Dietary supplement for brain health

Abstract

Brain Health Dietary Supplement. The invention relates to a dietary supplement comprising natural, fat-soluble ingredients derived from plants: a vegetable oil rich in omega-3 fatty acids, three synergistic essential oils, two fat-soluble vitamins, and a potent organic antioxidant. The combination of ingredients in NeuroZen Vital offers synergistic potential to support brain health and cognitive function. The essential oils of lavender, Roman chamomile, and bergamot provide anxiolytic and neuroprotective effects, while flaxseed oil, alpha-lipoic acid, vitamin D, and vitamin E provide anti-inflammatory, antioxidant, and neuroprotective effects. Together, these ingredients help reduce oxidative stress and inflammation and improve neurotransmission, thereby promoting overall brain health.

Description

Title of the invention: Dietary supplement for brain health

[0001] Technical field of the invention

[0002] This invention relates to a dietary supplement intended to improve brain health. It is a next-generation dietary supplement that acts on the fundamental causes of cellular aging and disease, in a preventative manner. It is the first next-generation dietary supplement to specifically target the causes of cellular aging, particularly in brain cells: • Oxidation • Glycation • Inflammation • Stress.

[0003] Context

[0004] The brain health products market is booming, with increasing demand for natural solutions. Consumers are looking for natural and effective solutions for cognitive support and stress management.

[0005] Based on extensive research, it appears that no formula exactly identical to ours currently exists on the market. Our unique combination of omega-3-rich flaxseed oil, specific essential oils, alpha-lipoic acid, vitamin D, and vitamin E for brain health represents an interesting innovation in the field of dietary supplements.

[0006] This food supplement has significant commercial potential with a "Unique Selling Proposition" (USP).

[0007] Object of the invention

[0008] Our research inventors have developed an optimal composition based on natural, biochemically identifiable ingredients recognized for their effectiveness in promoting brain health. Blended together, these ingredients create a synergy that enhances their efficacy, as they have been selected in optimal proportions. (0004) This dietary supplement is distinguished by its balanced and scientifically validated composition, including the recommended amounts of essential vitamins and nutrients to optimize brain health and cognitive function. The ingredients are carefully selected and dosed to ensure maximum synergy and optimal absorption, thus offering a holistic approach to the prevention of neurodegenerative diseases and stress management.

[0009] This food supplement is distinguished by its balanced composition and

[0010] scientifically validated, including the recommended amounts of essential vitamins and nutrients to optimize brain health and cognitive function. The ingredients are carefully selected and dosed to ensure maximum synergy and optimal absorption, thus offering a holistic approach to the prevention of neurodegenerative diseases and stress management.

[0011] I. Brief description of the invention

[0012] The present invention is a food supplement which contains ingredients of natural and plant origin.

[0013] This food supplement contains the following ingredients: • A vegetable oil rich in omega-3, • 3 essential oils that create a synergy • 2 fat-soluble vitamins • 1 powerful antioxidant, organic compound

[0014] According to the preferred embodiment of the invention, the food supplement contains fat-soluble ingredients, for better assimilation, of natural and plant origin, which is suitable for all consumers: • Vegans • Vegetarians • Omnivores The food supplement according to the invention is packaged in soft, plant-based, gastro-resistant capsules for greater effectiveness.

[0015] According to the preferred embodiment of the invention, the formula, developed by the inventors, is well designed to support brain health through a combination of soothing, antioxidant, and neuroprotective ingredients.

[0016] The choice of the name "NeuroZen Vital" helps to communicate the benefits of the product for cognitive and emotional health.

[0017] IL Detailed description:

[0018] Product Name: NeuroZen Vital

[0019] A. Qualitative Composition of the Product

[0020] According to a preferred embodiment of the invention, the qualitative composition of the food supplement is exclusively plant-based with biologically pure ingredients of pharmacological quality:

[0021] 1. Linseed oil (Linum usitatissimum L.) Main active compounds: - Alpha-linolenic acid (ALA): 50-60% - Linoleic acid: 15-20% - Oleic acid: 10-15% - Palmitic acid: 5-7% - Stearic acid: 2-4% 2. Essential oils:

[0022] o True lavender (Lavandula angustifolia) Main active compounds: - Linalool: CwHisO - Linalyl acetate: C12H2OO2 - Cineol (1,8-cineole): CwHisO - Camphor: CwHisO - Limonene: C10H16 - Ocimène: CwHw - Terpinene-4-ol: CwHisO - Lavandulol: CwHisO - Geraniol: CwHisO o Roman chamomile (Chamaemelum nobile) Main active compounds: - Isobutyl angelate: C7H12O2 - Isoamyl angelate: C8H14O2 - Methylallyl angelate: C7H12O2 - Anthemis: CwHie - Pinocarvone: CwHi40 - Camphor: CwHisO - B-Famesene: C15H24 o Bergamot (Citrus bergamia) Main active compounds: - Limonene: CwHw - Linalool: CwHisO - Linalyl acetate: C12H2OO2 - Bergapten: C12H8O4 (a furocoumarin) - Nerol: CwHisO - Geraniol: CwHisO - Terpineol: CwHisO 1. Alpha lipoic acid C8H14O2S2 (R 5(1,2-dithiolan3-pentanoic acid) 2. Vitamin D2 of plant origin (Ergocalciferol) C28H44O 3. Vitamin E of plant origin C29H50O2 Alpha-Tocopherol - Ingredients and their properties

[0023] 1. (0009) Linseed oil, biologically pure of pharmacological grade which has followed Rigorous procedures guarantee the purity, quality, and preservation of bioactive compounds, rich in omega-3 fatty acids (ALA) 60%, essential for neuronal health and cognitive function. Composition of flaxseed oil

[0024] Linseed oil (Linum usitatissimum) is mainly composed of: - Alpha-linolenic acid (ALA) (C18H3OO2): 50-60% - Linoleic acid (C18H32O2): 15-20% - Oleic acid (C18H34O2): 10-15% - Palmitic acid (C16H32O2): 5-7% - Stearic acid (C18H36O2): 3-5% - Lignans (notably secoisolariciresinol diglucoside (SDG)) - Reactions of linseed oil with brain cells

[0025] Flaxseed oil is rich in alpha-linolenic acid (ALA), an essential omega-3 fatty acid, which plays a crucial role in brain health. Here's how flaxseed oil and its components interact with brain cells: 1. Cognitive function and neuronal health: • Conversion to EPA and DHA: In the body, ALA can be converted into eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are omega-3 fatty acids essential for optimal brain function. DHA, in particular, is a major component of neuronal cell membranes and is crucial for the fluidity and functionality of these membranes. • Neurogenesis and synaptic plasticity: Omega-3s, including ALA, play a role in neurogenesis (the formation of new neurons) and synaptic plasticity (the ability of synapses to strengthen or weaken), thus improving memory and learning. • Anti-inflammatory properties: • Reduction of pro-inflammatory cytokines: ALA and its metabolites (EPA and DHA) can reduce the production of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), thereby reducing neuronal inflammation. Chronic inflammation in the brain is linked to neurodegenerative disorders such as Alzheimer's disease. • Modulation of inflammatory pathways: Omega-3s modulate inflammatory pathways, notably by influencing prostaglandins and leukotrienes, which contributes to better brain health. • Protection against oxidative stress: • Natural antioxidants: The lignans present in flaxseed oil have antioxidant properties. They help neutralize free radicals, thus protecting brain cells from oxidative damage. • Protection of cell membranes: ALA helps maintain the integrity of neuronal cell membranes, protecting them against damage caused by oxidative stress. • Mental health and mood: • Neurotransmitter regulation: Omega-3s play a role in regulating neurotransmitters such as dopamine and serotonin, which are crucial for mood, behavior, and cognition. A good balance of these neurotransmitters can help prevent mood disorders such as depression and anxiety. • Reducing the risk of mental disorders: Adequate levels of omega- 3, including those derived from ALA, are associated with a reduced risk of mental disorders such as depression, anxiety, and bipolar disorder. Conclusion

[0026] Linseed oil, thanks to its rich content of alpha-linolenic acid (ALA) and lignans, offers numerous benefits for brain cells. It contributes to cognitive function, neurogenesis, and the

[0027] synaptic plasticity, reduction of neuronal inflammation, protection against oxidative stress, and regulation of mental health and mood. By incorporating flaxseed oil into the diet, one can support brain health and reduce the risk of various neurodegenerative and mental disorders.

[0028] 2. Essential oils:

[0029] True lavender (Lavandula angustifolia) • Soothing and relaxing effects, helps reduce stress and anxiety, antimicrobial. • Main components and chemical formulas: - Linalool: CwHisO - Linalyl acetate: C12H2OO2 - Cineol (1,8-cineole): CwHisO - Camphor: CwHisO - Limonene: C10H16 - Ocimène: CwHw - Terpinene-4-ol: CwHisO - Lavandulol: CwHisO - Geraniol: CwHisO - Effects of true lavender essential oil on the brain

[0030] True lavender (Lavandula angustifolia) essential oil is recognized for its numerous therapeutic benefits, particularly for its effects on the peripheral nervous system and the brain (central nervous system). Here are the main actions of true lavender essential oil on the brain

[0031] : 1. Anxiolytic effect and stress reduction

[0032] Mechanism: Compounds in lavender essential oil, such as linalool and linalyl acetate, interact with GABA (gamma-aminobutyric acid) receptors in the brain, which play a key role in regulating anxiety.

[0033] Effects: This interaction helps to reduce excessive neuronal activity, thereby inducing a feeling of calm and relaxation, which can lower levels

[0034] of stress and anxiety. 1. Mood improvement

[0035] Mechanism: Lavender essential oil influences the release of neurotransmitters such as serotonin and dopamine, which are essential for mood regulation. 1. Sedative effect and improved sleep

[0036] Mechanism: The volatile compounds of lavender essential oil have a sedative effect by modulating the activity of the central nervous system.

[0037] Effects: Using lavender oil before bedtime can improve sleep quality, reduce insomnia and prolong the duration of deep sleep. 1. Neuroprotective effect

[0038] Mechanism: The antioxidant properties of lavender essential oil help to neutralize free radicals and reduce oxidative stress

[0039] in the brain.

[0040] Effects: This contributes to the protection of neuronal cells against damage, which may have preventive effects against diseases

[0041] neurodegenerative. 1. Pain reduction

[0042] Mechanism: Lavender essential oil acts on opioid receptors and pain signaling pathways in the nervous system.

[0043] Effects: It can reduce the perception of pain and is often used in aromatherapy to relieve headaches, migraines, and pain

[0044] neuropathic. 1. Improved cognition and memory

[0045] Mechanism: The relaxing and anti-anxiety effects of lavender oil may indirectly improve concentration, alertness and memory.

[0046] Effects: By reducing stress and anxiety, lavender oil can help improve cognitive performance and prevent memory deficits.

[0047] Conclusion

[0048] True lavender essential oil has numerous beneficial effects on the brain thanks to its anxiolytic, sedative, and neuroprotective properties.

[0049] and analgesic. These effects are mainly due to its active compounds, such as linalool and linalyl acetate, which interact with neurotransmission systems and reduce oxidative stress.

[0050] Therefore, lavender essential oil can be used to improve mental health, sleep quality, and general well-being.

[0051] - Reactions of true lavender essential oil with body cells 1. Calming and anxiolytic effects: • Interaction with the nervous system: Linalool and linalyl acetate act on the central nervous system by binding to GABA (gamma-aminobutyric acid) receptors. This increases the inhibitory effect of GABA, reducing neuronal excitability and inducing a state of relaxation and calm. • Cortisol reduction: These compounds can decrease levels of cortisol, the stress hormone, helping to reduce anxiety and stress. • Anti-inflammatory properties: • Modulation of inflammatory mediators: Compounds such as linalool and terpinene-4-ol inhibit the production of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-a), thereby reducing inflammation. • Inhibition of pro-inflammatory enzymes: They can inhibit enzymes such as cyclooxygenase (COX), reducing the production of prostaglandins involved in inflammation. • Analgesic properties: • Interaction with pain receptors: Linalool and linalyl acetate interact with pain receptors (nociceptors), reducing the perception of pain. • Effect on neurotransmitters: They influence the release of neurotransmitters such as serotonin and endorphins, thus modulating the sensation of pain. • Antimicrobial properties: • Disruption of microbial cell membranes: Compounds such as linalool and cineole disrupt the cell membranes of bacteria and fungi, inhibiting their growth and multiplication. • Antibacterial effect: These components can destroy the cell walls of bacteria, causing their lysis. • Antioxidant properties: • Neutralization of free radicals: The components of lavender oil possess antioxidant properties, helping to neutralize free radicals and protect cells against oxidative stress. • Cell protection: This helps protect cells from damage and premature aging. • Effects on cell regeneration: • Promotes wound healing: Linalool and lavandulol can promote skin cell regeneration, accelerating healing wounds and burns. • Stimulation of collagen synthesis: These compounds can stimulate collagen production, improving tissue repair and healing. • Conclusion True lavender essential oil interacts beneficially with our body's cells thanks to its calming, anti-inflammatory, analgesic, antimicrobial, antioxidant, and regenerative properties. These properties make it an excellent choice for managing

[0052] of stress, anxiety, pain, inflammation, infection and for the promotion of wound healing.

[0053] Roman chamomile (Chamaemelum nobile): • Calming effects, helps reduce anxiety and stress, improves digestion. • Main components and chemical formulas: - Isobutyl angelate: C7H12O2 - Isoamyl angelate: C8H14O2 - Methylallyl angelate: C7H12O2 - Anthemis: C10H16 - Pinocarvone: CioH-uO - Camphor: CwHieO - B-Farnesene: C15H24

[0054] Roman chamomile (Chamaemelum nobile) essential oil has many therapeutic properties thanks to its active components.

[0055] Here is how it interacts with the cells in our body:

[0056] - Reactions of Roman chamomile essential oil with body cells 1. Calming and anxiolytic effects: • Interaction with the nervous system: Compounds such as isobutyl angelate and isoamyl angelate act on the system central nervous system by modulating GABA (gamma-aminobutyric acid) receptors, which are inhibitory receptors. This leads to a reduction in neuronal excitation, promoting a state of relaxation and calm. • Reduction of cortisol levels: These compounds can also reduce levels of cortisol, the stress hormone, thus helping to alleviate anxiety and stress. 2. Anti-inflammatory properties: • Modulation of inflammatory mediators: Components of the essential oil, such as angelates, interact with immune cells to reduce the production of pro-inflammatory cytokines. This decreases inflammation and helps relieve inflammatory conditions such as arthritis. • Inhibition of pro-inflammatory enzymes: They can also inhibit the activity of enzymes such as cyclooxygenase (COX), thereby reducing the production of prostaglandins, which are mediators of inflammation. 3. Antispasmodic properties: • Smooth muscle relaxation: Components such as isobutyl angelate have relaxing effects on the smooth muscles of the gastrointestinal tract, which helps to relieve digestive spasms and cramps. • Interaction with muscarinic receptors: These compounds can modulate muscarinic acetylcholine receptors, thereby reducing involuntary muscle contractions. 4. Analgesic properties: • Interaction with pain receptors: The components of Roman chamomile essential oil can interact with pain receptors (nociceptors), thus reducing the sensation of pain. • Effect on neurotransmitters: They can also influence the release of neurotransmitters involved in pain modulation, such as serotonin and endorphins. 5. Antimicrobial properties: • Disruption of microbial cell membranes: Compounds such as angelates can disrupt the cell membranes of bacteria and fungi, inhibiting their growth and multiplication. • Stimulation of the immune response: These components can stimulate immune system cells, strengthening the body's defense against infections. 6. Antioxidant properties: • Neutralization of free radicals: The components of Roman chamomile essential oil possess antioxidant properties, which help to neutralize free radicals and protect cells against oxidative stress. • Cell protection: This helps protect cells from damage and premature aging. Conclusion

[0057] Roman chamomile essential oil interacts beneficially with the cells in our body, offering calming, anti-inflammatory, antispasmodic, analgesic, antimicrobial, and antioxidant effects. These properties make it an excellent choice for managing stress, anxiety, pain, inflammation, and infections.

[0058] - Actions of Roman chamomile essential oil on the cells of our brain

[0059] Roman chamomile (Chamaemelum nobile) essential oil is known for its calming and relaxing properties. It contains various bioactive compounds, such as angelica esters (isobutyl, isoamyl, and methylallyl angelates), bisabolol, and farnesene, which contribute to its therapeutic effects.

[0060] Here's how this essential oil acts on our brain cells

[0061] :

[0062] 1. Anxiolytic effect and stress reduction • Mechanism: Volatile compounds in Roman chamomile essential oil, such as angelica esters, interact with GABA (gamma-aminobutyric acid) receptors in the brain. • Effects: This interaction potentiates the inhibitory effect of GABA, thereby reducing neuronal excitability and inducing a feeling of calm and relaxation. This helps to decrease stress and anxiety levels. 2. Sedative effect and improved sleep • Mechanism: Components such as bisabolol and farnesene have sedative properties that modulate the activity of the central nervous system. • Effects: The use of Roman chamomile essential oil can promote relaxation, reduce insomnia and improve the quality and duration of sleep by facilitating falling asleep and increasing the proportion of deep sleep. 3. Anti-inflammatory effect • Mechanism: Anti-inflammatory compounds present in Roman chamomile essential oil, such as bisabolol, inhibit the production of pro-inflammatory cytokines and reduce the activity of inflammatory signaling pathways. • Effects: By reducing neuronal inflammation, Roman chamomile essential oil protects brain cells from inflammatory damage, which is beneficial for neuroinflammatory conditions. 4. Neuroprotective effect • Mechanism: The antioxidants present in Roman chamomile essential oil, such as flavonoids, neutralize free radicals and reduce oxidative stress in the brain. • Effects: This antioxidant action protects neurons against oxidative damage and environmental stresses, thus helping to prevent neurodegenerative diseases and maintain neuronal health. 5. Pain reduction • Mechanism: The active compounds in Roman chamomile essential oil interact with opioid receptors and pain signaling pathways in the nervous system. • Effects: It can lessen the perception of pain and is often used to relieve headaches, migraines, and other types of neuropathic pain. 6. Improved cognition and memory • Mechanism: By reducing stress and inflammation, Roman chamomile essential oil can improve cognitive function by preserving integrity neuronal and by facilitating neurotransmission. • Effects: Indirect anxiolytic and anti-inflammatory effects contribute to better concentration, improved memory and increased overall cognitive performance.

[0063] Conclusion

[0064] Roman chamomile essential oil exerts significant beneficial effects on the brain due to its anxiolytic, sedative, anti-inflammatory, and neuroprotective properties. The oil's bioactive compounds, such as angelica esters and bisabolol, play a key role in these effects by modulating GABA receptors, reducing inflammation, and neutralizing free radicals. Therefore, the essential oil of

[0065] Roman chamomile is a valuable tool for stress management, sleep improvement, pain reduction and cognitive health protection.

[0066] Bergamot (Citrus bergamia) essential oil

[0067] ■ Anxiolytic and antidepressant properties, improves mood.

[0068] The main constituents and their chemical formulas: - Limonene: CwHw - Linalool: CwHisO - Linalyl acetate: C12H2OO2 - Bergapten: C12H8O4 (a furocoumarin) - Nerol: CwHisO - Geraniol: CwHisO - Terpineol: CwHisO - Reactions of bergamot essential oil with body cells

[0069] Bergamot essential oil has several beneficial properties that interact with the cells of our body: 1. Anxiolytic and antidepressant effect: • Interaction with the nervous system: Components such as linalool and linalyl acetate act on the central nervous system by increasing the production of neurotransmitters such as serotonin and dopamine, which plays a crucial role in mood regulation. • Cortisol reduction: These components can also reduce levels of cortisol, a stress hormone, which helps to decrease anxiety and symptoms of depression. • Anti-inflammatory and analgesic properties: • Modulation of inflammatory mediators: Limonene and other terpenoids present in bergamot oil can modulate inflammatory mediators such as prostaglandins and cytokines, thus reducing inflammation. • Interaction with pain receptors: These compounds can interact with pain receptors (nociceptors), thereby decreasing the perception of pain. • Antimicrobial effect: • Disruption of microbial cell membranes: Compounds such as limonene and linalool can disrupt the cell membranes of bacteria and fungi, inhibiting their growth and multiplication. • Stimulation of the immune response: These components can also stimulate certain cells of the immune system, improving the immune response against infections. Conclusion

[0070] Bergamot essential oil interacts in various ways with the cells of our body, offering beneficial effects for

[0071] mood, pain, inflammation, and infections.

[0072] - Actions of bergamot essential oil on our brain cells

[0073] Bergamot (Citrus bergamia) essential oil is known for its beneficial effects on the nervous system and mental health. It contains various bioactive compounds, including limonene, linalool, linalyl acetate, and bergaptene, which contribute to its therapeutic properties.

[0074] Here's how this essential oil acts on our brain cells: 1. Anxiolytic effect and stress reduction • Mechanism: The main volatile compounds in bergamot essential oil, such as linalool and linalyl acetate, interact with GABA (gamma-aminobutyric acid) receptors in the brain. • Effects: This interaction potentiates the inhibitory effect of GABA, thereby reducing neuronal excitability and inducing a feeling of calm and relaxation. This helps to reduce stress and anxiety levels.

[0075] 2. Antidepressant effect and mood improvement • Mechanism: Bergamot essential oil influences the release of neurotransmitters such as serotonin and dopamine, which are essential for mood regulation. • Effects: Inhaling or applying bergamot oil may improve mood, increase feelings of well-being, and reduce symptoms of depression. 3. Sedative effect and improved sleep • Mechanism: Components such as linalool have sedative properties that modulate the activity of the central nervous system. • Effects: Using bergamot essential oil before bedtime can promote relaxation, reduce insomnia, and improve sleep quality. 4. Neuroprotective effect • Mechanism: The antioxidant properties of bergamot essential oil help to neutralize free radicals and reduce oxidative stress in the brain. • Effects: This antioxidant action protects neurons against oxidative damage and environmental stresses, thus helping to prevent neurodegenerative diseases and maintain neuronal health.

[0076] 5. Pain reduction • Mechanism: The active compounds in bergamot essential oil interact with opioid receptors and pain signaling pathways in the nervous system. • Effects: It can lessen the perception of pain and is often used to relieve headaches, migraines, and other types of neuropathic pain. 6. Improved cognition and memory • Mechanism: By reducing stress and inflammation, bergamot essential oil can improve cognitive function by preserving neuronal integrity. and by facilitating neurotransmission. • Effects: Indirect anxiolytic and anti-inflammatory effects contribute to better concentration, improved memory and increased overall cognitive performance. Conclusion

[0077] Bergamot essential oil exerts significant beneficial effects on the brain due to its anxiolytic and sedative properties,

[0078] antidepressant, anti-inflammatory, and neuroprotective. The bioactive compounds in the oil, such as linalool and linalyl acetate, play a key role in these effects by modulating GABA receptors, influencing mood neurotransmitters, and reducing oxidative stress. Therefore, bergamot essential oil is a valuable tool for the

[0079] stress management, mood improvement, pain reduction and protection of cognitive health.

[0080] 5. Alpha lipoic acid:

[0081] Chemical composition of alpha-lipoic acid

[0082] Alpha-lipoic acid (ALA), also known as thioctic acid, is an organosulfur compound derived from octanoic acid. Its chemical formula is C8H14O2S2, and its structure comprises two sulfur atoms and a hydrocarbon chain.

[0083] - Reactions of alpha-lipoic acid with brain cells

[0084] Alpha-lipoic acid plays several important roles in brain function and neuronal protection: 1. Powerful antioxidant: • Free radical neutralization: ALA is a powerful antioxidant that can neutralize free radicals and reduce oxidative stress in brain cells. It is unique in that it is soluble in both water and fats, thus providing broad antioxidant protection in different parts of the cell. • Regeneration of other antioxidants: ALA can regenerate other antioxidants such as vitamin C and vitamin E, as well as glutathione, prolonging their protective activity against oxidative damage. 2. Improvement of mitochondrial function: • Stimulation of energy production: ALA plays a crucial role in mitochondria, the energy powerhouses of cells. It is an essential cofactor for enzymes involved in the Krebs cycle, which enhances the production of ATP, the main source of energy for cells. • Mitochondrial protection: By reducing oxidative stress, ALA protects mitochondria from damage, thus ensuring efficient energy production and reducing the risk of mitochondrial dysfunction, often linked to neurodegenerative diseases. 3. Neuroprotective effect: • Reduction of neuronal inflammation: ALA can decrease inflammation in the brain by inhibiting the production of pro-inflammatory cytokines and modulating inflammatory signaling pathways, thus protecting neurons from inflammatory damage. • Protection against apoptosis: ALA can prevent apoptosis (programmed cell death) of neurons by modulating cell signaling pathways, which is crucial for preventing neurodegenerative diseases such as Alzheimer's and Parkinson's disease. 1. Improved cognition and memory: • Reduction of oxidative stress: By reducing oxidative stress, ALA can improve cognitive function and memory by protecting neurons and improving synaptic transmission. • Increased neurotransmitters: ALA can increase levels of neurotransmitters such as acetylcholine, which is crucial for memory and learning. This can improve abilities cognitive and information retention. 1. Protection against neurodegenerative diseases: • Reduction of toxic protein accumulation: ALA may help reduce the accumulation of toxic proteins such as beta-amyloid in the brain, a key feature of Alzheimer's disease. • Enhanced synaptic plasticity: By protecting neurons and improving synaptic signaling, ALA can promote synaptic plasticity, which is essential for learning and memory. Conclusion

[0085] Alpha-lipoic acid, with its powerful antioxidant activity and crucial role in mitochondrial function, offers numerous benefits for brain health. It protects brain cells against stress

[0086] oxidative, improves energy production, reduces neuronal inflammation, prevents apoptosis, and promotes cognition and memory. By incorporating ALA as a supplement, brain health can be supported and

[0087] potentially reduce the risk of neurodegenerative diseases. 1. Biologically pure, pharmacologically grade plant-based vitamin D2 (Ergocalciferol): • Chemical formula: C28H44O • Structure: Vitamin D2 is derived from ergosterol, a molecule found in plants and fungi. Its structure contains a steroid ring with a double bond in the side chain. • Source: Synthesized by plants and fungi when exposed to ultraviolet (UV) rays. Actions of vitamin D on brain cells 1. Neuronal protection: • Neuroprotective effects: Vitamin D has neuroprotective properties that help protect neurons against oxidative damage and degeneration. It also reduces the accumulation of toxic proteins, such as beta-amyloid, associated with Alzheimer's disease. • Prevention of apoptosis: Vitamin D helps prevent apoptosis (programmed cell death) of neurons by regulating cell signaling pathways. • Modulation of neurotransmission: • Neurotransmitter synthesis: Vitamin D is involved in the regulation of neurotransmitter synthesis, such as dopamine and serotonin, which play a crucial role in mood, cognition, and behavior. • GABA receptors: It influences GABA receptors, contributing to the modulation of neuronal excitability and the reduction of anxiety. • Promotion of neurogenesis and synaptic plasticity: • Neurogenesis: Vitamin D stimulates the formation of new neurons in the hippocampus, a brain region associated with memory and learning. • Synaptic plasticity: It promotes synaptic plasticity, which is essential for learning, memory, and cognitive adaptation. • Reduction of brain inflammation: • Modulation of brain cytokines: Vitamin D reduces brain inflammation by modulating levels of pro-inflammatory cytokines and increasing anti-inflammatory cytokines, thus contributing to a healthy brain environment. Conclusion

[0088] Vitamin D plays a multifaceted role in the body, ranging from the regulation of calcium and phosphorus metabolism to the modulation of the immune system and inflammation. In the brain, it exerts neuroprotective effects, regulates neurotransmission, promotes neurogenesis and synaptic plasticity, and reduces inflammation.

[0089] 7. Vitamin E Alpha-Tocopherol (of plant origin)

[0090] • Chemical formula: C29H50O2 o Powerful antioxidant, protects cells brain oxidative damage.

[0091] - Effects of vitamin E on the brain 1. Antioxidant protection: • Neutralization of free radicals: Vitamin E protects brain cells against oxidative damage by neutralizing free radicals. Free radicals can damage cell membranes, proteins, and DNA, thus contributing to neurodegeneration. • Protection of cell membranes: As a fat-soluble antioxidant, vitamin E localizes in cell membranes, where it protects membrane lipids from lipid peroxidation, thus maintaining the integrity and functionality of neuronal membranes. 2. Improvement of cognitive function: • Preservation of cognitive function: Adequate vitamin levels E are associated with better cognitive performance, particularly

[0092] in the elderly. It contributes to the preservation of cognitive functions and can help slow down age-related cognitive decline. • Prevention of neurodegenerative diseases: Vitamin E may play a protective role against neurodegenerative diseases such as Alzheimer's disease by reducing oxidative stress and protecting neurons. • Reduction of brain inflammation: • Cytokine modulation: Vitamin E has anti-inflammatory effects that help reduce inflammation in the brain. It can modulate the production of pro-inflammatory cytokines, thereby reducing inflammatory responses that can damage neurons. • Inhibition of inflammatory pathways: Vitamin E inhibits inflammatory signaling pathways, thereby reducing the activation of microglia and astrocytes, the immune cells of the brain. • Maintenance of neurotransmission: • Protection of synapses: By protecting neuronal membranes and reducing oxidative stress, vitamin E helps maintain the functionality of synapses, the communication points between neurons. • Influence on signaling: Vitamin E can influence neuronal signaling and neurotransmitter metabolism, thus contributing to efficient and balanced neurotransmission. • Prevention of neuronal apoptosis: • Protection against cell death: Vitamin E protects neurons against apoptosis (programmed cell death) induced by oxidative stress. By reducing oxidative damage, it helps maintain the survival of neuronal cells. • Regulation of survival genes: Vitamin E can influence the expression of genes involved in cell survival and stress response, thereby increasing the resistance of neurons to damage. Conclusion

[0093] Vitamin E plays a crucial role in protecting and maintaining brain health. Its antioxidant properties protect brain cells against oxidative damage and lipid peroxidation. It improves cognitive function, It reduces brain inflammation, maintains efficient neurotransmission, and prevents neuronal apoptosis. Therefore, an adequate intake of vitamin E is essential to protect the brain against aging and neurodegenerative diseases.

[0094] B. Analysis of the Composition of the Food Supplement

[0095] The combination of ingredients in NeuroZen Vital offers synergistic potential to support brain health and cognitive function. The essential oils of lavender, Roman chamomile, and bergamot provide anxiolytic and neuroprotective effects, while flaxseed oil, alpha-lipoic acid, vitamin D, and vitamin E provide anti-inflammatory, antioxidant, and neuroprotective effects. Together, these ingredients help reduce oxidative stress and inflammation and improve neurotransmission, thereby promoting overall brain health.

[0096] Stability: • Oxidation: Linseed oil is susceptible to oxidation. The addition of vitamin E improves its stability. • Interactions: Flaxseed oil, essential oils, alpha lipoic acid, vitamin D and E are biocompatible and synergistic. Synergy: • Linseed oil: Anti-inflammatory and cardiovascular properties. • Essential oils: Soothing, calming and neuroprotective effects. • Alpha lipoic acid: Protects against oxidative stress, regenerates other antioxidants. • Vitamin D: Vitamin D plays a crucial role in calcium regulation and neuronal health. It influences neurotransmitter production and plasticity. It is synaptic and protects against neuronal inflammation. Adequate vitamin D levels are associated with better cognitive function and a reduced risk of neurodegenerative diseases. • Vitamin E: Vitamin E protects neuronal cell membranes from oxidative damage by neutralizing free radicals. It is also involved in reducing inflammation and preventing the degradation of membrane lipids, which contributes to neuronal health and protection against neurodegenerative diseases.

[0098] C. Packaging of the food supplement

[0099] According to the preferred embodiment of the invention, the food supplement is packaged in vegetable capsules (Vcaps). • Description: Capsules made from plant-based materials such as hydroxypropyne imethoxycellulose (HPMC). • Advantages: Vegetarian alternatives to gelatin capsules, suitable for oils or oily solutions. • Suitable for vegans, vegetarians and omnivores. D. Quantitative composition of NeuroZen Vital for one size 0 capsule

[0100] According to the preferred embodiment of the invention, all the components of a NeuroZen Vital food supplement capsule are present in quantities corresponding to the Recommended Daily Allowance (RDA) by the High Authority for Health (HAS) for vitamins D and E as well as for omega-3. 1. Flaxseed oil (450 mg): 2. Essential oils: True Lavender (15 mg): - Linalool: CwHisO - Linalyl acetate: C12H2OO2 - Cineol (1,8-cineole): CwHisO - Camphor: CwHisO - Limonene: C10H16 - Ocimène: CwHw - Terpinene-4-ol: CwHisO - Lavandulol: CwHisO - Geraniol: CwHisO o Roman chamomile (10 mg): - Isobutyl angelate: C7H12O2 - Isoamyl angelate: C8H14O2 - Methylallyl angelate: C7H12O2 - Anthemis: CwHie - Pinocarvone: CwHi40 - Camphor: CwHisO - B-Farnesene: C15H24 o Bergamot (10 mg): - Limonene: CwHw - Linalool: CwHisO - Linalyl acetate: C12H2OO2 - Bergapten: C12H8O4 (a furocoumarin) - Nerol: CwHisO - Geraniol: CwHisO - Terpineol: CwHisO 1. Alpha lipoic acid C8H14O2S2 (R)-5-(l,2-dithiolan-3-yl) pentanoic acid (15 mg) 4.Vitamin E C29H50O2 Alpha-Tocopherol (5 mg)

[0101] 5.Vitamin D of plant origin (Ergocalciferol) C28H44O (0.02 mg / 20 pg)

[0102] E. Quantitative composition in percentage • Linseed oil: 89.11% • Lavender essential oil: 2.97% • Alpha lipoic acid: 2.97% • Roman chamomile essential oil: 1.98% • Bergamot essential oil: 1.98% • Vitamin E of plant origin: 0.99% • Vitamin D2 of plant origin: 0.00396% F. Therapeutic targets of the product:

[0103] • Addressing the causes of cellular aging:

[0104] o Oxidation, o Inflammation, o Glycation, o Stress, o

[0105] G. Use:

[0106] The food supplement according to the invention is presented in a form suitable for oral administration.

[0107] According to the preferred embodiment of the invention, the food supplement is in the form of a soft, plant-based capsule, size 0 or 00, gastro-resistant or acid-resistant for better absorption in the intestines. All the ingredients of the food supplement are exclusively fat-soluble for greater effectiveness.

[0108] The food supplement is reserved for adults from 15 years of age.

[0109] According to the preferred embodiment of the invention, the food supplement is intended for vegetarians, vegans and omnivores.

[0110] It can be used by taking one to two capsules daily.

[0111] Preferably, a course of treatment is recommended to improve brain function.

[0112] H. Benefits of the food supplement: • Neuroprotection through free radical neutralization • Protection of cell membranes and synaptic plasticity • Preservation of cognitive functions • Prevention of neurodegenerative diseases by reducing oxidative stress • Reduction of brain inflammation through cytokine modulation and inhibition of inflammatory pathways • Enhancement of neurotransmission by protecting synapses and influencing neuronal signaling, regulation of neurotransmitters such as dopamine and serotonin. • Prevention of neuronal apoptosis and stimulation of neurogenesis •

[0113] NeuroZen Vital protects the brain against aging and neurodegenerative diseases. It promotes neurogenesis, synaptic plasticity, and reduces inflammation.

[0114] A thorough study of the ingredients, their components and their synergy allows us to make the following claims:

[0115] I. Therapeutic effects of NeuroZen Vital: • Anxiolytic and antidepressant effects • Improved memory, concentration and learning, increased overall cognitive performance. • Improved mood and overall well-being • Sedative, analgesic and antispasmodic effects • Improved sleep quality: faster sleep onset, improved deep sleep without nighttime awakenings • Pain reduction and stimulation of the immune response • Reduction of stress and anxiety through the reduction of cortisol

Claims

Demands

1. Dietary supplement contains a vegetable oil, 3 essential oils and 2 fat-soluble vitamins and a powerful organic antioxidant.

2. The food supplement according to claim 1 contains the following ingredients: ab Linseed oil, Essential oils: • True lavender, • Roman chamomile, • Bergamot; cd Alpha lipoic acid; Vitamin D2 of plant origin; e. Vitamin E of plant origin.

4. The food supplement according to claim 3 comprises the following ingredients in the following quantities: a) Linseed oil: 89.11%; ab Lavender essential oil: 2.97%; Alpha lipoic acid: 2.97%; cd Roman chamomile essential oil: 1.98%; Bergamot essential oil: 1.98%; ef Vitamin E of plant origin: 0.99%; Vitamin D2 of plant origin: 0.00396%.

5. The food supplement according to claim 4 is presented in the form of a soft capsule, of vegetable origin 1' hydroxypropyl methylcellulose (HPMC).

6. The food supplement according to claim 5 can be used in a form suitable for oral administration for its use in supporting the health of the central and peripheral nervous systems.

7. Dietary supplement according to the preceding claims for its use in: Improved cognitive function, improved sleep quality, improved mood and overall well-being, reduced stress and anxiety Sedative, analgesic and antispasmodic effects Anxiolytic and antidepressant effects Pain reduction and stimulation of the immune response.

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