Aqueous composition based on a sennoside and at least one hydrotropic agent

Abstract

Aqueous composition based on an e sennoside and at least one hydrotropic agent The present invention relates to a cosmetic composition comprising at least one compound of formula (I) as defined below, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts, in particular of organic or mineral base or solvates such as hydrates, at least 8% by weight relative to the total weight of the composition of at least one hydrotropic agent, and water. Figure for the abstract: none

Description

Title of the invention: Aqueous composition based on a sennoside and at least one hydrotropic agent

[0001] The present invention relates to a cosmetic composition comprising: a. at least one compound of formula (I) as defined below, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts, in particular of organic or mineral base or solvated such as hydrates, b. at least 8% by weight relative to the total weight of the composition of at least one hydrotropic agent, and c. water.

[0002] Human skin is made up of two compartments, namely a deep compartment, the dermis, and a superficial compartment, the epidermis. The epidermis is in contact with the external environment, and its role is in particular to protect the body from dehydration and from external, chemical or mechanical attacks.

[0003] There is always a need for new cosmetic compositions having interesting properties, particularly on the skin.

[0004] Sennosides can be interesting active ingredients for this purpose. Indeed, this type of active ingredient is known in cosmetics, for example from application JP2002-255733.

[0005] However, sennosides are partially soluble in certain solvents such as methanol or acetone (which are not cosmetically acceptable solvents), and are not soluble in water, particularly at room temperature. They therefore do not allow, as such, the formulation of stable cosmetic compositions applicable to the skin.

[0006] The formulator is therefore looking for compositions comprising a sennoside such as sennoside A which are stable and applicable in particular topically (i.e. on the skin and / or mucous membranes).

[0007] Such compositions must further comprise a certain amount of water, in order to be able to formulate a sennoside such as sennoside A in a wide range of cosmetic carriers including lotions, gels or emulsions.

[0008] In this context, the inventors have surprisingly discovered that particular hydrotropic agents allow the solubilization of a sennoside such as sennoside A, and are compatible with a formulation in an aqueous medium.

[0009] The invention therefore aims to provide a cosmetic composition which responds to all these problems.

[0010] Indeed, as demonstrated in examples, the Applicant has discovered in a manner Surprisingly, sennoside A, although insoluble in water, glycols or various oils, is soluble from 0.5% by weight in an aqueous mixture comprising at least 8% by weight relative to the total weight of the composition of at least one hydrotropic agent.

[0011] Thus, the present invention relates to a cosmetic composition comprising: a. at least one compound of formula (I) as defined below, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts, in particular of organic or mineral base or solvated such as hydrates, b. at least 8% by weight relative to the total weight of the composition of at least one hydrotropic agent, and c. water.

[0012] Preferably, the present invention relates to a cosmetic composition consisting of: a. at least one compound of formula (I) as defined below, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts, in particular of organic or mineral base or solvated such as hydrates, b. at least 8% by weight relative to the total weight of the composition of at least one hydrotropic agent, and c. water.

[0013] For the purposes of the present invention, and unless otherwise indicated: - an “alkyl” radical is a saturated, linear or branched hydrocarbon radical, in particular C1-C6, preferably C1-C4; - a “(poly)(hydroxy) (C1-C6) alkyl” radical denotes a C1-C6 alkyl radical, preferably C1-C4, optionally substituted by one or more hydroxy radicals, preferably substituted by 1 to 4 hydroxy groups, more particularly between 1 and 3; - a "sugar" radical is a monosaccharide or disaccharide radical. Examples of sugar radicals include: sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose or lactose; - by "monosaccharide" is meant a monosaccharide sugar comprising at least 5 carbon atoms of formula CX(H2O)X, with x being an integer greater than or equal to 5, preferably x is greater than or equal to 6, in particular x is inclusively between 5 and 7, preferably x = 6. They may be of D or L configuration, and of alpha or beta anomer, as well as one of their salts or their solvates such as hydrates; - by "disaccharide" we mean a di-osidic sugar which is a compound consisting of two oses linked together by O-osidic bonds, said compounds being composed of two monosaccharides (also called mono-osidics) as defined above, said monosaccharide units comprising at least 5 carbon atoms, preferably 6, particularly the mono-osidic units are linked together in 1,4 or 1,6, in anomer α (alpha) or [3 (beta), each osidic unit being able to be of L or D configuration, as well as one of its salts or its solvates such as hydrates. A disaccharide is more particularly a polymer formed from two oses (or monosaccharides) having the general formula: -[Cx(H2O)y)]2- or -[(CH2O)X]2-, with x being an integer greater than or equal to 5, preferably x is greater than or equal to 6, in particular x is inclusively between 5 and 7, preferably x = 6, and y is an integer which represents x - 1; - by “organic or mineral base salt” we mean a salt of a base or alkaline agent such as alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, ammonia, amines, alkanolamines or salts of so-called “basic” amino acids such as lysine or arginine; - by “skin” we mean the skin of the face and / or body, the scalp; - by "annexes" we mean eyelashes, eyebrows, nails, and hair, in especially eyelashes and hair; - in what follows, and unless otherwise indicated, the limits of a domain of values ​​are included in this domain, in particular in the expressions “between” and “ranging from ... to ..."; - furthermore, the expression “at least one” used in this description is equivalent to the expression “one or more”.

[0014] The invention also relates to a method for caring for the skin and / or mucous membranes comprising the application of the composition according to the invention to the skin and / or mucous membranes.

[0015] The invention also relates to the use of a composition according to the invention for the care of the skin and / or mucous membranes.

[0016] The invention also relates to a final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight, preferably from 60% to 99%, and more preferably from 70% to 95% relative to the total weight of the composition of a composition as described above (i.e. comprising ingredients a) to c)). This final composition corresponds in particular to the final commercialized cosmetic product. Compound of formula (I) (compound (a))

[0017] The composition according to the invention comprises at least one compound of formula (I) or one of its optical isomers, cis-trans isomers (such as an alpha or beta anomer), tautomers or one of its salts, in particular of organic or mineral base, or one of its solvates such as hydrates:

[0018] [Chem.l]

[0019] in which:

[0020] - R' and R' ' are identical or different, preferably identical, and represent a H or a monosaccharide or a polysaccharide comprising up to 20 sugar units, preferably up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide possibly being substituted by a hydroxyl group which must be free, and optionally one or more amine function(s) which may be protected, and said monosaccharide or polysaccharide being optionally substituted on its -CH2OH group by a -C(O)-CO2 H group;

[0021] - R represents H or -C-(O)-O-Ri or -Alk-X-Rl, preferably -C-(O)-O-Ri or Alk- O-Ri,

[0022] with X being O, S or -NRi, preferably O; Ri being H or a saturated or unsaturated hydrocarbon chain, preferably saturated in C1-C6, more preferably RI corresponds to H, and Alk corresponds to a C1-C6 alkylene group, preferably -CH2-,

[0023] Advantageously, R' and R” are identical or different and represent a monosaccharide or a polysaccharide containing up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide having at least one hydroxyl function which is obligatorily free and / or optionally one or more amine functions which are obligatorily protected.

[0024] Advantageously, the monosaccharide is chosen from D-glucose, D-galactose, D-mannose, D-xylose, D-lyxose, L-fucose, L-arabinose, L-rhamnose, D-glucuronic acid, D-galacturonic acid, D-iduronic acid, N-acetyl-D-glucosamine and N-acetyl-D-galactosamine. The monosaccharide advantageously denotes D-glucose, L-rhamnose, D-xylose, N-acetyl-D-glucosamine or L-fucose, and more preferably D-glucose.

[0025] Advantageously, the polysaccharide containing up to 6 sugar units is chosen from D-maltose, D-lactose, D-cellobiose, D-maltotriose, a disaccharide combining a uronic acid chosen from D-iduronic acid or D-glucuronic acid with a hexosamine chosen from D-galactosamine, D-glucosamine, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, a disaccharide combining L-rhamnose and D-galactose, an oligosaccharide containing at least one xylose which may be advantageously chosen from xylobiose, methyl-[3-xylobioside, xylotriose, xylotetraose, xylopentaose and xylohexaose and in particular xylobiose which is composed of two xylose molecules linked by a 1-4 bond.

[0026] More preferably, R' and R' ' are identical and represent a monosaccharide chosen from D-glucose, D-xylose, L-fucose, L-rhamnose, D-galactose and D-maltose, preferably D-glucose.

[0027] The monosaccharide or polysaccharide of R' and / or R” may be substituted on one or more hydroxymethyl residue(s) by a -C(O)-COOH group.

[0028] Preferably, the compound of formula (I) or one of its optical isomers, cis-trans isomers (such as an alpha or beta anomer), tautomers or one of its salts, in particular of organic or mineral base or one of its solvates such as hydrates, is chosen from sennosides A, B, C, D, E and F, preferentially it is chosen from sennosides A and B, even more preferentially the compound of formula (I) is sennoside A or one of its salts.

[0029] The compound of formula (I) or one of its optical isomers, cis-trans isomers (such as an alpha or beta anomer), tautomers or one of its salts, in particular of organic or mineral base or one of its solvates such as hydrates, preferably sennoside A or one of its salts, is present in solubilized form in the composition. By "in solubilized form" is meant that said compound does not form crystals visible to the naked eye in the composition.

[0030] Sennoside A (C42H38O20) (or acid (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(h ydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid (IUP AC) is the chemical compound of formula (I') below:

[0031] [Chem.2]

[0032] Its CAS number is 81-27-6. It is a derivative of anthraquinone, found in plants of the genus Senna. It typically appears as a very hygroscopic yellow powder.

[0033] Sennoside A has 4 pKa, whose values ​​are pKal = 3.3, pKa2 = 3.9, pKa3 = 7.5 and its last pKa (pKa4) is equal to 8.2.

[0034] The compound of formula (I), preferably sennoside A, may also be in salt form. By "salt" is meant a cosmetically acceptable salt, i.e. compatible with application to the skin, mucous membranes and / or appendages. The salt of the compound of formula (I), preferably the salt of sennoside A, may be an alkali or alkaline earth metal salt, preferably a calcium, magnesium, sodium or potassium salt.

[0035] Typically, the salt of the compound of formula (I), preferably the sennoside salt such as sennoside A salt, may exist once the compound is introduced into the composition. Indeed, the compound of formula (I) is introduced in non-salified form into the composition.

[0036] Sennoside A is for example marketed by INTERCHIM under the name Sennoside A.

[0037] Preferably, the composition comprises between 0.1 and 5% by weight of the compound of formula (I) or one of its optical isomers, cis-trans isomers (such as an alpha or beta anomer), tautomers or one of its salts, in particular of organic or mineral base, or one of its solvates such as hydrates, relative to the total weight of the composition, preferably between 0.2 and 4% by weight, preferably between 0.3 and 3% by weight, preferably between 0.4 and 1% by weight.

[0038] Preferably, the composition comprises between 0.1 and 10% by weight of sennoside A or one of its salts relative to the total weight of the composition, preferably between 0.2 and 5% by weight, preferably between 0.3 and 3% by weight, preferably between 0.4 and 1% by weight. Hydrotropic agent

[0039] The composition according to the invention comprises at least 8% by weight relative to the total weight of the composition of at least one hydrotropic agent.

[0040] Preferably, the composition according to the invention comprises at least 8% by weight relative to the total weight of the composition of at least two hydrotropic agents.

[0041] Preferably, the hydrotropic agents are cosmetically acceptable hydrotropic agents.

[0042] By "hydrotrope" or "hydrotropic agent" is meant a water-soluble compound which has an amphiphilic molecular structure and which has the capacity to considerably increase the solubility of poorly water-soluble organic molecules.

[0043] Hydrotropes are similar to surfactants, but are distinguished by their hydrophobic part, which is shorter and does not allow spontaneous self-aggregation to occur. Unlike surfactants, these compounds do not have a critical micellar concentration.

[0044] Among the hydrotropic agents known from the prior art, mention may be made of sodium 1,3-benzenedisulfonate, sodium benzoate, sodium 4-pyridinecarboxylate (sodium PCA), sodium salicylate, sodium benzene sulfonate, caffeine, sodium p-toluene sulfonate, sodium butyl monoglycol sulfate, 4-aminobenzoic acid and its HCl salt, sodium cumene sulfonate, N,N-diethylnicotinamide, N-picolylnicotinamide, N-allylnicotinamide, 2-methacryloyloxyethyl phosphorylcholine, resorcinol, urea, hydroxyethyl urea, N,N-dimethyl urea, pyrogallol, N-picolylacetamide 3.5, procaine hydrochloride, proline hydrochloride, niacinamide (or nicotinamide), pyridine, 3-picolylamine, sodium ibuprofen, sodium xylene sulfonate, ethyl carbamate, pyridoxal hydrochloride, sodium benzoate, 2-pyrrolidone, ethylurea, N,N-dimethylacetamide, N-methylacetamide or isoniazid.

[0045] A list of hydrotropes is detailed in the following works: Lee J. et al, "Hy-drotropic Solubilization of Paclitaxel: Analysis of Chemical Structures for Hy-drotropic Property", Pharmaceutical Research, Vol. 20, No. 7, 2003, Lee S. et al, "Hy-drotropic Polymers: Synthesis and Characterization of Polymers Containing Picolylni-cotinamide Moieties", Macromolecules, 36, 2248-2255, 2003, and Hodgon TK, Kaler EW, "Hydrotropic Solutions", Current Opinion in Colloid and Interface Science,12, 121-128, 2007.

[0046] Cosmetically acceptable hydrotropes designate hydrotropes which are compatible with a cosmetic application, i.e. an application to the skin, mucous membranes and / or appendages.

[0047] Preferably, the appropriate hydrotrope according to the invention is chosen from the following hydrotropes and their mixtures:

[0048] [Tables 1] Name Structure Niacinamide (or nicotinamide) « TZ o= / O Caffeine ? PH3 N ch3 Urea î Cl ' NHg Sodium PCA 0: Mail Sodium Salicylate Na 0' . O Hydroxyethyl urea O z-\ jL.

[0049] Preferably, the composition according to the invention comprises at least one hydrotropic agent chosen from caffeine, niacinamide and their mixtures.

[0050] Preferably, the composition according to the invention comprises a mixture of caffeine and niacinamide.

[0051] Preferably, caffeine and niacinamide are present in the composition according to the invention in a caffeine:niacinamide weight ratio of between 0.5 and 1.5, preferably between 0.8 and 1.

[0052] Preferably, the amount of hydrotropic agent(s) in the composition according to the invention is between 8 and 20% by weight relative to the total weight of the composition, preferably between 8 and 15% by weight, preferably between 8 and 11% by weight.

[0053] Preferably, the weight ratio of hydrotropic agent(s): sennoside A or one of its salts in the composition according to the invention is at least 16:1. Water

[0054] The composition according to the invention comprises water.

[0055] The water used may be sterile demineralized water and / or a floral water such as rose water, cornflower water, chamomile water or linden water, and / or a natural thermal or mineral water such as VITTEL water, LUCAS water or LA ROCHE POSAY water.

[0056] The composition preferably comprises at least 30% by weight of water relative to the total weight of the composition, preferably at least 50% by weight, preferably at least 60% by weight, preferably at least 70% by weight.

[0057] The composition preferably comprises from 30% to 98% by weight of water relative to the total weight of the composition, more preferably from 50% to 97% by weight, even more preferably from 70% to 95% by weight.

[0058] Preferably, the composition according to the invention has a pH lower than the 4th pKa of the compound of formula (I), preferably lower than the 3rd pKa of the compound of formula (I). Preferably, the pH of the composition according to the invention is between 5.0 and 7.0, preferably between 6.0 and 7.0.

[0059] Indeed, in the present case, sennoside A is insoluble in water at its native pH, i.e. around 4.3. It is known that by raising the pH of a molecule beyond its last pKa, it becomes soluble. However, since sennoside A has 4 pKa and its last pKa is equal to 8.2, such a pH results in the formulation of sennoside A beyond 8.3, which is incompatible with topical cosmetic application, in particular on the skin and / or mucous membranes. Indeed, topical cosmetic compositions, in particular applicable to the skin and / or mucous membranes, must have an acceptable physiological pH, i.e. between 5.0 and 7.0.

[0060] Preferably, the composition according to the invention has a pH of less than 8.3, preferably less than 7.0.

[0061] Preferably, the present invention relates to a cosmetic composition comprising, preferably consisting of: a. sennoside A or one of its salts, b. at least 8% by weight relative to the total weight of the composition of at least two hydrotropic agents, and c. water.

[0062] Preferably, the present invention relates to a cosmetic composition comprising, preferably consisting of: a. sennoside A or one of its salts, b. at least 8% by weight relative to the total weight of the composition of a blend of caffeine and niacinamide, and c. water.

[0063] The composition according to the invention may also contain ingredients usual in the cosmetic field, such as preservatives, perfumes, fillers, oils, waxes, pasty fatty substances, sun protection filters or UV filters, odor absorbers, coloring materials, basic agents, sequestering agents or active ingredients.

[0064] The quantities of these different ingredients are those conventionally used in the field considered, and for example from 0.01 to 20% of the total weight of the composition. These ingredients, depending on their nature, can be introduced into the fatty phase and / or into the aqueous phase.

[0065] Of course, those skilled in the art will take care to choose the possible compound(s) to be added to the composition according to the invention and their quantities in such a way that the advantageous properties intrinsically attached to the composition in accordance with the invention are not, or not substantially, altered by the envisaged addition.

[0066] The composition in accordance with the invention can be obtained in a conventional manner by a person skilled in the art.

[0067] The invention also relates to a final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight relative to the total weight of the composition of a composition as described above (i.e. comprising ingredients a) to c)), preferably from 60 to 99% by weight, more preferably from 70 to 95% by weight. The final composition corresponds in particular to the final commercialized cosmetic product, based on sennoside. By cosmetically acceptable medium is meant a medium compatible with the skin and / or its appendages.

[0068] The invention also relates to a method for caring for the skin and / or mucous membranes comprising the application of the composition according to the invention or of the final composition according to the invention to the skin and / or mucous membranes.

[0069] The invention also relates to the use of a composition according to the invention or of the final composition according to the invention for the care of the skin and / or mucous membranes.

[0070] The following examples will allow a better understanding of the invention, without however being limiting in nature. The raw materials are named by their chemical or INCI name. The quantities indicated are in % by weight of raw materials relative to the total weight of the composition (% w / w), unless otherwise stated. Examples

[0071] Example 1: preparation of compositions according to the invention and evaluation by report to comparative compositions

[0072] Compositions according to the invention are compared with counterexamples. Procedure

[0073] The compositions of Tables 2 and 3 below are prepared as follows:

[0074] A caffeine and niacinamide mixture solution is made in water based on a rate of 4% or 5% caffeine and 5% niacinamide and a QS for 100% in water.

[0075] Sennoside A at 0.5% by weight is sprinkled into the beaker with the hydrotrope solution at different hydrotrope levels under magnetic stirring and heated to a maximum temperature of 50°C.

[0076] The stability of the compositions is evaluated after 2 months at 4°C (2M at 4°C) and after 2 months at room temperature (approximately 20°C) (2M at RT). Weight ratio caffeine: niacinamide = 1

[0077] [Tables2] Ingredients (% w / w) Example 1 according to the invention Example 2 according to the invention Counter-example 1 Counter-example 2 Counter-example 3 Sennoside A 0.5 0.5 0.5 0.5 0.5 Caffeine (CAFFEINE POWDER® from CSPC Innovation Pharma-ceutical) 4.98 4.5 3.5 2.5 Niacinamide (Niacinalide PC® from DSM NU-TRITIONAL PRODUCTS) 4.98 4.5 3.5 2.5 Water Qsp 100 Qsp 100 99.5 Qsp 100 Qsp 100 Sum caffeine+niacinamide (% w / w) 9.96 9 - 7 5 Observation Totally transparent solution Soluble Stable at 2M at 4°C and 2M at RT Totally transparent solution Soluble Stable at 2M at 4°C and 2M at RT Insoluble Soluble at RT but recrystallizes at 4°C Recrystallizes at RT and 4°C over time pH 4.6 4.6 4.5 4.6 4.6

[0078] TA = room temperature (approximately 20°C) Weight ratio caffeine: niacinamide = 0.8

[0079] [Tables3] Ingredients (% w / w) Example 3 according to the invention Example 4 according to the invention Counter-example 1 Counter-example 4 Counter-example 5 Sennoside A 0.5 0.5 0.5 0.5 0.5 Caffeine (CAFFEINE POWDER® from CSPC Innovation Pharma-ceutical) 3.98 3.6 2.8 2 Niacinamide (Niacinalide PC® from DSM NU-TRITIONAL PRODUCTS) 4.98 4.5 3.5 2.5 Water Qsp 100 Qsp 100 99.5 Qsp 100 Qsp 100 Sum caffeine+niacinamide (% w / w) 8.96 8.1 - 7.3 4.5 Observation Totally transparent solution Soluble Stable at 2M at 4°C and 2M at RT Totally transparent solution Soluble Stable at 2M at 4°C and 2M at RT Insoluble Soluble at RT but recrystallizes at 4°C Recrystallizes at RT and 4°C over time pH 4.8 4.7 4.5 4.7 4.7

[0080] TA = room temperature (approximately 20°C)

[0081] The results show that sennoside A is insoluble in water. However, by adding a mixture of hydrotropic agents caffeine and niacinamide in a total quantity greater than or equal to 8% by weight relative to the total weight of the composition, in particular for a caffeine:niacinamide weight ratio of between 0.8 and 1, sennoside A becomes soluble.

[0082] Sennoside A solutions remain clear over time, even at a pH of 4.7 (pH at which sennoside A is not soluble in water).

Claims

1. Claims Cosmetic composition comprising: (a) at least one compound of formula (I) or one of its optical isomers, cis-trans isomers, tautomers or one of its salts, in particular of organic or mineral base or its solvates such as hydrates: [Chem.l] (I) in which: - R' and R' ' are identical or different, preferably identical, and represent an H or a monosaccharide or a polysaccharide comprising up to 20 sugar units, preferably up to 6 sugar units, in pyranose and / or furanose form and of L and / or D series, said mono- or polysaccharide possibly being substituted by a hydroxyl group which must be free, and optionally one or more amine function(s) which may be protected, and said monosaccharide or polysaccharide being optionally substituted on its -CH2OH group by a -C(O)-CO2H group; - R represents H or -C-(O)-O-Ri or -Alk-X-Rl, preferably -C-(O)-OR! or Alk-O-Rj, with X being O, S or -NRb, preferably O; RI being H or a saturated or unsaturated hydrocarbon chain, preferably saturated in C1-C6, more preferably RI corresponds to H, and Alk corresponds to a C1-C6 alkylene group, preferably -CH2-, a. at least 8% by weight relative to the total weight of the composition of at least one hydrotropic agent, and b. water.

2. Composition according to claim 1, wherein the compound of formula (I) is such that R' and R' ' are identical and represent a monosaccharide chosen from D-glucose, D-galactose, D-mannose, D-xylose, D-lyxose, L-fucose, L-arabinose, L-rhamnose, D-glucuronic acid, D-galacturonic acid, D-iduronic acid, N-acetyl-D-glucosamine and N-acetyl-D-galactosamine, preferably chosen from D-glucose, L-rhamnose, D-xylose, N-acetyl-D-glucosamine and L-fucose, and more preferably D-glucose; preferably the compound of formula (I) or one of its optical isomers, cis-trans isomers, tautomers or one of its salts, in particular of organic or mineral base or one of its solvates such as hydrates, is chosen from sennosides A, B, C, D, E and F, preferentially it is chosen from sennosides A and B.

3. Composition according to one of the preceding claims, in which the compound of formula (I) is sennoside A or one of its salts.

4. Composition according to one of the preceding claims, which comprises between 0.1 and 10% by weight of compound of formula (I) or one of its salts relative to the total weight of the composition, preferably between 0.2 and 5% by weight, preferably between 0.3 and 3% by weight, preferably between 0.4 and 1% by weight.

5. Composition according to one of the preceding claims, in which the hydrotropic agent is chosen from niacinamide, caffeine, urea, sodium 4-pyridinecarboxylate (sodium PCA), sodium salicylate, hydroxyethyl urea and mixtures thereof; preferably the hydrotropic agent is chosen from caffeine, niacinamide and mixtures thereof.

6. Composition according to one of the preceding claims, which comprises at least 8% by weight relative to the total weight of the composition of at least two hydrotropic agents.

7. Composition according to one of the preceding claims, in which the quantity of hydrotropic agent(s) is between 8 and 20% by weight relative to the total weight of the composition, preferably between 8 and 15% by weight, preferably between 8 and 11% by weight.

8. Composition according to one of the preceding claims, in which the hydrotropic agent is a mixture of caffeine and niacinamide, preferably in a caffeine:niacinamide weight ratio of between 0.5 and 1.5, preferably between 0.8 and 1.

9. Composition according to one of the preceding claims, which comprises at least 30% by weight of water relative to the total weight of the composition, preferably at least 50% by weight, preferably at least 60% by weight, preferably at least 70% by weight; preferably comprises from 30% to 98% by weight of water relative to the total weight of the composition, more preferably from 50% to 97% by weight, even more preferably from 70% to 95% by weight.

10. Composition according to one of the preceding claims, which has a pH of less than 8.3, preferably less than 7.0, preferably between 5.0 and 7.0, preferably between 6.0 and 7.

0.

11. Composition according to one of the preceding claims, which consists of: a. at least one compound of formula (I) as defined below, or one of its optical isomers, cis-trans isomers, tautomers or one of its salts, in particular of organic or mineral base or solvated such as hydrates, b. at least 8% by weight relative to the total weight of the composition of at least one hydrotropic agent, and c. water.

12. Final cosmetic composition comprising, in a cosmetically acceptable medium, at least 50% by weight, preferably from 60% to 99% by weight, more preferably from 70% to 95% by weight relative to the total weight of the composition of a composition according to one of claims 1 to 11.

13. A method of caring for the skin and / or mucous membranes comprising the application of the composition according to one of the preceding claims to the skin and / or mucous membranes.

14. Use of a composition according to one of claims 1 to 11 or 12 for the care of the skin and / or mucous membranes.