume of the dispensed drop and / or cross-referenced with these to verify the results (quantity of liquid product dispensed, quantity of liquid product remaining) at the outlet of the processing system. of information. Advantageously, the means for measuring weight include a weight sensor, for example, a force-sensing resistor (FSR), which can be positioned below the tank when the dispensing device is at rest and / or above it when at rest. A suitable weight sensor is the Flexiforce pressure sensor, which operates in the force range of 0 to 4 N. Advantageously, the means for measuring weight include several weight sensors positioned around the tank to allow the weight of the dispensing device attached to the assistance device to be measured, regardless of its inclination.

[0014] The optical means comprise a transmitter and a receiver of an optical signal, configured to detect the presence of a droplet interfering with the optical signal and to measure the duration of this presence. The optical signal is, for example, an infrared beam. The transmitter and receiver may be positioned on opposite sides of the dispensing orifice when the assistive device is attached to the dispensing device, so that the optical signal passes through any dispensed droplet. Alternatively, the transmitter and receiver may be positioned on the same side of the dispensing orifice when the assistive device is attached to the dispensing device, with the optical signal being received by reflection off a surface that is at least partially reflective. A suitable infrared detector is an example of one from OSRAM Opto Semiconductors Inc. or Vishay Semiconductor Opto Division.Advantageously, the optical means include a second emitter and a second receiver of an optical signal, configured to validate the information on the distribution of a drop of the liquid product by the dispensing device. These second emitters and receivers confirm that the disturbance of the first optical signal is indeed due to the formation and subsequent detachment of a drop of the liquid product.

[0015] - Means of measuring inclination include an inclinometer. This is, for example, an electronic gyroscope or an accelerometer whose performance is chosen according to the need.

[0016] - The information processing system includes means for reading information carried by the dispensing device. The processing system then has access to various pieces of information about the liquid product contained in the dispensing device or about the dispensing device itself, limiting or eliminating the need for manual configuration of the assistance device to adapt the dispensing to the specific characteristics of the product to be dispensed and / or the dispensing device. This information includes, for example, the number of theoretical doses contained in the reservoir, the volume The theoretical value of a droplet, the physical or chemical properties of the liquid product such as viscosity, and the technical characteristics of the dispensing device such as valve dimensions are all factors considered. These characteristics and properties can be based on tables of predetermined values ​​and calculation tools. Some of this information can be useful for processing data provided by various means, for example, inclination measurement devices. The dispensing device may include information storage media in the form of digital chips, magnetic strips, barcodes, or any other type of electronically readable media.

[0017] - The information processing system is connected to an object external to the assistance device, for example to a server, a receiver, an intranet network or the internet. It can send information remotely, and possibly receive information.

[0018] The assistance device includes means for indicating information provided by the treatment system, for example, visual, audible, and / or tactile means. These means allow the user to be informed about the correct delivery of a dose, the quantity of product delivered and / or remaining, and / or other information about the liquid product (for example, read by the reading devices). The display means may include a screen displaying information in alphanumeric form and / or light signals, for example, of different colors or shapes.

[0019] The information processing system includes means for storing a variable value corresponding to the quantity of liquid product dispensed and / or the quantity of liquid product remaining in the reservoir. This variable value is used, for example, to determine the quantity of liquid product dispensed and to monitor the quantity of liquid product remaining in the reservoir. The variable value for the quantity of liquid product dispensed can also be used to monitor treatment adherence. The variable value is updated during each liquid dispensing. Advantageously, the storage means are capable of storing other values ​​and information useful to the processing system and / or the user.

[0020] The invention further relates to a kit for distributing a liquid product in the form of drops onto an organ of a subject, comprising a device for dispensing the liquid product and an assistance device as described above. The organ is, for example, an eye, an ear, or the skin. Preferably, the assistance device and the distribution devices are separate devices, placed one on top of the other and removable, but it is possible to consider that they are made from a single block of material.

[0021] The invention further relates to a method for determining the quantity of liquid product dispensed in drop form by a liquid dispensing device, using an assistance device as described above, comprising the following steps: - detection of a drop, - estimation of the volume of the detected droplet.

[0022] By applying the process throughout a use of the dispensing device and adding the estimated volume of each drop detected and therefore dispensed, we can obtain the total quantity of liquid product dispensed during that use.

[0023] Drop detection is performed by the optical means of the dispensing device. All the information provided by the optical means and the tilt measurement means is processed by the information processing system to estimate the volume of the detected drop and deduce the quantity of liquid product dispensed.

[0024] The determination method may also include one or more of the following characteristics, taken alone or in combination.

[0025] The determination process includes a step of calculating a new residual volume value by subtracting the volume of the detected droplet from the previous residual volume value. The information processing system and / or the user thus knows the quantity of liquid product remaining in the tank after dispensing, information which is not initially accessible from outside the tank. It should be noted that the first value corresponding to the "previous residual volume value" is the tank's fill volume.

[0026] The term “residual volume” generally refers to the volume of liquid product remaining in the reservoir of the dispensing device.

[0027] - The droplet detection step includes a step of identifying a disturbance in an optical signal provided by optical means and a step of measuring the duration of the disturbance in the optical signal. The disturbance could be, for example, a The absence of an optical signal or a weak optical signal is due to the absorption of the optical signal by the presence of the droplet in its path. The duration of the disturbance would a priori correspond to the duration of the droplet's presence near the distribution orifice.

[0028] The step for estimating the volume of the detected droplet includes a step for determining a theoretical volume of that droplet, preferably including a step for calculating this theoretical volume from information on the viscosity of the liquid product and / or the geometric characteristics of the dispensing orifice, or even on other characteristics of the dispensing nozzle and / or the dispensing device. The theoretical volume is the volume calculated from fixed data on the liquid product or the dispensing device, which do not vary according to the conditions of use of the latter. The fixed data can be determined by the information processing system, for example after reading the information carried by the dispensing device, or directly by reading.

[0029] - The droplet volume estimation step includes a step of weighting the detected droplet volume, during which at least one of the following parameters is taken into account to weight the estimate of the detected droplet volume: - the intensity of the activation pressure applied by the user to the reservoir to cause the droplet to form, - the variation profile of this activation pressure over time, - the inclination of the assistance device and / or the distribution device, - the duration of a disturbance in a signal provided by optical means, - measuring the weight of the distribution device. By taking into account at least one of these parameters, the calculated theoretical volume is adapted to the conditions of use of the distribution device, which makes it possible to obtain an estimate more in line with reality and therefore a more precise and reliable determination of the quantity of liquid product distributed.

[0030] The determination process includes a step to measure the weight of the dispensing device to validate the calculated residual volume. Knowing the residual volume value obtained by measuring the weight allows the quantity of liquid dispensed to be deduced. Thus, the weight measurement also validates the estimated volume of the detected droplet. The weight measurement step can be triggered conditionally based on the detected tilt, particularly based on maintaining a certain tilt of the dispensing device for a period of time. predetermined duration.

[0031] The determination process includes a test step to verify the presence of a protective cap on the dispensing device. Replacing the cap is beneficial for ensuring the protection of the dispensing device or for improving hygiene and antimicrobial function in the event of residual liquid product in the dispensing opening. This test verifies whether the cap has been correctly replaced at the end of use and, if necessary, alerts the user if it has not. Furthermore, when the determination process includes a step to measure the weight of the dispensing device, the presence or absence of the cap influences the measured weight and must therefore be taken into account when determining the residual volume.

[0032] - The drop detection stage is triggered by the detection of activation pressure applied by a user to the reservoir of the dispensing device, thus activating drop dispensing. Indeed, to activate drop dispensing, the user must apply activation pressure to the reservoir. The detection of this activation pressure marks the beginning of use and is an appropriate moment to trigger the drop detection stage without risk of missing a drop detection. The detection of this activation pressure can be: - direct, by measuring the pressure applied by the user to the support area to activate the dispensing device, or - indirect, for example by measuring the pressure exerted on the contact area intended to be in contact with the reservoir of the dispensing device when the user activates the reservoir or another support area.

[0033] We will now present specific embodiments of the invention, given by way of non-limiting examples and supported by the attached figures in which: - Figures 1A and 1B are perspective views of an assistance device according to one embodiment, Figure 1A representing the assistance device alone and Figure 1B representing the upper part of the entire assistance device and a distribution device attached to the assistance device, the assistance device being in the open position and the distribution device being provided with a protective cap for the distribution orifice, - Figures 2A, 2B to 4 are schematic longitudinal cross-sectional views, and a perspective view for Figure 3, of different parts of the whole of Figure 1B, - Figure 5 is a schematic view of part of an assembly of an assistance device and a distribution device according to another embodiment, - Figure 6 is a top perspective view of the assistance device in Figure 1A, without the upper part, - Figure 7 is a longitudinal cross-sectional view of the upper part of the distribution device shown in Figure 1B, - Figure 8 is a perspective view of different dispensing orifices for liquid product in droplet form, - Figure 9 is a graph showing the evolution of the volume of a drop as a function of the inclination of the dispensing device during the dispensing of a liquid product. - Figure 10 is a graph showing the steps of a process for determining the quantity of liquid product dispensed by the liquid dispensing device in Figure 1B, - Figure 11 is a combination of a graph showing information processed by the assistance device of Figure 1B and three longitudinal cross-sectional views of the upper part of the distribution device of Figure 1B at different stages of drop distribution, - Figures 12 and 13 are two graphs showing the steps of a process for determining the quantity of liquid product distributed according to two other embodiments.

[0034] Figure 1A illustrates an assistance device 10 for using a device for dispensing a liquid product in drop form, and Figure 1B illustrates a dispensing kit 12 comprising the assistance device 10 and a dispensing device 14 arranged inside the assistance device 10. The dispensing device 14 here comprises a reservoir 32 (visible in Figure 3) and a dispensing nozzle having a drop dispensing orifice 16 (visible in Figure 2B) protected by a cap 15, for example, screwed onto the dispensing nozzle. The assistance device 10 includes means 17 for securing it to the dispensing device 14 so that the dispensing kit 12 forms a single unit. The securing means 17 may include, for example, a snap-fit ​​mechanism for the reservoir 32 into the assistance device 10.In one variant among others, the distribution nozzle having the distribution orifice 16 could be part of the assistance device 10, attached to the reservoir 32 of the distribution device 14 at the time of joining the two assistance devices 10 and distribution device 14.

[0035] The assistance device 10 comprises a main body 18 in which one The dispensing device 14 and a support structure 20 are positioned against the user's skin during the dispensing of drops into a target organ, for example, an eye. The support structure 20 is removably mounted on the main body 18 between an open position for insertion of the dispensing device 14 and a closed position for use, for example, by means of a hinge 21. The support structure 20 can be designed to be sufficiently flexible to ensure comfortable contact with the user's skin and to adapt to the contours near the target organ, and / or sufficiently rigid to provide support and impose a predetermined distance between the dispensing orifice 16 and the target organ. The support structure 20 includes an axial orifice 30 for allowing the passage of drops of liquid product from the dispensing orifice 16 to the user's organ.The support structure 20 optionally includes recesses 19 on two opposite sides and at its end, notably to prevent the user's eye from being in darkness when the support device 10 is applied against the user's skin around their eye. The support structure 20 may have a closed or open contour, for example, a C-shaped contour. The C-shaped contour allows, for example, the user to pull the lower eyelid through the opening of the C to further open their eye and ensure that the drop reaches the eye.

[0036] The assistance device 10 also includes a support area 22 intended both for gripping and for providing support to the user when dispensing the liquid product. The support area 22 is located on two opposite sides of the main body 18. In another embodiment, a single support area located on only one side of the main body 18 may be used. Activation pressure exerted on the support area 22 is transmitted to the reservoir 32 of the dispensing device 14, specifically at a contact area 29 between the reservoir and the assistance device 10. The support area 22 may be made of a different material, particularly a more flexible one, than that of the rest of the main body 18. It may also include raised features that facilitate gripping by the user.Furthermore, thanks to the presence of the support area 22, the assistance device 10 increases the user's gripping surface and activation pressure on the reservoir 32 compared to that of the dispensing device 14 alone, which is particularly advantageous for users with neuromuscular diseases.

[0037] The assistance device 10 further includes tilt-measuring means configured to provide information on the tilt of the distribution device 14 attached to the assistance device 10. In one example, the tilt-measuring means include an inclinometer such as an electronic gyroscope or an accelerometer. The inclinometer is preferably placed in the main body 18, for example in an area intended to be placed near the dispensing nozzle.

[0038] The assistance device 10 includes an information processing system 23, specifically for processing information on the distribution of a drop and on the inclination of the dispensing device 14 attached to the assistance device 10, in order to provide information on the quantity of liquid product dispensed. The information processing system 23 is a system comprising a set of components (mechanical, electronic, chemical, photonic, and / or biological) capable of automatically processing information. It includes, for example, a printed circuit board (PCB), a set of transistors, and / or a computer.

[0039] Advantageously, the assistance device 10 includes an integrated power source, for example a portable battery, to power the various components, in particular the means for measuring the inclination and the information processing system 23. Alternatively, it is powered by an external power source.

[0040] The assistance device 10 advantageously includes means for indicating information provided by the processing system 23, for example, visual means 24, 25, audible means, and / or tactile means. In the embodiment shown in Figures 1A and 1B, it has a display screen 24 for information in alphanumeric form. As can be seen in Figure 6, the assistance device 10 further or alternatively includes light-emitting diodes 25 around the distribution orifice 16, which provide a light signal to indicate, for example, correct tilt or pressure force.

[0041] As illustrated in Figure 2B, the assistance device 10 comprises optical means 26, 28 intended to be disposed near the dispensing orifice 16 and configured to provide information on the dispensing of a drop of the liquid product by the dispensing device 14. The optical means 26, 28 here comprise a transmitter 26 and a receiver 28 of an optical signal 40, configured to detect the presence of a drop interfering with the optical signal 40 and to measure the duration of this presence. The transmitter 26 comprises, for example, infrared-emitting diodes, and the receiver 28 comprises, for example, phototransistors capable of detecting infrared rays. The transmitter 26 and the receiver 28 detect the presence of a droplet passing through the optical signal 40 when the optical rays are disturbed, for example by a variation in the intensity of the rays. The emitter 26 and the receiver 28 are preferably located at a distance between 1 and 3 mm, preferably 2 mm, from the distribution orifice 16.

[0042] With a receiver of limited dimensions, it is possible that, when the assistance device is tilted, the passage of a droplet may not be detected by the receiver. To overcome this problem, the receiver can advantageously have a receiving area extending axially and / or circumferentially, ensuring the detection of a droplet even when the assistance device is tilted.

[0043] As can be seen in Figure 3, the assistance device 10 includes means for measuring the weight 33 of the dispensing device 14 attached to the assistance device 10, configured to provide information on the quantity of liquid in the reservoir 32. The means for measuring the weight include a weight sensor 33, for example of the Force Sensing Resistor (FSR) type, located below the reservoir 32 to weigh the dispensing device 14 and deduce the weight, and therefore the volume, of the quantity of liquid remaining in the reservoir 32. In an alternative embodiment (not shown), the weight sensor is located above the reservoir. In another alternative embodiment (not shown), the assistance device has several weight sensors around the reservoir so that it can measure the weight of the dispensing device attached to the assistance device regardless of its inclination.

[0044] According to an embodiment not shown, the assistance device may include means for detecting the distribution device attached to the assistance device, for example a pressure sensor or an optical sensor, the information processing system being able to confirm to the user the presence of a distribution device and / or to inform him of the absence of a distribution device.

[0045] The assistance device 10 and the dispensing device 14 may include locking means to prevent the dispensing device 14 from rotating relative to the assistance device 10. These locking means are particularly useful when the reservoir 32 is cylindrical. The locking means may include additional engagement features provided respectively on the assistance device 10 and the dispensing device 14, for example, a lug housed in a notch. With rotation thus prevented, the user can screw the cap back onto the dispensing nozzle without it rotating freely. Furthermore, these means of blocking, contrary to a tight fit between the assistance device and the distribution device, do not prevent the measurement of the weight of the distribution device 14.

[0046] As can be seen in Figure 4, the contact area 29 between the reservoir 32 and the support area 22 of the assistance device 10 includes means for measuring the activation pressure exerted on the contact area 29 to trigger the optical means 26, 28 and / or provide additional information on the quantity of liquid dispensed. The means for measuring the activation pressure 34 can provide information on the intensity of the activation pressure applied to the contact area 29 and the duration of application of this activation pressure. The contact area 29 is located on an internal surface of the wall of the main body 18 carrying the support area 22. The means for measuring the activation pressure include, for example, an FSR-type pressure sensor 34, placed in contact with the reservoir 32.

[0047] As can be seen in the embodiment of Figure 5, which is also applicable to the embodiment of Figure 1A, the assistance device 10 includes means for reading information 38 carried by the dispensing device 14. The dispensing device 14 includes an electronically readable information carrier 36. This information carrier is, for example, a radio tag 36 (of the RFID or "radio frequency identification" type) affixed to the underside of the reservoir 32. The radio tag 36 includes information such as, in this example, the filling volume of the reservoir 32 (and / or translated into a theoretical number of drops), the diameter of the dispensing orifice 16, the viscosity of the liquid product, the dosage of the liquid product, and the expiration / manufacturing date.The reading means in this example include an antenna 38 capable of reading the radio tag 36 to extract the information necessary for data processing. The tag can also be affixed to the side of the tank or any other suitable location.

[0048] In one variant, the information processing system 23 is connected to an object external to the assistance device 10, for example to a server, a receiver, an intranet network or the internet.

[0049] Advantageously, the information processing system 23 includes storage means 39 of a variable value depending on the quantity of liquid product remaining in the tank 32.

[0050] The process for determining the quantity of product is now described. liquid distributed in the form of drops by the liquid distribution device 14, by means of the assistance device 10.

[0051] To determine the quantity of liquid dispensed, the presence of a droplet is first detected near the dispensing orifice 16 using optical means 26, 28, which triggers the measurement of the inclination of the assisting device 10. The information detected by the optical means 26, 28 and the inclination measurement means is then sent to the information processing system 23, which analyzes it to provide an estimate of the volume of the detected droplet. In another embodiment, the change in the inclination of the assisting device 10 is detected first before triggering the activation of the optical means 26, 28. Knowing the inclination of the assisting device 10 and the geometry of the assisting device 10 and the dispensing device 14, the inclination of the dispensing device 14 is known.Applying this method for determining the presence of a drop during the use of the dispensing device 14 yields a representative value for the quantity of liquid product dispensed drop by drop. From this value, a new residual volume can be calculated by subtracting the estimated volume of the detected drop or the quantity of liquid product dispensed from the previous residual volume of liquid product remaining in the reservoir 32. During initial use, the previous residual volume is the volume at which the reservoir 32 was filled. The residual volume value is a variable updated after the dispensing of a drop or after use (several drops dispensed) and can be stored in the storage means of the assistance device 10.

[0052] Preferably, the presence of a droplet is detected by identifying a disturbance in the optical signal 40 provided by the optical means 26, 28, a disturbance generated by the presence of a droplet in the optical signal 40 between the transmitter 26 and the receiver 28, and more preferably, by also measuring the duration of the disturbance of the optical signal 40.

[0053] Estimating the volume of the detected droplet can be done in two steps. The first step consists of determining a theoretical droplet volume, for example, from information on the viscosity of the liquid product and / or the geometric characteristics of the dispensing orifice 16, or even other characteristics of the dispensing nozzle. One method for determining the theoretical volume of a droplet is to take as a value the volume of a droplet when the dispensing device 14 is inclined at an angle α (alpha) of 90° to the horizontal, taking into account the The diameter of the dispensing orifice 16 and the viscosity of the liquid product are two fixed parameters that significantly influence the volume of a dispensed drop. A fixed parameter is defined as one that does not depend on the operating conditions of the assistance device 10, such as the angle of inclination, activation pressure, or application speed. These five pieces of information are, for example, read by the assistance device 14 from a radio tag. 36 of the distribution device 14. It is also understood that the angle of inclination a corresponds to the angle formed by the axis of the distribution device 14, corresponding to the axis of the distribution orifice 16, with respect to a horizontal direction, in reference to the direction of gravity which defines a vertical direction. 10

[0054] As shown in Figure 8, which illustrates six distribution valves V1 to V6 of a distribution device 14 with different shapes and dimensions, it can be seen that, in general, the volume of a drop increases with the diameter of the distribution orifice 16. The table below provides an example of the relationship between the diameter of the distribution orifice 16 and the theoretical volume of the drop. The results 15 were obtained with water, by tilting the distribution device 14 at an angle a of 90°.

[0055] Furthermore, it is observed that the viscosity of the liquid product influences the volume of a dispensed drop, even without considering variable parameters depending on the operating conditions of the dispensing device 14. Indeed, it is noted that the volume of a drop under theoretical operating conditions (dispensing device 14 inclined at an angle α of 90° to the horizontal with valve V3) increases with the viscosity of the liquid product. The table below is an example of the relationship between the viscosity of the liquid product and the theoretical volume of the drop. 5

[0056] A second step involves weighting the theoretical volume by taking into account at least one of the following parameters: - the intensity of the activation pressure applied by the user to reservoir 32 to cause the droplet to form, - the variation profile of this activation pressure over time, - the inclination of the assistance device 10 and the distribution device 14, - the duration of a disturbance of an optical signal 40 provided by optical means, - the measurement of the weight of the distribution device 14.

[0057] One method of weighting the theoretical volume consists for example of multiplying its value by a coefficient A1 linked to the inclination of the assistance device 10 and the distribution device 14 provided by the means of measuring the inclination and by a coefficient A2 linked to the duration of a disturbance of an optical signal 40 provided by the optical means 26, 28 and to the viscosity of the liquid product contained in the reservoir 32.

[0058] Indeed, it can be seen that the inclination of the dispensing device 14 during drop dispensing influences the volume of the drop. As shown in the graph in Figure 9, the volume of the dispensed drop (on the y-axis) increases with the angle of inclination α of the dispensing device 14 (on the x-axis) measured relative to the horizontal. For example, a volume of 34 mL is measured at an angle of inclination α of 45°, a volume of 37 mL at an angle of inclination α of 60°, and a volume of 40 mL at an angle of inclination α of 90°, the liquid product used being water and the valve used being the valve V3 is used as a reference. After receiving the inclination value provided by the inclination measurement means, the information processing system 23 calculates the coefficient A1 by dividing this inclination value by the theoretical volume of a water droplet when the distribution device 14 is inclined at an angle a of 90° to the horizontal taking valve V3, i.e. 40mI.

[0059] Furthermore, it is observed that the volume of the distributed droplet can vary with the viscosity of the liquid product depending on the droplet formation rate. It is therefore also useful to weight the theoretical volume of a droplet by a coefficient A2 that takes into account the viscosity of the liquid product and the droplet formation rate. This droplet formation rate is advantageously obtained using of the duration of optical signal perturbation 40 and / or the intensity and duration of the activation pressure exerted to dispense a drop. The table below gives an example of the correspondence between a set formed by the viscosity of the liquid product and the drop formation rate, and the coefficient A2.

[0060] In one variant, the theoretical volume of a drop can also be weighted by a coefficient related to the intensity of the activation pressure applied by the user on the reservoir 32 to cause the formation of the drop and / or the variation profile of this activation pressure over time.

[0061] An example of the steps in a determination process is described in Figure 10. The process begins with a first step E1 of detecting an activation pressure exerted by the user on the support area 22. This pressure is transmitted to the reservoir 32 of the dispensing device 14 via the contact area 29 between the dispensing device and the support device 10, where an activation pressure sensor is located. When the detected activation pressure exceeds a predetermined threshold, for example 15 N, the optical means 26, 28 and the tilt measurement means are activated in step E2 to detect a drop and measure the tilt of the dispensing device 14. The optical means 26, 28 monitor the drop formation area near the dispensing orifice 16 until they detect the presence of a drop (step E3). A timer is started at step E4 when the drop is detected.Time is counted as long as the drop does not leave the formation zone monitored by the optical means, i.e., does not detach from the dispensing orifice 16. Once the drop leaves the formation zone to be dispensed (step E5), the optical signal 40 from the optical means 26, 28 is modified; more precisely, the optical signal 40 is no longer disturbed, and the timer stops to provide a drop formation time to the information processing system 23, which increments the number of dispensed drops by one (step E6). The tilt measurement means provide the tilt measurements to the information processing system 23 for estimating the drop volume (step E6). In an optional step E7, the residual volume can be deduced, as well as the number of drops remaining in the reservoir 32. This process can be repeated several times as long as an activation pressure exceeding the... predetermined threshold is detected and / or optical means 26, 28 detect the presence of a drop.

[0062] Figure 11 shows a graph with time on the x-axis and the intensity of the activation pressure or perturbation of the optical signal 40 on the y-axis. The graph is an example of how the information received by the information processing system 23 comes from the optical means 26, 28 (curve C1) and from the means for measuring the activation pressure 34 (curve C2) exerted by the user during the dispensing of a drop. When the measured activation pressure exceeds a predetermined threshold, for example 15 N, the optical means 26, 28, here the emitter 26 and the receiver 28 of an optical signal 40, are activated. When a drop forms between the emitter 26 and the receiver 28, the optical signal 40 is perturbed, generating a high intensity of the perturbation. This perturbation disappears once the drop detaches from the dispensing orifice 16.

[0063] Another example of a determination method is shown in Figure 12, which verifies the residual volume value calculated in step E7 of the example in Figure 10 by measuring the weight of the dispensing device 14. Steps E1 to E7 are similar to those in the example in Figure 10 and are not repeated. Following the calculation of the residual volume in step E7, the tilt measurement means continue to provide data to the information processing system 23. The latter performs a step E8 to test the vertical position. Once the dispensing device 14 and / or the assistance device 10 returns to its rest position, the information processing system 23 validates the vertical position, and a step E9 to measure the weight of the dispensing device 14 is performed by suitable means for the assistance device 10.In one variant, step E8 is not performed; that is, the weight of the dispensing device 14 is measured regardless of the inclination of the dispensing device 14 and / or the assistance device 10, for example, after a significant change in the inclination of the dispensing device 14 following drop dispensing. The weight measured in step E9 differs depending on whether or not the cap 15 of the dispensing device 14 is present. A step E10 is then performed to verify that the cap 15 has been replaced. This verification is either performed manually by the user, who provides this information to the assistance device 10, or, more advantageously, by means for detecting the cap 15 located on the assistance device 10. The means for detecting the cap 15 may include, for example, a mechanical contact sensor or an activation pressure sensor, or, more advantageously, optical means.Indeed, depending on the nature of the optical signal disturbance. 40, the information processing system 23 and / or the optical means 26, 28 can differentiate the presence of a drop of liquid or a cap 15. Depending on the result obtained in step E10, the information processing system 23 calculates, in a step E11, the quantity of liquid remaining in the reservoir 32 from the measured weight.

[0064] Figure 13 shows a variant of the embodiment of Figure 12. In this variant, step E10, which verifies that the cap 15 has been replaced, is performed solely by the information processing system 23 using calculated, pre-configured, and / or read data from the dispensing device 14. This step E10' comprises two successive sub-steps, E10'a and E10'b. In step E10'a, the information processing system 23 estimates the weight of the dispensing device 14 with (respectively without) the cap 15 by adding the weight of the residual volume (obtained in step E6) and the empty weight of the dispensing device 14 with (respectively without) the cap 15. In step E10'b, the information processing system 23 compares the measured weight with the estimated weight of the dispensing device 14 with (respectively without) the cap 15.If the measured weight is significantly less than the estimated weight of the dispensing device 14 with cap 15 and / or approximately equal to the estimated weight of the dispensing device 14 without cap 15, then the information processing system 23 infers that the cap 15 has not been replaced on the dispensing device 14. If the measured weight is significantly greater than the estimated weight of the dispensing device 14 without cap 15 and / or approximately equal to the estimated weight of the dispensing device 14 with cap 15, then the system infers that the cap 15 has been correctly replaced. Based on the result obtained in step E10', the information processing system 23 calculates, in step E11, the quantity of liquid remaining in the reservoir 32 by subtracting the empty weight of the dispensing device 14 with or without cap 15 from the measured weight.

[0065] According to an alternative embodiment not shown, the activation pressure exerted by the user on the support area is determined by means of the weight-measuring device attached to the assistance device. With a flexible reservoir, the activation pressure deforms the reservoir radially in its diameter and also longitudinally in its length. The longitudinal deformation can be measured by the scale, and the activation pressure information deduced from this measurement. In this embodiment, the contact area is separate from the user's support area.

[0066] The invention is not limited to the embodiments shown, and other embodiments will be obvious to a person skilled in the art. For example, it may to make different combinations of the different means presented to obtain an assistance device, a distribution kit or a determination process adapted to the need.

Claims

Demands 1. A device (10) to assist the use of a device (14) for dispensing a liquid product in drop form, comprising a reservoir (32), the assistance device (10) comprising: - means of solidarity (17) to the distribution system (14), - optical means (26, 28) intended to be disposed in the vicinity of a distribution orifice (16) of the liquid product, configured to provide information on the distribution of a drop of the liquid product by the distribution device (14), characterized in that the assistance device (10) further comprises: - means for measuring inclination configured to provide information on the inclination of the distribution device (14) attached to the assistance device (10), and a system for processing information (23) on the distribution of a drop and on the inclination of the distribution device (14) attached to the assistance device (10) to provide information on the quantity of liquid product distributed.

2. Assistance device (10) according to the preceding claim, comprising a contact area (29) intended to be in contact with the reservoir (32) of the dispensing device (14) when the user activates the reservoir (32) to activate the dispensing of drops, the contact area (29) comprising means for measuring the activation pressure (34) exerted on the contact area (29) to trigger the optical means (26, 28) and / or providing additional information on the quantity of liquid product dispensed, preferably information on the intensity of the activation pressure applied and the duration of application of this activation pressure.

3. Assisting device (10) according to any one of the preceding claims, comprising means for measuring the weight (33) of the dispensing device (14) attached to the assisting device (10), configured to provide information on the quantity of liquid in the reservoir (32).

4. Assistance device (10) according to any one of the preceding claims, wherein the optical means (26, 28) comprise an emitter (26) and a receiver (28) of an optical signal (40), configured to detect the presence of a droplet interfering with the optical signal (40) and to measure the duration of this presence.

5. Assistance device (10) according to any one of the preceding claims, wherein the means for measuring the inclination include an inclinometer.

6. Assistance device (10) according to any one of the preceding claims, wherein the information processing system (23) includes means for reading (38) information carried by the distribution device (14).

7. Assistance device (10) according to any one of the preceding claims, wherein the information processing system (23) includes storage means (39) of a variable value corresponding to the quantity of liquid product dispensed and / or the quantity of liquid product remaining in the tank (32).

8. Kit for distributing (12) a liquid product in the form of drops onto an organ of a subject, comprising a distribution device (14) for the liquid product and an assistance device (10) according to any one of the preceding claims.

9. A method for determining the quantity of liquid product dispensed in drop form by a liquid dispensing device (14), by means of an assisting device (10) according to any one of claims 1 to 7, comprising the following steps: - detection of a drop (E3), - estimation of the volume of the detected droplet (E6).

10. Method of determination according to the preceding claim, comprising a step (E7) of calculating a new residual volume value by subtracting the detected drop volume from the previous residual volume value. 1 1. Method of determination according to any one of claims 9 to 10, during which the drop detection step (E3) includes a step of identifying a disturbance of an optical signal (40) provided by optical means (26, 28) and a step of measuring the duration of disturbance of the optical signal (40).

12. A method for determining the volume of the detected droplet according to any one of claims 9 to 11, wherein the step of estimating the volume of the detected droplet (E6) comprises a step of determining a theoretical volume of this droplet, preferably comprising a step of calculating this theoretical volume from information on the viscosity of the liquid product and / or the geometric characteristics of the dispensing orifice. (16), or even on other characteristics of the dispensing nozzle and / or dispensing device (14).

13. A method for determining the volume of the drop according to the preceding claim, wherein the step of estimating the volume of the drop (E6) includes a step of weighting the volume of the detected drop, during which at least one of the following parameters is taken into account to weight the estimation of the volume of the detected drop: - the intensity of the activation pressure applied by the user to the reservoir (32) to cause the droplet to form, - the variation profile of this activation pressure over time, - the inclination of the assistance device and / or the distribution device (14), - the duration of a perturbation of an optical signal (40) provided by optical means (26, 28), - the measurement of the weight of the distribution device (14).

14. Method of determination according to any one of claims 10 to 13, comprising a step (E9) of measuring the weight of the dispensing device (14) to validate the calculated value of residual volume.

15. Method of determination according to any one of claims 9 to 14, comprising a step (E10, E10') of testing on the presence of a protective cap (15) on the dispensing device (14).

16. Method of determination according to any one of claims 9 to 15, wherein the drop detection step (E3) is triggered by the detection of an activation pressure (E1) by a user on the reservoir of the dispensing device (14) to activate the dispensing of drops.