METHOD FOR PURIFIING BRANCHED POLYETHYLENE GLYCOL
DE602020062265T2Active Publication Date: 2025-11-12NOF CORP
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Patent Information
- Application Number
- DE602020062265
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2020-12-21
- Publication Date
- 2025-11-12
- Estimated Expiration
- 2040-12-21
AI Technical Summary
Technical Problem
Existing methods for producing branched polyethylene glycol compounds with reduced vinyl ether groups are inefficient and difficult to implement industrially, leading to impurities that cause dimerization issues during drug modification.
Method used
A purification method involving the use of solid acids like magnesium silicate, aluminum silicate, or aluminum magnesium silicate in an organic solvent to convert vinyl ether groups to hydroxyl groups in branched polyethylene glycol compounds, ensuring high purity and stability.
Benefits of technology
This method enables the production of high-purity branched polyethylene glycol compounds suitable for pharmaceutical uses by effectively reducing vinyl ether groups under mild conditions, suitable for industrial-scale applications.
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