Metering module with actuation window

Abstract

The invention relates to a metering module for use in a metering system, which is designed to output drops at an outlet opening of a nozzle tube via deformation of the nozzle tube. The metering module comprises a holder and a nozzle tube which is secured to the holder and has the outlet opening. The holder comprises an actuation window that penetrates through the holder and exposes a section of the nozzle tube that is elastically flexible in the radial direction, wherein sections of the nozzle tube that are spaced apart from one another in the longitudinal direction of the nozzle tube are fixed by sections of the holder arranged on opposing sides of the actuation window.

Description

[0001] Dosing module with operating window

[0002] Description

[0003] The present invention relates to devices and methods for dispensing one or more drops from a dosing system and, more particularly, to devices and methods for a dosing module having a holder including an actuation window.

[0004] Introduction

[0005] Microfluidics deals with the handling of liquids in the femtoliter to milliliter range. For the contactless dispensing of liquids in such small volumes, small components (e.g., a thin tube with a small hole diameter) are used, which are susceptible to unintentional mechanical influences (e.g., crushing). The generation of small, free-flying droplets requires sufficient energy transfer to separate the desired volumes from a liquid column or detach them from their generator structure. These components can be easily deformed and damaged, but should be able to be precisely and reproducibly inserted into a dispensing module and deformed therein for droplet dispensing. The components can include a nozzle tube (e.g., an elastic hose) that can receive a fluid and, upon deformation by an actuator, dispense at least a portion of the fluid from an outlet opening.

[0006] The correct insertion of the nozzle tube into a dispensing system can be complicated and time-consuming and can affect the precision of the drop dispensing. Furthermore, incorrect positioning of the nozzle tube in the dispensing system can result in damage during subsequent use (e.g., if it is deformed by an actuator). A dispensing system with an exchangeable nozzle tube can, for example, have a guide groove into which the nozzle tube is inserted and then covered and held in place with a flat plate. In such a dispensing system, an incorrectly oriented nozzle tube can protrude from the guide groove and be squeezed by the flat plate. Furthermore, a discrepancy between the dimensions of the nozzle tube and the guide groove can result in excessive pre-deformation of the nozzle tube or play between the nozzle tube and the guide groove. This can affect the precision of the nozzle tube (e.g.,regarding the amount and direction of discharge).

[0007] State of the art

[0008] The document US 2006 / 0147313 A1 discloses a microdosing device with a flexible polymer tube from which liquid can be dispensed as free-flying droplets or as a free-flying jet (primarily in the nanoliter to picoliter range) by means of a displacer.

[0009] The document US 1 1148164 B2 discloses a dosing device with a capillary tube which can be deformed by a piezoelectric actuator, wherein the capillary tube is replaceable.

[0010] Description of the invention

[0011] The object of the invention is to provide a dosing module and a method which simplify operation, improve precision and reduce the risk of damage to a nozzle tube or at least improve a compromise of these tasks.

[0012] This object is achieved by a dosing module according to claim 1 and a method according to claim 21.

[0013] Examples provide a dosing module with the following features: a holder, and a nozzle tube that is attached to the holder and has the outlet opening. The holder comprises an actuation window that penetrates the holder and in which a radially elastic section of the nozzle tube is exposed, wherein sections of the nozzle tube that are spaced apart from one another in the longitudinal direction of the nozzle tube are fixed by sections of the holder arranged on opposite sides of the actuation window. Since the nozzle tube is fixed to two sections of the holder, the nozzle tube has a fixed position and orientation with respect to the holder. The holder is more stable and thus allows indirect handling of the nozzle tube with a reduced risk of damaging the nozzle tube. The holder can be aligned with other components with less effort than the nozzle tube (e.g.by placing, inserting, snapping into or onto the components, or aligning using markings). The nozzle tube can be indirectly attached to other components via the holder, without the need to directly clamp the nozzle tube. The actuation window allows the nozzle tube to be deformed to eject liquids within it. The holder therefore reduces the risk of damage to the nozzle tube, but also allows access to the nozzle tube for deformation. The penetrating actuation window allows access to the nozzle tube from both sides. This means that an actuator can actuate the nozzle tube from one side, and a counterstructure can be attached from the other side, which can interact with the actuator to deform the nozzle tube. The penetrating actuation window allows the inclusion of counterstructures of various dimensions.The dosing module therefore exhibits improved compatibility with such differently designed counterstructures (e.g., a dosing system and / or a holding module). Since the actuation window allows for the accommodation of counterstructures, it is not necessary for the dosing module itself to provide the counterstructure. For example, the same counterstructure (e.g., of a dosing system) can be reused for different dosing modules (e.g., to provide new nozzle tubes). There is no need to manufacture and subsequently dispose of a separate counterstructure for these different dosing modules. The dosing module can therefore improve cost efficiency and resource utilization.

[0014] The nozzle tube can have a smaller dimension than the holder in the direction in which the actuation window penetrates the holder, so that the nozzle tube is recessed relative to at least one surface of the holder in which the actuation window is formed. By recessing the nozzle tube relative to the surface of the holder, the holder reduces the risk of the nozzle tube being deformed outside the actuation window. Therefore, the risk of a liquid discharge quantity of the nozzle tube deviating from an expected value due to deformation beyond the actuation window is reduced. The holder can further comprise a fluid inlet opening that is fluidically coupled to the nozzle tube. Especially in the field of microfluidics, the diameter of the nozzle tube can be so small that filling it with liquid and / or coupling it to a fluid reservoir is complex.However, since the nozzle tube is already fixed to the bracket, the fluid inlet opening of the bracket may already be fluidically connected to the nozzle tube. Consequently, the fluid inlet opening (beyond the fluidic connection) may have different dimensions than the nozzle tube.

[0015] The fluid inlet port can have a larger flow cross-section than the nozzle tube. This larger flow cross-section allows for easier coupling to a fluid reservoir and / or introduction of a liquid. Furthermore, the larger flow cross-section can be realized through a standard inlet port (e.g., the Luer system).

[0016] A flow direction perpendicular to the flow cross-section of the fluid inlet opening can be arranged at an angle to the longitudinal direction of the nozzle tube. The fluid inlet opening can thus be connected to a fluid reservoir provided laterally of the dosing module (e.g., on a holding module or an actuator module). The dosing module therefore does not need to support the weight of the fluid reservoir and can therefore be designed more compactly.

[0017] The holder can have a plate-shaped first section in which the nozzle tube and the actuation window are arranged, and a second section in which the fluid inlet opening is arranged, wherein the second section can protrude radially relative to the first section with respect to the nozzle tube. The division into two sections, which fulfill two different functions (providing the actuation window and providing the fluid inlet opening), allows for independent dimensioning of the two sections. Thus, the first section can be dimensioned flat and compact, and the second section can be dimensioned according to the dimensions of the fluid inlet opening.

[0018] First guide structures can be provided for engaging with matching second guide structures of a holding module and / or third guide structures of an actuator module. The guide structures make it easier for the user to correctly position the modules relative to one another. Since the dosing module holder has the actuation window, the elastic section of the nozzle tube accommodated therein is also correctly positioned relative to the holding module and / or actuator module.Examples provide a dosing system comprising: a dosing module as described herein; a holding module configured to hold the dosing module on a first side; and an actuator module configured to hold the dosing module on a side opposite the first side, and comprising an actuator configured to cause deformation of the nozzle tube to dispense drops at an outlet opening of the nozzle tube, wherein the dosing module and at least one of the holding module and the actuator module are separate modules configured to be coupled to one another in an operating state and to be separated from one another again.

[0019] The dosing system comprises a holding module and an actuator module, wherein the holding module is designed to hold the dosing module and can utilize the ability to hold the nozzle tube indirectly via the holder, and the actuator module can utilize the ability to deform the nozzle tube via the actuation window. Since the nozzle tube is fixed to the holder, the holding module and the actuator module can be designed such that the holding module and the actuation window are arranged at the level of the actuator. Therefore, the actuator can deform the nozzle tube precisely and reproducibly. Furthermore, the nozzle tube can be fixed with respect to the actuator module without having to be directly attached to the actuator module with frictional engagement (e.g., in a holding groove). The risk of excessive deformation or insufficient attachment in the holding groove is therefore reduced.Consequently, the accuracy of liquid dispensing is improved and the requirements for accuracy in the manufacturing of the nozzle tube are reduced.

[0020] The actuation window can be formed in a plate-shaped section of the dosing module, wherein the holding module can have a receiving section designed to at least partially receive the plate-shaped section in the operating state. Receiving the plate-shaped section in the receiving section allows the plate-shaped section and thus also the nozzle tube to be aligned in a predefined manner with respect to the dosing module, for example by applying surfaces, edges, or self-centering structures of the plate-shaped section and / or the receiving section. This facilitates the coupling of the dosing module and the holding module and reduces the risk of incorrect arrangement and / or alignment of the nozzle tube with respect to the holding module.

[0021] The receiving section can have side walls that, in the operating state, are arranged on opposite sides of the plate-shaped section of the dosing module, and a rear wall that, in the operating state, is arranged on the side of the dosing module facing away from the actuator module. Since the side walls are arranged on opposite sides, the side walls can define a position along a direction extending between the side walls when the dosing module is received. The rear wall enables a predefined positioning of the dosing module in a direction perpendicular to the rear wall when the dosing module is installed. The receiving section therefore allows the user to correctly position the dosing module with respect to the holding module in these two directions.

[0022] The holder can have a section protruding from the plate-shaped section, in which the fluid inlet opening is arranged and which protrudes radially relative to the first section with respect to the nozzle tube. In the operating state, the protruding section protrudes beyond an edge of the holding module, which edge is arranged longitudinally on the side of the holding module facing away from the nozzle opening. In the operating state, the protruding section protrudes beyond the edge of the holding module and can provide more space there for larger components (such as a fluid inlet opening with a larger cross-section). Furthermore, the protruding section can bear against the holding module and thus define the position of the nozzle tube with respect to the holding module.

[0023] The dosing module can have first guide structures, and the holding module can have matching second guide structures, which are designed to engage with the first guide structures and bring the holding module and the dosing module into a mechanically defined position relative to one another. The first and second guide structures can be dimensioned such that, upon engagement, the holding module and the dosing module are guided and arranged in a predetermined position relative to one another. By engaging the first and second guide structures, a user can correctly align the dosing module and thus also the nozzle tube with respect to the holding module.

[0024] The actuator module can have third guide structures configured to interact with the first and / or second guide structures to bring the actuator module, the dosing module, and the holding module into a mechanically defined position relative to one another. In the mechanically defined position, the actuator of the actuator module can be arranged relative to the actuation window such that, upon actuation, the actuator can deform the nozzle tube in the actuation window. Furthermore, the holding module can be brought into a correct arrangement relative to the dosing module (for example, to prevent unintentional crushing or to align a calibration structure relative to the actuation window).

[0025] The first guide structures can have one or more guide holes penetrating the dosing module, the second guide structures can have one or more guide pins, and the third guide structures can have one or more guide holes. A guide pin of each of the second guide structures can be configured to extend through a guide hole of the first guide structures into a third guide hole when the dosing module, the holding module, and the actuator module are coupled. The guide pins of the second guide structures can thus extend through guide holes of both the dosing module and the actuator module. This allows the dosing module and the actuator module to be aligned on the same guide structure, which improves the mechanically defined position.Furthermore, the holding module and the dispensing module can initially be coupled to form a single assembly, which can then be coupled to the actuator module via the guide pins. Since the dispensing module does not have a guide step, material costs and consumption are lower. This is particularly advantageous when the dispensing module is a module with a high replacement rate (e.g., as a disposable item).

[0026] The holding module and / or the actuator module can have a fastening mechanism designed to attach the holding module to the actuator module in order to couple the dosing module, the holding module, and the actuator module. The fastening mechanism enables the mechanically defined position to be maintained and improves the precision of ejecting the liquid. Since the fastening mechanism is part of the holding module and / or the actuator module, it is not necessary for the dosing module to have a fastening mechanism. This is particularly advantageous if the dosing module is a module with a higher replacement rate (e.g., as a disposable item).

[0027] The fastening mechanism can comprise magnets on the holding module and / or the actuator module. Such a fastening mechanism allows for simple, tool-free, and quick coupling. Furthermore, the attractive force of magnets can be used in conjunction with self-centering geometries.

[0028] The holding module may comprise a calibration structure designed to cause a defined deformation of the elastic portion of the nozzle tube exposed in the actuation window when the dosing module, the holding module and the actuator module are coupled to one another and before the actuator is actuated.

[0029] The calibration structure may include a projection on the holding module that projects into the actuation window in the operating state. The projection is therefore located close to the nozzle tube, reducing deflection of the nozzle tube. This improves the reproducibility of the nozzle tube deformation.

[0030] The calibration structure can deform the elastic portion of the nozzle tube on a first side, and the actuator can deform the elastic portion of the nozzle tube on a second side opposite the first side when the dosing module, the holding module, and the actuator module are coupled together and before the actuator is actuated. The calibration structure thus enables deformation of the nozzle tube by means of squeezing between the projection and the actuator, realizing deformation with improved reproducibility.

[0031] The holding module may include a handle provided on a side opposite the dosing module, allowing a user to couple the holding module to the dosing module and the actuator module. The handle facilitates coupling of the holding module to the dosing module and / or actuator module for the user.

[0032] Examples provide a method for dispensing a drop from a dispensing system as described herein. The method includes providing the dispensing module, the holding module, and the actuator module; coupling the dispensing module to the actuator module and the holding module, wherein the portion of the dispensing module is disposed between the actuator module and the holding module; actuating the actuator module to eject one or more drops from the outlet opening of the nozzle tube; and separating the dispensing module from at least the actuator module.

[0033] The dosing module, the holding module, and the actuator module can be provided as separate components, and the method can further comprise forming a composite comprising the dosing module and the holding module by inserting the portion of the dosing module into a receiving portion of the holding module, wherein coupling the dosing module to the actuator module and the holding module comprises coupling the composite to the actuator module. The provision of three separate components enables coupling of the dosing module to the holding module as an intermediate step. This can simplify coupling to the actuator module. Furthermore, different holding modules can be provided to improve compatibility with different types of dosing modules.

[0034] The method may further comprise, after separating the assembly from the actuator module, replacing the dosing module in the assembly with a new dosing module, coupling the assembly comprising the new dosing module to the actuator module by releasably coupling the holding module to the actuator module, wherein the portion of the new dosing module is arranged between the actuator module and the holding module, actuating the actuator module to eject one or more drops from the outlet opening of the nozzle tube of the new dosing module, and separating the assembly from the actuator module. The handling for both inserting and removing the nozzle tube can be carried out via the holder of the dosing module. Therefore, the operation of the dosing module is simplified. The assembly of the dosing module and the holding module also allows for easy decoupling from the actuator module.

[0035] The holding module and the actuator module can be provided as a coupled unit, and the dosing module can be provided as a separate component from the coupled unit, wherein coupling the dosing module to the actuator module and the holding module comprises coupling the dosing module to the coupled unit. The coupled unit can simplify coupling the dosing module to the coupled unit (e.g., since the holding module and the actuator module no longer need to be moved, or a movement can be guided relative to each other).

[0036] Examples thus create dosing modules, dosing systems, and methods for dispensing a drop. It was recognized that a nozzle tube fixed to two sections of an actuation window facilitates coupling of the dosing module with other modules, that the orientation of the nozzle tube can be mechanically defined by the mount, thus improving the precision of drop dispensing and reducing the risk of damage to the nozzle tube.

[0037] Short description of the drawings

[0038] Embodiments of the invention are explained in more detail below with reference to the accompanying drawings. Figure 1 shows a perspective view of an example of a dosing module with a holder and a nozzle tube;

[0039] Fig. 2A is a perspective view of the dosing module;

[0040] Fig. 2B is a perspective view of another example of the dosing module;

[0041] Fig. 2C is a perspective view of another example of the dosing module;

[0042] Fig. 2D is a perspective view of another example of the dosing module;

[0043] Fig. 3A is a perspective view of another example of the dosing module with guide holes;

[0044] Fig. 3B is a perspective view of another example of the dosing module with guide extinguishers and guide pins;

[0045] Fig. 4A is a perspective view of another example of the dosing module with a funnel-shaped fluid inlet opening;

[0046] Fig. 4B is a perspective view of another example of the dosing module with a funnel-shaped fluid inlet opening;

[0047] Fig. 5 is a perspective view of another example of the dosing module;

[0048] Fig. 6A shows a perspective view of another dosing module, the holder of which comprises a first housing part and a second housing part;

[0049] Fig. 6B shows a cross section of the dosing module of Fig. 6A through a parting plane between the first and second housing part;

[0050] Fig. 6C shows another perspective view of the dosing module of Fig. 6A;

[0051] Fig. 7A is a schematic view of a dosing system comprising a dosing module, a holding module, and an actuator module; Fig. 7B is another example of the dosing system with three separate modules;

[0052] Fig. 7C the three modules from Fig. 7B engaged;

[0053] Fig. 8 is a perspective view of an example of a holding module;

[0054] Fig. 9A shows a perspective front view of a back wall of the holding module from Fig. 8;

[0055] Fig. 9B shows a perspective side view of the holding module from Fig. 8;

[0056] Fig. 9C shows a perspective view of the holding module from Fig. 8;

[0057] Fig. 10A shows a schematic cross-section of an example of an actuator module;

[0058] Fig. 10B shows a schematic cross-sectional view of a dosing system comprising the dosing module of Fig. 5, the holding module of Fig. 8 and the actuator module of Fig. 10A; and

[0059] Fig. 1 1 is a flow diagram for a method for dispensing a drop from a dosing system.

[0060] Detailed description

[0061] Examples of the present disclosure are described in detail below with the use of the accompanying drawings. It should be noted that like elements or elements having the same functionality are provided with the same or similar reference numerals, and repeated description of elements provided with the same or similar reference numerals is typically omitted. In particular, like or similar elements may each be provided with reference numerals having the same number with a different or no lowercase letter. Descriptions of elements having the same or similar reference numerals may be interchangeable. In the following description, many details are described in order to provide a more thorough explanation of examples of the disclosure.However, it will be apparent to those skilled in the art that other examples may be implemented without these specific details. Features of the various examples described may be combined with each other, unless features of a corresponding combination are mutually exclusive or such a combination is expressly excluded.

[0062] Before further explaining examples of the present disclosure, definitions of some terms used herein are provided.

[0063] As will be apparent to those skilled in the art, the term liquid as used herein includes, in particular, liquids containing solid components, such as suspensions, biological samples and reagents.

[0064] The term nozzle tube, as used herein, includes in particular elongated hollow bodies (such as a hose) with at least one outlet opening into the free space.

[0065] Examples of the invention can be used in particular in the field of microfluidics, which involves the processing of liquids in the picoliter to milliliter range. Accordingly, the fluidic structures can have suitable dimensions in the micrometer range for handling corresponding liquid volumes.

[0066] When the term "radial" is used herein with respect to the nozzle tube, "radial" means perpendicular to a central axis parallel to a direction of extension of the nozzle tube. In the case of a nozzle tube with a circular cross-section, the radial direction extends perpendicular to the outer surface of the nozzle tube.

[0067] Unless otherwise stated herein, room temperature (20°C) shall be assumed with regard to temperature-dependent quantities.

[0068] Fig. 1 shows a perspective view of an example of a dosing module 100 with a holder 110 and a nozzle tube 130. The nozzle tube 130 is attached to the holder 110 and has an outlet opening 132 (indicated by dashed lines in Fig. 1). The holder 110 has an actuation window 112 which penetrates the holder 110 and in which a section 134 of the nozzle tube 130 which is elastic in the radial direction (in Fig. 1 in the x and y directions) is exposed, wherein sections 136a, b of the nozzle tube 130 which are spaced apart from one another in the longitudinal direction (in Fig. 1 in the z direction) of the nozzle tube 130 are fixed by sections of the holder arranged on opposite sides of the actuation window 112 (e.g. in order to fix the nozzle tube 130 against movement with respect to the fixing sections of the holder 110).

[0069] It was recognized that by fixing the nozzle tube 130 to two sections of the holder 110, the nozzle tube 130 can be oriented using the holder. Therefore, the nozzle tube 130 can be more easily positioned correctly by a user (e.g., relative to an actuator and / or a holding module). Therefore, the risk of damage, loss, or contamination is reduced. Reducing damage also allows for more frequent reuse of the dosing module 100. Furthermore, operation is more time-efficient. Since the nozzle tube 130 does not have to be clamped directly into a holding module, problems that depend on the dimensions of the nozzle tube and a holding module (e.g., excessively loose or excessively tight frictional connection between the nozzle tube and the holding module) are reduced.

[0070] The actuation window 112 of the dispensing module 100 not only allows for improved alignment with a holding module and / or actuator module, it can also improve fastening and / or alignment within a package. Thus, transport damage and packaging costs can be reduced.

[0071] The dosing module 100 includes a fluid inlet opening 140 which is fluidly coupled to the outlet opening 132. In the example of Fig. 1, one end of the nozzle tube 130 (opposite the outlet opening 132) forms the fluid inlet opening 140. However, the fluid inlet opening 140 may be (at least partially) part of another component (such as the holder 110).

[0072] In Fig. 1, the fluid inlet opening 140 and the outlet opening 132 are shown protruding from the holder 110. Alternatively, at least one of the fluid inlet opening 140 and the outlet opening 132 may be provided flush or recessed with respect to a surrounding surface of the holder 110.

[0073] In Fig. 1, the nozzle tube 130 is shown cylindrical at the end with the outlet opening 132. Alternatively, the nozzle tube 130 can have a taper, for example in the form of a cone, wherein the outlet opening 132 is formed at an opening through the tip of the cone. The nozzle tube 130 (e.g., the outlet opening 132) can be designed to dispense droplets in the femtoliter to milliliter range (e.g., in the nanoliter to picoliter range). The holder 110 comprises a frame that surrounds the actuation window 112. The frame in Fig. 1 has a rectangular shape with a circular actuation window 112. Alternatively, the frame can have a circular, elliptical, or square shape, wherein corners of the frame can optionally be rounded. The actuation window 112 can have a circular, elliptical, or square shape. The nozzle tube 130 may extend centrally through the actuation window 112 (e.g.along an axis of symmetry of the operating window) or offset laterally from it.

[0074] The holder 110 may comprise one, two, or more housing parts (e.g., housing parts that are immovable relative to one another). The holder 110 may, for example, comprise a single housing that is formed around the nozzle tube 130, for example, by injection molding. In another example, the holder 110 may comprise two housing parts, each having a groove, wherein the grooves form a cylindrical opening for the nozzle tube 130 when the two housing parts are connected to one another (e.g., by at least one of an adhesive bond, a fusion bond, and a snap-in bond). The grooves may be formed by a placeholder for the nozzle tube 130 or by the nozzle tube 130 itself.

[0075] The mount 110 may comprise or be formed from at least one of (hard) plastic, metal, and glass. The mount 110 (or at least one part, such as one or more housing parts thereof) may be manufactured by milling, additive manufacturing (e.g., 3D printing), or an injection molding process. Manufacturing the mount 110 may include a joining process. The joining process may include at least one of assembling connecting structures, gluing, welding, and forming.

[0076] The nozzle tube 130 can comprise or be an elastic hose. The hose can have a cylindrical shape with a round or oval cross-section. The hose can contain an elastic material. The hose can contain at least one of silicone, polytetrafluoroethylene, polyurethane, polyimide, polypropylene, rubber, and polyvinyl chloride. The hose can have an outer diameter of less than 10 mm, e.g., less than 5 mm, e.g., less than 2 mm. The hose can have an inner diameter of less than 4 mm, e.g., less than 1.5 mm, e.g., less than 0.5 mm (e.g., between 0.1 and 0.5 mm). The nozzle tube 130 comprises an elastic material, at least in the elastic section 134. The nozzle tube 130 is designed to deform under the action of a force in such a way that an internal volume of the nozzle tube 130 is reduced.Consequently, the application of force (e.g., by an actuator) may cause a reduction in the internal volume, forcing a portion of a fluid that may be contained in the nozzle tube 130 to the outlet opening 132.

[0077] The nozzle tube can have a smaller dimension than the holder 110 in the direction in which the actuation window 112 penetrates the holder 110 (in the y-direction in Fig. 1), so that the nozzle tube 130 is recessed relative to at least one surface of the holder 110 in which the actuation window 112 is formed. The holder 110 protects the nozzle tube 130 from unintentional deformation (e.g., during assembly or actuator actuation). The dosing accuracy of the dosing module 100 is thus increased.

[0078] The holder 110 may further comprise a fluid inlet opening fluidically coupled to the nozzle tube 130. As part of the holder 110, the fluid inlet opening may protect the elastic nozzle tube 130 from mechanical influences. For example, the risk of damage to the nozzle tube 130 when coupled to a fluid reservoir (e.g., due to tension, pressure, or torsion) is reduced. Furthermore, the fluid inlet opening may comprise or form an adapter for a fluid reservoir. The fluid inlet opening may be compatible with the Luer system (e.g., comprise a female or male Luer-Lock connector).

[0079] The fluid inlet opening may have a larger flow cross-section than the nozzle tube 130. The larger flow cross-section allows for easier coupling to a fluid reservoir and may have the dimensions of a standard inlet opening (e.g., the Luer system). Furthermore, the nozzle tube 130 can be selected independently of the fluid reservoir.

[0080] A flow direction perpendicular to the flow cross-section of the fluid inlet opening can be arranged at an angle (e.g., greater than zero, e.g., not parallel) to the longitudinal direction of the nozzle tube 130. The fluid inlet opening can thus be connected to a fluid reservoir provided laterally of the dosing module 100 (e.g., on a holding module or an actuator module). The dosing module 100 therefore does not have to support the weight of the fluid reservoir and can consequently be shaped more compactly. The holder 110 can have a plate-shaped first section in which the nozzle tube and the actuation window 112 are arranged, and a second section in which the fluid inlet opening is arranged. The second section can protrude radially relative to the first section with respect to the nozzle tube.The division into two sections, each serving two different functions (providing the actuation window and the fluid inlet opening), allows for independent dimensioning of the two sections. This allows the first section to be flat and compact, while the second section can be dimensioned according to the dimensions of the fluid inlet opening.

[0081] The dosing module 100 can have first guide structures for engaging with matching second guide structures of a holding module and / or third guide structures of an actuator module. The guide structures make it easier for the user to correctly position the modules relative to one another. Since the holder 110 of the dosing module 100 has the actuation window 112, the elastic section of the dosing nozzle 130 accommodated therein is also correctly positioned relative to the holding module and / or actuator module.

[0082] In the example shown in Fig. 1, the nozzle tube 130 in which the actuating window 112 penetrates the holder 110 (in the y-direction in Fig.) has a smaller dimension than the holder 110, so that the nozzle tube 130 is recessed with respect to at least one surface of the holder 110 in which the actuating window 112 is formed.

[0083] Fig. 2A shows a perspective view of the dosing module 100. As can be seen therein, the nozzle tube 130 has a smaller dimension (e.g., diameter) in the y-direction than the holder 110 (e.g., wall thickness). Such a dimension reduces the risk of accidental crushing of the nozzle tube 130 and improves the fixation of the nozzle tube in the holder 110.

[0084] Fig. 2B shows a perspective view of another example of the dosing module 100. The example of Fig. 2B differs essentially from the example of Fig. 2A in that the nozzle tube 130 has a larger dimension in the y-direction than the holder 110. Such a dimension increases the compactness of the dosing module 110 and optionally allows deformation of the nozzle tube 130 by an actuator beyond the actuation window 112. Fig. 2C shows a perspective view of another example of the dosing module 100. The example of Fig. 2C differs essentially from the example of Fig. 2A in that the holder 110 has different dimensions (e.g., wall thicknesses and / or wall heights) at the two sections for fixing the nozzle tube 130. Thus, in Fig. 2C, the section in the positive z-direction has a smaller dimension than in the negative z-direction. Therefore, the mount 110 has a step.

[0085] In the example of Fig. 2B, the holder 110 has a dimension that has a wall thickness between the dimension and half the dimension of the nozzle tube 130. Consequently, the holder 110 encompasses the nozzle tube 130 by more than 180°, which improves the attachment of the nozzle tube 130.

[0086] Fig. 2D shows a perspective view of another example of the dosing module 100. The holder 110 in Fig. 2D has a thin section and a ring section that at least partially surrounds the nozzle tube 130. The thin section does not surround the nozzle tube 130 and can therefore have a wall thickness less than half the dimension of the nozzle tube 130.

[0087] However, fixing the nozzle tube 130 to the holder 110 does not require the holder 110 to encompass the nozzle tube 130. Alternatively or additionally, the holder 110 may comprise another fastening element for fixing the nozzle tube 130 to the holder 110. The fastening element may comprise at least one of an adhesive, a bonding compound, a fusion (e.g., a material of the holder 110 and a material of the nozzle tube 130), a connection from a molding process, a connection from an injection molding process (e.g., fixing the nozzle tube 130 to the holder 110 by injection molding, e.g., the holder 110 or at least a portion thereof may be molded around the nozzle tube 130 by injection molding), a weld, a hook, and an eyelet. The fixation of the nozzle tube 130 to the holder 110 can be detachable (e.g.a detachable clamping connection between the nozzle tube 130 and the holder 110) or non-detachable (e.g. a fusion or fixed bond between the nozzle tube 130 and the holder 110).

[0088] The dosing module 100 in Fig. 1 shows an actuation window 112 with a circular opening. However, the actuation window 112 can have other shapes. The actuation window 112 can have an opening with an oval, (e.g., elongated) rectangular, square, or (e.g., regular) polygonal shape. The opening can have a shape with sharp or rounded corners.

[0089] The dosing module 100 in Fig. 1 shows an actuation window 112 with an opening having parallel surface lines (in the y-direction). Alternatively, the opening can be tapered (e.g., conical). This gives the opening a self-centering effect (e.g., for a piston of an actuator).

[0090] Fig. 3A shows a perspective view of another example of the dosing module 100. The dosing module in Fig. 3A differs from the dosing module in Fig. 1 essentially in that the dosing module 100 or its holder 110 has first guide structures 114 for engaging with matching second guide structures (not shown in Fig. 3A) of a holding module and / or third guide structures of an actuator module. The guide structures 114 allow correct positioning and / or alignment of the actuation window 112 and thus also correct positioning and / or alignment of the nozzle tube 130 (for example, relative to an actuator for deforming the nozzle tube 130 in the actuation window 112).

[0091] As shown in Fig. 3A, the guide structures 114 can comprise one or more guide holes 114a, b (e.g., with a straight and / or parallel extension direction). The guide holes 114a, b can have the same shape and / or dimensions. Alternatively, the guide holes 114, b can have different shapes (e.g., square, rectangular, oval, or round) and / or different dimensions. This can make it easier for a user to find the correct orientation of the dosing module 100.

[0092] Alternatively or additionally, the guide structures 114 may comprise one or more guide pins (e.g., with a rectilinear and / or parallel extension direction). The guide structure 114 may comprise a guide pin with a cylindrical shape (e.g., with a round, oval, rectangular, square, or polygonal cross-section). In the case of multiple guide pins, all guide pins may have the same shape and / or dimensions or different shapes and / or dimensions.

[0093] Fig. 3B shows a perspective view of another example of the dosing module 100. The example of Fig. 3B differs from the example of Fig. 3A essentially by guide structures 114, which have guide pins 114c, d (instead of the guide holes 114, b).

[0094] Alternatively or additionally, the guide structures may comprise one or more rails, e.g. on lateral sides of the support 1 10.

[0095] The guide structures 114 can be combined as desired. For example, the guide structures 114 can have guide holes 114a, b as well as guide pins 114c, d or rails. The guide structures 114 can have parallel surface lines and / or outer surfaces. For example, the guide holes 114a, b and the guide pins 114c, d in Figs. 3A, B have parallel surface lines. Alternatively, the guide structures 114 can have at least one of a taper, a widening, and a local protuberance. Such structures enable a frictional connection upon engagement (e.g., by the holding module and / or actuator module).

[0096] Fig. 4A shows a perspective view of another example of the dosing module 100 with a funnel-shaped fluid inlet opening 140. In the example of Fig. 4A, the fluid inlet opening 140 is part of the nozzle tube 130. The cross-section of the fluid inlet opening 140 can increase constantly (e.g., no curvature), increase increasingly (e.g., positive curvature), or increase decreasingly (e.g., negative curvature) in the direction of the opening (in Fig. 4A, in the positive z-direction).

[0097] The funnel-shaped fluid inlet opening 140 has a larger cross-section than the part of the nozzle tube 140 coupled to it. This makes it easier to couple the nozzle tube to a fluid reservoir. Furthermore, the fluid inlet opening 140 can have dimensions that are compatible with common fluid connectors (e.g., for laboratory applications, e.g., Luer system connectors).

[0098] The fluid inlet opening 140 can be used as a fluid reservoir. Thus, the liquid to be ejected can be admitted into the (e.g., funnel-shaped) fluid inlet opening 140 (e.g., using a pipette). The admitted liquid can be held in the fluid inlet opening 140 due to at least one of gravity (e.g., with an upwardly open fluid inlet opening 140), surface tension, and interfacial tension. The liquid can then be ejected from the outlet opening 132 of the nozzle tube 130 (e.g., by deformation by an actuator). The fluid inlet opening 140 can be supported by the holder 110. The holder 110 can comprise a first section 116a and a second section 116b. The second section 116b can support the fluid inlet opening. In Fig. 4A, the holder 110 has a plate-shaped first section 116a. The second section 116b of the holder is indicated by dashed lines.

[0099] Fig. 4B shows a perspective view of another example of the dosing module 100, wherein the holder 110 includes the fluid inlet opening 140. The fluid inlet opening 140 is fluidically coupled to the nozzle tube 130. For this purpose, the nozzle tube 130 can extend into a cavity that is fluidly coupled to the fluid inlet opening 140. The dosing module 100 can include a sealing agent (e.g., an adhesive) between the cavity and / or the fluid inlet opening 140, on the one hand, and the nozzle tube 130, on the other hand. However, a seal can also be realized by the nozzle tube 130 abutting against the cavity and / or the fluid inlet opening 140.

[0100] Fig. 5 shows a perspective view of another example of the dosing module 100. The dosing module 100 in Fig. 5 has several features from Figs. 3A and 4B.

[0101] The dosing module 100 comprises guide structures 114 in the form of guide holes 114a, b. Furthermore, the holder 110 comprises a first section 116a and a second section 116b.

[0102] The first section 116b comprises a plate-shaped body with the actuation window 112 and the nozzle tube 130. However, the second section can also comprise at least part of the nozzle tube 130. The second section comprises the fluid inlet opening 140. The fluid inlet opening 140 in Fig. 5 has a larger flow cross-section than the nozzle tube 130. In one embodiment, the fluid inlet opening 140 in Fig. 5 has a funnel shape. Furthermore, the funnel shape has a central axis which has a curved extension. As a result, a flow direction which is oriented perpendicular to the flow cross-section of the fluid inlet opening 140 is arranged at an angle (ie at an angle greater than zero) to a longitudinal direction of the nozzle tube 130 (in Fig. 5 in the z-direction). In the example in Fig. 5, the flow angle is arranged at an angle of approximately 80° to the longitudinal direction of the nozzle tube 130.Alternatively, the angle can be in a range between 5° (or 10° or 20°) and 175° (or 170° or 160°). For example, the angle can be at least substantially 10°, 30°, 45°, 60°, 90°, 120°, or 135°. Fig. 6A shows a perspective view of another dosing module 100, whose holder 110 comprises a first housing part 118a and a second housing part 118b.

[0103] Fig. 6B shows a cross-section of the dosing module 100 of Fig. 6A through an imaginary parting plane between the first and second housing parts 118a, b. The parting line also runs through the nozzle tube 130, so that the first and second housings 118a, b each have a groove 117, wherein both grooves 117 together form a cavity designed to accommodate the nozzle tube 130. The two housings 118a, b further each have a recess 119, wherein the two recesses 119 together (at least partially) form the fluid inlet opening 140 and a transition between the fluid inlet opening 140 and the nozzle tube 130. The transition can have at least substantially the same diameter as the inner diameter of the nozzle tube 130. This creates a smooth transition between the nozzle tube 130 and the fluid inlet opening 140 with improved flow properties and reduced air inclusions.Such a transition is not limited to the dosing module 100 with two housing parts 1 18a, b and can also be realized in combination with all dosing modules 100 described herein.

[0104] Fig. 6C shows another perspective view of the dosing module of Fig. 6A.

[0105] Fig. 6A-C show a dosing module with two housing parts 118a, b. Alternatively, the holder 110 can also comprise three, four, five, or more housing parts. For example, the first and second sections 116a, b can each comprise different housing parts. Furthermore, the first section 116 can comprise more than two (e.g., three or four) housings, for example, to enable a modular design for different guide structures.

[0106] The housing parts 118a, b are shown in Figs. 6A-C with flat connecting surfaces. However, the housing parts 118a, b may also have connecting structures (e.g., connecting pins and / or connecting openings).

[0107] Fig. 7A shows a schematic view of a dosing system 10 comprising a dosing module 100 as described herein, a holding module 150 (e.g., a holding module 150 provided separately from the dosing module 100), and an actuator module 160 (e.g., an actuator module 160 provided separately from the dosing module 100). The holding module is configured to hold the dosing module 100 on a first side. The actuator module 160 is configured to hold the dosing module 100 on a side opposite the first side and includes an actuator 162 configured to cause deformation of the nozzle tube 130 to dispense droplets at an outlet opening 132 of the nozzle tube 130. The dosing module 130, and at least one of the holding module 150 and the actuator module 160 are separate modules that are designed to be coupled to one another in an operating state and to be separated from one another again.

[0108] The dosing module 100, the holding module 150, and the actuator module 160 can, for example, be provided as three separable modules. Alternatively, the holding module 150 and the actuator module 160 can be a combined module that can be separated from the dosing module 100. In this case, for example, the holding module 150 can be designed to be displaceable relative to the actuator module 160, wherein the dosing module can be inserted into a gap between the holding module 150 and the actuator module 160. The holding module 150 can be provided separately from the dosing module 100 (in particular, separately from the holder 110).

[0109] The actuation window 112 can be formed in a plate-shaped portion 116a of the dosing module 100, wherein the holding module 112 has a receiving portion configured to at least partially receive the plate-shaped portion 116a in the operating state. The receiving portion can facilitate the user's alignment of the dosing module 100.

[0110] The holder 100 can have a section protruding from the plate-shaped section 116a, in which the fluid inlet opening 140 is arranged and which protrudes radially relative to the first section with respect to the nozzle tube 130. In the operating state, the protruding section protrudes beyond an edge of the holding module 150, which is arranged longitudinally on the side of the holding module facing away from the nozzle opening. By protruding the section, the holding module 150 can be arranged closer to the dosing module 100, so that a compact arrangement of the modules can be realized. Furthermore, a distance between the fluid inlet opening 140 and a fluid reservoir of (or near) the dosing module 100 can be reduced.

[0111] The dosing module 100 can have first guide structures 114a, b, and the holding module 150 can have matching second guide structures that are designed to engage with the first guide structures 114a, b and bring the holding module 150 and the dosing module 100 into a mechanically defined position relative to one another. The guide structures facilitate correct positioning of the holding module 150 with respect to the dosing module 100 and the exposed elastic portion 134 of the nozzle tube 130 received therein. The actuator module 160 can have third guide structures that are designed to cooperate with the first and / or second guide structures to bring the actuator module 160, the dosing module 100, and the holding module 150 into a mechanically defined position relative to one another.The third guide structures make it easier for the user to correctly align the actuator module 160 (and its actuator 162) and the dosing module 100 (and the exposed elastic portion 134 of the nozzle tube 130 accommodated therein).

[0112] The first guide structures may have one or more guide holes 114a, b penetrating the dosing module 100, the second guide structures may have one or more guide pins, and the third guide structures may have one or more guide holes. A guide pin of each of the second guide structures is configured to extend through a guide hole 114a, b of the first guide structures into a third guide hole when the dosing module, the holding module, and the actuator module are coupled. Since both the dosing module 100 and the actuator module 160 have guide holes, all three modules can be correctly aligned with each other simultaneously using the guide pins of the holding module.

[0113] The holding module 150 and / or the actuator module 160 can have a fastening mechanism designed to attach the holding module 150 to the actuator module 160 in order to couple the dosing module 100, the holding module 150, and the actuator module 160 together. The fastening mechanism allows all three modules to be fixed together. The number of required fastening mechanisms can thus be reduced.

[0114] The fastening mechanism can comprise one or more magnets on the holding module 150 and / or the actuator module 160. Such a fastening mechanism can be implemented with low complexity and can be operated in a time-efficient manner. The risk of inadvertent crushing of the nozzle tube 130 when the magnetic fastening mechanism engages is reduced due to the actuation window 112. Alternatively or additionally, the fastening mechanism can comprise one or more snap connections (e.g., snap hooks or ring snap connections).

[0115] The holding module 150 may include a calibration structure designed to effect a defined deformation of the elastic portion 134 of the nozzle tube 130 exposed in the actuation window 112 when the dosing module 100, the holding module 150, and the actuator module 160 are coupled together and before the actuator 162 is actuated. This improves the reproducibility of the deformation and reduces gradual wear of the nozzle tube 130.

[0116] The calibration structure may include a protrusion on the holding module 150 that, in the operating state, extends into the actuation window 112. The protrusion is therefore arranged close to the nozzle tube 130, reducing deflection of the nozzle tube 130. The calibration structure may be formed integrally with a rear wall of the holding module.

[0117] The calibration structure can deform the elastic portion 134 of the nozzle tube 130 on a first side, and the actuator 162 can deform the elastic portion 134 of the nozzle tube 130 on a second side opposite the first side when the dosing module 100, the holding module 150, and the actuator module 160 are coupled to each other and before the actuator 162 is actuated. The calibration structure thus enables deformation of the nozzle tube 130 by means of squeezing between the projection and the actuator 162, realizing deformation with improved reproducibility.

[0118] The holding module 150 may include a handle provided on a side opposite the dosing module 150, allowing a user to couple the holding module 150 to the dosing module 100 and the actuator module 160. The handle facilitates coupling for the user. In particular, if the holding module 150 includes guide pins and the dosing module 100 and the actuator module 160 include guide holes, the handle allows the user to guide the guide pins through the guide holes.

[0119] Fig. 7B shows another example of the dosing system 10 with three separate modules 100, 150, 160. The dosing module 100 comprises first guide structures 114, which in Fig. 7B have two guide holes 114A, B as an example.

[0120] Fig. 7C shows the three modules from Fig. 7B in engagement.

[0121] The holding module 150 has second guide structures 152 that match the first guide structures 114. In Fig. 7B, these second guide structures 152, by way of example, have two guide pins 152a, b that are designed to engage with the first guide structures 114 and to bring the holding module 150 and the dosing module 100 into a mechanically defined position relative to one another. In the example of Fig. 7B, the guide pins 152a, b can be passed through the guide holes 114a, b. This mechanically defines the position of the holding module 150 relative to the dosing module 100 in a plane perpendicular to the direction of extension of the guide pins 152a, b (the xz plane in Figs. 7B, C).If the guide pins 152a, b are inserted up to a stop (for example, until the holding module 150 rests against the dosing module 100 and / or front surfaces of the guide pins 152a, b rest against a stop of the actuator module 160), the position and orientation of the dosing module 100 (and thus also of the nozzle tube 130) with respect to the holding module 150 is mechanically defined.

[0122] As shown, for example, in Fig. 7B, the actuator module 160 can have third guide structures 164 configured to interact with the first guide structures 114 and / or second guide structures 152 to bring the actuator module 160, the dosing module 100, and the holding module 150 into a mechanically defined position relative to one another. The third guide structures 164 exemplarily have two third guide holes 164a, b. The third guide holes 164a, b are configured to receive the guide pins 152a, b of the holding module 150.

[0123] The first guide structures 114 thus have one or more guide holes 114a, b that penetrate the dosing module 100 (such as the first portion thereof), the second guide structures 152 have one or more guide pins 152a, b, and the third guide structures 162 have one or more guide holes 164a, b, wherein a guide pin 152a, b of the second guide structures is each configured to extend through a guide hole 114a, b of the first guide structures into a third guide hole 164a, b when the dosing module 100, the holding module 150, and the actuator module 160 are coupled.

[0124] The guide structures of the dosing module 100, the holding module 150, and the actuator module 160 can be configured to secure the coupling. At least one of the guide pins 152a, b can, for example, realize a frictional connection with at least one of the guide holes 114a, b, 164a, b. For this purpose, at least one of the guide holes 114a, b, 164a, b and / or the guide pins 152a, b can have a tapered portion or a widened portion.

[0125] Alternatively or additionally, the holding module 150 and / or the actuator module 160 can have a fastening mechanism designed to fasten the holding module 150 to the actuator module 160 in order to couple the dosing module 100, the holding module 150, and the actuator module 160 to one another. The fastening mechanism can comprise at least one of a screw, a magnet, a snap connection, a hook, and an eyelet. For example, the fastening mechanism can comprise one or more magnets on the holding module 150 and / or the actuator module. The magnetic coupling can occur between two magnets or a magnet and a ferromagnetic element. In particular, the dosing module 100 can comprise a ferromagnetic element, and the holding module 150 and / or the actuator module 160 can comprise one or more magnets. This reduces the manufacturing costs of the dosing module 100, particularly when used as a disposable product.A fastening mechanism that includes a magnet, a snap connection, or a similar connection can be operated without tools and facilitates operation. Furthermore, a fastening mechanism with a magnet or a snap connection does not require a degree of fastening (such as a screw with variable tension), thus reducing the risk of the user inadvertently using too high a degree of fastening, which could lead to damage to the nozzle tube 130. A fastening mechanism without magnets (e.g., with a snap connection and / or a screw) has improved compatibility with fluids susceptible to magnetic fields (e.g., a fluid containing metallic particles, magnetic microbeads).

[0126] Fig. 8 shows a perspective view of an example of a holding module 150. The holding module 150 can have a receiving section 154 that is designed to at least partially receive the plate-shaped section of the dosing module 100 (such as the holder 100 in Figs. 1 to 3B or the first section 116A in Figs. 4A to 7C) in the operating state. The receiving section 154 can have one or more lateral walls. In the example in Fig. 5, the receiving section 154 has two lateral walls 156a, b, which are arranged on opposite sides of the plate-shaped section of the dosing module 100 in the operating state. The lateral walls 156a, b can run parallel. The receiving section 154 can have a rear wall 158, which, in the operating state, is arranged on the side of the dosing module 150 facing away from the actuator module 160. The rear wall 158 can be oriented perpendicularly with respect to at least one of the lateral walls 156a, b.The back wall 158 and the side walls 156a, b form a recess which is designed to receive the plate-shaped section of the dosing module 100.

[0127] The receiving portion 154 may include one or more magnets. The one or more magnets may be attached to a surface of the receiving portion 154, recessed into the surface, or provided within the holding module 150. At least one of the side walls 156a, b and / or the rear wall 158 may include at least one magnet. The dosing module 100 may include a magnet and / or a ferromagnetic material that can interact with the magnet of the receiving portion 154 such that the dosing module 100 is held in the receiving portion 154. The holding module 150 may further comprise a calibration structure 159 designed to cause a defined deformation of the elastic portion 134 of the nozzle tube 130 exposed in the actuation window 112 when the dosing module 100, the holding module 150 and the actuator module 160 are coupled to one another and before the actuator 162 is actuated.

[0128] The calibration structure 159 may include a protrusion on the holding module that, in the operating state, projects into the actuation window 112. The protrusion may extend from the back wall 158. The protrusion may have a contact surface that, in the operating state, faces the exposed elastic portion 134 of the nozzle tube 130. The contact surface may be flat, as shown in Fig. 8. Alternatively, the contact surface may have a concave or convex curvature. Alternatively or additionally, the contact surface may include an elongated recess configured to receive a portion of the nozzle tube 130.

[0129] The projection may have a similar or at least substantially similar shape to the actuation window 112. If the actuation window 112 has a circular shape, for example, the projection may also have a circular cross-section and be formed, for example, as a circular cylinder. In particular, if the nozzle tube 130 is recessed relative to the surface of the holder 110, the projection may have a smaller dimension (e.g., diameter) than the actuation window 112, so that the projection can protrude into the actuation window 112.

[0130] The calibration structure 159 can be configured to deform the elastic portion 134 of the nozzle tube 130 on a first side. The actuator 162 can be configured to deform the elastic portion 134 of the nozzle tube 130 on a second side opposite the first side when the dosing module 100, the holding module 150, and the actuator module 160 are coupled to one another and before the actuator 162 is actuated. The deformation can reduce the cross-section of the elastic portion 134 of the nozzle tube 130 by less than 50%, less than 25%, less than 10%, less than 5%, or less than 1% compared to an undeformed cross-section.

[0131] Fig. 9A shows a perspective front view of the back wall 158 of the holding module 150 from Fig. 8. Fig. 9B shows a perspective side view of the holding module 150 from Fig. 8. The holding module 150 can have a handle 155 provided on a side opposite the dosing module 100 and allowing a user to couple the holding module 150 to the dosing module 100 and the actuator module 160. The handle 155 can comprise a plate-shaped attachment configured to be grasped, for example, between the thumb and index finger. The handle can comprise a mechanism (not shown) configured to control the fastening mechanism. The mechanism can comprise a lever or a rotary knob.

[0132] Fig. 9C shows a perspective view of the holding module 150 from Fig. 8.

[0133] The holding module 150 can be manufactured using one of the methods described herein for the holder. The holding module 150 or at least components thereof (e.g., guide pins 152a, b and / or the receiving portion 154) can be manufactured, for example, by milling, an additive process (e.g., 3D printing), or casting.

[0134] Fig. 10A shows a schematic cross-section of an example of an actuator module 160. The actuator module 160 in Fig. 10A comprises an actuator 160 with a plunger 165, a return element 166 (e.g., a spring), and a linear actuator 167. The linear actuator 167 is configured to deflect the plunger 165 during operation in the direction of the elastic section 134 of the nozzle tube 130 (as well as the calibration structure 159 located behind it). The linear actuator 167 is configured to deflect the plunger 165 counter to a restoring force of the return element 166. The return element 166 is configured to transfer the plunger into a non-deflected position when the linear actuator 167 does not cause a deflection. Alternatively, the linear actuator 167 can be designed to move the plunger in both directions (optionally with the aid of the return device 166).

[0135] The actuator 162 is thus configured to deform the nozzle tube 130 by means of the plunger. If the nozzle tube 130 is pre-deformed (or pre-tensioned) by means of the calibration structure 159, the nozzle tube 130 can be compressed or squeezed between the calibration structure 159 and the plunger upon actuation of the actuator 162. Alternatively, the nozzle tube can be deformed by the actuator 162 only by being fixed by the actuation window 112 (i.e., without pre-deformation by a calibration structure 159).

[0136] Fig. 10B shows a schematic cross-sectional view of a dosing system 10 comprising the dosing module of Fig. 5, the holding module of Fig. 8, and the actuator module of Fig. 10A. The modules are coupled together in an operating state. In the operating state, the calibration structure 159 extends into the actuation window 112 and bears against the elastic portion 134 of the nozzle tube 130 in such a way that the nozzle tube 130 is pre-deformed. Fig. 10B shows the plunger 165 of the actuator 162 in a deflected state. Consequently, the elastic portion 134 of the nozzle tube 130 is deformed by squeezing the nozzle tube 130 between the calibration structure 159 and the plunger. The resulting volume reduction within the nozzle tube 130 causes a discharge of a fluid contained in the nozzle tube 130 (not shown in Fig. 10B). The fluid can be discharged in the form of individual drops, in the form of a fluid jet, or in the form of multiple drops.At least one of a number of droplets, a dispensed fluid quantity, and a droplet volume can be controlled by the speed and / or deflection of the plungers. The droplets can, for example, have a volume in the nanoliter to picoliter range (e.g., between 50 pl and 500 nl) and / or a diameter between 50 pm and 1 mm.

[0137] Fig. 1 1 shows a flow diagram 200 for a method of dispensing a drop from a dosing system 10 as described herein.

[0138] The method comprises, in step 202, providing the dosing module 100 with the section 116a, the holding module 150 and the actuator module 160.

[0139] The method comprises, in step 204, coupling the dosing module 100 to the actuator module 160 and the holding module 150, wherein the portion of the dosing module is arranged between the actuator module and the holding module.

[0140] The method includes, in step 206, actuating the actuator module to eject one or more drops from the outlet opening of the nozzle tube.

[0141] The method includes separating the assembly from the actuator module in step 208.

[0142] The method enables the assembly of a dosing module and the ejection of one or more drops from the dosing module. When coupling the assembly, the risk of incorrectly arranging the nozzle tube 130 relative to the holding module 150 and the actuator module 160 is reduced because the nozzle tube 130 is fixed to two sections of the holder 110. Therefore, the arrangement of the nozzle tube 130 is guided by the receiving section 154 when inserting the dosing module 100.

[0143] The method may include filling the nozzle tube 130 and / or the fluid inlet opening 140 with the liquid to be ejected. Filling may include dripping using a pipette (e.g., into the fluid inlet opening 140) and / or coupling a fluid reservoir to the fluid inlet opening 140.

[0144] The dosing module 100, the holding module 150, and the actuator module 160 may be provided as separate components, and the method may further comprise forming a composite comprising the dosing module 100 and the holding module 150 by inserting the portion 116a of the dosing module 100 into a receiving portion 154 of the holding module 150, wherein coupling 204 of the dosing module 100 to the actuator module 160 and the holding module 150 comprises coupling the composite to the actuator module 160. Coupling the composite to the actuator module 160 may comprise releasably coupling the holding module 150 to the actuator module 160.

[0145] The method may further comprise, after separating the assembly from the actuator module 160, replacing the dosing module 100 in the assembly with a new dosing module.

[0146] The method may include coupling the assembly having the new dosing module to the actuator module 160 by releasably coupling the holding module 150 to the actuator module 160, wherein the portion of the new dosing module is disposed between the actuator module 160 and the holding module 150.

[0147] The holding module 150 and the actuator module 160 can be provided as a coupled unit, and the dosing module 150 can be provided as a separate component from the coupled unit, wherein the coupling 204 of the dosing module 100 to the actuator module 160 and the holding module 150 comprises coupling the dosing module 100 to the coupled unit. The holding module 150 in the coupled unit can be rigidly arranged relative to the actuator module 160. In this case, the coupling of the dosing module 100 can comprise inserting it into an opening (e.g., slot) between the holding module 150 and the actuator module 160. Alternatively, the holding module 150 and the actuator module 160 can be arranged in the coupled unit so as to be movable relative to one another (e.g., on a rail or by means of a rotation axis).In this case, coupling the dosing module 100 may include arranging the dosing module between the holding module 150 and the actuator module 160 and merging the holding module 150 and the actuator module 160.

[0148] The method may further comprise actuating the actuator module 160 to eject one or more drops from the outlet opening of the nozzle tube of the new dosing module. The method may comprise separating the assembly from the actuator module.

[0149] The actuation window of the two dosing modules improves the probability of the corresponding nozzle tube being aligned with respect to the actuator.

[0150] Inserting the portion of the dosing module 100 into the receiving portion 154 of the holding module 150 may involve engaging the first guide structures of the dosing module 100 with matching second guide structures of the holding module and / or third guide structures of the actuator module. Inserting the portion of the dosing module 100 into the receiving portion 154 of the holding module 150 may involve inserting one or more guide pins 152a, b into a respective first guide hole 114a, b and / or second guide hole 164a, b.

[0151] Forming the assembly may include inserting or placing the dosing module 100 into the receiving section 154 of the holding module 150 so that the calibration structure 159 is mechanically aligned with the actuation window 112. The dosing module 100 and the holding module 150 form a mechanically defined unit that can be received in the assembly by the actuator module 160. When the assembly is received in the actuator module 160, the calibration structure 159, the actuation window 112 with the nozzle tube 130, and the actuator 162 (e.g., a plunger thereof) can be brought into a mechanically predefined geometric arrangement relative to one another.

[0152] Coupling the assembly may include actuating the fastening mechanism. Releasing the coupled assembly may include releasing the fastening mechanism. Coupling the assembly may include connecting the fluid inlet opening 140 to a fluid reservoir.

[0153] Actuating the actuator module 162 may include providing power to a motor of the actuator 162. Actuating the actuator module 162 may include operating a user interface (e.g., an electrical switch, a rotary knob, or a touch-sensitive surface). Actuating the actuator module 162 may include repeatedly moving an actuator piston to repeatedly eject one or more droplets from the outlet opening 132 (e.g., by repeatedly squeezing and relaxing the elastic portion 134 of the nozzle tube 130).

[0154] Although features of the invention have been described in each case with reference to device features or method features, it will be apparent to those skilled in the art that corresponding features can also be part of a method or device. Thus, the device can be configured to perform corresponding method steps, and the respective functionality of the device can represent corresponding method steps.

[0155] In the foregoing Detailed Description, various features have been grouped together in examples in order to streamline the disclosure. This manner of disclosure should not be interpreted as intending that the claimed examples include more features than are expressly recited in each claim. Rather, as the following claims reflect, the subject matter may lie in fewer than all of the features of a single disclosed example. Accordingly, the following claims are hereby incorporated into the Detailed Description, with each claim being capable of standing as its own separate example.While each claim may stand as its own separate example, it should be noted that although dependent claims in the claims refer to a specific combination with one or more other claims, other examples also include a combination of dependent claims with the subject matter of any other dependent claim or a combination of any feature with other dependent or independent claims. Such combinations are intended to be encompassed unless it is stated that a specific combination is not intended. Furthermore, it is intended to encompass a combination of features of a claim with any other independent claim, even if that claim is not directly dependent on the independent claim.

[0156] The examples described above are merely illustrative of the principles of the present disclosure. It is understood that modifications and variations of the arrangements and details described will be apparent to those skilled in the art. Therefore, it is intended that the disclosure be limited only by the appended claims and not by the specific details set forth for the purpose of describing and explaining the examples.

Claims

Patent claims 1. Dosing module (100) for use in a dosing system, which is designed to dispense drops at an outlet opening (132) of the nozzle tube (130) by deformation of a nozzle tube (130), wherein the dosing module (100) has the following features: a holder (110), and a nozzle tube (130) which is fastened to the holder (110) and has the outlet opening (132), wherein the holder (110) has the following features: an actuation window (112) which penetrates the holder (110) and in which a section (134) of the nozzle tube (130) which is elastic in the radial direction is exposed, wherein sections (136a, b) of the nozzle tube (130) which are spaced apart from one another in the longitudinal direction of the nozzle tube (130) are formed by sections of the holder arranged on opposite sides of the actuation window (112). (110) are fixed.

2. Dosing module (100) according to claim 1, wherein the nozzle tube (130) has a smaller dimension than the holder (110) in the direction in which the actuating window (112) penetrates the holder (110), so that the nozzle tube is set back with respect to at least one surface of the holder (110) in which the actuating window (112) is formed.

3. Dosing module (100) according to claim 1 or 2, wherein the holder (110) further comprises a fluid inlet opening (140) fluidly coupled to the nozzle tube (130).

4. Dosing module (100) according to claim 3, wherein the fluid inlet opening (140) has a larger flow cross-section than the nozzle tube (130).

5. Dosing module (100) according to one of claims 3 or 4, wherein a flow direction perpendicular to the flow cross-section of the fluid inlet opening (140) is arranged at an angle to the longitudinal direction of the nozzle tube (130).

6. Dosing module (100) according to one of claims 3 to 5, wherein the holder (110) has a plate-shaped first section (116a) in which the nozzle tube (130) and the actuating window (112) are arranged, and a second section (116b) in which the fluid inlet opening (140) is arranged, wherein the second section (116b) protrudes radially relative to the first section (116a) with respect to the nozzle tube (130).

7. Dosing module (100) according to one of claims 1 to 6, which has first guide structures (114) for engaging with matching second guide structures (152) of a holding module (150) and / or third guide structures (164) of an actuator module (160).

8. A dosing system (10) comprising: a dosing module (100) according to any one of claims 1 to 7; a holding module (150) configured to hold the dosing module (100) on a first side; and an actuator module (160) configured to hold the dosing module (100) on a side opposite the first side, and comprising an actuator (162) configured to cause deformation of the nozzle tube (130) to dispense drops at an outlet opening (132) of the nozzle tube (130), wherein the dosing module (100) and at least one of the holding module (150) and the actuator module (160) are separate modules configured to be coupled to one another in an operating state and to be separated from one another again.

9. Dosing system (10) according to claim 8, wherein the actuating window (112) is formed in a plate-shaped portion (116a) of the dosing module (100), wherein the holding module (150) has a receiving portion (154) which is designed to at least partially receive the plate-shaped portion (116a) in the operating state.

10. Dosing system (10) according to claim 9, wherein the receiving section (154) has lateral walls (156a, b) which, in the operating state, are arranged on opposite sides of the plate-shaped section of the dosing module (100) and a rear wall (158) which, in the operating state, is arranged on the side of the dosing module (100) facing away from the actuator module (160). 1 1. Dosing system (10) according to claim 9 or 10 when dependent at least on claim 3, wherein the holder (1 10) has a section (1 16b) protruding from the plate-shaped section (1 16a), in which section the fluid inlet opening (140) is arranged and which protrudes radially relative to the first section (116a) with respect to the nozzle tube (130), wherein in the operating state the protruding section (116b) protrudes beyond an edge of the holding module (150) which is arranged in the longitudinal direction on the side of the holding module (150) facing away from the nozzle opening.

12. Dosing system (10) according to one of claims 8 to 11, wherein the dosing module (100) has first guide structures (114) and the holding module (150) has matching second guide structures (152) which are designed to engage with the first guide structures (114) and to bring the holding module (150) and the dosing module (100) into a mechanically defined position relative to one another.

13. Dosing system (10) according to claim 12, wherein the actuator module (160) has third guide structures (164) which are designed to cooperate with the first and / or second guide structures (114, 152) in order to bring the actuator module (160), the dosing module (100) and the holding module (150) into a mechanically defined position relative to one another.

14. Dosing system (10) according to claim 13, wherein the first guide structures (114) have one or more guide holes (114a, b) penetrating the dosing module (100), the second guide structures (152) have one or more guide pins (152a, b) and the third guide structures (164) have one or more guide holes (164a, b), wherein a guide pin (152a, b) of the second guide structures (152) is each configured to extend through a guide hole (114a, b) of the first guide structures (114) into a third guide hole (152a, b) when the dosing module (100), the holding module (150) and the actuator module (160) are coupled.

15. Dosing system (10) according to one of claims 8 to 14, wherein the holding module (150) and / or the actuator module (160) have a fastening mechanism designed to fasten the holding module (150) to the actuator module (160) in order to couple the dosing module (100), the holding module (150) and the actuator module (160) to one another.

16. Dosing system (10) according to one of claims 8 to 15, wherein the fastening mechanism comprises magnets on the holding module (150) and the actuator module (160).

17. Dosing system (10) according to one of claims 8 to 16, wherein the holding module (150) has a calibration structure (159) which is designed to cause a defined deformation of the elastic section (134) of the nozzle tube (130) exposed in the actuation window (112) when the dosing module (100), the holding module (150) and the actuator module (160) are coupled to one another and before the actuator (162) is actuated.

18. Dosing system (10) according to claim 17, wherein the calibration structure (159) has a projection on the holding module (150) which projects into the actuation window (112) in the operating state.

19. Dosing system (10) according to claim 17 or 18, wherein the calibration structure (159) deforms the elastic portion (134) of the nozzle tube (130) on a first side and the actuator (162) deforms the elastic portion (134) of the nozzle tube (130) on a second side opposite the first side when the dosing module (100), the holding module (150) and the actuator module (160) are coupled to one another and before the actuator (162) is actuated.

20. Dosing system (10) according to one of claims 8 to 19, wherein the holding module (150) has a handle (155) provided on a side opposite the dosing module (100) and allowing a user to couple the holding module (150) to the dosing module (100) and the actuator module (160).

21. A method (200) for dispensing a drop from a dosing system (10) according to any one of claims 8 to 20, comprising the following features: Providing (202) the dosing module (100) with a section (116a), the holding module (150) and the actuator module (160); Coupling (204) the dosing module (100) to the actuator module (160) and the holding module (150), wherein the portion (116a) of the dosing module (100) is arranged between the actuator module (160) and the holding module (150); Actuating (206) the actuator module (160) to eject one or more drops from the outlet opening (132) of the nozzle tube (130); and Separating (208) the dosing module (100) at least from the actuator module (160).

22. The method (200) according to claim 21, wherein the dosing module (100), the holding module (150) and the actuator module (160) are provided as separate components and the method (200) further comprises Forming a composite comprising the dosing module (100) and the holding module (150) by introducing the section (116a) of the dosing module (100) into a receiving section (154) of the holding module (150), wherein coupling (204) of the dosing module (100) to the actuator module (160) and the holding module (150) comprises coupling the composite to the actuator module (160).

23. The method (200) of claim 22, further comprising: after separating the assembly from the actuator module (160), replacing the dosing module (100) in the assembly with a new dosing module; Coupling the assembly containing the new dosing module with the actuator module (160) by detachably coupling the holding module (150) to the actuator module (160), wherein the portion of the new dosing module is arranged between the actuator module (160) and the holding module (150); Actuating the actuator module (160) to eject one or more drops from the outlet opening (132) of the nozzle tube (130) of the new dosing module; and separating the assembly from the actuator module (160).

24. The method (200) according to claim 21, wherein the holding module (150) and the actuator module (160) are provided as a coupled unit and the dosing module (150) is provided as a component separate from the coupled unit, wherein the coupling (204) of the dosing module (100) with the actuator module (160) and the holding module (150) is a Coupling the dosing module (100) to the coupled unit.

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